Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 24, 2012 - Issue 14
407
Views
85
CrossRef citations to date
0
Altmetric
Research Article

NLRP3 inflammasome activation in murine alveolar macrophages and related lung pathology is associated with MWCNT nickel contamination

, , , &
Pages 995-1008 | Received 24 Jul 2012, Accepted 29 Oct 2012, Published online: 10 Dec 2012

References

  • Arend WP, Palmer G, Gabay C. 2008. IL-1, IL-18, and IL-33 families of cytokines. Immunol Rev 223:20–38.
  • Bonner JC. 2010. Nanoparticles as a potential cause of pleural and interstitial lung disease. Proc Am Thorac Soc 7:138–141.
  • Boya P, Kroemer G. 2008. Lysosomal membrane permeabilization in cell death. Oncogene 27:6434–6451.
  • Buford MC, Hamilton RF Jr, Holian A. 2007. A comparison of dispersing media for various engineered carbon nanoparticles. Part Fibre Toxicol 4:6.
  • Caicedo MS, Desai R, McAllister K, Reddy A, Jacobs JJ, Hallab NJ. 2009. Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: a novel mechanism for implant debris reactivity. J Orthop Res 27:847–854.
  • Cassel SL, Joly S, Sutterwala FS. 2009. The NLRP3 inflammasome: a sensor of immune danger signals. Semin Immunol 21:194–198.
  • Cho WS, Duffin R, Poland CA, Howie SE, MacNee W, Bradley M, Megson IL, Donaldson K. 2010. Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing. Environ Health Perspect 118:1699–1706.
  • Davis MJ, Swanson JA. 2010. Technical advance: Caspase-1 activation and IL-1ß release correlate with the degree of lysosome damage, as illustrated by a novel imaging method to quantify phagolysosome damage. J Leukoc Biol 88:813–822.
  • Dinarello CA. 2011. Blocking interleukin-1ß in acute and chronic autoinflammatory diseases. J Intern Med 269:16–28.
  • Dostert C, Pétrilli V, Van Bruggen R, Steele C, Mossman BT, Tschopp J. 2008. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 320:674–677.
  • Drenth JP, van der Meer JW. 2006. The inflammasome–a linebacker of innate defense. N Engl J Med 355:730–732.
  • Fenoglio I, Tomatis M, Lison D, Muller J, Fonseca A, Nagy JB, Fubini B. 2006. Reactivity of carbon nanotubes: free radical generation or scavenging activity? Free Radic Biol Med 40:1227–1233.
  • Gasse P, Mary C, Guenon I, Noulin N, Charron S, Schnyder-Candrian S, Schnyder B, Akira S, Quesniaux VF, Lagente V, Ryffel B, Couillin I. 2007. IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J Clin Invest 117:3786–3799.
  • Hamilton RF, Wu N, Porter D, Buford M, Wolfarth M, Holian A. 2009. Particle length-dependent titanium dioxide nanomaterials toxicity and bioactivity. Part Fibre Toxicol 6:35.
  • Johnston HJ, Hutchison GR, Christensen FM, Peters S, Hankin S, Aschberger K, Stone V. 2010. A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: The contribution of physico-chemical characteristics. Nanotoxicology 4:207–246.
  • Kroeger KM, Sullivan BM, Locksley RM. 2009. IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway. J Leukoc Biol 86:769–778.
  • Lam CW, James JT, McCluskey R, Arepalli S, Hunter RL. 2006. A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks. Crit Rev Toxicol 36:189–217.
  • Lanone S, Boczkowski J. 2006. Biomedical applications and potential health risks of nanomaterials: molecular mechanisms. Curr Mol Med 6:651–663.
  • Lewinski N, Colvin V, Drezek R. 2008. Cytotoxicity of nanoparticles. Small 4:26–49.
