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Research Article

In Vitro Inhibition of Cellular Immune Responses by Benzodiazepines and Pk 11195 Effects on Mitogen-and Alloantigen-driven Lymphocyte Proliferation and on IL-1, IL-2 Synthesis and IL-2 Receptor Expression

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Pages 557-582 | Published online: 28 Sep 2008

References

  • Tecoma E., Huey L. Psychic distress and the immune response. Life Sci. 1985; 36: 1799
  • Skolnick P., Paul S. M. Molecular pharmacology of the benzodiazepines. Int. Rev. Neurobiol. 1982; 23: 103
  • Marangos P. J., Patel J., Boulenger J. P., Clark-Rosenberg R. Characterization of peripheral-type benzodiazepine binding sites in brain using [3H] Ro 5–4864. Mol. Pharmac 1982; 22: 26
  • Zavala F., Lenfant M. Benzodiazepines and PK 11195 exert im-munomodulating activities by binding on a specific receptor on macrophages. Ann. New York Acad. Sci. 1987; 496: 240
  • Schlumpf M., Parmar R., Ramseier H, Lichtensteiger W. Prenatal benzodiazepine induced immunosuppression: possible involvement of peripherall benzodiazepine site. Dev. Pharmac. Ther. 1990; 15: 178
  • Schlumpf M., Pamar R., Ramseier H., Lichtensteiger A. Prenatal benzodiazepine induced immunosuppression: possible involvement of peripheral benzodiazepine sites. Dev. Pharmac. Ther. 1992, in press
  • Dinarello C. A., Mier J. W. Lymphokines. New Engl. J. Med. 1987; 317: 940
  • Smith K. A. lnterleukin-2: inception, impact, and implications. Science 1988; 240: 1169
  • Balkwill F. R., Burke F. The cytokine network. Immun. Today 1989; 10: 299
  • Dinarello C. A. lnterleukin-1 and its biologically related cytokines. Adv. Immmun. 1989; 44: 153
  • Munoz E., Beutner U., Zubiaga A., Huber B. IL-1 activates two separate signal transduction pathways in T helper type II cells. J. Immun. 1990; 144: 964
  • Weaver C. T., Unanue E. R. The costimulatory function of antigen-presenting cells. Immun. Today 1990; 11: 49
  • Swain S. L. Lymphokines and the immune response: the central role of interleukin-2. Curr. Opin. Immun. 1991; 3: 304
  • Smith K. A. The interleukin-2 receptor. Ann. Rev. Cell. Biol. 1989; 5: 397
  • Click R. E., Benck L., Alter B. J. Immune responses in vitro. Culture conditions for antibody synthesis. Cell. Immunol. 1972; 3: 264
  • Ramseier H. Reconstitution of primary mixed-lymphocyte culture reactions inhibited with class I antibodies by a product of histoincompatible spleen cells. Cell. Immunol. 1987; 110: 95
  • Kaye J., Porcelli S., Tite J., Jones B., Janeway C. A. Both a monoclonall antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen presenting cells in the activation of T cells. J. Exp. Med. 1983; 158: 836
  • Drach J., Gattringer C., Glassl H., Schwarting R., Stein H., Huber H. Simultaneous flow cytometric analysis of surface markers and nuclear Ki-67 antigen in leukemia and lymphoma. Cytometry 1989; 10: 743
  • Hansen T. H., Spinella D. G., Lee D. R., Shreffler D. C. The im-munogenetics of the mouse histocompatibility complex. Annu. Rev. Genet. 1984; 18: 99
  • Schlumpf M., Ramseier H., Lichtensteiger W. Prenatal diazepam induced persisting depression of cellular immune responses. Life Sci. 1989; 44: 493
  • Greenblatt D. J., Shader R. I. Benzodiazepines in clinical practice. Raven Press, New York 1974
  • Rey E., d'Athis Ph., Giraux P., de Lauture D., Turquais J. M., Chavinie J., Olive G. Pharmacokinetics of chlorazepate in pregnant and non-pregnant women. Eur. J. clin. Pharmacol. 1979; 15: 175
