489
Views
28
CrossRef citations to date
0
Altmetric
Articles

Ubiquitination-mediated regulation of interferon responses

Pages 141-148 | Received 30 Jan 2012, Accepted 21 Feb 2012, Published online: 07 Mar 2012

References

  • Ali S, Nouhi Z, Chughtai N. 2003. SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptor. J Biol Chem. 278:52021–52031.
  • Ashour J, Laurent-Rolle M, Shi PY, Garcia-Sastre A. 2009. NS5 of dengue virus mediates STAT2 binding and degradation. J Virol. 83:5408–5418.
  • Bhattacharya S, HuangFu WC, Liu J, Veeranki S, Baker DP, Koumenis C, Diehl JA, Fuchs Y. 2010. Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor. J Biol Chem. 285:2318–2325.
  • Bhattacharya S, Zheng H, Tzimas C, Carroll M, Baker DP, Fuchs Y. 2011. Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFNalpha via accelerating the degradation of its receptor. Blood. 118:4179–4187.
  • Bibeau-Poirier A, Servant J. 2008. Roles of ubiquitination in pattern-recognition receptors and type I interferon receptor signaling. Cytokine. 43:359–367.
  • Boname JM, Lehner J. 2011. What has the study of the K3 and K5 viral ubiquitin E3 ligases taught us about ubiquitin-mediated receptor regulation?. Viruses. 3:118–131.
  • Boname JM, de Lima BD, Lehner PJ, Stevenson G. 2004. Viral degradation of the MHC class I peptide loading complex. Immunity. 20:305–317.
  • Boname JM, Thomas M, Stagg HR, Xu P, Peng J, Lehner J. 2010. Efficient internalization of MHC I requires lysine-11 and lysine-63 mixed linkage polyubiquitin chains. Traffic. 11:210–220.
  • Bonnet MC, Weil R, Dam E, Hovanessian AG, Meurs F. 2000. PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex. Mol Cell Biol. 20:4532–4542.
  • Burr ML, Cano F, Svobodova S, Boyle LH, Boname JM, Lehner J. 2011. HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation. Proc Natl Acad Sci USA. 108:2034–2039.
  • Chen ZJ. 2005. Ubiquitin signalling in the NF-kappaB pathway. Nat Cell Biol. 7:758–765.
  • Cho IR, Oh M, Koh SS, Malilas W, Srisuttee R, Jhun BH, Pallegrini S, Fuchs SY, Chung YH. 2012. Hepatitis B virus X protein inhibits extracellular IFN-alpha-mediated signal transduction by downregulation of type I IFN receptor. Int J Mol Med. 29:581–586.
  • Chu WM, Ostertag D, Li ZW, Chang L, Chen Y, Hu Y, Williams B, Perrault J, Karin M. 1999. JNK2 and IKKbeta are required for activating the innate response to viral infection. Immunity. 11:721–731.
  • Crow MK, Kirou A. 2004. Interferon-alpha in systemic lupus erythematosus. Curr Opin Rheumatol. 16:541–547.
  • Datta S, Hazari S, Chandra PK, Samara M, Poat B, Gunduz F, Wimley WC, Hauser H, Koster M, Lamaze C, Balart LA, Garry RF, Dash S. 2011. Mechanism of HCV's resistance to IFN-alpha in cell culture involves expression of functional IFN-alpha receptor 1. Virol J. 8:351.
  • de Bie P, Ciechanover A. 2011. Ubiquitination of E3 ligases: Self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms. Cell Death Differ. 18:1393–1402.
  • Donnelly RP, Kotenko V. 2010. Interferon-lambda: A new addition to an old family. J Interferon Cytokine Res. 30:555–564.
  • Douglas JL, Gustin JK, Viswanathan K, Mansouri M, Moses AV, Fruh K. 2010. The great escape: Viral strategies to counter BST-2/tetherin. PLoS Pathog. 6:e1000913.
