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Inhalation Toxicology
International Forum for Respiratory Research
Volume 25, 2013 - Issue 1
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Letters to the Editor

Particle diameter estimates of Creutzenberg et al. (2012) are distorted due to the slicing bias of transmission electron microscopy

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Pages 63-64 | Received 09 Nov 2012, Accepted 23 Nov 2012, Published online: 07 Jan 2013

References

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  • Creutzenberg O, Bellmann B, Korolewitz R, Koch W, Mangelsdorf I, Tillmann T, Schaudien D. 2012. Change in agglomeration status and toxicokinetic fate of various nanoparticles in vivo following lung exposure in rats. Inhal Toxicol 24:821–830.
  • Cruz-Orive LM. 1987. Particle number can be estimated using a disector of unknown thickness: The selector. J Microsc 145:121–142.
  • Deutsche Forschungsgemeinschaft (DFG). 2012. List of MAK and BAT Values 2012: Maximum Concentrations and Biological Tolerance Values at the Workplace, Chapter 5 (Aerosols), p. 192. Available at: http://onlinelibrary.wiley.com/book/10.1002/9783527666034. Accessed on 29 October 2012.
  • Hayat MA. (1986). Basic techniques for transmission electron microscopy. Orlando: Academic Press.
  • Hsia CC, Hyde DM, Ochs M, Weibel ER. 2010. An official research policy statement of the American Thoracic Society/European Respiratory Society: standards for quantitative assessment of lung structure. Am J Respir Crit Care Med 181:394–418.
  • Morfeld P, Treumann S, Ma-Hock L, Bruch J, Landsiedel R. 2012. Deposition behaviour of inhaled nanostructured TiO2 in rats: Fractions of particle diameters below 100 nm (nanoscale) and the slicing bias of transmission electron microscopy. Inhal Toxicol 24:939–951.
  • Schaudien D, Knebel JW, Mangesldorf I, Voss J-U, Koch W, Creutzenberg O. 2012. Dispersion and retention of dusts consisting of ultrafine primary particles in lungs. Research Project F 2133. Dortmund/Berlin/Dresden: Federal Institute for Occupational Safety and Health (BAuA). Available at: http://www.baua.de/en/Publications/Expert-Papers/F2133.html. Accessed on 29th October 2012.

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