Inhaled whole exhaust and its effect on exercise performance and vascular function

References

• Adir Y, Merdler A, Ben Haim S, Front A, Harduf R, Bitterman H. 1999. Effects of exposure to low concentrations of carbon monoxide on exercise performance and myocardial perfusion in young healthy men. Occup Environ Med 56:535–538.
   PubMed Web of Science ®Google Scholar
• Barraza-Villarreal A, Sunyer J, Hernandez-Cadena L, Escamilla-Nuñez MC, Sienra-Monge JJ, Ramírez-Aguilar M, Cortez-Lugo M, Holguin F, Diaz-Sánchez D, Olin AC, Romieu I. 2008. Air pollution, airway inflammation, and lung function in a cohort study of Mexico City schoolchildren. Environ Health Perspect 116:832–838.
   PubMed Web of Science ®Google Scholar
• Batalha JR, Saldiva PH, Clarke RW, Coull BA, Stearns RC, Lawrence J, Murthy GG, Koutrakis P, Godleski JJ. 2002. Concentrated ambient air particles induce vasoconstriction of small pulmonary arteries in rats. Environ Health Perspect 110:1191–1197.
   PubMed Web of Science ®Google Scholar
• Bossone E, Bodini BD, Mazza A, Allegra L. 2005. Pulmonary arterial hypertension: the key role of echocardiography. Chest 127:1836–1843.
   PubMed Web of Science ®Google Scholar
• Brook RD, Brook JR, Urch B, Vincent R, Rajagopalan S, Silverman F. 2002. Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults. Circulation 105:1534–1536.
   PubMed Web of Science ®Google Scholar
• Brook RD, Urch B, Dvonch JT, Bard RL, Speck M, Keeler G, Morishita M, Marsik FJ, Kamal AS, Kaciroti N, Harkema J, Corey P, Silverman F, Gold DR, Wellenius G, Mittleman MA, Rajagopalan S, Brook JR. 2009. Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans. Hypertension 54:659–667.
   PubMed Web of Science ®Google Scholar
• Chuang KJ, Coull BA, Zanobetti A, Suh H, Schwartz J, Stone PH, Litonjua A, Speizer FE, Gold DR. 2008. Particulate air pollution as a risk factor for ST-segment depression in patients with coronary artery disease. Circulation 118:1314–1320.
   PubMed Web of Science ®Google Scholar
• Chuang GC, Yang Z, Westbrook DG, Pompilius M, Ballinger CA, White CR, Krzywanski DM, Postlethwait EM, Ballinger SW. 2009. Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis. Am J Physiol Lung Cell Mol Physiol 297:L209–L216.
   PubMed Web of Science ®Google Scholar
• Cho WS, Choi M, Han BS, Cho M, Oh J, Park K, Kim SJ, Kim SH, Jeong J. 2007. Inflammatory mediators induced by intratracheal instillation of ultrafine amorphous silica particles. Toxicol Lett 175:24–33.
   PubMed Web of Science ®Google Scholar
• Courtois A, Andujar P, Ladeiro Y, Baudrimont I, Delannoy E, Leblais V, Begueret H, Galland MA, Brochard P, Marano F, Marthan R, Muller B. 2008. Impairment of NO-dependent relaxation in intralobar pulmonary arteries: comparison of urban particulate matter and manufactured nanoparticles. Environ Health Perspect 116:1294–1299.
   PubMed Web of Science ®Google Scholar
• Daigle CC, Chalupa DC, Gibb FR, Morrow PE, Oberdörster G, Utell MJ, Frampton MW. 2003. Ultrafine particle deposition in humans during rest and exercise. Inhal Toxicol 15:539–552.
   PubMed Web of Science ®Google Scholar
• Dales R, Liu L, Szyszkowicz M, Dalipaj M, Willey J, Kulka R, Ruddy TD. 2007. Particulate air pollution and vascular reactivity: the bus stop study. Int Arch Occup Environ Health 81:159–164.
