Omega-3 fatty acid concentrate from Dunaliella salina possesses anti-inflammatory properties including blockade of NF-κB nuclear translocation

References

• Cross RK, Wilson KT. Nitric oxide in inflammatory bowel disease. Inflammatory Bowel Diseases 2003;9:179–189
   PubMed Web of Science ®Google Scholar
• Uto T, Suangkaew N, Morinaga O, et al. Eriobotryae folium extract suppresses LPS-induced iNOS and COX-2 expression by inhibition of NF-kappaB and MAPK activation in murine macrophages. Am J Chin Med 2010;38:985–994
   PubMed Web of Science ®Google Scholar
• Li Q, Verma IM. NF-kappaB regulation in the immune system. Nat Rev Immunol 2002;2:725–734
   PubMed Web of Science ®Google Scholar
• Arend WP, Gabay C. Cytokines in the rheumatic diseases. Rheumat Dis Clin North Am 2004;30:41–67
   PubMed Web of Science ®Google Scholar
• Beinke S, Ley SC. Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem J 2004;382:393–409
   PubMed Web of Science ®Google Scholar
• Sarada S, Himadri P, Mishra C, et al. Role of oxidative stress and NFkB in hypoxia-induced pulmonary edema. Exp Biol Med (Maywood) 2008;233:1088–1098
   PubMed Web of Science ®Google Scholar
• Parks WC, Wilson CL, Lopez-Boado YS. Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat Rev Immunol 2004;4:617–629
   PubMed Web of Science ®Google Scholar
• Goetzl EJ, Banda MJ, Leppert D. Matrix metalloproteinases in immunity. J Immunol 1996;156:1–4
   PubMed Web of Science ®Google Scholar
• Calder PC. Polyunsaturated fatty acids, inflammation, and immunity. Lipids 2001;36:1007–1024
   PubMed Web of Science ®Google Scholar
• Calder PC. Dietary modification of inflammation with lipids. Proc Nutr Soc 2002;61:345–358
   PubMed Web of Science ®Google Scholar
• Fisher M, Pick U, Zamir A. A salt-induced 60-kilodalton plasma membrane protein plays a potential role in the extreme halotolerance of the alga Dunaliella. Plant Physiol 1994;106:1359–1365
   PubMed Web of Science ®Google Scholar
• Griffiths M, Harrison SL. Lipid productivity as a key characteristic for choosing algal species for biodiesel production. J Appl Phycol 2009;21:493–507
   Web of Science ®Google Scholar
• Guillard RR, Ryther JH. Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran. Can J Microbiol 1962;8:229–239
   PubMed Web of Science ®Google Scholar
• Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959;37:911–917
   PubMedGoogle Scholar
• Christie WW. Gas chromatography and lipids: a practical guide. Bridgwater, Somerset, England: The Oily Press; 1989
   Google Scholar
• Farag MA, Huhman DV, Lei Z, Sumner LW. Metabolic profiling and systematic identification of flavonoids and isoflavonoids in roots and cell suspension cultures of Medicago truncatula using HPLC-UV-ESI-MS and GC-MS. Phytochemistry 2007;68:342–354
   PubMed Web of Science ®Google Scholar
• Radhika A, Jacob SS, Sudhakaran PR. Influence of oxidatively modified LDL on monocyte-macrophage differentiation. Mol Cell Biochem 2007;305:133–143
   PubMed Web of Science ®Google Scholar
• Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265–275
   PubMed Web of Science ®Google Scholar
• Sladowski D, Steer SJ, Clothier RH, Balls M. An improved MTT assay. J Immunol Methods 1993;157:203–207
   PubMed Web of Science ®Google Scholar
• Engvall E, Perlmann P. Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. Immunochemistry 1971;8:871–874
   PubMedGoogle Scholar
• Herren B, Levkau B, Raines EW, Ross R. Cleavage of beta-catenin and plakoglobin and shedding of VE-cadherin during endothelial apoptosis: evidence for a role for caspases and metalloproteinases. Mol Biol Cell 1998;9:1589–1601
   PubMed Web of Science ®Google Scholar
• Douglas G, Hayes YCB, Van Alstine JM, Setterwall F. Urea complexation for the rapid, ecologically responsible fractionation of fatty acids from seed oil. J Am Oil Chemists’ Soc 1998;75:1403–1409
   Web of Science ®Google Scholar
• Bar-Or A, Nuttall RK, Duddy M, et al. Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis. Brain 2003;126:2738–2749
   PubMed Web of Science ®Google Scholar
• Kuwano T, Nakao S, Yamamoto H, et al. Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis. FASEB J 2004;18:300–310
   PubMed Web of Science ®Google Scholar
• Kim SY, Jun TW, Lee YS, et al. Effects of exercise on cyclooxygenase-2 expression and nuclear factor-kappaB DNA binding in human peripheral blood mononuclear cells. Ann NY Acad Sci 2009;1171:464–471
   PubMed Web of Science ®Google Scholar