  • Elliott J, Lynch OT, Suessmuth Y, Qian P, Boyd CR, Burrows JF, Buick R, Stevenson NJ, Touzelet O, Gadina M, Power UF, Johnston A. 2007. Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase. J Virol. 81:3428–3436.
  • Fuchs SY. 2002. The role of ubiquitin-proteasome pathway in oncogenic signaling. Cancer Biol Ther. 1:337–341.
  • Fuchs SY, Spiegelman VS, Kumar G. 2004. The many faces of beta-TrCP E3 ubiquitin ligases: Reflections in the magic mirror of cancer. Oncogene. 23:2028–2036.
  • Gao C, Guo H, Mi Z, Grusby MJ, Kuo C. Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages. J Immunol. 2007a; 178:1870–1881.
  • Gao C, Mi Z, Guo H, Kuo C. Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells. Neoplasia. 2007b; 9:699–706.
  • Garcin D, Marq JB, Strahle L, le Mercier P, Kolakofsky D. 2002. All four Sendai Virus C proteins bind Stat1, but only the larger forms also induce its mono-ubiquitination and degradation. Virology. 295:256–265.
  • Gauzzi MC, Barbieri G, Richter MF, Uze G, Ling L, Fellous M, Pellegrini S. 1997. The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor. Proc Natl Acad Sci USA. 94:11839–11844.
  • Goila-Gaur R, Strebel K. 2008. HIV-1 Vif, APOBEC, and intrinsic immunity. Retrovirology. 5:51.
  • Guo H, Mi Z, Bowles DE, Bhattacharya SD, Kuo C. 2010. Osteopontin and protein kinase C regulate PDLIM2 activation and STAT1 ubiquitination in LPS-treated murine macrophages. J Biol Chem. 285:37787–37796.
  • Hewitt EW, Duncan L, Mufti D, Baker J, Stevenson PG, Lehner J. 2002. Ubiquitylation of MHC class I by the K3 viral protein signals internalization and TSG101-dependent degradation. EMBO J. 21:2418–2429.
  • Huangfu WC, Fuchs Y. 2010. Ubiquitination-dependent regulation of signaling receptors in cancer. Genes Cancer. 1:725–734.
  • Huangfu WC, Qian J, Liu C, Liu J, Lokshin AE, Baker DP, Rui H, Fuchs SY. 2012. Inflammatory signaling compromises cell responses to interferon alpha. Oncogene. 31:161–172.
  • Ishii T, Kwon H, Hiscott J, Mosialos G, Koromilas E. 2001. Activation of the I kappa B alpha kinase (IKK) complex by double-stranded RNA-binding defective and catalytic inactive mutants of the interferon-inducible protein kinase PKR. Oncogene. 20:1900–1912.
  • Jackson PK. 2001. A new RING for SUMO: Wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases. Genes Dev. 15:3053–3058.
  • Kamizono S, Hanada T, Yasukawa H, Minoguchi S, Kato R, Minoguchi M, Hattori K, Hatakeyama S, Yada M, Morita S, Kitamura T, Kato H, Nakayama K, Yoshimura A. 2001. The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2. J Biol Chem. 276:12530–12538.
  • Kamura T, Sato S, Haque D, Liu L, Kaelin WGJr, Conaway RC, Conaway W. 1998. The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev. 12:3872–3881.
  • Kim TK, Maniatis T. 1996. Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway. Science. 273:1717–1719.
  • Kirkin V, Dikic I. 2011. Ubiquitin networks in cancer. Curr Opin Genet Dev. 21:21–28.
  • Komuro A, Bamming D, Horvath M. 2008. Negative regulation of cytoplasmic RNA-mediated antiviral signaling. Cytokine. 43:350–358.
  • Kumar KG, Tang W, Ravindranath AK, Clark WA, Croze E, Fuchs Y. 2003. SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor. EMBO J. 22:5480–5490.
