Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 22, 2010 - Issue sup2: Air Pollution and Health
425
Views
43
CrossRef citations to date
0
Altmetric
AAAR Supplement

New developments in aerosol dosimetry

, &
Pages 6-14 | Received 16 Jun 2010, Accepted 12 Aug 2010, Published online: 12 Oct 2010

References

  • Alexander DJ, Collins CJ, Coombs DW, Gilkison IS, Hardy CJ, Healey G, Karantabias G, Johnson N, Karlsson A, Kilgour JD, McDonald P. 2008. Association of Inhalation Toxicologists (AIT) Working Party recommendation for standard delivered dose calculation and expression in non-clinical aerosol inhalation toxicology studies with pharmaceuticals. Inhal Toxicol 20:1179–1189.
  • Bailey MR, Ansoborolo E, Etherington G, Gregoratto D, Guilmette R, Marsh J, Paquet F, Smith J. 2008. Proposed updating of the ICRP human respiratory tract model. Proceedings of the 12th International Congress of the International Radiation Protection Association. Buenos Aires, Argentina, pp. 1–10.
  • Bailey MR, Ansoborlo E, Guilmette RA, Paquet F. 2007. Updating the ICRP human respiratory tract model. Radn Prot Dosim 127(special issue):31–34.
  • Balásházy I, Hofmann W, Heistracher T. 1999. Computation of local enhancement factors for the quantification of particle deposition patterns in airway bifurcations. J Aerosol Sci 30:185–203.
  • Balásházy I, Hofmann W, Heistracher T. 2003. Local particle deposition patterns may play a key role in the development of lung cancer. J Appl Physiol 94:1719–1725.
  • Bennett WD, Zeman KL. 2005. Effect of race on fine particle deposition for oral and nasal breathing. Inhal Toxicol 17:641–648.
  • Bennett WD, Zeman KL, Jarabek AM. 2003. Nasal contribution to breathing with exercise: Effect of race and gender. J Appl Physiol 95:497–503.
  • Bennett WD, Zeman KL, Kim C. 1996. Variability of fine particle deposition in healthy adults: Effect of age and gender. Am J Respir Crit Care Med 153:1641–1647.
  • Brodie M, Elvidge AR. 1934. The portal of entry and transmission of the virus of poliomyelitis. Science 79(2045):235–236.
  • Brown JS, Zeman KL, Bennett WD. 2002. Ultrafine particle deposition and clearance in the healthy and obstructed lung. Am J Respir Crit Care Med 166:1240–1247.
  • Brown LM, Collings N, Harrison RM, Maynard AD, Maynard RL. 2000. Ultrafine Particles in the Atmosphere. Imperial College Press, London.
  • Brunauer S, Emmett PH, Teller E. 1938. Adsorption of gases in multimolecular layers. J Am Chem Soc 60:309–319.
  • Churg A, Vedal S. 1996. Carinal and tubular airway particle concentrations in the large airways of non-smokers in the general population: Evidence for high particle concentration at airway carinas. Occup Environ Med 53:553–558.
  • Cox CS, Wathes CM. 1995. Bioaerosols Handbook. Lewis Publishers (CRC Press), Boca Raton, FL.
  • Donaldson K, Borm P, Eds. 2007. Particle Toxicology. CRC Press, Boca Raton, FL.
  • Dorman DC, Struve MF, James RA, Marshall MW, Parkinson CU, Wong BA. 2001. Influence of particle solubility on the delivery of inhaled manganese to the rat brain: Manganese sulfate and manganese tetroxide pharmacokinetics following repeated (14-day) exposure. Toxicol Appl Pharmacol 170:79–87.
  • Doty RL. 2009. Do environmental agents enter the brain via the olfactory mucosa to induce neurodegenerative diseases? Ann NY Acad Sci 1170:610–614.
  • Doty RL. 2008. The olfactory vector hypothesis of neurodegenerative disease: Is it viable? Ann Neurol 63:7–15.
  • Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Finkelstein J, Oberdörster G. 2006. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ Health Perspect 114:1172–1178.
  • Farkas A, Balásházy I. 2008. Quantification of particle deposition in asymmetrical tracheobronchial model geometry. Computers Biol Med 38:508–518.
  • Fechter LD, Johnson DL, Lynch RA. 2002. The relationship of particle size to olfactory nerve uptake of a non-soluble form of manganese to the brain. Neurotoxicology 23:177–183.
