Rat models of cardiometabolic diseases: baseline clinical chemistries, and rationale for their use in examining air pollution health effects

References

• Abumiya T, Sakata T, Enjyoji K, et al. (2000). Does hypertension confer a hypercoagulable state in stroke-prone spontaneously hypertensive rats? J Hypertens 18:901–9
   PubMed Web of Science ®Google Scholar
• Aneas I, Rodrigues MV, Pauletti BA, et al. (2009). Congenic strains provide evidence that four mapped loci in chromosomes 2, 4, and 16 influence hypertension in the SHR. Physiol Genomics 37:52–7
   PubMed Web of Science ®Google Scholar
• Bader M. (2010). Rat models of cardiovascular diseases. Methods Mol Biol 597:403–14
   PubMedGoogle Scholar
• Bailey EL, Wardlaw JM, Graham D, et al. (2011). Cerebral small vessel endothelial structural changes predate hypertension in stroke-prone spontaneously hypertensive rats: a blinded, controlled immunohistochemical study of 5- to 21-week-old rats. Neuropathol Appl Neurobiol 37:711–26
   PubMed Web of Science ®Google Scholar
• Baker HJ, Lindsey JR, Weisbroth SH, eds. (1979). The laboratory rat. Vol. I. New York: Academic Press
   Google Scholar
• Bernatova I, Conde MV, Kopincova J, et al. (2009). Endothelial dysfunction in spontaneously hypertensive rats: focus on methodological aspects. J Hypertens Suppl 27:S27–31
   PubMedGoogle Scholar
• Bonnet S, Michelakis ED, Porter CJ, et al. (2006). An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension. Circulation 113:2630–41
   PubMed Web of Science ®Google Scholar
• Brain JD, Valberg PA, Mensah GA. (1988). Species differences. In: Brain JD, Beck BD, Warren AJ, Shaikh RA, eds. Variations in susceptibility to inhaled pollutants. Identification, mechanisms, and policy implications. Baltimore, MD: The Johns Hopkins University Press, 89–103
   Google Scholar
• Burke M, Pabbidi MR, Fan F, et al. (2012). Genetic basis of the impaired renal myogenic response in FHH rats. Am J Physiol Renal Physiol 304:F565–77
   PubMed Web of Science ®Google Scholar
• Carll AP, Lust RM, Hazari MS, et al. (2013). Diesel exhaust inhalation increases cardiac output, bradyarrhythmias, and parasympathetic tone in aged heart failure-prone rats. Toxicol Sci 131:583–95
   PubMed Web of Science ®Google Scholar
• Carll AP, Willis MS, Lust RM, et al. (2011). Merits of non-invasive rat models of left ventricular heart failure. Cardiovasc Toxicol 11:91–112
   PubMed Web of Science ®Google Scholar
• Chang CC, Hwang JS, Chan CC, Cheng TJ. (2007). Interaction effects of ultrafine carbon black with iron and nickel on heart rate variability in spontaneously hypertensive rats. Environ Health Perspect 115:1012–17
   PubMed Web of Science ®Google Scholar
• Cho HM, Lee HA, Kim HY, et al. (2011). Expression of Na+-K+ -2Cl- cotransporter 1 is epigenetically regulated during postnatal development of hypertension. Am J Hypertens 24:1286–93
   PubMed Web of Science ®Google Scholar
• Colais P, Faustini A, Stafoggia M, et al. (2012). Particulate air pollution and hospital admissions for cardiac diseases in potentially sensitive subgroups. Epidemiology 23:473–81
   PubMed Web of Science ®Google Scholar
• Dye JA, Ledbetter AD, Schladweiler MC, et al. (2015). Whole body plethysmography reveals differential ventilatory responses to ozone in rat models of cardiovascular disease. Inhal Toxicol 27(S1):14–25
   PubMedGoogle Scholar
