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Articles

Biology and significance of signalling pathways activated by IGF-II

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Pages 1-12 | Received 17 Oct 2011, Accepted 08 Nov 2011, Published online: 05 Dec 2011

References

  • Abuzzahab MJ, Schneider A, Goddard A, Grigorescu F, Lautier C, Keller E, Kiess W, Klammt J, Kratzsch J, Osgood D, Pfaffle R, Raile K, Seidel B, Smith RJ, Chernausek SD. 2003. IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation. N Engl J Med. 349:2211–2222.
  • Adkins RM, Somes G, Morrison JC, Hill JB, Watson EM, Magann EF, Krushkal J. 2010. Association of birth weight with polymorphisms in the IGF2, H19, and IGF2R genes. Pediatr Res. 68:429–434.
  • Bach LA, Headey SJ, Norton RS. 2005. IGF-binding proteins—The pieces are falling into place. Trends Endocrinol Metab. 16:228–234.
  • Bajoria R, Gibson JM, Ward S, Sooranna SR, Neilson JP, Westwood M. 2001. Placental regulation of IGF axis in monochorionic twins with chronic twin-twin transfusion syndrome. J Clin Endocrinol Metab. 86:3150–3156.
  • Baker J, Liu JP, Robertson EJ, Efstratiadis A. 1993. Role of insulin-like growth factors in embryonic and postnatal growth. Cell. 75:73–82.
  • Belfiore A, Frasca F, Pandini G, Sciacca L, Vigneri R. 2009. Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. Endocr Rev. 30:586–623.
  • Bennett A, Wilson DM, Liu F, Nagashima R, Rosenfeld RG, Hintz RL. 1983. Levels of insulin-like growth factors I and II in human cord blood. J Clin Endocrinol Metab. 57:609–612.
  • Brierley GV, Macaulay SL, Forbes BE, Wallace JC, Cosgrove LJ, Macaulay VM. 2010. Silencing of the insulin receptor isoform A favors formation of type 1 insulin-like growth factor receptor (IGF-IR) homodimers and enhances ligand-induced IGF-IR activation and viability of human colon carcinoma cells. Endocrinology. 151:1418–1427.
  • bu-Amero SN, Ali Z, Bennett P, Vaughan JI, Moore GE. 1998. Expression of the insulin-like growth factors and their receptors in term placentas: A comparison between normal and IUGR births. Mol Reprod Dev. 49:229–235.
  • Buchanan CM, Phillips AR, Cooper GJ. 2010. A novel two-chain IGF-II-derived peptide from purified beta-cell granules. Growth Horm IGF Res. 20:360–366.
  • Carter EJ, Cosgrove RA, Gonzalez I, Eisemann JH, Lovett FA, Cobb LJ, Pell JM. 2009. MEK5 and ERK5 are mediators of the pro-myogenic actions of IGF-2. J Cell Sci. 122:3104–3112.
  • Chang MH, Kuo WW, Chen RJ, Lu MC, Tsai FJ, Kuo WH, Chen LY, Wu WJ, Huang CY, Chu CH. 2008. IGF-II/mannose 6-phosphate receptor activation induces metalloproteinase-9 matrix activity and increases plasminogen activator expression in H9c2 cardiomyoblast cells. J Mol Endocrinol. 41:65–74.
  • Chen Z, Ge Y, Kang JX. 2004. Down-regulation of the M6P/IGF-II receptor increases cell proliferation and reduces apoptosis in neonatal rat cardiac myocytes. BMC Cell Biol. 5:15.
  • Chen RJ, Wu HC, Chang MH, Lai CH, Tien YC, Hwang JM, Kuo WH, Tsai FJ, Tsai CH, Chen LM, Huang CY, Chu CH. 2009. Leu27IGF2 plays an opposite role to IGF1 to induce H9c2 cardiomyoblast cell apoptosis via Galphaq signaling. J Mol Endocrinol. 43:221–230.
  • Christofori G, Naik P, Hanahan D. 1994. A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis. Nature. 369:414–418.
