Inhalation dosimetry of hexamethylene diisocyanate vapor in the rat and human respiratory tracts

References

• Agency for Toxic Substances Disease Registry (ATSDR). (1998). Toxicological profile for hexamethylene diisocyanate. Atlanta, GA: U. S. Department for Health and Human Services, Public Health Service
   Google Scholar
• Alexandersson R, Plato N, Kolmodin-Hedman B, Hedenstierna G. (1987). Exposure, lung function, and symptoms in car painters exposed to hexamethylene and biuret modified hexmethylendiisocyanate. Arch Environ Health 42:367–73
   PubMed Web of Science ®Google Scholar
• Anjilvel S, Asgharian B. (1995). A multiple-path model of particle deposition in the rat lung. Fund Appl Toxicol 28:41–50
   PubMedGoogle Scholar
• Asgharian B, Hofmann W, Bergmann R. (2001). Particle deposition in a multiple-path model of the human lung. Aerosol Sci Technol 34:332–9
   Web of Science ®Google Scholar
• Asgharian B, Price OT, Schroeter JD, et al. (2012). A lung dosimetry model of vapor uptake and tissue disposition. Inhal Toxicol 24:182–93
   PubMed Web of Science ®Google Scholar
• Berode M, Testa B, Savolainen H. (1991). Bicarbonate-catalyzed hydrolysis of hexamethylene diisocyanate to 1,6-diaminohexane. Toxicol Lett 56:173–8
   PubMed Web of Science ®Google Scholar
• Brorson T, Skarping G, Nielsen J. (1990). Biological monitoring of isocyanates and related amines. Int Arch Occup Environ Health 62:385–9
   PubMed Web of Science ®Google Scholar
• Bush ML, Zhang W, Ben-Jebria A, Ultman JS. (2001). Longitudinal distribution of ozone and chlorine in the human respiratory tract: simulation of nasal and oral breathing with the single-path diffusion model. Toxicol Appl Pharmacol 173:137–45
   PubMed Web of Science ®Google Scholar
• Cassidy LD, Molenaar DM, Hathaway JA, et al. (2010). Trends in pulmonary function and prevalence of asthma in hexamethylene diisocyanate workers during a 19-year period. JOEM 52:988–94
   Google Scholar
• Cohen Hubal EA, Kimbell JS, Fedkiw PS. (1996). Incorporation of nasal-lining mass-transfer resistance into a CFD model for prediction of ozone dosimetry in the upper respiratory tract. Inhal Toxicol 8:831–57
   Web of Science ®Google Scholar
• Corley RA, Kabilan S, Kuprat AP, et al. (2012). Comparative computational modeling of airflows and vapor dosimetry in the respiratory tracts of a rat, monkey, and human. Toxicol Sci 128:500–16
   PubMed Web of Science ®Google Scholar
• Foureman GL, Greenberg MM, Sangha GK, et al. (1994). Evaluation of nasal tract lesions in derivation of the inhalation reference concentration for hexamethylene diisocyanate. Inhal Toxicol 6:341–55
   Web of Science ®Google Scholar
• Frederick CB, Bush ML, Lomax LB, et al. (1998). Application of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry extrapolation of acidic vapors in the upper airways. Toxicol Appl Pharmacol 152:211–31
   PubMed Web of Science ®Google Scholar
• Gaines LGT, Fent KW, Flack SL, et al. (2010). Urine 1,6-hexamethylene diamine (HDA) levels among workers exposed to 1,6-hexamethylene diisocyanate (HDI). Ann Occup Hyg 54:678–91
   PubMed Web of Science ®Google Scholar
• Garcia GJM, Schroeter JD, Segal RA, et al. (2009). Dosimetry of nasal uptake of water-soluble and reactive gases: a first study of interhuman variability. Inhal Toxicol 21:607–18
   PubMed Web of Science ®Google Scholar
• Gloede E, Cichocki JA, Baldino JB, Morris, JB. (2011). A validated hybrid computational fluid dynamics-physiologically based pharmacokinetic model for respiratory tract vapor absorption in the human and rat and its application to inhalation dosimetry of diacetyl. Toxicol Sci 123:231–46
   PubMed Web of Science ®Google Scholar
• Guyton AC. (1947). Analysis of respiratory patterns in laboratory animals. Am J Physiol 150:78–83
   PubMed Web of Science ®Google Scholar
• Hatch GE, Wiester MJ, Overton JH, Aissa M. (1989). Respiratory tract dosimetry of 18O-labeled ozone in rats: implications for a rat-human extrapolation of dose. In: Schneider T, Lee SD, Walters GTR, Grant LD, eds. Atmospheric ozone research and its policy implications. Amsterdam: Elsevier, 553–65
   Google Scholar
• Hathaway JA, DeWilde A, Shepperly DC, et al. (1999). Evaluation of pulmonary function in workers exposed to hexamethylene diisocyanate. J Occup Environ Med 41:378–83
   PubMed Web of Science ®Google Scholar
• Holdren W, Spicer CW, Riggin RM. (1984). Gas phase reaction of toluene diisocyanate with water vapor. Am Ind Hyg Assoc J 45:626–33
   Web of Science ®Google Scholar
• Kimbell JS, Godo MN, Gross EA, et al. (1997). Computer simulation of inspiratory airflow in all regions of the F344 rat nasal passages. Toxicol Appl Pharmacol 145:388–98
   PubMed Web of Science ®Google Scholar