   PubMed Web of Science ®Google Scholar
• Dockery DW. 2001. Epidemiologic evidence of cardiovascular effects of particulate air pollution. Environ Health Perspect 109 Suppl 4:483–486.
   PubMed Web of Science ®Google Scholar
• Donaldson K, Tran CL. 2002. Inflammation caused by particles and fibers. Inhal Toxicol 14:5–27.
   PubMed Web of Science ®Google Scholar
• Environmental Protection Agency (EPA). (2010). National Ambient Air Quality Standards. [online] Available from: http://www.epa.gov/air/criteria.html.
   Google Scholar
• Frampton MW. 2007. Does inhalation of ultrafine particles cause pulmonary vascular effects in humans? Inhal Toxicol 19 Suppl 1:75–79.
   PubMed Web of Science ®Google Scholar
• Fresquet F, Pourageaud F, Leblais V, Brandes RP, Savineau JP, Marthan R, Muller B. 2006. Role of reactive oxygen species and gp91phox in endothelial dysfunction of pulmonary arteries induced by chronic hypoxia. Br J Pharmacol 148:714–723.
   PubMedGoogle Scholar
• Ghofrani HA, Reichenberger F, Kohstall MG, Mrosek EH, Seeger T, Olschewski H, Seeger W, Grimminger F. 2004. Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: a randomized, double-blind, placebo-controlled crossover trial. Ann Intern Med 141:169–177.
   PubMed Web of Science ®Google Scholar
• Gladwin MT, Sachdev V, Jison ML, Shizukuda Y, Plehn JF, Minter K, Brown B, Coles WA, Nichols JS, Ernst I, Hunter LA, Blackwelder WC, Schechter AN, Rodgers GP, Castro O, Ognibene FP. 2004. Pulmonary hypertension as a risk factor for death in patients with sickle cell disease. N Engl J Med 350:886–895.
   PubMed Web of Science ®Google Scholar
• Hesterberg TW, Bunn WB, McClellan RO, Hamade AK, Long CM, Valberg PA. 2009. Critical review of the human data on short-term nitrogen dioxide (NO2) exposures: evidence for NO2 no-effect levels. Crit Rev Toxicol 39:743–781.
   PubMed Web of Science ®Google Scholar
• Horvath SM, Bedi JF. 1989. Alteration in carboxyhemoglobin concentrations during exposure to 9 ppm carbon monoxide for 8 hours at sea level and 2134 m altitude in a hypobaric chamber. JAPCA 39:1323–1327.
   PubMed Web of Science ®Google Scholar
• Langrish JP, Lundbäck M, Barath S, Söderberg S, Mills NL, Newby DE, Sandström T, Blomberg A. 2010. Exposure to nitrogen dioxide is not associated with vascular dysfunction in man. Inhal Toxicol 22:192–198.
   PubMed Web of Science ®Google Scholar
• Larsson BM, Sehlstedt M, Grunewald J, Sköld CM, Lundin A, Blomberg A, Sandström T, Eklund A, Svartengren M. 2007. Road tunnel air pollution induces bronchoalveolar inflammation in healthy subjects. Eur Respir J 29:699–705.
   PubMed Web of Science ®Google Scholar
• Lauer T, Heiss C, Balzer J, Keymel S, Kelm M, Preik M, Rassaf T. 2008. Resting microvascular resistance and conduit artery tone: relevance to endothelium-dependent flow-mediated dilation. Eur J Cardiovasc Prev Rehabil 15:677–682.
   PubMedGoogle Scholar
• LeBlanc AJ, Moseley AM, Chen BT, Frazer D, Castranova V, Nurkiewicz TR. 2010. Nanoparticle inhalation impairs coronary microvascular reactivity via a local reactive oxygen species-dependent mechanism. Cardiovasc Toxicol 10:27–36.
   PubMed Web of Science ®Google Scholar
• Li Z, Hyseni X, Carter JD, Soukup JM, Dailey LA, Huang YC. 2006. Pollutant particles enhanced H2O2 production from NAD(P)H oxidase and mitochondria in human pulmonary artery endothelial cells. Am J Physiol, Cell Physiol 291:C357–C365.