  • Christofori G, Naik P, Hanahan D. 1995. Deregulation of both imprinted and expressed alleles of the insulin-like growth factor 2 gene during beta-cell tumorigenesis. Nat Genet. 10:196–201.
  • Chu CH, Tzang BS, Chen LM, Kuo CH, Cheng YC, Chen LY, Tsai FJ, Tsai CH, Kuo WW, Huang CY. 2008. IGF-II/mannose-6-phosphate receptor signaling induced cell hypertrophy and atrial natriuretic peptide/BNP expression via Galphaq interaction and protein kinase C-alpha/CaMKII activation in H9c2 cardiomyoblast cells. J Endocrinol. 197:381–390.
  • Chu CH, Tzang BS, Chen LM, Liu CJ, Tsai FJ, Tsai CH, Lin JA, Kuo WW, Bau DT, Yao CH, Huang CY. 2009. Activation of insulin-like growth factor II receptor induces mitochondrial-dependent apoptosis through G(alpha)q and downstream calcineurin signaling in myocardial cells. Endocrinology. 150:2723–2731.
  • Constancia M, Hemberger M, Hughes J, Dean W, Ferguson-Smith A, Fundele R, Stewart F, Kelsey G, Fowden A, Sibley CP, Reik W. 2002. Placental-specific IGF2 is a mafor modulator of placental and fetal growth. Nat Med. 417:945–948.
  • DeChiara TM, Efstratiadis A, Robertson EJ. 1990. A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature. 345:78–80.
  • DeChiara TM, Robertson EJ, Efstratiadis A. 1991. Parental imprinting of the mouse insulin-like growth factor II gene. Cell. 64:849–859.
  • Dejeux E, Olaso R, Dousset B, Audebourg A, Gut IG, Terris B, Tost J. 2009. Hypermethylation of the IGF2 differentially methylated region 2 is a specific event in insulinomas leading to loss-of-imprinting and overexpression. Endocr Relat Cancer. 16:939–952.
  • Desoye G, Hartmann M, Blaschitz A, Dohr G, Hahn T, Kohnen G, Kaufmann P. 1994. Insulin receptors in syncytiotrophoblast and fetal endothelium of human placenta. Immunohistochemical evidence for developmental changes in distribution pattern. Histochemistry. 101:277–285.
  • Diaz LE, Chuan YC, Lewitt M, Fernandez-Perez L, Carrasco-Rodriguez S, Sanchez-Gomez M, Flores-Morales A. 2007. IGF-II regulates metastatic properties of choriocarcinoma cells through the activation of the insulin receptor. Mol Hum Reprod. 13:567–576.
  • Douc-Rasy S, Barrois M, Fogel S, Ahomadegbe JC, Stehelin D, Coll J, Riou G. 1996. High incidence of loss of heterozygosity and abnormal imprinting of H19 and IGF2 genes in invasive cervical carcinomas. Uncoupling of H19 and IGF2 expression and biallelic hypomethylation of H19. Oncogene. 12:423–430.
  • Douglas JB, Silverman DT, Pollak MN, Tao Y, Soliman AS, Stolzenberg-Solomon RZ. 2010. Serum IGF-I, IGF-II, IGFBP-3, and IGF-I/IGFBP-3 molar ratio and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol Biomarkers Prev. 19:2298–2306.
  • Duan C, Xu Q. 2005. Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions. Gen Comp Endocrinol. 142:44–52.
  • Duguay SJ, Jin Y, Stein J, Duguay AN, Gardner P, Steiner DF. 1998. Post-translational processing of the insulin-like growth factor-2 precursor: Analysis of O-glycosylation and endoproteolysis. J Biol Chem. 273:18443–18451.
  • El-Shewy HM, Luttrell LM. 2009. Insulin-like growth factor-2/mannose-6 phosphate receptors. Vitam Horm. 80:667–697.
  • El-Shewy HM, Lee MH, Obeid LM, Jaffa AA, Luttrell LM. 2007. The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells. J Biol Chem. 282:26150–26157.
