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Research Article

Lung transcriptional profiling: insights into the mechanisms of ozone-induced pulmonary injury in Wistar Kyoto rats

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Pages 80-92 | Received 14 Apr 2014, Accepted 07 Aug 2014, Published online: 15 Dec 2015

References

  • Ahmad S, Ahmad A, McConville G, et al. (2005). Lung epithelial cells release ATP during ozone exposure: signaling for cell survival. Free Radic Biol Med 39:213–26
  • Anenberg SC, Horowitz LW, Tong DQ, West JJ. (2010). An estimate of the global burden of anthropogenic ozone and fine particulate matter on premature human mortality using atmospheric modeling. Environ Health Perspect 118:1189–95
  • Araneda S, Commin L, Atlagich M, et al. (2008). VEGF overexpression in the astroglial cells of rat brainstem following ozone exposure. Neurotoxicology 29:920–7
  • Baldi P, Long AD. (2001). A Bayesian framework for the analysis of microarray expression data: regularized t-test and statistical inferences of gene changes. Bioinformatics 17:509–19
  • Barry WT, Nobel AB, Wright FA. (2005). Significance analysis of functional categories in gene expression studies: a structured permutation approach. Bioinformatics 21:1943–9
  • Bell ML, Dominici F. (2008). Effect modification by community characteristics on the short-term effects of ozone exposure and mortality in 98 US communities. Am J Epidemiol 167:986–97
  • Bocci V, Borrelli E, Travagli V, Zanardi I. (2009). The ozone paradox: ozone is a strong oxidant as well as a medical drug. Med Res Rev 29:646–82
  • Broeckaert F, Clippe A, Wattiez R, et al. (2003). Lung hyperpermeability, Clara-cell secretory protein (CC16), and susceptibility to ozone of five inbred strains of mice. Inhal Toxicol 15:1209–30
  • Cho HY, Kleeberger SR. (2007). Genetic mechanisms of susceptibility to oxidative lung injury in mice. Free Radic Biol Med 42:433–45
  • Cho HY, Morgan DL, Bauer AK, Kleeberger SR. (2007). Signal transduction pathways of tumor necrosis factor--mediated lung injury induced by ozone in mice. Am J Respir Crit Care Med 175:829–39
  • Choe SE, Boutros M, Michelson AM, et al. (2005). Preferred analysis methods for Affymetrix GeneChips revealed by a wholly defined control dataset. Genome Biol 6:R1–16
  • Chuang GC, Yang Z, Westbrook DG, et al. (2009). Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis. Am J Physiol Lung Cell Mol Physiol 297:L209–16
  • Damera G, Zhao H, Wang M, et al. (2009). Ozone modulates IL-6 secretion in human airway epithelial and smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 296:L674–83
  • Dang CV. (2012). MYC on the path to cancer. Cell 149:22–35
  • Doherty GJ, McMahon HT. (2009). Mechanisms of endocytosis. Annu Rev Biochem 78:857–902
  • Dormans JA, van Bree L, Boere AJ, et al. (1999). Interspecies differences in time course of pulmonary toxicity following repeated exposure to ozone. Inhal Toxicol 11:309–29
  • Duan X, Plopper C, Brennan P, Buckpitt A. (1996). Rates of glutathione synthesis in lung subcompartments of mice and monkeys: possible role in species and site selective injury. J Pharmacol Exp Ther 277:1402–9
  • Dye JA, Ledbetter AD, Schladweiler MC, et al. (2015). Whole body plethysmography reveals differential ventilatory responses to ozone in Rat models of cardiovascular disease. Inhal Toxicol 27(S1):14–25
  • Fakhrzadeh L, Laskin JD, Laskin DL. (2002). Deficiency in inducible nitric oxide synthase protects mice from ozone-induced lung inflammation and tissue injury. Am J Respir Cell Mol Biol 26:413–19
  • Fakhrzadeh L, Laskin JD, Laskin DL. (2004). Ozone-induced production of nitric oxide and TNF-alpha and tissue injury are dependent on NF-kappaB p50. Am J Physiol Lung Cell Mol Physiol 287:L279–85
  • Friedman M, Madden MC, Samet JM, Koren HS. (1992). Effects of ozone exposure on lipid metabolism in human alveolar macrophages. Environ Health Perspect 97:95–101
  • Gilmore TD, Gerondakis S. (2011). The c-Rel transcription factor in development and disease. Genes Cancer 2:695–711
  • Glinka Y, Stoilova S, Mohammed N, Prud'homme GJ. (2011). Neuropilin-1 exerts co-receptor function for TGF-beta-1 on the membrane of cancer cells and enhances responses to both latent and active TGF-beta. Carcinogenesis 32:613–21
  • Gogna R, Madan E, Kuppusamy P, Pati U. (2012). Chaperoning of mutant p53 protein by wild-type p53 protein causes hypoxic tumor regression. J Biol Chem 287:2907–14