   PubMed Web of Science ®Google Scholar
• Liuni A, Luca MC, Lisi M, Dragoni S, di Stolfo G, Mariani JA, Uxa A, Gori T, Parker JD. 2010. Observations of time-based measures of flow-mediated dilation of forearm conduit arteries: implications for the accurate assessment of endothelial function. Am J Physiol Heart Circ Physiol 299:H939–H945.
   PubMed Web of Science ®Google Scholar
• Löndahl J, Massling A, Pagels J, Swietlicki E, Vaclavik E, Loft S. 2007. Size-resolved respiratory-tract deposition of fine and ultrafine hydrophobic and hygroscopic aerosol particles during rest and exercise. Inhal Toxicol 19:109–116.
   PubMed Web of Science ®Google Scholar
• Marr LC, Ely MR. 2010. Effect of air pollution on marathon running performance. Med Sci Sports Exerc 42:585–591.
   PubMed Web of Science ®Google Scholar
• McQuillan BM, Picard MH, Leavitt M, Weyman AE. 2001. Clinical correlates and reference intervals for pulmonary artery systolic pressure among echocardiographically normal subjects. Circulation 104:2797–2802.
   PubMed Web of Science ®Google Scholar
• Nightingale JA, Maggs R, Cullinan P, Donnelly LE, Rogers DF, Kinnersley R, Chung KF, Barnes PJ, Ashmore M, Newman-Taylor A. 2000. Airway inflammation after controlled exposure to diesel exhaust particulates. Am J Respir Crit Care Med 162:161–166.
   PubMed Web of Science ®Google Scholar
• Nurkiewicz TR, Porter DW, Barger M, Castranova V, Boegehold MA. 2004. Particulate matter exposure impairs systemic microvascular endothelium-dependent dilation. Environ Health Perspect 112:1299–1306.
   PubMed Web of Science ®Google Scholar
• Nurkiewicz TR, Porter DW, Barger M, Millecchia L, Rao KM, Marvar PJ, Hubbs AF, Castranova V, Boegehold MA. 2006. Systemic microvascular dysfunction and inflammation after pulmonary particulate matter exposure. Environ Health Perspect 114:412–419.
   PubMed Web of Science ®Google Scholar
• Nurkiewicz TR, Porter DW, Hubbs AF, Cumpston JL, Chen BT, Frazer DG, Castranova V. 2008. Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction. Part Fibre Toxicol 5:1.
   PubMed Web of Science ®Google Scholar
• Oliveira RS, Barros Neto TL, Braga AL, Raso V, Pereira LA, Morette SR, Carneiro RC. 2006. Impact of acute exposure to air pollution on the cardiorespiratory performance of military firemen. Braz J Med Biol Res 39:1643–1649.
   PubMedGoogle Scholar
• Palmgren F, Wahlin P, Kildeso J, Afshari A, Fogh CL. 2003. Characterisation of particle emissions from the driving car fleet and the contribution to ambient and indoor particle concentrations. Phys Chem Earth 28:327–334.
   Google Scholar
• Peretz A, Sullivan JH, Leotta DF, Trenga CA, Sands FN, Allen J, Carlsten C, Wilkinson CW, Gill EA, Kaufman JD. 2008. Diesel exhaust inhalation elicits acute vasoconstriction in vivo. Environ Health Perspect 116:937–942.
   PubMed Web of Science ®Google Scholar
• Pietropaoli AP, Frampton MW, Hyde RW, Morrow PE, Oberdörster G, Cox C, Speers DM, Frasier LM, Chalupa DC, Huang LS, Utell MJ. 2004. Pulmonary function, diffusing capacity, and inflammation in healthy and asthmatic subjects exposed to ultrafine particles. Inhal Toxicol 16 Suppl 1:59–72.
   PubMedGoogle Scholar
• Penttinen P, Timonen KL, Tiittanen P, Mirme A, Ruuskanen J, Pekkanen J. 2001. Number concentration and size of particles in urban air: effects on spirometric lung function in adult asthmatic subjects. Environ Health Perspect 109:319–323.
