Glycine Pretreatment Ameliorates Liver Injury After Partial Hepatectomy in the Rat

REFERENCES

• Giakoustidis D, Papageorgiou G, Iliadis S, Intramuscular administration of very high dose of α-tocopherol protects liver from severe ischemia/reperfusion injury. World J Surg. 2002;26:872–877.
   PubMed Web of Science ®Google Scholar
• Bailey SM, Reinke LA. Antioxidants and gadolinium chloride attenuate hepatic parenchymal and endothelial cell injury induced by low flow ischemia and reperfusion in perfused rat livers. Free Rad Res. 2000;32:497–506.
   PubMed Web of Science ®Google Scholar
• Bartels M, Biesalski HK, Engelhart K, Pilot study on the effect of parenteral vitamin E on ischemia and reperfusion induced liver injury: a double blind, randomized, placebo-controlled trial. Clin Nutr. 2004;23:1360–1370.
   PubMed Web of Science ®Google Scholar
• Rauen U, Polzar B, Stephan H, Cold-induced apoptosis in cultured hepatocytes and liver endothelial cells: mediation by reactive oxygen species. FASEB J. 1999;13:155–168.
   PubMed Web of Science ®Google Scholar
• Saller R, Meier R, Brignoli R. The use of silymarin in the treatment of liver diseases. Drugs. 2001;61:2035–2063.
   PubMed Web of Science ®Google Scholar
• de Groot H, Rauen U. Tissue injury by reactive oxygen species and the protective effect of flavonoids. Fundam Clin Pharmacol. 1998;12:249–255.
   PubMed Web of Science ®Google Scholar
• Carini R, Bellomo G, de Cesaris MG, Glycine protects against hepatocyte killing by KCN or hypoxia by preventing intracellular Na++ overload in the rat. Hepatology. 1997;26:107–112.
   PubMed Web of Science ®Google Scholar
• Brecht M, de Groot H. Protection from hypoxic injury in cultured hepatocytes by glycine, alanine, and serine. Amino Acids. 1994;6:25–35.
   PubMed Web of Science ®Google Scholar
• Frank A, Rauen U, de Groot H. Protection by glycine against hypoxic injury of rat hepatocytes: inhibition of ion fluxes through nonspecific leaks. J Hepatol. 2000;32:58–66.
   PubMed Web of Science ®Google Scholar
• Dong Z, Patel Y, Saikumar P, Development of porous defects in plasma membranes of adenosine triphosphate-depleted Madin-Darby canine kidney cells and its inhibition by glycine. Lab Invest. 1998;78:657–668.
   PubMed Web of Science ®Google Scholar
• Marsh DC, Vreugdenhil PK, Mack VE, Glycine protects hepatocytes from injury caused by anoxia, cold ischemia, and mitochondrial inhibitors, but not injury caused by calcium ionophors or oxidative stress. Hepatology. 1993;17:91–98.
   PubMed Web of Science ®Google Scholar
• Nichols JC, Bronk SF, Mellgren RL, Inhibition of nonlysosomal calcium-dependent proteolysis by glycine during anoxic injury of rat hepatocytes. Gastroenterology. 1994;106:168– 176.
   PubMed Web of Science ®Google Scholar
• Moran JH, Schnellmann, RG. Diverse cytoprotectants prevent cell lysis and promote recovery of respiration and ion transport. Biochem Biophys Res Commun. 1997;234:275–277.
   PubMed Web of Science ®Google Scholar
• Schemmer P, Enomoto N, Bradford BU, Activated Kupffer cells cause a hypermetabolic state after gentle in situ manipulation of liver in rats. Am J Physiol. 2001;280:G1076–G1082.
   Google Scholar
• Schemmer P, Schoonhoven R, Swenberg JA, Gentle in situ liver manipulation during organ harvest decreases survival after rat liver transplantation: role of Kupffer cells. Transplantation. 1998;65:1015–1020.
   PubMed Web of Science ®Google Scholar
• Schemmer P, Mehrabi A, Kraus T, New aspects on reperfusion injury to the liver—impact of organ harvest. Nephrol Dial Transplant. 2004;19(Suppl 4):iv26–iv35.
   PubMedGoogle Scholar
• Crocenzi FA, Sánchez Pozzi EJ, Pellegrino JM, Beneficial effects of silymarin on estrogen-induced cholestasis in the rat: a study in vivo and in isolated hepatocyte couplets. Hepatology. 2001;34:329–339.