  • Finlay WH, Martin AR. 2008. Recent advances in predictive understanding of respiratory tract deposition. J Aerosol Med Pulm Drug Del 21:189–205.
  • Foos B, Marty M, Schwartz J, Bennett W, Moya J, Jarabek AM, Salmon AG. 2008. Focusing on children’s inhalation dosimetry and health effects for risk assessment: An introduction. J Toxicol Environ Health-Part A 71:149–165.
  • Foos B, Sonawane B. 2008. Overview: Workshop on Children’s Inhalation Dosimetry and Health Effects for Risk Assessment. J Toxicol Environ Health-Part A 71:147–148.
  • Ganong WF. 1999. Smell and taste. In: Review of Medical Physiology, 19th ed. Appleton & Lange, Stanford, CT, Chapter 10.
  • Gardner DE, Ed. 2006. Toxicology of the Lung, 4th ed. CRC Press, Boca Raton, FL.
  • Gehr P, Heyder J, Eds. 2000. Particle–Lung Interactions. Marcel Dekker, New York, NY.
  • Geiser M, Kreyling WG. 2010. Deposition and biokinetics of inhaled nanoparticles. Particle Fibre Toxicol 7: article #2 (online).
  • Genter MB, Kendig EL, Knutson MD. 2009. Uptake of materials from the nasal cavity into the blood and brain. Ann NY Acad Sci 1170:623–628.
  • Gerde P. 2008. How do we compare dose to cells in-vitro with dose to live animals and humans?: Some experiences with inhaled substances. Exp Toxicol Pathol 60:181–184.
  • Giechaskiel B, Alfoldy B, Drossinos Y. 2009. A metric for health effects studies of diesel exhaust particles. J Aerosol Sci 40:639–651.
  • Ginsberg GL, Asgharian B, Kimbell JS, Ultman JS, Jarabek AM. 2008. Modeling approaches for estimating the dosimetry of inhaled toxicants in children. J Toxicol Environ Health-Part A 71:166–195.
  • Ginsberg GL, Foos BP, Firestone MP. 2005. Review and analysis of inhalation dosimetry methods for application to children’s risk assessment. J Toxicol Environ Health-Part A 68:573–615.
  • Hickey AJ, Ed. 2007. Inhalation Aerosols: Physical and Biological Basis for Therapy, 2nd ed. Informa Healthcare, New York, NY.
  • Hinds WC. 1999. Aerosol Technology: Properties, Behavior, and Measurement of Airborne Particles, 2nd ed. John Wiley & Sons, New York, NY.
  • ICRP (International Commission on Radiological Protection, Task Group of Committee 2). 1994. Human Respiratory Tract Model for Radiological Protection, Publication 66. Pergamon Press, New York, NY.
  • Isaacs KK, Martonen TB. 2005. Particle deposition in children’s lungs: Theory and experiment. J Aerosol Med-Depos Clear Effects Lung 18:337–353.
  • Jarabek AM, Asgharian B, Miller FJ. 2005. Dosimetric adjustments for interspecies extrapolation of inhaled poorly soluble particles. Inhal Toxicol 17:317–334.
  • Kane DB, Asgharian B, Price OT, Rostami A, Oldham MJ. 2010. Effect of smoking parameters on the particle size distribution and predicted airway deposition of mainstream cigarette smoke. Inhal Toxicol 22:199–209.
  • Kim CS, Hu SC. 2006. Total respiratory tract deposition of fine micrometer-sized particles in healthy adults: Empirical equations for sex and breathing pattern. J Appl Physiol 101:401–412.
  • Kim CS, Jaques PA. 2005. Total lung deposition of ultrafine particles in elderly subjects during controlled breathing. Inhal Toxicol 17:387–399.
  • Kleinstreuer C, Zhang Z. 2010. Airflow and particle transport in the human respiratory system. Ann Rev Fluid Mech 42:301–334.
  • Kreyling WG, Semmler-Behnke M, Moller W. 2006a. Health implications of nanoparticles. J Nanoparticle Res 8:543–562.
  • Kreyling WG, Semmler-Behnke M, Moller W. 2006b. Ultrafine particle–lung interactions: Does size matter? J Aerosol Med 19:74–83.