  • Fang J, Mao D, Smith CH, Fant ME. 2006. IGF regulation of neutral amino acid transport in the BeWo choriocarcinoma cell line (b30 clone): Evidence for MAP kinase-dependent and MAP kinase-independent mechanisms. Growth Horm IGF Res. 16:318–325.
  • Forbes K, Westwood M. 2008. The IGF axis and placental function: A mini review. Horm Res. 69:129–137.
  • Forbes K, Westwood M. 2010. Maternal growth factor regulation of placental development and fetal growth. J Endocrinol. 207:1–16.
  • Forbes BE, Hartfield PJ, McNeil KA, Surinya KH, Milner SJ, Cosgrove LJ, Wallace JC. 2002. Characteristics of binding of insulin-like growth factor (IGF)-I and IGF-II analogues to the type 1 IGF receptor determined by BIAcore analysis. Eur J Biochem. 269:961–968.
  • Forbes K, Westwood M, Baker PN, Aplin JD. 2008. Insulin-like growth factor-I and -II regulate the life cycle of trophoblast in the developing human placenta. Am J Physiol Cell Physiol. 294:C1313–C1322.
  • Forbes K, West G, Garside R, Aplin JD, Westwood M. 2009. The protein-tyrosine phosphatase, SRC homology-2 domain containing protein tyrosine phosphatase-2, is a crucial mediator of exogenous insulin-like growth factor signaling to human trophoblast. Endocrinology. 150:4744–4754.
  • Frasca F, Pandini G, Scalia P, Sciacca L, Mineo R, Costantino A, Goldfine ID, Belfiore A, Vigneri R. 1999. Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Mol Cell Biol. 19:3278–3288.
  • Giannoukakis N, Deal C, Paquette J, Goodyer CG, Polychronakos C. 1993. Parental genomic imprinting of the human IGF2 gene. Nat Genet. 4:98–101.
  • Giudice LC, de-Zegher F, Gargosky SE, Dsupin BA, de-las Fuentes L, Crystal RA, Hintz RL, Rosenfeld RG. 1995. Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth. J Clin Endocrinol Metab. 80:1548–1555.
  • Haig D, Graham C. 1991. Genomic imprinting and the strange case of the insulin-like growth factor-II receptor. Cell. 64:1045–1046.
  • Hamilton GS, Lysiak JJ, Han VKM, Lala PK. 1998. Autocrine-paracrine regulation of human trophoblast invasiveness by insulin-like growth factor (IGF)-II and IGF-binding protein (IGFBP)-1. Exp Cell Res. 244:147–156.
  • Han VKM, Bassett N, Walton J, Challis JR. 1996. The expression of insulin-like growth factor (IGF) and IGF-binding protein (IGFBP) genes in the human placenta and membranes: Evidence for IGF-IGFBP interactions at the feto-maternal interface. J Clin Endocrinol Metab. 81:2680–2693.
  • Harris LK, Crocker IP, Baker PN, Aplin JD, Westwood M. 2011. IGF2 actions on trophoblast in human placenta are regulated by the insulin-like growth factor 2 receptor, which can function as both a signaling and clearance receptor. Biol Reprod. 84:440–446.
  • Hashimoto K, Azuma C, Koyama M, Ohashi K, Kamiura S, Nobunaga T, Kimura T, Tokugawa Y, Kanai T, Saji F. 1995. Loss of imprinting in choriocarcinoma. Nat Genet. 9:109–110.
  • Holly J, Perks C. 2006. The role of insulin-like growth factor binding proteins. Neuroendocrinology. 83:154–160.
  • Holmes R, Porter H, Newcomb B, Holly JM, Soothill P. 1999. An immunohistochemicalstudy of type 1 insulin-like growth factor receptors in the placentae of pregnancies with appropriately or growth restricted fetuses. Placenta. 20:325–330.
  • Irving JA, Lala PK. 1995. Functional role of cell surface integrins on human trophoblast cell migration: Regulation by TGF-beta, IGF-II, and IGFBP-1. Exp Cell Res. 217:419–427.
