Exposure of mice to concentrated ambient particulate matter results in platelet and systemic cytokine activation

References

• Amrani DL. 1990. Regulation of fibrinogen biosynthesis: Glucocorticoid and interleukin-6 control. Blood Coagul Fibrinolysis 1:443–446.
   PubMedGoogle Scholar
• Baccarelli A, Zanobetti A, Martinelli I, Grillo P, Hou L, Giacomini S, Bonzini M, Lanzani G, Mannucci PM, Bertazzi PA, Schwartz J. 2007. Effects of exposure to air pollution on blood coagulation. J Thromb Haemost 5:252–260.
   PubMed Web of Science ®Google Scholar
• Baccarelli A, Martinelli I, Zanobetti A, Grillo P, Hou LF, Bertazzi PA, Mannucci PM, Schwartz J. 2008. Exposure to particulate air pollution and risk of deep vein thrombosis. Arch Intern Med 168:920–927.
   PubMed Web of Science ®Google Scholar
• Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M. 2008. Growth factors and cytokines in wound healing. Wound Repair Regen 16:585–601.
   PubMed Web of Science ®Google Scholar
• Bazzoni G, Dejana E, DelMaschio A. 1991. Platelet-neutrophil interactions Possible relevance in the pathogenesis of thrombosis and inflammation. Haematologica 76:491–499.
   PubMed Web of Science ®Google Scholar
• Becker S, Dailey LA, Soukup JM, GrambowSC Develin, RB, Huang YC. 2005. Seasonal variations in air pollution-induced inflammatory mediator release and oxidative stress. Environ Health Perspect 113:1032–1038.
   PubMed Web of Science ®Google Scholar
• Bobrowski WF, McDuffie JE, Sobocinski G, Chupka J, Olle E, Bowman A, Albassam M. 2005. Comparative methods for multiplex analysis of cytokine protein expression in plasma of lipopolysaccharide-treated mice. Cytokine 32:194–198.
   PubMedGoogle Scholar
• Boehlen F, Clemetson KJ 2001 Platelet chemokines and their receptors: What is their relvance to platelet storage and transfusion practice? Transfus Med 11:403–417.
   PubMed Web of Science ®Google Scholar
• Boscia J, Chalupa D, Utell M, Zareba W, Konecki JA, Morrow PE. 2000. Airway and cardiovascular effects of inhaled ultrafine carbon particles in resting healthy nonsmoking adults. Am J Respir Crit Care Med 161:A239
   Google Scholar
• Bouthillier L, Vincent R, Goegan P, Adamson IY, Bjarnason S, Stewart M, Guenette J, Potvin M, Kumarathasan P. 1998. Acute effects of inhaled urban particles and ozone: Lung morphology macrophage activity and plasma endothelin-1. Am J Pathol 153:1873–1884.
   PubMed Web of Science ®Google Scholar
• Braga AL, Zanobetti A, Schwartz J. 2001. The lag structure between particulate air pollution and respiratory and cardiovascular deaths in 10 US cities. J Occup Environ Med 43:927–933.
   PubMed Web of Science ®Google Scholar
• Brass L. 2004. Fifty (or more) ways to leave your platelets (in a thrombus). Arterioscler Thromb Vasc Biol 24:989–991.
   Google Scholar
• Burstein SA, Peng J, Friese P, Wolf RF, Harrison P, Downs T, HamiltonK Comp, P, Dale GL. 1996. Cytokine-induced alteration of platelet and hemostatic function. Stem Cells 14(Suppl 1):154–162.
   Google Scholar
• Capron A, Joseph M, Ameisen JC, Capron M, Pancre V, Auriault C. 1987. Platelets as effectors in immune and hypersensitivity reactions. Int Arch Allergy Appl Immunol 82:307–312.
   PubMedGoogle Scholar
• Cascio WE, Cozzi E, Hazarika S, Devlin RB, HenriksenRA Lust, RM, Van Scott MR, Wingard CJ. 2007. Cardiac and vascular changes in mice after exposure to ultrafine particulate matter. Inhal Toxicol 19(S1):67–73.