  • Kumar KG, Krolewski JJ, Fuchs Y. 2004. Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor. J Biol Chem. 279:46614–46620.
  • Kumar KG, Barriere H, Carbone CJ, Liu J, Swaminathan G, Xu P, Li Y, Baker DP, Peng J, Lukacs GL, Fuchs Y. 2007. Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis. J Cell Biol. 179:935–950.
  • Kumar KG, Varghese B, Banerjee A, Baker DP, Constantinescu SN, Pellegrini S, Fuchs Y. 2008. Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif. J Biol Chem. 283:18566–18572.
  • Le VT, Trilling M, Wilborn M, Hengel H, Zimmermann A. 2008. Human cytomegalovirus interferes with signal transducer and activator of transcription (STAT) 2 protein stability and tyrosine phosphorylation. J Gen Virol. 89:2416–2426.
  • Lee Y, Hyung SW, Jung HJ, Kim HJ, Staerk J, Constantinescu SN, Chang EJ, Lee ZH, Lee SW, Kim H. 2008. The ubiquitin-mediated degradation of Jak1 modulates osteoclastogenesis by limiting interferon-beta-induced inhibitory signaling. Blood. 111:885–893.
  • Lehner PJ, Hoer S, Dodd R, Duncan M. 2005. Downregulation of cell surface receptors by the K3 family of viral and cellular ubiquitin E3 ligases. Immunol Rev. 207:112–125.
  • Liberatore RA, Bieniasz D. 2011. Tetherin is a key effector of the antiretroviral activity of type I interferon in vitro and in vivo. Proc Natl Acad Sci USA. 108:18097–18101.
  • Liu J, HuangFu WC, Kumar KG, Qian J, Casey JP, Hamanaka RB, Grigoriadou C, Aldabe R, Diehl JA, Fuchs Y. 2009. Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylation-dependent degradation of the type I interferon receptor. Cell Host Microbe. 5:72–83.
  • Li Y, Gazdoiu S, Pan ZQ, Fuchs Y. 2004. Stability of homologue of Slimb F-box protein is regulated by availability of its substrate. J Biol Chem. 279:11074–11080.
  • Li Q, Means R, Lang S, Jung U. 2007. Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5. J Virol. 81:2117–2127.
  • Mangeat B, Gers-Huber G, Lehmann M, Zufferey M, Luban J, Piguet V. 2009. HIV-1 Vpu neutralizes the antiviral factor tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation. PLoS Pathog. 5:e1000574.
  • Mansouri M, Viswanathan K, Douglas JL, Hines J, Gustin J, Moses AV, Fruh K. 2009. Molecular mechanism of BST2/tetherin downregulation by K5/MIR2 of Kaposi's sarcoma-associated herpesvirus. J Virol. 83:9672–9681.
  • Marijanovic Z, Ragimbeau J, Kumar KG, Fuchs SY, Pellegrini S. 2006. TYK2 activity promotes ligand-induced IFNAR1 proteolysis. Biochem J. 397:31–38.
  • Minakshi R, Padhan K, Rani M, Khan N, Ahmad F, Jameel S. 2009. The SARS coronavirus 3a protein causes endoplasmic reticulum stress and induces ligand-independent downregulation of the type 1 interferon receptor. PLoS One. 4:e8342.
  • Mitchell RS, Katsura C, Skasko MA, Fitzpatrick K, Lau D, Ruiz A, Stephens EB, Margottin-Goguet F, Benarous R, Guatelli C. 2009. Vpu antagonizes BST-2-mediated restriction of HIV-1 release via beta-TrCP and endo-lysosomal trafficking. PLoS Pathog. 5:e1000450.
  • Nie L, Zhao Y, Wu W, Yang YZ, Wang HC, Sun H. 2011. Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes. Cell Res. 21:754–769.
  • Pardieu C, Vigan R, Wilson SJ, Calvi A, Zang T, Bieniasz P, Kellam P, Towers GJ, Neil J. 2010. The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin. PLoS Pathog. 6:e1000843.