  • Joshi RL, Lamothe B, Cordonnier N, Mesbah K, Monthioux E, Jami J, Bucchini D. 1996. Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality. EMBO J. 15:1542–1547.
  • Kaku K, Osada H, Seki K, Sekiya S. 2007. Insulin-like growth factor 2 (IGF2) and IGF2 receptor gene variants are associated with fetal growth. Acta Paediatr. 96:363–367.
  • Kalscheuer VM, Mariman EC, Schepens MT, Rehder H, Ropers HH. 1993. The insulin-like growth factor type-2 receptor gene is imprinted in the mouse but not in humans. Nat Genet. 5:74–78.
  • Kaneda A, Feinberg AP. 2005. Loss of imprinting of IGF2: A common epigenetic modifier of intestinal tumor risk. Cancer Res. 65:11236–11240.
  • Kaneda A, Wang CJ, Cheong R, Timp W, Onyango P, Wen B, Iacobuzio-Donahue CA, Ohlsson R, Andraos R, Pearson MA, Sharov AA, Longo DL, Ko MS, Levchenko A, Feinberg AP. 2007. Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc Natl Acad Sci U S A. 104:20926–20931.
  • Karl PI. 1995. Insulin-like growth factor-I stimulates amino acid uptake by the cultured human placental trophoblast. J Cell Physiol. 165:83–88.
  • Kasuya J, Paz IB, Maddux BA, Goldfine ID, Hefta SA, Fujita-Yamaguchi Y. 1993. Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification. Biochemistry. 32:13531–13536.
  • Klauwer D, Blum WF, Hanitsch S, Rascher W, Lee PD, Kiess W. 1997. IGF-I, IGF-II, free IGF-I and IGFBP-1, -2 and -3 levels in venous cord blood: Relationship to birthweight, length and gestational age in healthy newborns. Acta Paediatr. 86:826–833.
  • Kniss DA, Shubert PJ, Zimmerman PD, Landon MB, Gabbe SG. 1994. Insulin-like growth factors: Their regulation of glucose and amino acid transport in placental trophoblasts isolated from first-trimester chorionic villi. J Reprod Med. 39:249–256.
  • Kuhlmann JD, Schwarzenbach H, Otterbach F, Heubner M, Wimberger P, Worm KH, Kimmig R, Kasimir-Bauer S. 2011. Loss of heterozygosity proximal to the M6P/IGF2R locus is predictive for the presence of disseminated tumor cells in the bone marrow of ovarian cancer patients before and after chemotherapy. Genes Chromosomes Cancer. 50:598–605.
  • Lau MMH, Stewart CEH, Liu Z, Bhatt H, Rotwein P, Stewart CL. 1994. Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality. Genes Dev. 8:2953–2963.
  • Laviola L, Perrini S, Belsanti G, Natalicchio A, Montrone C, Leonardini A, Vimercati A, Scioscia M, Selvaggi L, Giorgino R, Greco P, Giorgino F. 2005. Intrauterine growth restriction in humans is associated with abnormalities in placental insulin-like growth factor signaling. Endocrinology. 146:1498–1505.
  • Laviola L, Natalicchio A, Giorgino F. 2007. The IGF-I signaling pathway. Curr Pharm Des. 13:663–669.
  • Lee JE, Pintar J, Efstratiadis A. 1990. Pattern of the insulin-like growth factor II gene expression during early mouse embryogenesis. Development. 110:151–159.
  • Lee SD, Chu CH, Huang EJ, Lu MC, Liu JY, Liu CJ, Hsu HH, Lin JA, Kuo WW, Huang CY. 2006. Roles of insulin-like growth factor II in cardiomyoblast apoptosis and in hypertensive rat heart with abdominal aorta ligation. Am J Physiol Endocrinol Metab. 291:E306–E314.
  • Leger J, Oury JF, Noel M, Baron S, Benali K, Blot P, Czernichow P. 1996. Growth factors and intrauterine growth retardation. I. Serum growth hormone, insulin-like growth factor (IGF)-I, IGF-II, and IGF binding protein 3 levels in normally grown and growth-retarded human fetuses during the second half of gestation. Pediatr Res. 40:94–100.
