Downregulation of serum epidermal growth factor in patients with inflammatory bowel disease. Is there a link with mucosal damage?

References

• Beck PL, Podolsky DK. 1999. Growth factors in inflammatory bowel disease. Inflamm Bowel Dis. 5:44–60.
   PubMed Web of Science ®Google Scholar
• Best WR, Becktel JM, Singleton JW, Kern FJr.. 1976. Development of a Crohn's disease activity index. National cooperative Crohn's disease study. Gastroenterology. 70:439–444.
   PubMed Web of Science ®Google Scholar
• Bulut K, Felderbauer P, Hoeck K, Schmidt WE, Hoffmann P. 2008. Increased duodenal expression of transforming growth factor-alpha and epidermal growth factor during experimental colitis in rats. Eur J Gastroenterol Hepatol. 20:989–994.
   PubMed Web of Science ®Google Scholar
• Chowdhury A, Fukuda R, Fukumoto S. 1996. Growth factor mRNA expression in normal colorectal mucosa and in uninvolved mucosa from ulcerative colitis patients. J Gastroenterol. 31:353–360.
   PubMed Web of Science ®Google Scholar
• Cohen S. 1962. Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. J Biol Chem. 237:1555–1562.
   PubMed Web of Science ®Google Scholar
• Deban L, Correale C, Vetrano S, . 2008. Multiple pathogenic roles of microvasculature in inflammatory bowel disease: A Jack of all trades. Am J Pathol. 172:1457–1466.
   PubMed Web of Science ®Google Scholar
• Dignass AU, Baumgart DC, Sturm A. 2004. Review article: The aetiopathogenesis of inflammatory bowel disease–immunology and repair mechanisms. Aliment Pharmacol Ther. 20 Suppl 4: 9–17.
   PubMedGoogle Scholar
• Farrell RJ. 2003. Epidermal growth factor for ulcerative colitis. N Engl J Med. 349:395–397.
   PubMed Web of Science ®Google Scholar
• Hormi K, Cadiot G, Kermorgant S, Dessirier V, Le Romancer M, Lewin MJ, Mignon M, Lehy T. 2000. Transforming growth factor-alpha and epidermal growth factor receptor in colonic mucosa in active and inactive inflammatory bowel disease. Growth Factors. 18:79–91.
   PubMed Web of Science ®Google Scholar
• Ido A, Numata M, Kodama M, Tsubouchi H. 2005. Mucosal repair and growth factors: Recombinant human hepatocyte growth factor as an innovative therapy for inflammatory bowel disease. J Gastroenterol. 40:925–931.
   PubMed Web of Science ®Google Scholar
• Jahanshahi G, Motavasel V, Rezaie A, Hashtroudi AA, Daryani NE, Abdollahi M. 2004. Alterations in antioxidant power and levels of epidermal growth factor and nitric oxide in saliva of patients with inflammatory bowel diseases. Dig Dis Sci. 49:1752–1757.
   PubMed Web of Science ®Google Scholar
• Kasselberg AG, Orth DN, Gray ME, Stahlman MT. 1985. Immunocytochemical localization of human epidermal growth factor/urogastrone in several human tissues. J Histochem Cytochem. 33:315–322.
   PubMed Web of Science ®Google Scholar
• Kato Y, Tapping RI, Huang S, Watson MH, Ulevitch RJ, Lee JD. 1998. Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor. Nature. 395:713–716.
   PubMed Web of Science ®Google Scholar
• Konturek JW, Bielanski W, Konturek SJ, Bogdal J, Oleksy J. 1989. Distribution and release of epidermal growth factor in man. Gut. 30:1194–1200.
   PubMed Web of Science ®Google Scholar
• Lennard-Jones JE. 1989. Classification of inflammatory bowel disease. Scand J Gastroenterol Suppl. 170 2–6; discussion 16–19.
   PubMedGoogle Scholar
• Ma L, Wang WP, Chow JY, Yuen ST, Cho CH. 2000. Reduction of EGF is associated with the delay of ulcer healing by cigarette smoking. Am J Physiol Gastrointest Liver Physiol. 278:G10–17.
   Web of Science ®Google Scholar
• Miettinen PJ, Berger JE, Meneses J, Phung Y, Pedersen RA, Werb Z, Derynck R. 1995. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature. 376:337–341.
   PubMed Web of Science ®Google Scholar
• Petit AM, Rak J, Hung MC, Rockwell P, Goldstein N, Fendly B, Kerbel RS. 1997. Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors. Am J Pathol. 151:1523–1530.
   PubMed Web of Science ®Google Scholar
• Playford RJ. 1995. Peptides and gastrointestinal mucosal integrity. Gut. 37:595–597.
   PubMed Web of Science ®Google Scholar
• Rachmilewitz D. 1989. Coated mesalazine (5-aminosalicylic acid) versus sulphasalazine in the treatment of active ulcerative colitis: A randomised trial. BMJ. 298:82–86.
   PubMed Web of Science ®Google Scholar
• Schultz G, Rotatori DS, Clark W. 1991. EGF and TGF-alpha in wound healing and repair. J Cell Biochem. 45:346–352.
   PubMed Web of Science ®Google Scholar
• Sinha A, Nightingale J, West KP, Berlanga-Acosta J, Playford RJ. 2003. Epidermal growth factor enemas with oral mesalamine for mild-to-moderate left-sided ulcerative colitis or proctitis. N Engl J Med. 349:350–357.
   PubMed Web of Science ®Google Scholar
• Sipos F, Molnár B, Zágoni T, Berczi L, Tulassay Z. 2005. Growth in epithelial cell proliferation and apoptosis correlates specifically to the inflammation activity of inflammatory bowel diseases: Ulcerative colitis shows specific p53- and EGFR expression alterations. Dis Colon Rectum. 48:775–786.
   PubMed Web of Science ®Google Scholar
• Sturm A, Dignass AU. 2008. Epithelial restitution and wound healing in inflammatory bowel disease. World J Gastroenterol. 14:348–353.
   PubMed Web of Science ®Google Scholar
• Sullivan PB, Lewindon PJ, Cheng C, Lenehan PF, Kuo BS, Haskins JR, Goodlad RA, Wright NA, de la Iglesia FA. 2007. Intestinal mucosa remodeling by recombinant human epidermal growth factor(1–48) in neonates with severe necrotizing enterocolitis. J Pediatr Surg. 42:1470 42:462–9. Erratum in: J Pediatr Surg.
   Web of Science ®Google Scholar
• Svrcek M, Cosnes J, Tiret E, Bennis M, Parc Y, Fléjou JF. 2007. Expression of epidermal growth factor receptor (EGFR) is frequent in inflammatory bowel disease (IBD)-associated intestinal cancer. Virchows Arch. 450:243–244.
   PubMed Web of Science ®Google Scholar
• Szabo S, Kusstatscher S, Sakoulas G, Sandor Z, Vincze A, Jadus M. 1995. Growth factors: New ‘endogenous drugs’ for ulcer healing. Scand J Gastroenterol Suppl. 210:15–18.
   PubMedGoogle Scholar
• Tarnawski AS, Jones MK. 1998. The role of epidermal growth factor (EGF) and its receptor in mucosal protection, adaptation to injury, and ulcer healing: Involvement of EGF-R signal transduction pathways. J Clin Gastroenterol. 27 Suppl 1: S12–S20.
   PubMed Web of Science ®Google Scholar
• Walmsley RS, Ayres RC, Pounder RE, . 1998. A simple clinical colitis activity index. Gut. 43:29–32.
   PubMed Web of Science ®Google Scholar