103
Views
5
CrossRef citations to date
0
Altmetric
Articles

B2A, a receptor modulator, increases the growth of pluripotent and preosteoblast cells through bone morphogenetic protein receptors

, , &
Pages 410-417 | Received 24 Sep 2012, Accepted 29 Oct 2012, Published online: 11 Dec 2012

References

  • Boergermann JH, Kopf J, Yu PB, Knaus P. 2010. Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. Int J Biochem Cell Biol. 42:1802–1807.
  • Bragdon B, Moseychuk O, Saldanha S, King D, Julian J, Nohe A. 2011. Bone morphogenetic proteins: a critical review. Cell Signal. 23:609–620.
  • Castano E, Dalmau M, Marti M, Berrocal F, Bartrons R, Gil J. 1997. Inhibition of DNA synthesis by aspirin in Swiss 3T3 fibroblasts. J Pharmacol Exp Ther. 280:366–372.
  • Chambard JC, Lefloch R, Pouyssegur J, Lenormand P. 2007. ERK implication in cell cycle regulation. Biochim Biophys Acta. 1773:1299–1310.
  • Cunningham BW, Atkinson BL, Hu N, Kikkawa J, Jenis L, Bryant J, Zamora PO, McAfee PC. 2009. Ceramic granules enhanced with B2A peptide for lumbar interbody spine fusion: An experimental study using an instrumented model in sheep. J Neurosurg Spine. 10:300–307.
  • Fehrenbacher JC, Burkey TH, Nicol GD, Vasko MR. 2005. Tumor necrosis factor alpha and interleukin-1beta stimulate the expression of cyclooxygenase II but do not alter prostaglandin E2 receptor mRNA levels in cultured dorsal root ganglia cells. Pain. 113:113–122.
  • Gallea S, Lallemand F, Atfi A, Rawadi G, Ramez V, Spinella-Jaegle S, Kawai S, Faucheu C, Huet L, Baron R, Roman-Roman S. 2001. Activation of mitogen-activated protein kinase cascades is involved in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2C12 cells. Bone. 28:491–498.
  • Guicheux J, Lemonnier J, Ghayor C, Suzuki A, Palmer G, Caverzasio J. 2003. Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation. J Bone Miner Res. 18:2060–2068.
  • Hong CC, Yu PB. 2009. Applications of small molecule BMP inhibitors in physiology and disease. Cytokine Growth Factor Rev. 20:409–418.
  • Li G, White G, Connolly C, Marsh D. 2002. Cell proliferation and apoptosis during fracture healing. J Bone Miner Res. 17 5: 791–799.
  • Lin X, Zamora PO, Albright S, Glass JD, Pena LA. 2005. Multidomain synthetic peptide B2A2 synergistically enhances BMP-2 in vitro. J Bone Miner Res. 20:693–703.
  • Lin X, Elliot JJ, Carnes DL, Fox WC, Pena LA, Campion SL, Takahashi K, Atkinson BL, Zamora PO. Augmentation of osseous phenotypes in vivo with a synthetic peptide. J Orthop Res. 2007a; 25:531–539.
  • Lin X, Takahashi K, Liu Y, Derrien A, Zamora PO. A synthetic, bioactive PDGF mimetic with binding to both alpha-PDGF and beta-PDGF receptors. Growth Factors. 2007b; 25:87–93.
  • Lin X, Guo H, Takahashi K, Liu Y, Zamora PO. B2A as a positive BMP receptor modulator. Growth Factors. 2012a; 30:149–157.
  • Lin X, Shanmugasundaram S, Liu Y, Derrien A, Nurminskaya M, Zamora PO. B2A peptide induces chondrogenic differentiation in vitro and enhances cartilage repair in rats. J Orthop Res. 2012b; 30:1221–1228.
  • Manning BD, Cantley LC. 2007. AKT/PKB signaling: Navigating downstream. Cell. 129:1261–1274.
  • McCanless JD, Cole JA, Slack SM, Bumgardner JD, Zamora PO, Haggard WO. Modeling nucleus pulposus regeneration in vitro: Mesenchymal stem cells, alginate beads, hypoxia, BMP-2, and synthetic peptide B2A. Spine (Phila Pa 1976). 20112275–2285.
  • Miyazono K, Kamiya Y, Morikawa M. 2010. Bone morphogenetic protein receptors and signal transduction. J Biochem. 147:35–51.
  • Moustakas A, Heldin CH. 2005. Non-Smad TGF-beta signals. J Cell Sci. 118:3573–3584.
  • Nohe A, Hassel S, Ehrlich M, Neubauer F, Sebald W, Henis YI, Knaus P. 2002. The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways. J Biol Chem. 277:5330–5338.
  • Nohe A, Keating E, Knaus P, Petersen NO. 2004. Signal transduction of bone morphogenetic protein receptors. Cell Signal. 16:291–299.
  • Rawadi G, Vayssiere B, Dunn F, Baron R, Roman-Roman S. 2003. BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop. J Bone Miner Res. 18:1842–1853.
  • Smucker JD, Bobst JA, Petersen EB, Nepola JV, Fredericks DC. 2008. B2A peptide on ceramic granules enhance posterolateral spinal fusion in rabbits compared with autograft. Spine (Phila Pa 1976). 33:1324–1329.
  • Thawani JP, Wang AC, Than KD, Lin CY, La Marca F, Park P. 2010. Bone morphogenetic proteins and cancer: Review of the literature. Neurosurgery. 66:233–246 discussion 246.
  • Vaes BL, Dechering KJ, van Someren EP, Hendriks JM, van de Ven CJ, Feijen A, Mummery CL, Reinders MJ, Olijve W, van Zoelen EJ, Steegenga WT. 2005. Microarray analysis reveals expression regulation of Wnt antagonists in differentiating osteoblasts. Bone. 36:803–811.
  • Zhang YE. 2009. Non-Smad pathways in TGF-beta signaling. Cell Res. 19:128–139.
  • Zhang JL, Huang Y, Qiu LY, Nickel J, Sebald W. 2007. von Willebrand factor type C domain-containing proteins regulate bone morphogenetic protein signaling through different recognition mechanisms. J Biol Chem. 282:20002–20014.
  • Zhang JL, Qiu LY, Kotzsch A, Weidauer S, Patterson L, Hammerschmidt M, Sebald W, Mueller TD. 2008. Crystal structure analysis reveals how the chordin family member crossveinless 2 blocks BMP-2 receptor binding. Dev Cell. 14:739–750.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.