   Google Scholar
• Cass GR, Hughes LA, Bhave P, Kleeman MJ, Allen JO, Salmon LG. 2000. The chemical composition of atmospheric ultrafine particles. Phil Trans R Soc Lond A Math Phys Eng Sci 358:2581–2592.
   Web of Science ®Google Scholar
• Chen LC, Nadziejko C. 2005. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. V. CAPs exacerbate aortic plaque development in hyperlipidemic mice. Inhal Toxicol 17:217–224.
   PubMed Web of Science ®Google Scholar
• Chuang KJ, Chan CC, Su TC, Lee CT, Tang CS. 2007. The effect of urban air pollution on inflammation oxidative stress coagulation and autonomic dysfunction in young adults. Am J Respir Crit Care Med 176:370–376.
   PubMed Web of Science ®Google Scholar
• Chung A, Herner JD, Kleeman MJ. 2001a. Detection of alkaline ultrafine atmospheric particles at Bakersfield, California. Environ Sci Technol 35:2184–2190.
   PubMed Web of Science ®Google Scholar
• Clemetson KJ, Clemetson JM, Proudfoot AE, Power CA, Baggiolini M, Wells TN. 2000. Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human blood platelets. Blood 96:4046–4054.
   PubMed Web of Science ®Google Scholar
• Coyle AJ, Spina D, Page CP. 1990. PAF-induced bronchial hyperresponsiveness in the rabbit: Contribution of platelets and airway smooth muscle. Br J Pharmacol 101:31–38.
   PubMed Web of Science ®Google Scholar
• Coyle AJ, AckermanSJ Irvin, CG. 1993 Cationic proteins induce airway hyperresponsiveness dependent on charge interactions. Am Rev Respir Dis 147:896–900.
   PubMed Web of Science ®Google Scholar
• Cozzi E, Wingard CJ, Cascio WE, Devlin RB, Miles JJ, Bofferding AR, Lust RM, Van Scott MR, Henriksen RA. 2007. Effect of ambient particulate matter exposure on hemostasis. Transl Res 149:324–332.
   PubMed Web of Science ®Google Scholar
• Dales R, Liu L, Szyszkowicz M, Dalipaj M, Willey J, Kulka R, Ruddy TD. 2007. Particulate air pollution and vascular reactivity: The bus stop study. Int Arch Occup Environ Health 81:159–164.
   PubMed Web of Science ®Google Scholar
• Dockery DW, Pope DA 3rd Xu S, Spengler JD, Ware JH, Fay ME, Ferris BG Jr, Speizer FE. 1993. An association between air pollution and mortality in six U.S. cities. N Engl J Med 329:1753–1759.
   PubMed Web of Science ®Google Scholar
• Donaldson K, Stone V, Seaton A, MacNee W. 2001 Ambient particle inhalation and the cardiovascular system: Potential mechanisms. Environ Health Perspect 109(Suppl 4):523–527.
   PubMedGoogle Scholar
• Elder ACP, Gelein R, Azadniv M, Frampton M, Finkelstein J, Oberdorster G. 2004. Systemic effects of inhalted ultrafine particles in two compromised aged rat strains. Inhal Toxicol 16:461–471.
   PubMed Web of Science ®Google Scholar
• Elzey BD, Tian J, Jensen RJ, Swanson AK, Lees JR, Lentz SR, Stein CS, Niewswandt B, Wang Y, Davidson BL, Ratliff TL. 2003. Platelet-mediated modulation of adaptive immunity: A communication link between innate and adaptive immune compartments. Immunity 19:9–19.
   PubMed Web of Science ®Google Scholar
• Faraday N, Goldschmidt-Clermont P, Dise K, Bray PF. 1994. Quantitation of soluble fibrinogen binding to platelets by fluorescence-activated flow cytometry. J Lab Clin Med 123:728–740.
   PubMed Web of Science ®Google Scholar
• Frampton MW, Utell MJ, Zareba W, Oberdorster G, Cox C, Huang LS, Morrow PE, Lee FE, Chalupa D, Frasier LM, Speers DM, Stewart J. 2004. Effects of exposure to ultrafine carbon particles in healthy subjects and subjects with asthma. Res Rep Health Eff Inst 1–47; discussion 49–63.