  • Li P, Cavallero S, Gu Y, Chen TH, Hughes J, Hassan AB, Bruning JC, Pashmforoush M, Sucov HM. 2011. IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development. Development. 138:1795–1805.
  • Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A. 1993. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell. 75:59–72.
  • Ludwig T, Eggenschwiler J, Fisher P, D'Ercole AJ, Davenport ML, Efstratiadis A. 1996. Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgrounds. Dev Biol. 177:517–535.
  • Maeng YS, Choi HJ, Kwon JY, Park YW, Choi KS, Min JK, Kim YH, Suh PG, Kang KS, Won MH, Kim YM, Kwon YG. 2009. Endothelial progenitor cell homing: Prominent role of the IGF2-IGF2R-PLCbeta2 axis. Blood. 113:233–243.
  • Mann JR, Szabo PE, Reed MR, Singer-Sam J. 2000. Methylated DNA sequences in genomic imprinting. Crit Rev Eukaryot Gene Expr. 10:241–257.
  • Marks AG, Carroll JM, Purnell JQ, Roberts CTJr. 2011. Plasma distribution and signaling activities of IGF-II precursors. Endocrinology. 152:922–930.
  • Martin-Kleiner I, Gall TK. 2010. Mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) in carcinogenesis. Cancer Lett. 289:11–22.
  • McCann AH, Miller N, O'Meara A, Pedersen I, Keogh K, Gorey T, Dervan PA. 1996. Biallelic expression of the IGF2 gene in human breast disease. Hum Mol Genet. 5:1123–1127.
  • McKinnon T, Chakraborty C, Gleeson LM, Chidiac P, Lala PK. 2001. Stimulation of human extravillous trophoblast migration by IGF-II is mediated by IGF type 2 receptor involving inhibitory G protein(s) and phosphorylation of MAPK. J Clin Endocrinol Metab. 86:3665–3674.
  • McLaren A. 1965. Placental weight loss in late pregnancy. J Reprod Fertil. 9:343–346.
  • Micha AE, Hahnel S, Friess H, Buchler MW, Adler G, Gress TM. 1999. Genomic imprinting of IGF-II and H19 in adult human pancreatic tissues. Digestion. 60:477–483.
  • Minniti CP, Kohn EC, Grubb JH, Sly WS, Oh Y, Muller HL, Rosenfeld RG, Helman LJ. 1992. The insulin-like growth factor II (IGF-II)/mannose 6-phosphate receptor mediates IGF-II-induced motility in human rhabdomyosarcoma cells. J Biol Chem. 267:9000–9004.
  • Morali OG, Jouneau A, McLaughlin KJ, Thiery JP, Larue L. 2000. IGF-II promotes mesoderm formation. Dev Biol. 227:133–145.
  • Morgan DO, Edman JC, Standring DN, Fried VA, Smith MC, Roth RA, Rutter WJ. 1987. Insulin-like growth factor II receptor as a multifunctional binding protein. Nature. 329:301–307.
  • Nissley P, Kiess W, Sklar M. 1993. Developmental expression of the IGF-II/mannose 6-phosphate receptor. Mol Reprod Dev. 35:408–413.
  • Norris K, Norris F, Kono DH, Vestergaard H, Pedersen O, Theofilopoulos AN, Moller NP. 1997. Expression of protein-tyrosine phosphatases in the major insulin target tissues. FEBS Lett. 415:243–248.
  • O'Gorman DB, Costello M, Weiss J, Firth SM, Scott CD. 1999. Decreased insulin-like growth factor-II/mannose 6-phosphate receptor expression enhances tumorigenicity in JEG-3 cells. Cancer Res. 59:5692–5694.
  • O'Gorman DB, Weiss J, Hettiaratchi A, Firth SM, Scott CD. 2002. Insulin-like growth factor-II/mannose 6-phosphate receptor overexpression reduces growth of choriocarcinoma cells in vitro and in vivo. Endocrinology. 143:4287–4294.