  • Gohil K, Cross CE, Last JA. (2003). Ozone-induced disruptions of lung transcriptomes. Biochem Biophys Res Commun 305:719–28
  • Halonen JI, Lanki T, Tiittanen P, et al. (2009). Ozone and cause-specific cardiorespiratory morbidity and mortality. J Epidemiol Community Health 64:814–20
  • Hampel R, Breitner S, Zareba W, et al.; for the Cooperative Health Research in the Region of Augsburg (KORA) Study Group. (2012). Immediate ozone effects on heart rate and repolarisation parameters in potentially susceptible individuals. Occup Environ Med 69:428–36
  • Harkema JR, Hotchkiss JA. (1993). Ozone- and endotoxin-induced mucous cell metaplasias in rat airway epithelium: novel animal models to study toxicant-induced epithelial transformation in airways. Toxicol Lett 68:251–63
  • Hatch GE, McKee J, Brown J, et al. (2013). Biomarkers of dose and effect of inhaled ozone in resting versus exercising human subjects: comparison with resting rats. Biomark Insights 8:53–67
  • Hatch GE, Slade R, Harris LP, et al. (1994). Ozone dose and effect in humans and rats. A comparison using oxygen-18 labeling and bronchoalveolar lavage. Am J Respir Crit Care Med 150:676–83
  • Hicks A, Kourteva G, Hilton H, et al. (2010). Cellular and molecular characterization of ozone-induced pulmonary inflammation in the Cynomolgus monkey. Inflammation 33:144–56
  • Ho Sui SJ, Fulton DL, Arenillas DJ, et al. (2007). oPOSSUM: integrated tools for analysis of regulatory motif over-representation. Nucleic Acids Res 35:W245–52
  • Hollingsworth JW, Kleeberger SR, Foster WM. (2007). Ozone and pulmonary innate immunity. Proc Am Thorac Soc 4:240–6
  • Huang da W, Sherman BT, Lempicki RA. (2009). Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4:44–57
  • Ito K, De Leon SF, Lippmann M. (2005). Associations between ozone and daily mortality: analysis and meta-analysis. Epidemiology 16:446–57
  • Iuliano L. (2011). Pathways of cholesterol oxidation via non-enzymatic mechanisms. Chem Phys Lipids 164:457–68
  • Jerrett M, Burnett RT, Pope CA III, et al. (2009). Long-term ozone exposure and mortality. N Engl J Med 360:1085–95
  • Kafoury RM, Hernandez JM, Lasky JA, et al. 2007. Activation of transcription factor IL-6 (NF-IL-6) and nuclear factor-kappaB (NF-kappaB) by lipid ozonation products is crucial to interleukin-8 gene expression in human airway epithelial cells. Environ Toxicol 22:159–68
  • Kafoury RM, Pryor WA, Squadrito GL, et al. (1998). Lipid ozonation products activate phospholipases A2, C, and D. Toxicol Appl Pharmacol 150:338–49
  • Kenyon NJ, van der Vliet A, Schock BC, et al. (2002). Susceptibility to ozone-induced acute lung injury in iNOS-deficient mice. Am J Physiol Lung Cell Mol Physiol 282:L540–5
  • Kiffin R, Bandyopadhyay U, Cuervo AM. (2006). Oxidative stress and autophagy. Antioxid Redox Signal 8:152–62
  • Kim HI, Kim H, Shin YS, et al. (2010). Interfacial reactions of ozone with surfactant protein B in a model lung surfactant system. J Am Chem Soc 132:2254–63
  • Kimura T, Kawabe H, Jiang C, et al. (2011). Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease. Proc Natl Acad Sci U S A 108:3216–21
  • Kirschvink N, Fiévez L, Bureau F, et al. (2002). Adaptation to multiday ozone exposure is associated with a sustained increase of bronchoalveolar uric acid. Free Radic Res 36:23–32
  • Kodavanti UP, Thomas R, Ledbetter AD, et al. (2011). Vascular and cardiac impairments in rats inhaling ozone and diesel exhaust particles. Environ Health Perspect 119:312–18
  • Kodavanti UP, Russell JC, Costa DL. (2015a). Rat models of cardiometabolic diseases: baseline clinical chemistries, and rationale for their use in examining air pollution health effects. Inhal Toxicol 27(S1):2–13
  • Kodavanti UP, Ledbetter AD, Thomas RF, et al. (2015b). Variability in ozone-induced pulmonary injury and inflammation in healthy and cardiovascular compromised rat models. Inhal Toxicol 27(S1):39–53
  • Kosmider B, Loader JE, Murphy RC, Mason RJ. (2010). Apoptosis induced by ozone and oxysterols in human alveolar epithelial cells. Free Radic Biol Med 48:1513–24
  • Laskin DL, Fakhrzadeh L, Heck DE, et al. (2002). Upregulation of phosphoinositide 3-kinase and protein kinase B in alveolar macrophages following ozone inhalation. Role of NF-kappaB and STAT-1 in ozone-induced nitric oxide production and toxicity. Mol Cell Biochem 234–35:91–8
  • Laskin DL, Sunil VR, Fakhrzadeh L, et al. (2010). Macrophages, reactive nitrogen species, and lung injury. Ann N Y Acad Sci 1203:60–5