   Google Scholar
• Gallucci S, Matzinger P. 2001. Danger signals: SOS to the immune system. Curr Opin Immunol 13:114–119.
   PubMed Web of Science ®Google Scholar
• Ghio AJ, Kim C, Devlin RB. 2000. Concentrated ambient air particles induce mild pulmonary inflammation in healthy human volunteers. Am J Resp Crit Care Med 162:981–988.
   PubMed Web of Science ®Google Scholar
• Goulaouic S, Foucaud L, Bennasroune A, Laval-Gilly P, Falla J. 2008. Effect of polycyclic aromatic hydrocarbons and carbon black particles on proinflammatory cytokine secretion: Impact of PAH coating onto particles. J Immuntoxicol 5:337–345.
   PubMed Web of Science ®Google Scholar
• Gresele P, Falcinelli E, Momi S. 2008. Potentiation and priming of platelet activation: A potential target for antiplatelet therapy. Trends Pharmacol Sci 29:352–360.
   PubMed Web of Science ®Google Scholar
• Happo MS, Hirvonen M-R, Halilnen AI, Jalava PI, Pennanen AS, Sillanpaa M, Hillamo R, Salonen RO. 2008. Chemical compositions responsible for inflammation and tissue damage in the mouse lung by coarse and fine particulate samples from contrasting air pollution in Europe. Inhal Toxicol 20:1215–1231.
   PubMed Web of Science ®Google Scholar
• Heilmann E, Hynes LA, Burstein SA, George JN, Dale GL. 1994. Fluorescein derivatization of fibrinogen for flow cytometric analysis of fibrinogen binding to platelets. Cytometry 17:287–293.
   PubMedGoogle Scholar
• Herd CM, Page CP. 1994. Pulmonary immune cells in health and disease: Platelets. Eur Respir J 7:1145–1160.
   PubMed Web of Science ®Google Scholar
• Herner JD, Aw J, Gao O, Chang DP, Kleeman MJ. 2005. Size and composition distribution of airborne particulate matter in northern California: I—Particulate mass carbon and water-soluble ions. J Air Waste Manag Assoc 55:30–51.
   PubMedGoogle Scholar
• Kameyoshi Y, Dorschner A, Mallet AI, Christophers E, Schroder J-M. 1992. Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils. J Exp Med 176:587–592.
   PubMed Web of Science ®Google Scholar
• Kang YJ, Li YA, Zhanxiang Z, Roberts AM, Cai L, Myers SR, Wang L, Schuschke DA. 2002. Elevation of serum endothelins and cardiotoxicity induced by particulate matter (PM25) in rats with acute myocardial infarction. Cardiovasc Toxicol 2:253–262.
   PubMedGoogle Scholar
• Kannel WB, Sytkowski PA. 1987. Atherosclerosis risk factors. Pharmacol Ther 32:207–235.
   PubMedGoogle Scholar
• Kerr R, Sitrling D, Ludlam CA. 2001. Interleukin 6 and haemostasis. Br J Haemotol 115:3–12.
   PubMed Web of Science ®Google Scholar
• Klinger MHF. 1997. Platelets and inflammation. Anat Embrol 196:1–11.
   PubMedGoogle Scholar
• Kim S, Jaques PA, Chang MC, Froines JR, Sioutas C. 2001a. Versatile aerosol concentration enrichment system (VACES) for simultaneous in vivo and in vitro evaluation of toxic effects of ultrafine fine and coarse ambient particles—Part I: Development and laboratory characterization. J Aerosol Sci 32:1281–1297.
   Web of Science ®Google Scholar
• Kim S, Jaques PA, Chang MC, Barone T, Xiong C, Friedlander SK, Sioutas C. 2001a. Versatile aerosol concentration enrichment system (VACES) for simultaneous in vivo and in vitro evaluation of toxic effects of ultrafine fine and coarse ambient particles—Part II: Field evaluation. J Aerosol Sci 32:1299–1314.
   Web of Science ®Google Scholar
• Kissel K, Berbers Nockher, S, Santoso S, Bein G, Hackstein H. 2006. Human platelets target dendritic cell differentiation and production of proinflammatory cytokines. Transfusion 46:818–827.