   PubMed Web of Science ®Google Scholar
• Pope CA 3rd, Burnett RT, Thun MJ, Calle EE, Krewski D, Ito K, Thurston GD. 2002. Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA 287:1132–1141.
   PubMed Web of Science ®Google Scholar
• Rundell KW. 2004. Pulmonary function decay in women ice hockey players: is there a relationship to ice rink air quality? Inhal Toxicol 16:117–123.
   PubMed Web of Science ®Google Scholar
• Rundell KW, Caviston R. 2008. Ultrafine and fine particulate matter inhalation decreases exercise performance in healthy subjects. J Strength Cond Res 22:2–5.
   PubMedGoogle Scholar
• Rundell KW, Caviston R, Hollenbach AM, Murphy K. 2006. Vehicular air pollution, playgrounds, and youth athletic fields. Inhal Toxicol 18:541–547.
   PubMed Web of Science ®Google Scholar
• Rundell KW, Hoffman JR, Caviston R, Bulbulian R, Hollenbach AM. 2007. Inhalation of ultrafine and fine particulate matter disrupts systemic vascular function. Inhal Toxicol 19:133–140.
   PubMed Web of Science ®Google Scholar
• Rundell KW, Slee JB, Caviston R, Hollenbach AM. 2008. Decreased lung function after inhalation of ultrafine and fine particulate matter during exercise is related to decreased total nitrate in exhaled breath condensate. Inhal Toxicol 20:1–9.
   PubMed Web of Science ®Google Scholar
• Rundell KW, Steigerwald MD, Fisk MZ. 2010. Montelukast prevents vascular endothelial dysfunction from internal combustion exhaust inhalation during exercise. Inhal Toxicol 22:754–759.
   PubMed Web of Science ®Google Scholar
• Stenfors N, Nordenhäll C, Salvi SS. (2004). Different airway inflammatory responses in asthmatic and healthy humans exposed to diesel. European Respir J 23, 82–86.
   PubMed Web of Science ®Google Scholar
• Törnqvist H, Mills NL, Gonzalez M, Miller MR, Robinson SD, Megson IL, Macnee W, Donaldson K, Söderberg S, Newby DE, Sandström T, Blomberg A. 2007. Persistent endothelial dysfunction in humans after diesel exhaust inhalation. Am J Respir Crit Care Med 176:395–400.
   PubMed Web of Science ®Google Scholar
• Tsang, H, Kwok, R, Migues, AH. 2008. Pedestraian exposure to ultrafine particles in Hong Kong under heavy traffic conditions. Aerosol and Air Quality Research 8:19–27.
   Google Scholar
• Venkataraman C, Kao AS. 1999. Comparison of particle lung doses from the fine and coarse fractions of urban PM-10 aerosols. Inhal Toxicol 11:151–169.
   PubMed Web of Science ®Google Scholar
• Vinzents PS, Møller P, Sørensen M, Knudsen LE, Hertel O, Jensen FP, Schibye B, Loft S. 2005. Personal exposure to ultrafine particles and oxidative DNA damage. Environ Health Perspect 113:1485–1490.
   PubMed Web of Science ®Google Scholar
• von Klot S, Wölke G, Tuch T, Heinrich J, Dockery DW, Schwartz J, Kreyling WG, Wichmann HE, Peters A. 2002. Increased asthma medication use in association with ambient fine and ultrafine particles. Eur Respir J 20:691–702.
   PubMed Web of Science ®Google Scholar
• Zhu Y, Shen S, Sioutas C, Hinds WC, Kim S. 2002. Study of ultrafine particles near a major highway with heavy-duty diesel traffic. Atmos Environ 36:4323–4335.
   Web of Science ®Google Scholar
• Zhu Y, Eiguren-Fernandez A, Hinds WC, Miguel AH. 2007. In-cabin commuter exposure to ultrafine particles on Los Angeles freeways. Environ Sci Technol 41:2138–2145.
   PubMed Web of Science ®Google Scholar