Vascular Endothelial Growth Factor Receptor-1 Activation Mediates Epithelial to Mesenchymal Transition in Hepatocellular Carcinoma Cells

REFERENCES

• Altekruse SF, McGlynn KA, Reichman ME. Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J Clin Oncol. 2009;27(9):1485–1491.
   PubMed Web of Science ®Google Scholar
• Fong G-H, Rossant J, Gertsenstein M, Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 1995;376:66–70.
   PubMed Web of Science ®Google Scholar
• Junhua A, Shuguo Z, Yongyi Z, Expression and significance of vascular endothelial growth factor and its receptors in hepatocellular carcinoma cell lines with various potentiality of metastasis. Zhonghua Ganzangbing Zazhi 2008;16:105–108.
   Google Scholar
• Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002;2:442–454.
   PubMed Web of Science ®Google Scholar
• Elliott BE, Hung WL, Boag AH, The role of hepatocyte growth factor (scatter factor) in epithelial-mesenchymal transition and breast cancer. Can J Physiol Pharmacol. 2002;80(2):91–102.
   Google Scholar
• Thiery JP, Chopin D. Epithelial cell plasticity in development and tumor progression. Cancer Metastasis Rev. 1999;18:31–42.
   PubMed Web of Science ®Google Scholar
• Bates RC, Goldsmith JD, Bachelder RE, Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids. Curr Biol CB. 2003;13(19):1721–1727.
   Google Scholar
• Akagi M, Kawaguchi M, Liu W, Induction of neuropilin-1 and vascular endothelial growth factor by epidermal growth factor in human gastric cancer cells. Br J Cancer 2003;88:796–802.
   Google Scholar
• Cavallaro U, Christofori G. Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer 2004;4:118–132.
   PubMed Web of Science ®Google Scholar
• Nieto MA. The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol. 2002;3:155–166.
   PubMed Web of Science ®Google Scholar
• Ferrara N, Gerber H-P, LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003;9:669–676.
   PubMed Web of Science ®Google Scholar
• Plouet J, Moukadiri H. Characterization of the receptor to vasculotropin on bovine adrenal cortex-derived capillary endothelial cells. J Biol Chem. 1990;265:22071–22074.
   PubMed Web of Science ®Google Scholar
• Barleon B, Sozzani S, Zhou D, Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 1996;87:3336–3343.
   PubMed Web of Science ®Google Scholar
• LeCouter J, Moritz DR, Li B, Angiogenesis-independent endothelial protection of liver: role of VEGFR-1. Science 2003;299:890–893.
   Google Scholar
• Wu Y, Zhong Z, Huber J, Anti-vascular endothelial growth factor receptor-1 antagonist antibody as a therapeutic agent for cancer. Clin Cancer Res. 2006;12(21):6573–6584.
   PubMed Web of Science ®Google Scholar
• Shibuya M. Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis. J Biochem Mol Biol. 2006;39(5):469–478.
   PubMedGoogle Scholar
• Kosaka Y, Mimori K, Fukagawa T, Identification of the high-risk group for metastasis of gastric cancer cases by vascular endothelial growth factor receptor-1 overexpression in peripheral blood. Br J Cancer 2007;96(11):1723–1728.
   Google Scholar
• Boocock CA, Charnock-Jones DS, Sharkey AM, Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma. J Natl Cancer Inst. 1995;87: 506–516.
   PubMed Web of Science ®Google Scholar
• Ferrer FA, Miller LJ, Lindquist R, Expression of vascular endothelial growth factor receptors in human prostate cancer. Urology 1999;54:567–572.
   PubMed Web of Science ®Google Scholar
• Decaussin M, Sartelet H, Robert C, Expression of vascular endothelial growth factor (VEGF) and its two receptors (VEGF-R1-Flt1 and VEGF-R2-Flk1/KDR) in nonsmall cell lung carcinomas (NSCLCs): correlation with angiogenesis and survival. J Pathol. 1999;188:369–377.
   PubMed Web of Science ®Google Scholar
• Zhang H, Wu J, Meng L, Expression of vascular endothelial growth factor and its receptors KDR and Flt-1 in gastric cancer cells. World J Gastroenterol. 2002;8:994–998.
   Google Scholar
• Graeven U, Fiedler W, Karpinski S, Melanoma-associated expression of vascular endothelial growth factor and its receptors FLT-1 and KDR. J Cancer Res Clin Oncol. 1999;125:621–629.
   PubMed Web of Science ®Google Scholar
• Boyer B, Vallés AM, Edme N. Induction and regulation of epithelial-mesenchymal transitions. Biochem Pharmacol. 2000;60:1091–1099.
   PubMed Web of Science ®Google Scholar
• Wanga F, Kaurb S, Cavinc LG, Nuclear-factor-κB (NF-κB) and radical oxygen species play contrary roles in transforming growth factor-b1 (TGF-b1)-induced apoptosis in hepatocellular carcinoma (HCC) cells. Biochem Bioph Res Commun. 2008;10:1–6.
   Google Scholar
• Sabbah M, Emami S, Redeuilh G., et al. Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers. Drug Resist Update. 2008;11:123–151.
   PubMed Web of Science ®Google Scholar
• Graff JR, Greenberg VE, Herman JG, Distinct patterns of E-cadherin CpG island methylation in papillary, follicular, Hurthle's cell, and poorly differentiated human thyroid carcinoma. Cancer Res. 1998;58:2063–2066.
   PubMed Web of Science ®Google Scholar
• Hurwitz H, Fehrenbacher L, Novotny W, Bevacizumab plUA irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004;350:2335–2342.
   PubMed Web of Science ®Google Scholar
• Akagi M, Kawaguchi M, Liu W, Induction of neuropilin-1 and vascular endothelial growth factor by epidermal growth factor in human gastric cancer cells. Br J Cancer. 2003;88:796–802.
   Google Scholar
• Jung YD, Nakano K, Liu W, Extracellular signal-regulated kinase activation is required for up-regulation of vascular endothelial growth factor by serum starvation in human colon carcinoma cells. Cancer Res. 1999;59:4804–4807.
   PubMed Web of Science ®Google Scholar
• Lim SO, Gu JM, Kim MS, Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter. Gastroenterology 2008;135(6):2128–2140.
   PubMed Web of Science ®Google Scholar
• Cannito S, Novo E, Compagnone A, Redox-sensitive Gsk-3beta inhibition and late VEGF release mediate hypoxia-dependent epithelial-mesenchymal transition and increased invasiveness in human HEPG2 cells. J Hepatol. 2008;48(Suppl. 2):S58–S59.
   Google Scholar
• Ansieau S, Bastid J, Doreau A, Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. Cancer Cell 2008;14(1): 79–89.
   PubMed Web of Science ®Google Scholar
• Gavert N, Ben-Ze'ev A. Epithelial–mesenchymal transition and the invasive potential of tumors. Trend Mol Med. 2008;14(5):199–209.
   Google Scholar