• Franchini M, Guida A, Tufano A, Coppola A. (2012). Air pollution, vascular disease and thrombosis: linking clinical data and pathogenic mechanisms. J Thromb Haemost 10:2438–51
   PubMed Web of Science ®Google Scholar
• Friese RS, Schmid-Schönbein GW, O'Connor DT. (2011). Systematic polymorphism discovery after genome-wide identification of potential susceptibility loci in a hereditary rodent model of human hypertension. Blood Press 20:222–31
   PubMed Web of Science ®Google Scholar
• Frohlich ED. (2001). Fibrosis and ischemia: the real risks in hypertensive heart disease. Am J Hypertens 14:194S–9S
   PubMed Web of Science ®Google Scholar
• Fukuda S, Tsuchikura S, Iida H. (2004). Age-related changes in blood pressure, hematological values, concentrations of serum biochemical constituents and weights of organs in the SHR/Izm, SHRSP/Izm and WKY/Izm. Exp Anim 53:67–72
   PubMed Web of Science ®Google Scholar
• Gent JF, Bell ML. (2010). Air pollution, population vulnerability, and standards for ambient air quality. Am J Respir Crit Care Med 182:296–7
   PubMed Web of Science ®Google Scholar
• Gill EA, Curl CL, Adar SD, et al. (2011). Air pollution and cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. Prog Cardiovasc Dis 53:353–60
   PubMed Web of Science ®Google Scholar
• Glazier AM, Scott J, Aitman TJ. (2002). Molecular basis of the Cd36 chromosomal deletion underlying SHR defects in insulin action and fatty acid metabolism. Mamm Genome 13:108–13
   PubMed Web of Science ®Google Scholar
• Gómez-Roso M, Montero MJ, Carrón R, Sevilla MA. (2009). Cardiovascular changes in spontaneously hypertensive rats are improved by chronic treatment with zofenopril. Br J Pharmacol 158:1911–21
   PubMed Web of Science ®Google Scholar
• Gottipolu RR, Wallenborn JG, Karoly ED, et al. (2009). One-month diesel exhaust inhalation produces hypertensive gene expression pattern in healthy rats. Environ Health Perspect 117:38–46
   PubMed Web of Science ®Google Scholar
• Hansen CT. (1983). Two new congenic rat strains for nutrition and obesity research. Fed Proc 42:537 (abstract)
   Google Scholar
• Hwang H, Kloner RA, Kleinman MT, Simkhovich BZ. (2008). Direct and acute cardiotoxic effects of ultrafine air pollutants in spontaneously hypertensive rats and Wistar--Kyoto rats. J Cardiovasc Pharmacol Ther 13:189–98
   PubMed Web of Science ®Google Scholar
• Johnson MD, He L, Herman D, et al. (2009). Dissection of chromosome 18 blood pressure and salt-sensitivity quantitative trait loci in the spontaneously hypertensive rat. Hypertension 54:639–45
   PubMed Web of Science ®Google Scholar
• Kai H, Kudo H, Takayama N, et al. (2009). Large blood pressure variability and hypertensive cardiac remodeling – role of cardiac inflammation. Circ J 73:2198–203
   PubMed Web of Science ®Google Scholar
• Kato N, Mashimo T, Nabika T, et al. (2003). Genome-wide searches for blood pressure quantitative trait loci in the stroke-prone spontaneously hypertensive rat of a Japanese colony. J Hypertens 21:295–303
   PubMed Web of Science ®Google Scholar
• Klöting I, van den Brandt J, Kuttler B. (2001). Genes of SHR rats protect spontaneously diabetic BB/OK rats from diabetes: lessons from congenic BB. SHR rat strains. Biochem Biophys Res Commun 283:399–405
   PubMed Web of Science ®Google Scholar
• Kodavanti UP, Costa DL, Bromberg PA. (1998). Rodent models of cardiopulmonary disease: their potential applicability in studies of air pollutant susceptibility. Environ Health Perspect 106:111–30
