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Inhalation Toxicology
International Forum for Respiratory Research
Volume 23, 2011 - Issue 13
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Research Article

Siderite (FeCO3) and magnetite (Fe3O4) overload-dependent pulmonary toxicity is determined by the poorly soluble particle not the iron content

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Pages 763-783 | Received 31 May 2011, Accepted 15 Jul 2011, Published online: 31 Oct 2011

References

  • Alkhateeb AA, Connor JR. 2010. Nuclear ferritin: A new role for ferritin in cell biology. Biochim Biophys Acta 1800:793–797.
  • Anjilvel S, Asgharian B. 1995. A multiple-path model of particle deposition in the rat lung. Fundam Appl Toxicol 28:41–50.
  • Aust SD. 1995. Ferritin as a source of iron and protection from iron-induced toxicities. Toxicol Lett 82-83:941–944.
  • Bacon BR, Britton RS. 1990. The pathology of hepatic iron overload: a free radical–mediated process? Hepatology 11:127–137.
  • Buxbaum G, Pfaff G. (2005). Industrial Inorganic Pigments, 3rd, completely revised Ed., Wiley-VCH Verlag GmbH, Weinheim pp. 99–209.
  • Carraway MS, Ghio AJ, Taylor JL, Piantadosi CA. 1998. Induction of ferritin and heme oxygenase-1 by endotoxin in the lung. Am J Physiol 275:L583–L592.
  • Cornell RM, Schwertmann U. 2003. The Iron Oxides: Structure, Properties, Reactions, Occurrences and Uses. Wiley-VCH Verlag GmbH, Weinheim.
  • Crichton RR, Ward RJ. 2003. An overview of iron metabolism: molecular and cellular criteria for the selection of iron chelators. Curr Med Chem 10:997–1004.
  • Directive 86/609/EEC (1986). Guideline of the Council dated November 24, 1986 on the Reconciliation of Legal and Administrative Regulations of the Member Countries for the Protection of Animals used for Studies and other Scientific Purposes. Journal of the European Community, Legal Specifications L358, 29:1–28.
  • Eisenstein RS, Garcia-Mayol D, Pettingell W, Munro HN. 1991. Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron. Proc Natl Acad Sci USA 88:688–692.
  • Ghio AJ. 2009. Disruption of iron homeostasis and lung disease. Biochim Biophys Acta 1790:731–739.
  • Ghio AJ, Richards JH, Crissman KM, Carter JD. 2000. Iron disequilibrium in the rat lung after instilled blood. Chest 118:814–823.
  • Heilmann P, Beisker W, Miaskowski U, Camner P, Kreyling WG. 1992. Intraphagolysosomal pH in canine and rat alveolar macrophages: flow cytometric measurements. Environ Health Perspect 97:115–120.
  • Hentze MW, Muckenthaler MU, Galy B, Camaschella C. 2010. Two to tango: regulation of Mammalian iron metabolism. Cell 142:24–38.
  • Kreyling WG, Nyberg K, Nolibé D, Collier CG, Camner P, Heimann P, Lirsac PN, Lundborg M, Matejkova E. (1991). Interspecies comparison of phagolysosomal pH in alveolar macrophages. Inhal Toxicol 3:91–100.
  • Liedert B, Pluim D, Schellens J, Thomale J. 2006. Adduct-specific monoclonal antibodies for the measurement of cisplatin-induced DNA lesions in individual cell nuclei. Nucleic Acids Res 34:e47.
  • Li WL, Pauluhn J. 2010. Comparative assessment of the sensory irritation potency in mice and rats nose-only exposed to ammonia in dry and humidified atmospheres. Toxicology 276:135–142.
  • Nagatomo H, Morimoto Y, Oyabu T, Hirohashi M, Ogami A, Yamato H, Kuroda K, Higashi T, Tanaka I. 2005. Expression of heme oxygenase-1 in the lungs of rats exposed to crocidolite asbestos. Inhal Toxicol 17:293–296.
  • Organisation for Economic Cooperation and Development (OECD) (2009). CD Guideline for the testing of chemicals # 412: Subacute Inhalation Toxicity: 28-day Study. Environment Directorate, Organization for Economic Cooperation and Development, 7. September, 2009). http://www.oecd.org/
  • Organisation for Economic Cooperation and Development (OECD) (2009). Environment, Health and Safety Publications, Series on Testing and Assessment No. 39: Guidance Document for Acute Inhalation Toxicity Testing, [ENV/JM/MONO 28; July 21, 2009; 71 pp.]. Available at: http://www.oecd.org/
