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Immunopharmacology and Immunotoxicology Volume 17, 1995 - Issue 4
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Research Article

Detoxified Venom from Crotalus Durissus Terrificus is Devoid of Cytotoxic Activity and Induces Mitogenesis

L. Flores-Romo Department of Immunology, Birmingham University, Birmingham, England
,
Luiz G.D. Heneine Department of Immunology, Birmingham University, Birmingham, England
&
Ibrahim F. Heneine Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, 31 270-901, Belo Horizonte, MG, Brazil
Pages 783-789 | Published online: 27 Sep 2008

References

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  • Tu A. T. Snake Venoms: properties and actions. Snake Venoms: chemistry and molecular biology. John Wiley & Sons, New York 1977
  • Lewis G. M., Minton S. A., Slack J. H. BALB/cAn B cells and T cells have distinct susceptibilities to cytotoxic effects of snake venoms. Toxicon 1990; 28: 351–358
  • WHO. Progress in Characterization and Standartization of Antivenoms. WHO Offset Publication, Geneva 1981; 8–9, N. 58
  • Heneine L. G.D., Cardoso V. N., Daniel J. P., Heneine I. F. Detoxification of the T2 fraction from a scorpion (Tityus serrulatus, Lutz and Mello) venom by iodination and some immunogenic properties of the derivatives. Toxicon 1986; 24: 501–505
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  • Bicalho R. X., Rocha O. A., Heneine L. G.D., Magalhães A., Heneine I. F. The effect of stepwise iodination on biological properties of Bothrops jararaca venom. Toxicon 1990; 28: 171–179
  • Rocha O. A., Silveira J. N., Lopes E. S., Bicalho A. F.X., Heneine I. F. A Nontoxic Derivative of Bothrops jararaca Venom Suitable to Generate Antisera Against the Native Venom. Dtsch. tierärtzl. Wschr. 1992; 99: 143–145
  • Soares H. R., Nunes R. L., Prado S. M.A., Higashi H. G., Heneine I. F. An effective toxoid from tetanus toxin prepared by stepwise iodination of purified toxin. Biologicals 1994; 22: 29–33
  • Heneine I. F., Lahmann W. M., Rocha O. A. A toxoid prepared from cholera toxin by iodination. Brazilian J. Med. Biol. Res. 1992; 25: 913–917
  • Heneine I. F., Rocha O. A., Cassali G. D. The effect of cholera toxin and its toxoid on ileal loops of the rat. Mem. Inst. Oswaldo Cruz 1994; 89(1)117
  • Passos M. R., Chavez C. O., Pereira L. H., Chamone M., Heneine I. F. Iodinated Soluble Worm Adult Proteins (SWAP) Preparations from Schistosoma mansoni Are Unable to Induce Immediate Hypersensitivity Reactions but Retain Other Immunogenic Properties. Brazilian J. Med. Biol. Res. 1991; 24: 787–790
  • Borkow G., Chaim-Mathyas A., Ovadia M. Effect of iodination on the activity of cytotoxin P4 of Naja nigricollis nigricolis. Biochem. Internat. 1991; 25: 261–269
  • Flores-Romo L., Foster D., Guy G. R., Gordon J. Phorbol ester and calcium ionophore are sufficient to promote cell replication in cultures of quiescent human B lymphoctes. Immunology 1989; 66: 228–232

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