  • Payelle-Brogard B, Pellegrini S. 2010. Biochemical monitoring of the early endocytic traffic of the type I interferon receptor. J Interferon Cytokine Res. 30:89–98.
  • Pfeffer LM. 2011. The role of nuclear factor kappaB in the interferon response. J Interferon Cytokine Res. 31:553–559.
  • Piganis RA, De Weerd NA, Gould JA, Schindler CW, Mansell A, Nicholson SE, Hertzog J. 2011. Suppressor of cytokine signaling (SOCS) 1 inhibits type I interferon (IFN) signaling via the interferon alpha receptor (IFNAR1)-associated tyrosine kinase Tyk2. J Biol Chem. 286:33811–33818.
  • Platanias LC. 2005. Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol. 5:375–386.
  • Poat B, Hazari S, Chandra PK, Gunduz F, Balart LA, Alvarez X, Dash S. 2010. SH2 modified STAT1 induces HLA-I expression and improves IFN-gamma signaling in IFN-alpha resistant HCV replicon cells. PLoS One. 5:e13117.
  • Precious B, Childs K, Fitzpatrick-Swallow V, Goodbourn S, Randall E. 2005. Simian virus 5 V protein acts as an adaptor, linking DDB1 to STAT2, to facilitate the ubiquitination of STAT1. J Virol. 79:13434–13441.
  • Puri M, Lemon K, Duprex WP, Rima BK, Horvath M. 2009. A point mutation, E95D, in the mumps virus V protein disengages STAT3 targeting from STAT1 targeting. J Virol. 83:6347–6356.
  • Qian J, Zheng H, Huangfu WC, Liu J, Carbone CJ, Leu NA, Baker DP, Fuchs Y. 2011. Pathogen recognition receptor signaling accelerates phosphorylation-dependent degradation of IFNAR1. PLoS Pathog. 7:e1002065.
  • Ragimbeau J, Dondi E, Alcover A, Eid P, Uze G, Pellegrini S. 2003. The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression. EMBO J. 22:537–547.
  • Ramachandran A, Horvath M. 2009. Paramyxovirus disruption of interferon signal transduction: STATus report. J Interferon Cytokine Res. 29:531–537.
  • Ren J, Kolli D, Liu T, Xu R, Garofalo RP, Casola A, Bao X. 2011. Human metapneumovirus inhibits IFN-beta signaling by downregulating Jak1 and Tyk2 cellular levels. PLoS One. 6:e24496.
  • Schmidt K, Wies E, Neipel F. 2011. Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 3 inhibits gamma interferon and major histocompatibility complex class II expression. J Virol. 85:4530–4537.
  • Seth RB, Sun L, Chen J. 2006. Antiviral innate immunity pathways. Cell Res. 16:141–147.
  • Shah KM, Stewart SE, Wei W, Woodman CB, O'Neil JD, Dawson CW, Young S. 2009. The EBV-encoded latent membrane proteins, LMP2A and LMP2B, limit the actions of interferon by targeting interferon receptors for degradation. Oncogene. 28:3903–3914.
  • Soond SM, Townsend PA, Barry SP, Knight RA, Latchman DS, Stephanou A. 2008. ERK and the F-box protein betaTRCP target STAT1 for degradation. J Biol Chem. 283:16077–16083.
  • Straub CP, Lau WH, Preston FM, Headlam MJ, Gorman JJ, Collins PL, Spann M. 2011. Mutation of the elongin C binding domain of human respiratory syncytial virus non-structural protein 1 (NS1) results in degradation of NS1 and attenuation of the virus. Virol J. 8:252.
  • Tanaka T, Soriano MA, Grusby J. 2005. SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling. Immunity. 22:729–736.
  • Tanaka T, Yamamoto Y, Muromoto R, Ikeda O, Sekine Y, Grusby MJ, Kaisho T, Matsuda T. 2011. PDLIM2 inhibits T helper 17 cell development and granulomatous inflammation through degradation of STAT3. Sci Signal. 4:ra85.
