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Inhalation Toxicology
International Forum for Respiratory Research
Volume 21, 2009 - Issue 13
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Research Article

Source category-specific PM2.5 and urinary levels of Clara cell protein CC16. The ULTRA study

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Pages 1068-1076 | Received 21 Dec 2007, Accepted 06 Jan 2009, Published online: 23 Oct 2009

References

  • Andersson L, Lundberg PA, Barregard L. Methodological aspects on measurement of Clara cell protein in urine as a biomarker for airway toxicity, compared with serum levels. Journal of Applied Toxicology 2007; 27(1): 60–66.
  • Blomberg A, Mudway I, Svensson M, Hagenbjork-Gustafsson A, Thomasson L, Helleday R, et al. Clara cell protein as a biomarker for ozone-induced lung injury in humans. European Respiratory Journal 2003; 22(6): 883–888.
  • Bonvallot V, Baeza-Squiban A, Baulig A, Brulant S, Boland S, Muzeau F, et al. Organic compounds from diesel exhaust particles elicit a proinflammatory response in human airway epithelial cells and induce cytochrome p450 1A1 expression. American Journal of Respiratory Cell and Molecular Biology 2001; 25(4): 515–521.
  • Broeckaert F, Arsalane K, Hermans C, Bergamaschi E, Brustolin A, Mutti A, et al. Serum Clara cell protein: A sensitive biomarker of increased lung epithelium permeability caused by ambient ozone. Environmental Health Perspectives 2000; 108(6): 533–537.
  • Broeckaert F, Clippe A, Wattiez R, Falmagne P, Bernard A. Lung hyperpermeability, CLARA-CELL secretory protein (CC16), and susceptibility to ozone of five inbred strains of mice. Inhalation Toxicology 2003; 15(12): 1209–1230.
  • Brunekreef B, Holgate ST. Air pollution and health. Lancet 2002; 360(9341): 1233–1242.
  • Cyrys J, Heinrich J, Hoek G, Meliefste K, Lewne M, Gehring U, et al. Comparison between different traffic-related particle indicators: elemental carbon (EC), PM2.5 mass, and absorbance. Journal of Exposure Analysis and Environmental Epidemiology 2003; 13(2): 134–143.
  • de Hartog JJ, Hoek G, Mirme A, Tuch T, Kos GPA, ten Brink HM, et al. Relationship between different size classes of particulate matter and meteorology in three European cities. Journal of Environmental Monitoring 2005; 7(4): 302–310.
  • Grahame TJ, Schlesinger RB. Health effects of airborne particulate matter: do we know enough to consider regulating specific particle types or sources? Inhalation Toxicology 2007; 19(6): 457–481.
  • Hantson P, Bernard A, Hermans C. Kinetics and determinants of the changes of CC16, a lung secretory protein in a rat model of toxic lung injury. Clinical Toxicology 2008; 46(3): 230–238.
  • Health Effects Institute (HEI). Revised Analyses of Time-Series Studies of Air Pollution and Health. Special Report. Boston: HEI, 2003
  • Hermans C, Bernard A. Lung epithelium-specific proteins—Characteristics and potential applications as markers. American Journal of Respiratory and Critical Care Medicine 1999; 159(2): 646–678.
  • Hermans C, Knoops B, Wiedig M, Arsalane K, Toubeau G, Falmagne P, et al. Clara cell protein as a marker of Clara cell damage and bronchoalveolar blood barrier permeability. European Respiratory Journal 1999; 13(5): 1014–1021.
  • Hiura TS, Kaszubowski MP, Li N, Nel AE. Chemicals in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages. Journal of Immunology 1999; 163(10): 5582–5591.
  • Hiura TS, Li N, Kaplan R, Horwitz M, Seagrave JC, Nel AE. The role of a mitochondrial pathway in the induction of apoptosis by chemicals extracted from diesel exhaust particles. Journal of Immunology 2000; 165(5): 2703–2711.
  • Hopke PK, Ito K, Mar T, Christensen WF, Eatough DJ, Henry RC, et al. PM source apportionment and health effects: 1. Intercomparison of source apportionment results. Journal of Exposure Science and Environmental Epidemiology 2006; 16(3): 275–286.