• Kimbell JS, Subramaniam RP, Gross EA, et al. (2001). Dosimetry modeling of inhaled formaldehyde: comparisons of local flux predictions in the rat, monkey, and human nasal passages. Toxicol Sci 64:100–10
   PubMed Web of Science ®Google Scholar
• Miles, Inc. (1989). Chronic inhalation toxicity and oncogenicity study with 1, 6-hexamethylene diisocyanate (HDI) in rats. TSCATS/405187. EPA/OTS Document 86-900000055
   Google Scholar
• Miller FJ, Overton JH, Jaskot RH, Menzel DB. (1985). A model of the regional uptake of gaseous pollutants in the lung. I. The sensitivity of the uptake of ozone in the human lung to lower respiratory tract secretions and exercise. Toxicol Appl Pharmacol 79:11–27
   PubMed Web of Science ®Google Scholar
• Monso E, Cloutier Y, Lesage J, et al. (2000). What is the respiratory retention of inhaled hexamethylene di-isocyanate? Eur Respir J 16:729–30
   PubMed Web of Science ®Google Scholar
• Morris JB. (1999). A method for measuring upper respiratory tract vapor uptake and its applicability to quantitative inhalation risk assessment. Inhal Toxicol 11:943–65
   PubMed Web of Science ®Google Scholar
• Morris JB, Hubbs AF. (2009). Inhalation dosimetry of diacetyl and butyric acid, two components of butter flavoring vapors. Toxicol Sci 108:173–83
   PubMed Web of Science ®Google Scholar
• Morris JB, Wilkie WS, Shusterman DJ. (2005). Acute respiratory responses of the mouse to chlorine. Toxicol Sci 83:380–7
   PubMed Web of Science ®Google Scholar
• Musk AW, Peters JM, Wegman DH. (1988). Isocyanates and respiratory disease: current status. Amer J Ind Med 13:331–49
   PubMed Web of Science ®Google Scholar
• Nodelman V, Ultman JS. (1999). Longitudinal distribution of chlorine absorption in human airways: a comparison to ozone absorption. J Appl Physiol 87:2073–80
   PubMed Web of Science ®Google Scholar
• Overton JH, Graham RC, Miller FJ. (1987). A model of the regional uptake of gaseous pollutants in the lung. II. The sensitivity of ozone uptake in laboratory animal lungs to anatomical and ventilatory parameters. Toxicol Appl Pharmacol 88:418–32
   PubMed Web of Science ®Google Scholar
• Overton JH, Kimbell JS, Miller FJ. (2001). Dosimetry modeling of inhaled formaldehyde: the human respiratory tract. Toxicol Sci 64:122–34
   PubMed Web of Science ®Google Scholar
• Ranz WE, Marshall WR. (1952). Evaporation from drops. Chem Eng Prog 487:141–6
   Google Scholar
• Scherer PW, Shendalman LH, Greene NM, Bouhuys A. (1975). Measurement of axial diffusivities in a model of the bronchial airways. J Appl Physiol 38:719–23
   PubMed Web of Science ®Google Scholar
• Schroeter JD, Kimbell JS, Andersen ME, Dorman DC. (2006a). Use of a pharmacokinetic-driven computational fluid dynamics model to predict nasal extraction of hydrogen sulfide in rats and humans. Toxicol Sci 94:359–67
   PubMed Web of Science ®Google Scholar
• Schroeter JD, Kimbell JS, Bonner AM, et al. (2006b). Incorporation of tissue reaction kinetics in a computational fluid dynamics model for nasal extraction of inhaled hydrogen sulfide in rats. Toxicol Sci 90:198–207
   PubMed Web of Science ®Google Scholar
• Schroeter JD, Kimbell JS, Gross EA, et al. (2008). Application of physiological computational fluid dynamics models to predict interspecies nasal dosimetry of inhaled acrolein. Inhal Toxicol 20:227–43
   PubMed Web of Science ®Google Scholar
• Struve MF, Wong VA, Marshall MW, et al. (2008). Nasal uptake of inhaled acrolein in rats. Inhal Toxicol 20:217–25
   PubMed Web of Science ®Google Scholar
• Subramaniam RP, Richardson RB, Morgan KT, et al. (1998). Computational fluid dynamics simulations of inspiratory airflow in the human nose and nasopharynx. Inhal Toxicol 10:91–120
   Web of Science ®Google Scholar
• Tornling G, Alexandersson R, Hedenstierna G, Plato N. (1990). Decreased lung function and exposure to diisocyanates (HDI and HDI-BT) in car repair painters: observations on re-examination 6 years after initial study. Amer J Ind Med 17:299–310
   PubMed Web of Science ®Google Scholar
• U. S. Environmental Protection Agency (U. S. EPA). (1994). Methods for derivation of inhaled reference concentrations and application of inhalation dosimetry. Washington, DC: Office of Research and Development. EPA/600/8-90-066F
   Google Scholar
• Vandenplas O, Malo JL, Saetta M, et al. (1993). Occupational asthma and extrinsic alveolitis due to isocyanates: current status and perspectives. Br J Ind Med 50:213–28
   PubMedGoogle Scholar
• Yeh HC, Schum GM. (1980). Models of human lung airways and their application to inhaled particle deposition. Bull Math Biol 42:461–78
   PubMed Web of Science ®Google Scholar
• Yeh HC, Schum GM, Duggan MT. (1979). Anatomic models of the tracheobronchial and pulmonary regions of the rat. Anat Rec 195:483–92
   PubMedGoogle Scholar