  • Organisation for Economic Cooperation and Development (OECD), (1998). OECD Principles on Good Laboratory Practice (as revised in 1997). ENV/MC/CHEM(98)17, distributed 26 January 1998. Organisation for Economic Cooperation and Development, Paris.
  • Paintal AS. 1969. Mechanism of stimulation of type J receptors. J Physiol 203, 511–532.
  • Paintal AS. 1981. Effects of drugs on chemoreceptors, pulmonary and cardiovascular receptors in Widdicombe JG (ed) International encyclopedia of pharmacology and therapeutics, Section 104, respiratory pharmacology. Pergamon Press, Oxford, pp. 217–239.
  • Papanikolaou G, Pantopoulos K. 2005. Iron metabolism and toxicity. Toxicol Appl Pharmacol 202:199–211.
  • Pauluhn J, Mohr U. 1999. Repeated 4-week inhalation exposure of rats: effect of low-, intermediate, and high-humidity chamber atmospheres. Exp Toxicol Pathol 51:178–187.
  • Pauluhn J. 2010. Subchronic 13-week inhalation exposure of rats to multiwalled carbon nanotubes: toxic effects are determined by density of agglomerate structures, not fibrillar structures. Toxicol Sci 113:226–242.
  • Pauluhn J. 2011a. Subchronic inhalation toxicity of iron oxide (magnetite, Fe3O4) in rats: pulmonary toxicity is determined by the particle kinetics typical of poorly soluble particles. J Appl Toxicol. 2011 Apr 1. doi: 10.1002/jat.1668.
  • Pauluhn J. 2011b. Poorly soluble particulates: searching for a unifying denominator of nanoparticles and fine particles for DNEL estimation. Toxicology 279:176–188.
  • Pauluhn J, Mohr U. (2000). Inhalation studies in laboratory animals – current concepts and alternatives. Review. Toxicol Pathol 28:734–753.
  • RIVM (National Institute for Public Health and the Environment). 2002. Multiple Path Particle Dosimetry Model (MPPD2 v. 1.0): A Model for Human and Rat Airway Particle Dosimetry. Bilthoven, The Netherlands. RIVA Report 650010030;2002.
  • Reif DW. 1992. Ferritin as a source of iron for oxidative damage. Free Radic Biol Med 12:417–427.
  • Ryter SW, Tyrrell RM. 2000. The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties. Free Radic Biol Med 28:289–309.
  • Seiler F, Rehn B, Rehn S, Hermann M, Bruch J. 2001. Quartz exposure of the rat lung leads to a linear dose response in inflammation but not in oxidative DNA damage and mutagenicity. Am J Respir Cell Mol Biol 24:492–498.
  • Tao F, Gonzalez-Flecha B, Kobzik L. 2003. Reactive oxygen species in pulmonary inflammation by ambient particulates. Free Radic Biol Med 35:327–340.
  • Thiery J, Teupser D, Walli AK, Ivandic B, Nebendahl K, Stein O, Stein Y, Seidel D. 1996. Study of causes underlying the low atherosclerotic response to dietary hypercholesterolemia in a selected strain of rabbits. Atherosclerosis 121:63–73.
  • Ullmann’s (1992). Pigments, Inorganic. Ullmann’s Encyclopedia of Industrial Chemistry. VCH Verlagsgesellschaft GmbH, Weinheim pp. 243–369.
  • US-EPA (1994). Method for Derivation of Inhalation Reference Concentrations and Application of Inhalation Dosimetry. US Environmental Protection Agency (US EPA).
  • US-EPA (2002). A review of the reference dose and reference concentration process. US Environmental Protection Agency (US EPA).
  • Vijayaraghavan R, Schaper M, Thompson R, Stock MF, Alarie Y. 1993. Characteristic modifications of the breathing pattern of mice to evaluate the effects of airborne chemicals on the respiratory tract. Arch Toxicol 67:478–490.
  • Wang J, Pantopoulos K. 2011. Regulation of cellular iron metabolism. Biochem J 434:365–381.
  • Wesselius LJ, Smirnov IM, Nelson ME, O’Brien-Ladner AR, Flowers CH, Skikne BS. 1996. Alveolar macrophages accumulate iron and ferritin after in vivo exposure to iron or tungsten dusts. J Lab Clin Med 127:401–409.
  • White K, Munro HN. 1988. Induction of ferritin subunit synthesis by iron is regulated at both the transcriptional and translational levels. J Biol Chem 263:8938–8942.
  • Winterbourn CC. 1995. Toxicity of iron and hydrogen peroxide: the Fenton reaction. Toxicol Lett 82-83:969–974.

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