  • Ito K, Christensen WF, Eatough DJ, Henry RC, Kim E, Laden F, et al. PM source apportionment, and healtheffects: 2. An investigation of intermethod variability in associations between source-apportioned fine particle mass and daily mortality in Washington, DC. Journal of Exposure Science and Environmental Epidemiology 2006; 16(4): 300–310.
  • Janssen NA, de Hartog JJ, Hoek G, Brunekreef B, Lanki T, Timonen KL, et al. Personal exposure to fine particulate matter in elderly subjects: Relation between personal, indoor, and outdoor concentrations. Journal of Air and Waste Management Association 2000; 50(7): 1133–1143.
  • Lanki T, de Hartog JJ, Heinrich J, Hoek G, Janssen NAH, Peters A, et al. Can we identify sources of fine particles responsible for exercise-induced ischemia on days with elevated air pollution? The ULTRA study. Environmental Health Perspectives 2006; 114(5): 655–660.
  • Li N, Kim S, Wang M, Froines J, Sioutas C, Nel A. Use of a stratified oxidative stress model to study the biological effects of ambient concentrated and diesel exhaust particulate matter. Inhalation Toxicology 2002; 14(5): 459–486.
  • Li N, Wang M, Oberley TD, Sempf JM, Nel AE. Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages. Journal of Immunology 2002; 169(8): 4531–4541.
  • Mar TF, Ito K, Koenig JQ, Larson TV, Eatough DJ, Henry RC, et al. PM source apportionment and health effects. 3. Investigation of inter-method variations in associations between estimated source contributions of PM2.5 and daily mortality in Phoenix, AZ. Journal of Exposure Science and Environmental Epidemiology 2006; 16(4): 311–320.
  • Mar TF, Norris GA, Koenig JQ, Larson TV. Associations between air pollution and mortality in Phoenix, 1995–1997. Environment Health Perspectives 2000; 108(4): 347–353.
  • Normand SL. Meta-analysis: Formulating, evaluating, combining, and reporting. Statistics in Medecine 1999; 18(3): 321–359.
  • Ozkaynak H, Thurston GD. Associations between 1980 U.S. mortality rates and alternative measures of airborne particle concentration. Risk Analysis 1987; 7(4): 449–461.
  • Pekkanen J, Timonan KL, Tiitanen P, Vallius M, Lanki T, Sinkko H, et al. Exposure and risk assessment for fine and ultrafine particles in ambient air. Study manual and data book. 2000. Kuopio: National Public Health Institute
  • Penttinen P, Vallius M, Tiittanen P, Ruuskanen J, Pekkanen J. Source-specific fine particles in urban air and respiratory function among adult asthmatics. Inhalation Toxicology 2006; 18(3): 191–198.
  • Rogge, W.F., Hildemann, L.M., Mazurek, M.A., Cass, G.R., Simoneit, B.R.T.. Sources of fine organic aerosol. 2. Noncatalyst and catalyst-equipped automobiles and heavy-duty diesel trucks. Environmental Science & Technology 1993; 27(4): 636–651.
  • Schwartz J, Litonjua A, Suh H, Verrier M, Zanobetti A, Syring M, Nearing B, Verrier R, Stone P, MacCallum G, Speizer FE, Gold DR. Traffic related pollution and heart rate variability in a panel of elderly subjects. Thorax 2005; 60(6): 455–461.
  • Timonen KL, Hoek G, Heinrich J, Bernard A, Brunekreef B, de Hartog J, et al. Daily variation in fine and ultrafine particulate air pollution and urinary concentrations of lung Clara cell protein CC16. Occupational and Environmental Medicine 2004; 61(11): 908–914.
  • Tsai FC, Apte MG, Daisey JM. An exploratory analysis of the relationship between mortality and the chemical composition of airborne particulate matter. Inhalation Toxicology 2000; 12: 121–135.
  • Van Miert E, Dumont X, Bernard A. CC16 as a marker of lung epithelial hyperpermeability in an acute model of rats exposed to mainstream cigarette smoke. Toxicol Lett. 2005; 159(2): 115–123.
  • Vallius M, Janssen NAH, Heinrich J, Hoek G, Ruuskanen J, Cyrys J, et al. Sources and elemental composition of ambient PM2.5 in three European cities. Science of the Total Environment 2005; 337(1–3): 147–162.
  • Yli-Tuomi T, Lanki T, Hoek G, Brunekreef B, Pekkanen J. Source apportionment of indoor PM2.5 for groups of coronary heart disease patients. Environmental Science & Technology 2008; 42: 4440–4446.

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