  • Ogawa O, McNoe LA, Eccles MR, Morison IM, Reeve AE. 1993. Human insulin-like growth factor type I and type II receptors are not imprinted. Hum Mol Genet. 2:2163–2165.
  • Ong K, Kratzsch J, Kiess W, Costello M, Scott C, Dunger D. 2000. Size at birth and cord blood levels of insulin, insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-1 (IGFBP-1), IGFBP-3, and the soluble IGF-II/mannose-6-phosphate receptor in term human infants. The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. J Clin Endocrinol Metab. 85:4266–4269.
  • Osorio M, Torres J, Moya F, Pezzullo J, Salafia C, Baxter R, Schwander J, Fant M. 1996. Insulin-like growth factors (IGFs) and IGF binding proteins-1, -2, and -3 in newborn serum: Relationships to fetoplacental growth at term. Early Hum Dev. 46:15–26.
  • Pandini G, Conte E, Medico E, Sciacca L, Vigneri R, Belfiore A. 2004. IGF-II binding to insulin receptor isoform A induces a partially different gene expression profile from insulin binding. Ann N Y Acad Sci. 1028:450–456.
  • Pravtcheva DD, Wise TL. 1998. Metastasizing mammary carcinomas in H19 enhancers-Igf2 transgenic mice. J Exp Zool. 281:43–57.
  • Pringle KG, Roberts CT. 2007. New light on early post-implantation pregnancy in the mouse: Roles for insulin-like growth factor-II (IGF-II)?. Placenta. 28:286–297.
  • Ravenel JD, Broman KW, Perlman EJ, Niemitz EL, Jayawardena TM, Bell DW, Haber DA, Uejima H, Feinberg AP. 2001. Loss of imprinting of insulin-like growth factor-II (IGF2) gene in distinguishing specific biologic subtypes of Wilms tumor. J Natl Cancer Inst. 93:1698–1703.
  • Rebourcet R, de Ceuninck CF, Deborde S, Willeput J, Ferre F. 1998. Differential distribution of binding sites for 125I-insulin-like growth factor II on trophoblast membranes of human term placenta. Biol Reprod. 58:37–44.
  • Ren J, Samson WK, Sowers JR. 1999. Insulin-like growth factor I as a cardiac hormone: Physiological and pathophysiological implications in heart disease. J Mol Cell Cardiol. 31:2049–2061.
  • Richardson AE, Hamilton N, Davis W, Brito C, De Leon LD. 2011. Insulin-like growth factor-2 (IGF-2) activates estrogen receptor-alpha and -beta via the IGF-1 and the insulin receptors in breast cancer cells. Growth Factors. 29:82–93.
  • Riedemann J, Macaulay VM. 2006. IGF1R signalling and its inhibition. Endocr Relat Cancer. 13 Suppl 1: S33–S43.
  • Roberts CT, Sohlstrom A, Kind KL, Grant PA, Earl RA, Robinson JS, Khong TY, Owens PC, Owens JA. 2001. Altered placental structure induced by maternal food restriction in guinea pigs: A role for circulating IGF-II and IGFBP-2 in the mother?. Placenta. 22 Suppl A: S77–S82.
  • Roy RN, Gerulath AH, Cecutti A, Bhavnani BR. 2000. Loss of IGF-II imprinting in endometrial tumors: Overexpression in carcinosarcoma. Cancer Lett. 153:67–73.
  • Sakatani T, Kaneda A, Iacobuzio-Donahue CA, Carter MG, de Boom WS, Okano H, Ko MS, Ohlsson R, Longo DL, Feinberg AP. 2005. Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science. 307:1976–1978.
  • Sciacca L, Costantino A, Pandini G, Mineo R, Frasca F, Scalia P, Sbraccia P, Goldfine ID, Vigneri R, Belfiore A. 1999. Insulin receptor activation by IGF-II in breast cancers: Evidence for a new autocrine/paracrine mechanism. Oncogene. 18:2471–2479.