   PubMed Web of Science ®Google Scholar
• Kodavanti UP, Schladweiler MC, Ledbetter AD, et al. (2002). Temporal association between pulmonary and systemic effects of particulate matter in healthy and cardiovascular compromised rats. J Toxicol Environ Health A 65:1545–69
   PubMed Web of Science ®Google Scholar
• Kodavanti UP, Schladweiler MC, Ledbetter AD, et al. (2006). The spontaneously hypertensive rat: an experimental model of sulfur dioxide-induced airways disease. Toxicol Sci 94:193–205
   PubMed Web of Science ®Google Scholar
• Kodavanti UP, Schladweiler MC, Ledbetter AD, et al. (2000). The spontaneously hypertensive rat as a model of human cardiovascular disease: evidence of exacerbated cardiopulmonary injury and oxidative stress from inhaled emission particulate matter. Toxicol Appl Pharmacol 164:250–63
   PubMed Web of Science ®Google Scholar
• Kodavanti UP, Schladweiler MC, Richards JR, Costa DL. (2001). Acute lung injury from intratracheal exposure to fugitive residual oil fly ash and its constituent metals in normo- and spontaneously hypertensive rats. Inhal Toxicol 13:37–54
   PubMed Web of Science ®Google Scholar
• Kodavanti UP, Thomas R, Ledbetter AD, et al. (2013). Diesel exhaust-induced pulmonary and cardiovascular impairment: the role of hypertension intervention. Toxicol Appl Pharmacol 268:232–40
   PubMed Web of Science ®Google Scholar
• Kodavanti UP, Ledbetter AD, Thomas RF, et al. (2015). Variability in ozone-induced pulmonary injury and inflammation in healthy and cardiovascular compromised rat models. Inhal Toxicol 27(S1):39–59
   PubMedGoogle Scholar
• Koeners MP, Braam B, van der Giezen DM, et al. (2010). Perinatal micronutrient supplements ameliorate hypertension and proteinuria in adult fawn-hooded hypertensive rats. Am J Hypertens 23:802–8
   PubMed Web of Science ®Google Scholar
• Koletsky S. (1975). Pathologic findings and laboratory data in a new strain of obese hypertensive rats. Am J Pathol 80:129–42
   PubMed Web of Science ®Google Scholar
• Kooter IM, Boere AJ, Fokkens PH, et al. (2006). Response of spontaneously hypertensive rats to inhalation of fine and ultrafine particles from traffic: experimental controlled study. Part Fibre Toxicol 3:1–14
   PubMed Web of Science ®Google Scholar
• Krafft PR, Bailey EL, Lekic T, et al. (2012). Etiology of stroke and choice of models. Int J Stroke 7:398–406
   PubMed Web of Science ®Google Scholar
• Lacolley P, Poitevin P, Koen R, Levy BI. (1998). Different effects of calcium antagonists on fluid filtration of large arteries and albumin permeability in spontaneously hypertensive rats. J Hypertens 16:349–55
   PubMed Web of Science ®Google Scholar
• Lamb CM, Hazari MS, Haykal-Coates N, et al. (2012). Divergent electrocardiographic responses to whole and particle-free diesel exhaust inhalation in spontaneously hypertensive rats. Toxicol Sci 125:558–68
   PubMed Web of Science ®Google Scholar
• Lee HA, Cho HM, Lee DY, et al. (2012a). Tissue-specific upregulation of angiotensin-converting enzyme 1 in spontaneously hypertensive rats through histone code modifications. Hypertension 59:621–6
   PubMed Web of Science ®Google Scholar
• Lee NH. (2007). Physiogenomic strategies and resources to associate genes with rat models of heart, lung and blood disorders. Exp Physiol 92:992–1002
   PubMed Web of Science ®Google Scholar