  • Mosmann T. R., Coffman R. L. TH1 and TH2 cells: Different patterns of lympnokine secretion lead to different functional properties. Ann. Rev. Immunol. 1989; 7: 145
  • Coffman R. L., Seymour B. W., Lebman D. A., Hiraki D. D., Christiansen J. A., Shrader B., Cherwinski H. M., Savelkoul H. F.J., Finkelman F. D., Bond M. W., Mosmann T. R. The role of helper T cell products in mouse B cell differentiation and isotope regulation. Immunol. Rev. 1988; 102: 5
  • Stevens T. L., Bossie A., Sanders V. M., Fernadez-Botran R., Coffman R. L., Mosmann T. R, Vitetta E. S. Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells. Nature 1988; 334: 255
  • Descotes J., Tedone R., Evreux J. C. Suppression of humoral and cellular immunity in normal mice by diazepam. Immunol. Letters 1982; 5: 41
  • Ballantyne D. L, Harper A. D. Prolongation of skin allograft survival by valium (diazepam). Transplant. Proa 1975; 7: 581
  • Ballantyne D. L., Harper A. D. Prologation of survival in mouse tail skin allografts by valium (diazepam). Transplantation 1977; 23: 163
  • Laschi A., Descotes J., Tachon P., Evreux J. C. Adverse influence of diazepam upon resistance to Klebsiella pneumoniae infection in mice. Toxicol. Lett. 1983; 16: 281
  • Arora P. K., Hanna E. E., Paul S. M., Skolnick P. Suppression of the immune response by benzodiazepine receptor inverse agonists. J. Neuroimmunol. 1987; 15: 1
  • Richards G., Möhler H., Haefely W. Benzodiazepine receptors and their ligands, in Mechanisms of Drug Action, G. N. Woodruff. MacMillan, London 1986; Vol. 1: 131
  • Cantrell D. A., Smith K. A. The interleukin 2 T-cell system: a new cell growth model. Science 1984; 224: 1312
  • Covelli V., Decandia P., Altamura M., Jirillo E. Diazepam inhibits phagocytosis and killing exerted by polymorphonuclear cells and monocytes from healthy donors. In vitro studies. Immunopharmacol. Immunotoxicol. 1989; 11: 701
  • Krumholz W., Käbisch S., Biscoping J., Hempelman G. Ueber Veränderung der Adhärenz polymorphkerniger neutrophiler Granulozyten durch die interavenösen Anästhetika Midazolam und Ketamin, Anästh. Intensivther. Notfallmed. 1987; 22: 211
  • Zavala F., Taupin V., Descamps-Latscha B. In vivo treatment with benzodiazepines inhibits murine phagocyte oxidative metabolism and production of interleukin 1, tumor necrosis factor and interleukin-6. J. Pharmacol, exp. Ther. 1990; 255: 442
  • Chang M. P., Castle S. C., Norman D. C. Suppressive effects of alprazolam on the immune response of mice. Int. J. Immunopharmac 1991; 13: 259
  • Stoeck M., Lees M., Szamel M., Pantaleo G., MacDonald H. R. Comparison of phorbol-12-myristate-13-acetate and diactanoyl-ns-glyc-erol in the activation of EL4/6.1 thymoma cells. J. Cell. Physiol. 1989; 138: 541
  • Szamei M. M., Kracht B., Krebs B., Hubner U., Resch K. Activation signals in human lymphocytes: interleukin 2 synthesis and expression of high affinity interleukin 2 receptors require differential signalling for the activation of protein kinase C. Cell. Immun. 1990; 126: 117
  • Neckers L. M., Bauer S., McGlennen R. C., Trepel J. B., Rao K., Greene W. C. Diltiazem inhibits transferrin receptor expression and causes G1 arrest in normal and neoplastic T cells. Mol. Cell Biol. 1986; 6: 4244
  • Chang M. P., Castle S. C., Norman D. C. Mechanism of immunosuppressive effect of alprazolam: alprazolam suppresses T-cell proliferation by selectively inhibiting the production of IL2 but not acquisition of IL2 receptor. Int. J. Immunopharmac 1992; 14: 227

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