  • Liang XJ, Chen C, Zhao Y, Jia L, Wang PC. 2008. Biopharmaceutics and therapeutic potential of engineered nanomaterials. Curr Drug Metab 9:697–709.
  • Liu XY, Gurel V, Morris D, Murray DW, Zhitkovich A, Kane AB, Hurt RH. 2007. Bioavailability of nickel in single-wall carbon nanotubes. Advanced Materials 19:2790.
  • Lu S, Duffin R, Poland C, Daly P, Murphy F, Drost E, Macnee W, Stone V, Donaldson K. 2009. Efficacy of simple short-term in vitro assays for predicting the potential of metal oxide nanoparticles to cause pulmonary inflammation. Environ Health Perspect 117:241–247.
  • Martinon F, Mayor A, Tschopp J. 2009. The inflammasomes: guardians of the body. Annu Rev Immunol 27:229–265.
  • McNeilly JD, Heal MR, Beverland IJ, Howe A, Gibson MD, Hibbs LR, MacNee W, Donaldson K. 2004. Soluble transition metals cause the pro-inflammatory effects of welding fumes in vitro. Toxicol Appl Pharmacol 196:95–107.
  • Mercer RR, Hubbs AF, Scabilloni JF, Wang L, Battelli LA, Schwegler-Berry D, Castranova V, Porter DW. 2010. Distribution and persistence of pleural penetrations by multi-walled carbon nanotubes. Part Fibre Toxicol 7:28.
  • Murthy RC, Holovack MJ. 1991. Ultrastructural changes in rat lungs exposed to combinations of cadmium, zinc, copper, and nickel. J Submicrosc Cytol Pathol 23:289–293.
  • Nel A, Xia T, Mädler L, Li N. 2006. Toxic potential of materials at the nanolevel. Science 311:622–627.
  • Palomäki J, Välimäki E, Sund J, Vippola M, Clausen PA, Jensen KA, Savolainen K, Matikainen S, Alenius H. 2011. Long, needle-like carbon nanotubes and asbestos activate the NLRP3 inflammasome through a similar mechanism. ACS Nano 5:6861–6870.
  • Poizot P, Laruelle S, Grugeon S, Dupont L, Tarascon JM. 2000. Nano-sized transition-metal oxides as negative-electrode materials for lithium-ion batteries. Nature 407:496–499.
  • Porter D, Wu N, Hubbs A, Mercer R, Funk K, Meng F, Li J, Wolfarth M, Battelli L, Friend S, Andrew M, Hamilton R, Sriram K, Yang F, Castranova V, Holian A. 2012. Differential mouse ulmonary dose- and time course- responses to titanium dioxide nanospheres and nanobelts. Toxicol Sciences. [E-pub ahead of print]
  • Pourahmad J, O’Brien PJ, Jokar F, Daraei B. 2003. Carcinogenic metal induced sites of reactive oxygen species formation in hepatocytes. Toxicol In Vitro 17:803–810.
  • Qu GB, Bai YH, Zhang Y, Jia Q, Zhang WD, Yan B. 2009. The effect of multiwalled carbon nanotube agglomeration on their accumulation in and damage to organs in mice. Carbon 47:2060–2069.
  • RNCOS. 2009. Nanotechnology market forecast to 2013 [Online]. Available: http://www.rncos.com/report/IM185.htm. Accessed 16 January 2010.
  • Shvedova AA, Kisin ER, Mercer R, Murray AR, Johnson VJ, Potapovich AI, Tyurina YY, Gorelik O, Arepalli S, Schwegler-Berry D, Hubbs AF, Antonini J, Evans DE, Ku BK, Ramsey D, Maynard A, Kagan VE, Castranova V, Baron P. 2005. Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. Am J Physiol Lung Cell Mol Physiol 289:L698–L708.
  • Tschopp J, Schroder K. 2010. NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production? Nat Rev Immunol 10:210–215.
  • Warheit DB, Laurence BR, Reed KL, Roach DH, Reynolds GA, Webb TR. 2004. Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol Sci 77:117–125.
  • Yazdi AS, Guarda G, Riteau N, Drexler SK, Tardivel A, Couillin I, Tschopp J. 2010. Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1a and IL-1ß. Proc Natl Acad Sci USA 107:19449–19454.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.