• Lee WC, Wong HY, Chai YY, et al. (2012b). Lipid peroxidation dysregulation in ischemic stroke: plasma 4-HNE as a potential biomarker? Biochem Biophys Res Commun 425:842–7
   PubMed Web of Science ®Google Scholar
• McArthur MD, Graham SE, Russell JC, Brindley DN. (1998). Exaggerated stress-induced release of nonesterified fatty acids in JCR:LA-corpulent rats. Metabolism 47:1383–90
   PubMed Web of Science ®Google Scholar
• Mitra S, Goyal T, Mehta JL. (2011). Oxidized LDL, LOX-1 and atherosclerosis. Cardiovasc Drugs Ther 25:419–29
   PubMed Web of Science ®Google Scholar
• Misra T, Gilchrist JS, Russell JC, Pierce GN. (1999). Cardiac myofibrillar and sarcoplasmic reticulum function are not depressed in insulin-resistant JCR:LA-cp rats. Am J Physiol 276:H1811–17
   PubMed Web of Science ®Google Scholar
• Mutlu GM, Bryce PJ, Budinger GR. (2011). Linking air pollution exposure with thrombosis. Blood 118:2636–7
   PubMed Web of Science ®Google Scholar
• Nestor Kalinoski AL, Ramdath RS, Langenderfer KM, et al. (2010). Neointimal hyperplasia and vasoreactivity are controlled by genetic elements on rat chromosome 3. Hypertension 55:555–61
   PubMed Web of Science ®Google Scholar
• Ochodnický P, Henning RH, Buikema HJ, et al. (2010). Renal vascular dysfunction precedes the development of renal damage in the hypertensive Fawn-Hooded rat. Am J Physiol Renal Physiol 298:F625–33
   PubMed Web of Science ®Google Scholar
• Porritt MJ, Chen M, Rewell SS, et al. (2010). ACE inhibition reduces infarction in normotensive but not hypertensive rats: correlation with cortical ACE activity. J Cereb Blood Flow Metab 30:1520–6
   PubMed Web of Science ®Google Scholar
• Pravenec M, Kurtz TW. (2010). Recent advances in genetics of the spontaneously hypertensive rat. Curr Hypertens Rep 12:5–9
   PubMed Web of Science ®Google Scholar
• Proctor SD, Russell JC. (2006). Small animal models of cardiovascular disease: Tools for study of roles of the metabolic syndrome, dyslipidemias and atherosclerosis. J Cardiovasc Pathol 15:318–30
   PubMed Web of Science ®Google Scholar
• Ramasamy R, Yan SF, Schmidt AM. (2011). Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications. Ann NY Acad Sci 1243:88–102
   PubMed Web of Science ®Google Scholar
• Rohr AC, Kamal A, Morishita M, et al. (2011). Altered heart rate variability in spontaneously hypertensive rats is associated with specific particulate matter components in Detroit, Michigan. Environ Health Perspect 119:474–80
   PubMed Web of Science ®Google Scholar
• Roncalli J, Smih F, Desmoulin F, et al. (2007). NMR and cDNA array analysis prior to heart failure reveals an increase of unsaturated lipids, a glutamine/glutamate ratio decrease and a specific transcriptome adaptation in obese rat heart. J Mol Cell Cardiol 42:526–39
   PubMed Web of Science ®Google Scholar
• Russell JC, Graham SE, Richardson M. (1998). Cardiovascular disease in the JCR:LA-cp rat. Mol Cell Biochem 188:113–26
   PubMed Web of Science ®Google Scholar
• Russell JC, McKendrick JD, Dubé PJ, et al. (2001). Effects of LY117018 and the estrogen analogue, 17alpha-ethinylestradiol, on vascular reactivity, platelet aggregation, and lipid metabolism in the insulin-resistant JCR:LA-cp male rat: role of nitric oxide. J Cardiovasc Pharmacol 37:119–28
   PubMed Web of Science ®Google Scholar
• Sacks JD, Stanek LW, Luben TJ, et al. (2011). Particulate matter-induced health effects: who is susceptible? Environ Health Perspect 119:446–54
   PubMed Web of Science ®Google Scholar