   PubMed Web of Science ®Google Scholar
• McIntyre TM, Prescott SM, Weyrich AS, Zimmerman GA. 2003. Cell-cell interactions: Leukocyte-endothelial interactions. Curr Opin Hematol 10:150–158.
   PubMed Web of Science ®Google Scholar
• Morley J, Sanjhar S, Page CP. 1984. The platelet in asthma. Lancet 2:1142–1144.
   PubMed Web of Science ®Google Scholar
• Mutlu GM, Green D, BellmeyerA Baker, CM, Burgess Z, Rajamannan N, Christman JW, Foiles N, Kamp DW, Ghio AJ, Chandel NS, Dean DA, Sznajder JI, Budinger GRS. 2007. Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway. J Clin Invest 117:2952–2961.
   PubMed Web of Science ®Google Scholar
• Nemmar A, Hoylaerts MF, Hoet PH, Dinsdale D, Smith T, Xu H, Vermylen J, Nemery B. 2002. Ultrafine particles affect experimental thrombosis in an in vivo hamster model. Am J Respir Crit Care Med 166:998–1004.
   PubMed Web of Science ®Google Scholar
• Nemmar A, Hoet PH, Dinsdale D, Vermylen J, Hoylaerts MF, Nemery B. 2003. Diesel exhaust particles in lung acutely enhance experimental peripheral thrombosis. Circulation 107:1202–1208.
   PubMed Web of Science ®Google Scholar
• Nemmar A, Hoet PH, Vandervoort P, Dinsdale D, Nemery B, Hoylaerts MF. 2007. Enhanced peripheral thrombogenicity after lung inflammation is mediated by platelet-leukocyte activation: Role of P-selectin. J Thromb Haemost 5:1217–1226.
   PubMed Web of Science ®Google Scholar
• Neumann FJ, OttI Marx, N, LutherT, KenngottS, Gawaz M, Kotzsch M, Schomig A. 1997. Effect of human recombinant interleukin-6 and interleukin-8 on monocyte procoagulant activity. Arterioscler Thromb Vasc Biol 17:3399–3405.
   PubMed Web of Science ®Google Scholar
• Norris JW, Pratt SM, Auh J-H, Wilson SJ, Clutter D, Magdesian KG, Ferraro GL, Tablin F. 2006. Investigation of a novel heritable bleeding diathesis of Thoroughbred horses and development of a screening assay. J Vet Intern Med 20:1450–1456.
   Google Scholar
• Oberdorster G. 2001. Pulmonary effects of inhaled ultrafine particles. Int Arch Occup Environ Health 74:1–8.
   PubMed Web of Science ®Google Scholar
• Page CP. 1989. Platelets as inflammatory cells Immunopharmacology. 17:51–59.
   PubMed Web of Science ®Google Scholar
• Pei X-H, NakanishiY, InoueH, TakayamaK Bai, F, Hara N. 2002. Polycyclic aromatic hydrocarbons induce IL-8 expression through nuclear factor κB activation in A549 cell line. Cytokine 19:236–241.
   PubMed Web of Science ®Google Scholar
• Peretz A, Sullivan JH, Leotta DF, Trenga CA, Sands FN, Allen J, Carlsten C, Wilkinson CW, Gill EA, Kaufman JD. 2008. Diesel exhaust inhalation elicits acute vasoconstriction in vivo. Environ Health Perspect 116:937–942.
   PubMed Web of Science ®Google Scholar
• Peters A, Dockery DW, Muller JE, Mittleman MA. 2001. Increased particulate air pollution and the triggering of myocardial infarction. Circulation 103:2810–2815.
   PubMed Web of Science ®Google Scholar
• Pope CA, Burnett RT, Thurston GD, Thun MJ M, Calle E, Krewski D, Godleski JJ. 2004. Cardiovascular mortality and long term exposure to particulate air pollution. Circulation 109:71–77.
   PubMed Web of Science ®Google Scholar
• Ruckerl R, Phipps RP, Schneider A, Frampton M, Cyrys J, Oberdorster G, Wichmann HE, Peters A. 2007. Ultrafine particles and platelet activation in patients with coronary heart disease—Results from a prospective panel study. Part Fibre Toxicol 4:1.