  • Sciacca L, Mineo R, Pandini G, Murabito A, Vigneri R, Belfiore A. 2002. In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A. Oncogene. 21:8240–8250.
  • Scott CD, Weiss J. 2000. Soluble insulin-like growth factor II/mannose 6-phosphate receptor inhibits DNA synthesis in insulin-like growth factor II sensitive cells. J Cell Physiol. 182:62–68.
  • Scott CD, Ballesteros M, Madrid J, Baxter RC. 1996. Soluble insulin-like growth factor-II/mannose 6-P receptor inhibits deoxyribonucleic acid synthesis in cultured rat hepatocytes. Endocrinology. 137:873–878.
  • Sferruzzi-Perri AN, Owens JA, Pringle KG, Robinson JS, Roberts CT. 2006. Maternal insulin-like growth factors-I and -II act via different pathways to promote fetal growth. Endocrinology. 147:3344–3355.
  • Sferruzzi-Perri AN, Owens JA, Standen P, Taylor RL, Heinemann GK, Robinson JS, Roberts CT. Early treatment of the pregnant guinea pig with IGFs promotes placental transport and nutrient partitioning near term. Am J Physiol Endocrinol Metab. 2007a; 292:E668–E676.
  • Sferruzzi-Perri AN, Owens JA, Standen P, Taylor RL, Robinson JS, Roberts CT. Early pregnancy maternal endocrine insulin-like growth factor I programs the placenta for increased functional capacity throughout gestation. Endocrinology. 2007b; 148:4362–4370.
  • Sferruzzi-Perri AN, Owens JA, Standen P, Roberts CT. 2008. Maternal insulin-like growth factor-II promotes placental functional development via the type 2 IGF receptor in the guinea pig. Placenta. 29:347–355.
  • Sferruzzi-Perri AN, Vaughan OR, Coan PM, Suciu MC, Darbyshire R, Constancia M, Burton GJ, Fowden AL. 2011. Placental-specific igf2 deficiency alters developmental adaptations to undernutrition in mice. Endocrinology. 152:3202–3212.
  • Shields SK, Nicola C, Chakraborty C. 2007. Rho guanosine 5′-triphosphatases differentially regulate insulin-like growth factor I (IGF-I) receptor-dependent and -independent actions of IGF-II on human trophoblast migration. Endocrinology. 148:4906–4917.
  • Sibley CP, Coan PM, Ferguson-Smith A, Dean W, Hughes J, Smith P, Reik W, Burton GJ, Fowden A, Constancia M. 2004. Placental-specific insulin-like growth factor 2 (igf2) regulates the diffusional exchange characteristics of the mouse placenta. Proc Natl Acad Sci USA. 101:8204–8208.
  • Silha JV, Murphy LJ. 2005. Insulin-like growth factor binding proteins in development. Adv Exp Med Biol. 567:55–89.
  • Singh SK, Moretta D, Almaguel F, De Leon LM, De Leon DD. 2008. Precursor IGF-II (proIGF-II) and mature IGF-II (mIGF-II) induce Bcl-2 And Bcl-X L expression through different signaling pathways in breast cancer cells. Growth Factors. 26:92–103.
  • Soroceanu L, Kharbanda S, Chen R, Soriano RH, Aldape K, Misra A, Zha J, Forrest WF, Nigro JM, Modrusan Z, Feuerstein BG, Phillips HS. 2007. Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma. Proc Natl Acad Sci U S A. 104:3466–3471.
  • Stoger R, Kubicka P, Liu CG, Kafri T, Razin A, Cedar H, Barlow DP. 1993. Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal. Cell. 73:61–71.
  • Street ME, Viani I, Ziveri MA, Volta C, Smerieri A, Bernasconi S. 2011. Impairment of insulin receptor signal transduction in placentas of intra-uterine growth-restricted newborns and its relationship with fetal growth. Eur J Endocrinol. 164:45–52.
  • Suzuki H, Ueda R, Takahashi T, Takahashi T. 1994. Altered imprinting in lung cancer. Nat Genet. 6:332–333.