  • Lippmann M. 2010. Targeting the components most responsible for airborne particulate matter health risks. J Expo Sci Environ Epidemiol 20:117–118.
  • Longest PW, Oldham MJ. 2006. Mutual enhancements of CFD modeling and experimental data: A case study of 1 μm particle deposition in a branching airway model. Inhal Toxicol 18:761–771.
  • Martonen TB, Ed. 2001. Medical Applications of Computer Modeling: Respiratory System. WIT Press, Southampton, UK.
  • Matsui Y, Sakai N, Tsuda A, Terada Y, Takaoka M, Fujimaki H, Uchiyama I. 2009. Tracking the pathway of diesel exhaust particles from the nose to the brain by x-ray florescence analysis. Spectrochem Acta Part-B 64(special issue):796–801.
  • Mauderly JL, McCunney RJ, Eds. 1996. Particle Overload in the Rat Lung and Lung Cancer: Implications for Human Risk Assessment. Taylor & Francis, Washington, DC.
  • Maynard AD, Kuempel ED. 2005. Airborne nanostructued particles and occupational health. J Nanopart Res 7:587–614.
  • McClellan RO, Henderson RF, Eds. 1995. Concepts in Inhalation Toxicology, 2nd ed. Taylor & Francis, Washington, DC.
  • Ménache MG, Hofman W, Ashgarian B, Miller FG. 2008. Airway geometry of children’s lungs for use in dosimetry modeling. Inhal Toxicol 20:101–126.
  • Meyer T, Müllinger B, Sommerer K, Scheuch G, Brand P, Beckmann H, Häusinger K, Weber N. 2003. Pulmonary deposition of monodisperse aerosols in patients with chronic obstructive pulmonary disease. Exp Lung Res 29:475–484.
  • Miller FJ, Ed. 1995. Nasal Toxicity and Dosimetry of Inhaled Xenobiotics: Implications for Human Health. Taylor & Francis, Washington, DC.
  • Mistry A, Glud SZ, Kjems J, Randel J, Howard KA, Stolnik S, Illum L. 2009. Effect of physicochemical properties on intranasal nanoparticle transit into murine olfactory epithelium. J Drug Target 17:543–552.
  • Moss OR, Oldham JJ. 2006. Dosimetry counts: Molecular hypersensitivity may not drive pulmonary hyperresponsiveness. J Aerosol Med 19:555–564.
  • NCRP (National Council on Radiation Protection and Measurements). 1997. Deposition, Retention and Dosimetry of Inhaled Radioactive Substances, NCRP Report No. 125. National Council on Radiation Protection and Measurements, Bethesda, MD.
  • Newton PE. 1995. Inhalation toxicology. In: CRC Handbook of Toxicology. Derelanko MJ, Hollinger MA, Eds. CRC Press, Boca Raton, Chapter 5, pp. 217–276.
  • Oberdörster G. 2010. Safety assessment for nanotechnology and nanomedicine: Concepts of nanotoxicology. J Intern Med 267:89–105.
  • Oberdörster G, Elder A, Rinderknecht A. 2009. Nanoparticles and the brain: Cause for concern? J Nanosci Nanotechnol 8:4996–5007.
  • Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, Cox C. 2004. Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol 16:437–445.
  • Oldham MJ. 2006. Challenges in validating CFD-derived inhaled aerosol predictions. Inhal Toxicol 18:781–786.
  • Oldham MJ, Phalen RF. 2002. Dosimetry implications of upper tracheobronchial anatomy in two mouse varieties. Anat Rec 268:59–65.
  • Phalen RF, Mendez LB. 2009. Dosimetry considerations for animal inhalation studies. Biomarkers 14(S1):63–66.
  • Phalen RF, Oldham MJ, Nel AE. 2006. Tracheobronchial particle dose considerations for in-vitro toxicology studies. Toxicol Sci 92:126–132.
  • Phalen RF, Oldham MJ, Wolff RK. 2008. The relevance of animal models for aerosol studies. J Aerosol Med Pulm Drug Del 21:125–144.
  • Philipson K, Falk R, Svartengren M, Jarvis N, Bailey M, Bergmann R, Hofmann W, Camner P. 2000. Does lung retention of inhaled particles depend on their geometric diameter? Exp Lung Res 26:437–455.
  • Robinson RJ, Snyder P, Oldham MJ. 2008. Comparison of analytical and numerical particle deposition using commercial CFD packages: Impaction and sedimentation. Inhal Toxicol 20:485–497.