  • Tenno T, Fujiwara K, Tochio H, Iwai K, Morita EH, Hayashi H, Murata S, Hiroaki H, Sato M, Tanaka K, Shirakawa M. 2004. Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains. Genes Cells. 9:865–875.
  • Trilling M, Le VT, Fiedler M, Zimmermann A, Bleifuss E, Hengel H. 2011. Identification of DNA-damage DNA-binding protein 1 as a conditional essential factor for cytomegalovirus replication in interferon-gamma-stimulated cells. PLoS Pathog. 7:e1002069.
  • Ulane CM, Horvath M. 2002. Paramyxoviruses SV5 and HPIV2 assemble STAT protein ubiquitin ligase complexes from cellular components. Virology. 304:160–166.
  • Ulane CM, Rodriguez JJ, Parisien JP, Horvath M. 2003. STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling. J Virol. 77:6385–6393.
  • Ulane CM, Kentsis A, Cruz CD, Parisien JP, Schneider KL, Horvath M. 2005. Composition and assembly of STAT-targeting ubiquitin ligase complexes: Paramyxovirus V protein carboxyl terminus is an oligomerization domain. J Virol. 79:10180–10189.
  • Ungureanu D, Silvennoinen O. 2005. SLIM trims STATs: Ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling. Sci STKE. 2005:pe49.
  • Ungureanu D, Saharinen P, Junttila I, Hilton DJ, Silvennoinen O. 2002. Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1. Mol Cell Biol. 22:3316–3326.
  • Uze G, Schreiber G, Piehler J, Pellegrini S. 2007. The receptor of the type I interferon family. Curr Top Microbiol Immunol. 316:71–95.
  • Viswanathan K, Fruh K, DeFilippis V. 2010. Viral hijacking of the host ubiquitin system to evade interferon responses. Curr Opin Microbiol. 13:517–523.
  • Viswanathan K, Smith MS, Malouli D, Mansouri M, Nelson JA, Fruh K. 2011. BST2/tetherin enhances entry of human cytomegalovirus. PLoS Pathog. 7:e1002332.
  • Yang CH, Murti A, Pfeffer SR, Fan M, Du Z, Pfeffer M. 2008. The role of TRAF2 binding to the type I interferon receptor in alternative NF kappaB activation and antiviral response. J Biol Chem. 283:14309–14316.
  • Yokosawa N, Yokota S, Kubota T, Fujii N. 2002. C-terminal region of STAT-1alpha is not necessary for its ubiquitination and degradation caused by mumps virus V protein. J Virol. 76:12683–12690.
  • Yu J, Li X, Wang Y, Li B, Li H, Li Y, Zhou W, Zhang C, Rao Z, Bartlam M, Cao Y. 2011. PDlim2 selectively interacts with the PDZ binding motif of highly pathogenic avian H5N1 influenza A virus NS1. PLoS One. 6:e19511.
  • Zhang D, Zhang E. 2011. Interferon-stimulated gene 15 and the protein ISGylation system. J Interferon Cytokine Res. 31:119–130.
  • Zheng H, Qian J, Baker DP, Fuchs Y. Tyrosine phosphorylation of protein kinase D2 mediates ligand-inducible elimination of the Type 1 interferon receptor. J Biol Chem. 2011a; 286:35733–35741.
  • Zheng H, Qian J, Carbone CJ, Leu NA, Baker DP, Fuchs Y. Vascular endothelial growth factor-induced elimination of the type 1 interferon receptor is required for efficient angiogenesis. Blood. 2011b; 118:4003–4006.
  • Zheng H, Qian J, Varghese B, Baker DP, Fuchs S. Ligand-stimulated downregulation of the alpha interferon receptor: Role of protein kinase D2. Mol Cell Biol. 2011c; 31:710–720.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.