  • Su EJ, Cioffi CL, Stefansson S, Mittereder N, Garay M, Hreniuk D, Liau G. 2003. Gene therapy vector-mediated expression of insulin-like growth factors protects cardiomyocytes from apoptosis and enhances neovascularization. Am J Physiol Heart Circ Physiol. 284:H1429–H1440.
  • Tao Y, Pinzi V, Bourhis J, Deutsch E. 2007. Mechanisms of disease: Signaling of the insulin-like growth factor 1 receptor pathway–therapeutic perspectives in cancer. Nat Clin Pract Oncol. 4:591–602.
  • Taylor SI. 1992. Lilly Lecture: Molecular mechanisms of insulin resistance. Lessons from patients with mutations in the insulin-receptor gene. Diabetes. 41:1473–1490.
  • Thomsen BM, Clausen HV, Larsen LG, Nurnberg L, Ottesen B, Thomsen HK. 1997. Patterns in expression of insulin-like growth factor-II and of proliferative activity in the normal human first and third trimester placenta demonstrated by non-isotopic in situ hybridization and immunohistochemical staining for MIB-1. Placenta. 18:145–154.
  • Toretsky JA, Helman LJ. 1996. Involvement of IGF-II in human cancer. J Endocrinol. 149:367–372.
  • van Gurp RJ, Oosterhuis JW, Kalscheuer V, Mariman EC, Looijenga LH. 1994. Biallelic expression of the H19 and IGF2 genes in human testicular germ cell tumors. J Natl Cancer Inst. 86:1070–1075.
  • Vella V, Pandini G, Sciacca L, Mineo R, Vigneri R, Pezzino V, Belfiore A. 2002. A novel autocrine loop involving IGF-II and the insulin receptor isoform-A stimulates growth of thyroid cancer. J Clin Endocrinol Metab. 87:245–254.
  • Volpert O, Jackson D, Bouck N, Linzer DI. 1996. The insulin-like growth factor-II / mannose 6-phosphate receptor is required for proliferin-induced angiogenesis. Endocrinology. 137:3871–3876.
  • Vu TH, Yballe C, Boonyanit S, Hoffman AR. 1995. Insulin-like growth factor II in uterine smooth-muscle tumors: Maintenance of genomic imprinting in leiomyomata and loss of imprinting in leiomyosarcomata. J Clin Endocrinol Metab. 80:1670–1676.
  • Ward A. 1997. Beckwith–Wiedemann syndrome and Wilms' tumour. Mol Hum Reprod. 3:157–168.
  • Westwood M, Gibson JM, Sooranna SR, Ward S, Neilson JP, Bajoria R. 2001. Genes or placenta as modulator of fetal growth: Evidence from the insulin-like growth factor axis in twins with discordant growth. Mol Hum Reprod. 7:387–395.
  • Wise TL, Pravtcheva DD. 2006. Delayed onset of Igf2-induced mammary tumors in Igf2r transgenic mice. Cancer Res. 66:1327–1336.
  • Xu Y, Goodyer CG, Deal C, Polychronakos C. 1993. Functional polymorphism in the parental imprinting of the human IGF2R gene. Biochem Biophys Res Commun. 197:747–754.
  • Xu YQ, Grundy P, Polychronakos C. 1997. Aberrant imprinting of the insulin-like growth factor II receptor gene in Wilms' tumor. Oncogene. 14:1041–1046.
  • Yu J, Iwashita M, Kudo Y, Takeda Y. 1998. Phosphorylated insulin-like growth factor (IGF)-binding protein-1 (IGFBP-1) inhibits while non-phosphorylated IGFBP-1 stimulated IGF-I induced amino acid uptake by cultured trophoblast cells. Growth Hormone & IGF Research. 8:65–70.
  • Zhu CQ, Popova SN, Brown ER, Barsyte-Lovejoy D, Navab R, Shih W, Li M, Lu M, Jurisica I, Penn LZ, Gullberg D, Tsao MS. 2007. Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells. Proc Natl Acad Sci U S A. 104:11754–11759.

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