  • Last JA, Gohil K, Mathrani VC, Kenyon NJ. (2005). Systemic responses to inhaled ozone in mice: cachexia and down-regulation of liver xenobiotic metabolizing genes. Toxicol Appl Pharmacol 208:117–26
  • Mansano FV, Kazaoka RM, Ronsein GE, et al. (2010). Highly sensitive fluorescent method for the detection of cholesterol aldehydes formed by ozone and singlet molecular oxygen. Anal Chem 82:6775–81
  • Maret W. (2008). Metallothionein redox biology in the cytoprotective and cytotoxic functions of zinc. Exp Gerontol 43:363–9
  • Martínez-Ruiz A, Villanueva L, González de Orduña C, et al. (2005). S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities. Proc Natl Acad Sci U S A 102:8525–30
  • Medina-Navarro R, Mercado-Pichardo E, Hernández-Pérez O, Hicks JJ. (1999). Identification of acrolein from the ozone oxidation of unsaturated fatty acids. Hum Exp Toxicol 18:677–82
  • Morrison D, Rahman I, MacNee W. (2006). Permeability, inflammation and oxidant status in airspace epithelium exposed to ozone. Respir Med 100:2227–34
  • Postlethwait EM, Cueto R, Velsor LW, Pryor WA. (1998). O3-induced formation of bioactive lipids: estimated surface concentrations and lining layer effects. Am J Physiol 274:L1006–16
  • Pulfer MK, Murphy RC. (2004). Formation of biologically active oxysterols during ozonolysis of cholesterol present in lung surfactant. J Biol Chem 279:26331–8
  • Pulfer MK, Taube C, Gelfand E, Murphy RC. (2005). Ozone exposure in vivo and formation of biologically active oxysterols in the lung. J Pharmacol Exp Ther 312:256–64
  • Samoli E, Zanobetti A, Schwartz J, et al. (2009). The temporal pattern of mortality responses to ambient ozone in the APHEA project. J Epidemiol Commun Health 63:960–6
  • Servais S, Boussouar A, Molnar A, et al. (2005). Age-related sensitivity to lung oxidative stress during ozone exposure. Free Radic Res 39:305–16
  • Smedsrød B, Melkko J, Araki N, et al. (1997). Advanced glycation end products are eliminated by scavenger-receptor-mediated endocytosis in hepatic sinusoidal Kupffer and endothelial cells. Biochem J 322:567–73
  • Stafoggia M, Forastiere F, Faustini A, et al.; EpiAir Group. (2010). Susceptibility factors to ozone-related mortality: a population-based case-crossover analysis. Am J Respir Crit Care Med 182:376–84
  • Stephen SL, Freestone K, Dunn S, et al. (2010). Scavenger receptors and their potential as therapeutic targets in the treatment of cardiovascular disease. Int J Hypertens 2010:1–21
  • Sterner-Kock A, Kock M, Braun R, Hyde DM. (2000). Ozone-induced epithelial injury in the ferret is similar to nonhuman primates. Am J Respir Crit Care Med 162:1152–6
  • Thomson E, Kumarathasan P, Vincent R. (2006). Pulmonary expression of preproET-1 and preproET-3 mRNAs is altered reciprocally in rats after inhalation of air pollutants. Exp Biol Med (Maywood) 231:979–84
  • Torres A, Utell MJ, Morow PE, et al. (1997). Airway inflammation in smokers and nonsmokers with varying responsiveness to ozone. Am J Respir Crit Care Med 156:728–36
  • Uysal N, Schapira RM. (2003). Effects of ozone on lung function and lung diseases. Curr Opin Pulm Med 9:144–50
  • van Bree L, Dormans JA, Koren HS, et al. (2002). Attenuation and recovery of pulmonary injury in rats following short-term, repeated daily exposure to ozone. Inhal Toxicol 14:883–900
  • Vasu VT, Oommen S, Lim Y, et al. (2010). Modulation of ozone-sensitive genes in alpha-tocopherol transfer protein null mice. Inhal Toxicol 22:1–16
  • Voynow JA, Fischer BM, Zheng S, et al. (2009). NAD(P)H quinone oxidoreductase 1 is essential for ozone-induced oxidative stress in mice and humans. Am J Respir Cell Mol Biol 41:107–13
  • Wagner JG, Jiang Q, Harkema JR, et al. (2007). Ozone enhancement of lower airway allergic inflammation is prevented by gamma-tocopherol. Free Radic Biol Med 43:1176–88
  • Wakabayashi N, Slocum SL, Skoko JJ, et al. (2010). When NRF2 talks, who's listening? Antioxid Redox Signal 13:1649–63
  • Ward WO, Kodavanti UP. (2015b). Pulmonary transcriptional response to ozone in healthy and cardiovascular compromised rat models. Inhal Toxicol 27(S1):93–104
  • Williams AS, Issa R, Leung SY, et al. (2007). Attenuation of ozone-induced airway inflammation and hyper-responsiveness by c-Jun NH2 terminal kinase inhibitor SP600125. J Pharmacol Exp Ther 322:351–9
  • Wynalda KM, Murphy RC. (2010). Low-concentration ozone reacts with plasmalogen glycerophosphoethanolamine lipids in lung surfactant. Chem Res Toxicol 23:108–17

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