• Sandhagen B. (1999). Red cell fluidity in hypertension. Clin Hemorheol Microcirc 21:179–81
   PubMed Web of Science ®Google Scholar
• Saxena RK, Gilmour MI, Schladweiler MC, et al. (2009). Differential pulmonary retention of diesel exhaust particles in Wistar Kyoto and spontaneously hypertensive rats. Toxicol Sci 111:392–401
   PubMed Web of Science ®Google Scholar
• Shannahan JH, Schladweiler MC, Richards JE, et al. (2010). Pulmonary oxidative stress, inflammation, and dysregulated iron homeostasis in rat models of cardiovascular diseases. J Toxicol Environ Health Part A 73:641–56
   PubMed Web of Science ®Google Scholar
• Shannahan JH, Nyska A, Cesta M, et al. (2012). Subchronic pulmonary pathology, iron overload, and transcriptional activity after Libby amphibole exposure in rat models of cardiovascular disease. Environ Health Perspect 120:85–91
   PubMed Web of Science ®Google Scholar
• Tofovic SP, Jackson EK. (2003). Rat models of the metabolic syndrome. Methods Mol Med 86:29–46
   PubMedGoogle Scholar
• Upadhyay S, Ganguly K, Stoeger T, et al. (2010). Cardiovascular and inflammatory effects of intratracheally instilled ambient dust from Augsburg, Germany, in spontaneously hypertensive rats (SHRs). Part Fibre Toxicol 7:1–20
   PubMed Web of Science ®Google Scholar
• Van Eeden S, Leipsic J, Man SF, Sin DD. (2012). The relationship between lung inflammation and cardiovascular disease. Am J Respir Crit Care Med 186:11–16
   PubMed Web of Science ®Google Scholar
• Varga O, Harangi M, Olsson IA, Hansen AK. (2010). Contribution of animal models to the understanding of the metabolic syndrome: a systematic overview. Obes Rev 11:792–807
   PubMed Web of Science ®Google Scholar
• Vykoukal D, Davies MG. (2011). Vascular biology of metabolic syndrome. J Vasc Surg 54:819–31
   PubMed Web of Science ®Google Scholar
• Wallenborn JG, Schladweiler MC, Nyska A, et al. (2007). Cardiopulmonary responses of Wistar Kyoto, spontaneously hypertensive, and stroke-prone spontaneously hypertensive rats to particulate matter (PM) exposure. J Toxicol Environ Health A 70:1912–22
   PubMed Web of Science ®Google Scholar
• Wang L, Yang J, Guo L, et al. (2012). Use of a soluble epoxide hydrolase inhibitor in smoke-induced chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 46:614–22
   PubMed Web of Science ®Google Scholar
• Weichert W, Paliege A, Provoost AP, Bachmann S. (2001). Upregulation of juxtaglomerular NOS1 and COX-2 precedes glomerulosclerosis in fawn-hooded hypertensive rats. Am J Physiol Renal Physiol 280:F706–14
   PubMed Web of Science ®Google Scholar
• Wesseling S, Essers PB, Koeners MP, et al. (2011). Perinatal exogenous nitric oxide in fawn-hooded hypertensive rats reduces renal ribosomal biogenesis in early life. Front Genet 2:1–21
   PubMedGoogle Scholar
• Yoshioka M, Aoyama K, Matsushita T. (1985). Effects of ascorbic acid on blood pressure and ascorbic acid metabolism in spontaneously hypertensive rats (SH rats). Int J Vitam Nutr Res 55:301–7
   PubMed Web of Science ®Google Scholar
• Yu B, Kodavanti UP, Takeuchi M, et al. (2008). Acute tobacco smoke-induced airways inflammation in spontaneously hypertensive rats. Inhal Toxicol 20:623–33
   PubMed Web of Science ®Google Scholar
• Zanobetti A, Baccarelli A, Schwartz J. (2011). Gene-air pollution interaction and cardiovascular disease: a review. Prog Cardiovasc Dis 53:344–52
   PubMed Web of Science ®Google Scholar