• King CC, Sastri M, Chang P, et al. The rate of NF-kappaB nuclear translocation is regulated by PKA and A kinase interacting protein 1. PLoS One 2011;6:e18713
   PubMed Web of Science ®Google Scholar
• Scott ML, Fujita T, Liou HC, et al. The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms. Genes Dev 1993;7:1266–1276
   PubMed Web of Science ®Google Scholar
• Olinga P, Merema MT, de Jager MH, et al. Rat liver slices as a tool to study LPS-induced inflammatory response in the liver. J Hepatol 2001;35:187–194
   PubMed Web of Science ®Google Scholar
• O'Shea JJ, Ma A, Lipsky P. Cytokines and autoimmunity. Nat Rev Immunol 2002;2:37–45
   PubMed Web of Science ®Google Scholar
• Simon LS. Role and regulation of cyclooxygenase-2 during inflammation. American J Med 1999;106:37S–42S
   PubMedGoogle Scholar
• Cerchietti LC, Navigante AH, Castro MA. Effects of eicosapentaenoic and docosahexaenoic n-3 fatty acids from fish oil and preferential Cox-2 inhibition on systemic syndromes in patients with advanced lung cancer. Nutr Cancer 2007;59:14–20
   PubMed Web of Science ®Google Scholar
• Grimble RF, Howell WM, O'Reilly G, et al. The ability of fish oil to suppress tumor necrosis factor alpha production by peripheral blood mononuclear cells in healthy men is associated with polymorphisms in genes that influence tumor necrosis factor alpha production. Am J Clin Nutr 2002;76:454–459
   PubMed Web of Science ®Google Scholar
• Lo CJ, Chiu KC, Fu M, et al. Fish oil decreases macrophage tumor necrosis factor gene transcription by altering the NF kappa B activity. J Surgical Res 1999;82:216–221
   PubMed Web of Science ®Google Scholar
• Chisti Y. Biodiesel from microalgae. Biotechnol Adv 2007;25:294–306
   PubMed Web of Science ®Google Scholar
• Bernstein AM, Ding EL, Willett WC, Rimm EB. A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease. J Nutr 2012;142:99–104
   PubMed Web of Science ®Google Scholar
• Park DH, Ruy HW, Lee KY, et al. The production of hydrocarbons from photoautotrophic growth of Dunaliella salina 1650. Appl Biochem Biotechnol 1998;70–72:739–746
   PubMed Web of Science ®Google Scholar
• Sara Rasoul-Amini PM, Montazeri-Najafabady N, et al. Biodiesel properties of native strain of Dunaliella Salina. Int J Renewable Energy Res 2014;4:39–41
   Google Scholar
• Corbel M, Boichot E, Lagente V. Role of gelatinases MMP-2 and MMP-9 in tissue remodeling following acute lung injury. Brazil J Med Biol Res 2000;33:749–754
   PubMed Web of Science ®Google Scholar
• Xu X, Jackson PL, Tanner S, et al. A self-propagating matrix metalloprotease-9 (MMP-9) dependent cycle of chronic neutrophilic inflammation. PLoS One 2011;6:e15781
   PubMed Web of Science ®Google Scholar
• Lee YC, Lee HB, Rhee YK, Song CH. The involvement of matrix metalloproteinase-9 in airway inflammation of patients with acute asthma. Clin Exp Allergy 2001;31:1623–1630
   PubMed Web of Science ®Google Scholar
• Wenzel SE, Balzar S, Cundall M, Chu HW. Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation, and wound repair. J Allergy Clin Immunol 2003;111:1345–1352
   PubMed Web of Science ®Google Scholar
• Shapiro SD, Senior RM. Matrix metalloproteinases. Matrix degradation and more. Am J Respir Cell Mol Biol 1999;20:1100–1102
   PubMed Web of Science ®Google Scholar
• Shinto L, Marracci G, Bumgarner L, Yadav V. The effects of omega-3 Fatty acids on matrix metalloproteinase-9 production and cell migration in human immune cells: implications for multiple sclerosis. Autoimmune Dis 2011;2011:Article ID 134592, 6 pages
   PubMedGoogle Scholar
• Li X, Yu Y, Funk CD. Cyclooxygenase-2 induction in macrophages is modulated by docosahexaenoic acid via interactions with free fatty acid receptor 4 (FFA4). FASEB J 2013;27:4987–4997
   PubMed Web of Science ®Google Scholar
• Aggarwal BB, Shishodia S. Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning. Ann NY Acad Sci 2004;1030:434–441
   PubMed Web of Science ®Google Scholar
• Celec P. Nuclear factor kappa B-molecular biomedicine: the next generation. Biomed Pharmacother 2004;58:365–371
   PubMed Web of Science ®Google Scholar
• Baeuerle PA, Baltimore D. NF-kappa B: ten years after. Cell 1996;87:13–20
   PubMed Web of Science ®Google Scholar
• Hayden MS, Ghosh S. Signaling to NF-kappaB. Genes Dev 2004;18:2195–2224
   PubMed Web of Science ®Google Scholar
• Israel A. The IKK complex: an integrator of all signals that activate NF-kappaB? Trends Cell Biol 2000;10:129–133
   PubMed Web of Science ®Google Scholar