   PubMed Web of Science ®Google Scholar
• Higgins GM, Anderson RM. Experimental pathology of the liver. I. Restoration of the liver of the white rat following partial surgical removal. Arch Pathol. 1931;12:186–202.
   Google Scholar
• Weinberg JM. The effect of amino acids on ischemic and toxic injury to the kidney. Semin Nephrol. 1990;10:491–500.
   PubMed Web of Science ®Google Scholar
• Zhang K, Weinberg JM, Venkatachalam MA, Glycine protection of PC-12 cells against injury by ATP depletion. Neurochem Res. 2003;28:893–901.
   PubMed Web of Science ®Google Scholar
• Nishimura Y, Lemasters JJ. Glycine blocks opening of a death channel in cultured hepatic sinusoidal endothelial cells during chemical hypoxia. Cell Death Differ. 2001;8:850–858.
   PubMed Web of Science ®Google Scholar
• Omasa M, Fukuse T, Toyokuni S, Glycine ameliorates lung reperfusion injury after cold preservation in an ex vivo rat lung model. Transplantation. 2003;75:591–598.
   PubMed Web of Science ®Google Scholar
• Ruiz-Meana M, Pina P, Garcia-Dorado D, Glycine protects cardiomyocytes against lethal reoxygenation injury by inhibiting mitochondrial permeability transition. J Physiol. 2004;558:873–882.
   PubMed Web of Science ®Google Scholar
• Zhong Z, Wheeler MD, Li X, L-Glycine: a novel anti-inflammatory, immunomodulatory, and cytoprotective agent. Curr Opin Clin Nutr Metab Care. 2003;6:229–240.
   PubMed Web of Science ®Google Scholar
• Ikejima K, Qu W, Stachlewitz RF, Kupffer cells contain a glycine-gated chloride channel. Am J Physiol. 1997;272:G1581–G1586.
   PubMed Web of Science ®Google Scholar
• Fandrey J, Gorr TA, Gassmann M. Regulating cellular oxygen sensing by hydroxylation. Cardiovasc Res. 2006;71:642–651.
   PubMed Web of Science ®Google Scholar
• Semenza GL. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol. 1999;15:551–578.
   PubMed Web of Science ®Google Scholar
• Wenger RH. Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. FASEB J. 2002;16:1151–1162.
   PubMed Web of Science ®Google Scholar
• Mole DR, Ratcliffe PJ. Cellular oxygen sensing in health and disease. Pediatr Nephrol. 2008;23:681–694.
   PubMed Web of Science ®Google Scholar
• Frede S, Berchner-Pfannschmidt U, Fandrey J. Regulation of hypoxia-inducible factors during inflammation. Methods Enzymol. 2007;435:405–419.
   PubMed Web of Science ®Google Scholar
• Zhou J, Brüne B. Cytokines and hormones in the regulation of hypoxia inducible factor-1alpha (HIF-1alpha). Cardiovasc Hematol Agents Med Chem. 2006;4:189–197.
   PubMedGoogle Scholar
• Milkiewicz M, Doyle JL, Fudalewski T, HIF-1a and HIF-2a play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle. J Physiol. 2007;583:753–766.
   PubMed Web of Science ®Google Scholar
• Milkiewicz M, Haas TL. Effect of mechanical stretch on HIF-1a and MMP-2 expression in capillaries isolated from overloaded skeletal muscles: laser capture microdissection study. Am J Physiol Heart Circ Physiol. 2005;289:H1315–H1320.
   Web of Science ®Google Scholar
• Man K, Lo C-M, Ng IO-L, Liver transplantation in rats using small-for-size grafts: a study of hemodynamic and morphological changes. Arch Surg. 2001;136:280–285.
   PubMedGoogle Scholar
• Selzner N, Selzner M, Tian Y, Cold ischemia decreases liver regeneration after partial liver transplantation in the rat: a TNF-α/IL-6-dependent mechanism. Hepatology. 2002;36:812–818.
   PubMed Web of Science ®Google Scholar
• Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine. Oxford: Oxford University Press; 1999:200–219.
   Google Scholar
• Dehmlow C, Erhard J, de Groot H. Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silibinin. Hepatology. 1996;23:749–754.
   PubMed Web of Science ®Google Scholar
• Dehmlow C, Murawski N, de Groot H. Scavenging of reactive oxygen species and inhibition of arachidonic acid metabolism by silibinin in human cells. Life Sci. 1996;58:1591–1600.
   PubMed Web of Science ®Google Scholar