  • Rostami AA. 2009. Computational modeling of aerosol deposition in (the) respiratory tract: A review. Inhal Toxicol 21:262–290.
  • Ruzer LS, Harley NH, Eds. 2005. Aerosols Handbook: Measurement, Dosimetry, and Health Effects. CRC Press, Boca Raton, FL.
  • Saxena RK, Gilmour MI, Schladweiler MC, McClure M, Hays M, Kodavanti UP. 2009. Differential pulmonary retention of diesel exhaust particles in Wistar Kyoto and spontaneously hypertensive rats. Toxicol Sci 111:392–401.
  • Sayes CM, Reed KL, Warheit DB. 2007. Assessing toxicity of fine and nanoparticles: Comparing in-vitro and in-vivo pulmonary toxicity profiles. Toxicol Sci 97:163–180.
  • Scheuch G, Kohlhäufl M, Möller W, Brand P, Meyer T, Häussinger K, Sommerer K, Heyder J. 2008. Particle clearance from the airways of subjects with bronchial hyperresponsivemess and with chronic obstructive pulmonary disease. Exp Lung Res 34:531–549.
  • Schlesinger RB. 1985. Comparative deposition of inhaled aerosols in experimental animals and humans: A review. Toxicol Environ Health 15:197–214.
  • Schmid O, Möller W, Semmler-Behnke M, Ferron GA, Karg E, Lipka J, Schulz H, Kreyling WG, Stoeger T. 2009. Dosimetry and toxicology of inhaled ultrafine particles. Biomarkers 14(S1):67–73.
  • Schwarze PE, Ovrevik J, Lag M, Refsnes M, Nafstad P, Hetland RB, Dybing E. 2006. Particulate matter properties and health effects: Consistency of epidemiological and toxicological studies. Hum Exp Toxicol 25:559–579.
  • Smaldone GC. 2001. Deposition and clearance: Unique problems in the proximal airways and oral cavity in the young and elderly. Respir Physiol 128:33–38.
  • Smaldone GC, Foster WM, Oriordan TG, Messina MS, Perry RJ, Langenback EG. 1993. Regional impairment of mucociliary clearance in chronic obstructive pulmonary disease. Chest 103:1390–1396.
  • Smith JRH, Bailey MR, Etherington G, Shutt AL, Youngman MJ. 2008. Effect of particle size on slow particle clearance from the bronchial tree. Exp Lung Res 34:287–312.
  • Sturm R, Hofmann W. 2006. A computer program for the simulation of fiber deposition in the human respiratory tract. Computers Biol Med 36:1252–1267.
  • Svartengren M, Falk R, Phillpson K. 2005. Long-term clearance from small airways decreases with age. Eur Respir J 26:609–615.
  • Svartengren M, Sommerer K, Scheuch G, Kohlhaeful M, Heyder J, Falk R, Bergmann R, Hofmann W, Bailey M, Philipson K, Camner P. 2001. Comparison of clearance of particles inhaled with bolus and extremely slow inhalation techniques. Exp Lung Res 27:367–386.
  • Svartengren M, Svartengren K, Europe E, Falk R, Hofmann W, Sturm R, Philipson K, Camner P. 2004. Long-term clearance from small airways in patients with chronic bronchitis: Experimental and theoretical data. Exp Lung Res 30:333–353.
  • Teeguarden JG, Hinderliter PM, Orr G, Thrall BD, Pounds JG. 2007. Particokinetics in-vitro: Dosimetry considerations for in-vitro nanoparticle assessments. Toxicol Sci 95:300–312.
  • Tjalve H, Henriksson I. 1999. Uptake of metals in the brain via olfactory pathways. Neurotoxicology 20:181–195.
  • U.S. EPA. Integrated Science Assessment for Particulate Matter. 2009. EPA/600/R-08/139F, U.S. Environmental Protection Agency, Research Triangle Park, NC. Chapters 4: Dosimetry; and 8: Populations Susceptible to PM-Related Health Effects.
  • Vincent JH. 1995. Aerosol Science for Industrial Hygienists. Pergamon (Elsevier Science), Tarrytown, NY.
  • Warheit DB. 2008. How meaningful are the results of nanotoxicology studies in the absence of adequate material characterization? Toxicol Sci 101:183–185.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.