   PubMedGoogle Scholar
• Sallusto F, Lanzavecchia A, Mackay CR. 1998. Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses. Immunol Today 19:568–574.
   PubMedGoogle Scholar
• Samet JM, Dominici F, Curiero FC, Coursac I, Zeger SL. 2000. Fine particulate air pollution and mortality in 20 US cities, 1987–1994. N Engl J Med 343:1742–1749.
   PubMed Web of Science ®Google Scholar
• Schober A, Mankta D, von Hundelshausen P, Huo Y, Hanrath P, Sarembock IJ, Ley K, Weber C. 2002. Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury. Circulation xx:xx–xx.
   Google Scholar
• Schwartz J. 1994. What are people dying of on high air pollution days? Environ Res 64:26–35.
   PubMed Web of Science ®Google Scholar
• Silverstein RL, Febbraio M. 1992. Identification of lysosome-associated membrane protein-2 as an activation-dependent platelet surface glycoprotein. Blood 80:1470–1475.
   PubMed Web of Science ®Google Scholar
• Smith KR, Veranth JM, Kodavanti UP, Aust AE, Pinkerton KE. 2006. Acute pulmonary and systemic effects of inhaled coal fly ash in rats: Comparison to ambient environmental particles. Toxicol Sci 93:390–399.
   PubMed Web of Science ®Google Scholar
• Stirling D, Hannant WA, Ludlam CA. 1998. Transcriptional activation of the factor VIII gene in liver cell lines by interleukin-6. Thromb Haemost 79:74–78.
   PubMedGoogle Scholar
• Stouthard JM, Levi M, Hack CE, Veenhof CH, Romijn HA, Sauerwein HP, van der Poll T. 1996. Interleukin-6 stimulates coagulation not fibrinolysis in humans. Thromb Haemost 76:738–742.
   PubMed Web of Science ®Google Scholar
• Sun Q, Yue P, Kirk RI, Wang A, Moatti D, Jin X, Lu B, Schecter AD, Lippmann M, Gordon T, Chen LC, Rajagopalan S. 2008. Ambient air particulate matter exposure and tissue factor expression in atherosclerosis. Inhal Toxicol 20:127–137.
   PubMed Web of Science ®Google Scholar
• Totlandsdal AI, Refsnes M, SkomedalT Osnes, J-B, Schwarze PE, Lag M. 2008. Particle-induced cytokine respones in cardiac cell cultures—the effect of particles versus soluble mediators released by particle-exposed lung cells. Toxicol Sci 106:233–241.
   PubMed Web of Science ®Google Scholar
• van Eeden S, Tan WC, Suwa T, Mukae H, Terashima T, Fujii T, Qui D, Vincent R, Hogg JC. 2001. Cytokines involved in the systemic inflammatory response induced by exposure to particulate matter air pollutants (PM(10)). Am J Respir Crit Care Med 164:826–830.
   PubMed Web of Science ®Google Scholar
• von Hundelshausen P, Weber KS, Huo Y, Proudfoot AE, Nelson PJ, Ley K, Weber C. 2001. RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium. Circulation 103:1772–1777.
   PubMed Web of Science ®Google Scholar
• Weyrich AS, Elstad MR, McEver RP, McIntyre TM, Moore KL, Morrisey JH, Prescott SM, Zimmerman GA. 1996. Activated platelets signal chemokine synthesis in human monocytes. J Clin Invest 15:1525–1534.
   Google Scholar
• Zani BG, Kojima K, Vacanti CA, Edelman ER. 2008. Tissue-engineered endothelial and epithelial implants differentially and synergistically regulate airway repair. Proc Natl Acad Sci USA 105:7046–7051.
   PubMed Web of Science ®Google Scholar
• Zanobetti A, Schwartz J, Samoli E, Gryparis A, Touloumi G, Atkinson R, Le Tertre A, Bobros J, Celko M, Goren A, Forsberg B, Michelozzi P, Rabczenko D, Aranguez Ruiz E, Katsouyanni K. 2002. The temporal pattern of mortality responses to air pollution: A multicity assessment of mortality displacement. Epidemiology 13:87–93.
   PubMed Web of Science ®Google Scholar