Expression levels of insulin receptor substrate-1 modulate the osteoblastic differentiation of mesenchymal stem cells and osteosarcoma cells

References

• Baserga R. 2000. The contradictions of the insulin-like growth factor 1 receptor. Oncogene 19:5574–5581
   PubMed Web of Science ®Google Scholar
• Baserga R. 2013. The decline and fall of the IGF-I receptor. J Cell Physiol 228:675–679
   PubMed Web of Science ®Google Scholar
• Baserga R. 2009. The insulin receptor substrate-1: A biomarker for cancer? Exp Cell Res 315:727–732
   PubMedGoogle Scholar
• Benini S, Baldini N, Manara MC, Chano T, Serra M, Rizzi S, Lollini PL, et al. 1999. Redundancy of autocrine loops in human osteosarcoma cells. Int J Cancer 80:581–588
   PubMed Web of Science ®Google Scholar
• Birnbaum RS, Bowsher RR, Wiren KM. 1995. Changes in IGF-I and -II expression and secretion during the proliferation and differentiation of normal rat osteoblasts. J Endocrinol 144:251–259
   Google Scholar
• Chang Q, Li Y, White MF, Fletcher JA, Xiao S. 2002. Constitutive activation of insulin receptor substrate 1 is a frequent event in human tumors: Therapeutic implications. Cancer Res 62:6035–6038
   PubMed Web of Science ®Google Scholar
• Chen J, Capozza F, Wu A, Deangelis T, Sun H, Lisanti M, Baserga R. 2008. Regulation of insulin receptor substrate-1 expression levels by caveolin-1. J Cell Physiol 217:281–289
   PubMedGoogle Scholar
• Chen J, Wu A, Sun H, Drakas R, Garofalo C, Cascio S, Surmacz E, Baserga R. 2005. Functional significance of type 1 insulin-like growth factor-mediated nuclear translocation of the insulin receptor substrate-1 and beta-catenin. J Biol Chem 280:29912–29920
   PubMed Web of Science ®Google Scholar
• Cypess AM, Zhang H, Schulz TJ, Huang TL, Espinoza DO, Kristiansen K, Unterman TG, Tseng YH. 2011. Insulin/IGF-I regulation of necdin and brown adipocyte differentiation via CREB- and FoxO1-associated pathways. Endocrinology 152:3680–3689
   Google Scholar
• D'Ambrosio C, Keller SR, Morrione A, Lienhard GE, Baserga R, Surmacz E. 1995. Transforming potential of the insulin receptor substrate 1. Cell Growth Differ 6:557–562
   PubMedGoogle Scholar
• Dupont J, Holzenberger M. 2003. Biology of insulin-like growth factors in development. Birth Defects Res C Embryo Today 69:257–271
   PubMedGoogle Scholar
• Fei ZL, D'Ambrosio C, Li S, Surmacz E, Baserga R. 1995. Association of insulin receptor substrate 1 with simian virus 40 large T antigen. Mol Cell Biol 15:4232–4239
   PubMedGoogle Scholar
• Gallagher EJ, LeRoith D. 2011. Minireview: IGF, insulin, and cancer. Endocrinology 152:2546–2551
   PubMed Web of Science ®Google Scholar
• Garofalo C, Manara MC, Nicoletti G, Marino MT, Lollini PL, Astolfi A, Pandini G, et al. 2011. Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signaling. Oncogene 30:2730–2740
   Web of Science ®Google Scholar
• Garofalo C, Mancarella C, Grilli A, Manara MC, Astolfi A, Marino MT, Conte A, et al. 2012. Identification of common and distinctive mechanisms of resistance to different anti-IGF-IR agents in Ewing's sarcoma. Mol Endocrinol 26:1603–1616
   PubMed Web of Science ®Google Scholar
• Good MC, Zalatan JG, Lim WA. 2011. Scaffold proteins: Hubs for controlling the flow of cellular information. Science 332:680–686
   PubMed Web of Science ®Google Scholar
• Granero-Molto F, Myers TJ, Weis JA, Longobardi L, Li T, Yan Y, Case N, et al. 2011. Mesenchymal stem cells expressing insulin-like growth factor-I (MSCIGF) promote fracture healing and restore new bone formation in Irs1 knockout mice: Analyses of MSCIGF autocrine and paracrine regenerative effects. Stem Cells 29:1537–1548
   PubMed Web of Science ®Google Scholar
• Ito T, Sasaki Y, Wands JR. 1996. Overexpression of human insulin receptor substrate 1 induces cellular transformation with activation of mitogen-activated protein kinases. Mol Cell Biol 16:943–951
   PubMedGoogle Scholar
• Koda M, Sulkowska M, Kanczuga-Koda L, Sulkowski S. 2005. Expression of insulin receptor substrate 1 in primary breast cancer and lymph node metastases. J Clin Pathol 58:645–649
   PubMed Web of Science ®Google Scholar
• Langlois JA, Rosen CJ, Visser M, Hannan MT, Harris T, Wilson PW, Kiel DP. 1998. Association between insulin-like growth factor I and bone mineral density in older women and men: The Framingham Heart Study. J Clin Endocrinol Metab 83:4257–4262
   PubMed Web of Science ®Google Scholar
• Longobardi L, Granero-Moltó F, O'Rear L, Myers TJ, Li T, Kregor PJ, Spagnoli A. 2009. Subcellular localization of IRS-1 in IGF-I-mediated chondrogenic proliferation, differentiation and hypertrophy of bone marrow mesenchymal stem cells. Growth Factors 27:309–320
   PubMed Web of Science ®Google Scholar
• Merriman HL, La Tour D, Linkhart TA, Mohan S, Baylink DJ, Strong DD. 1990. Insulin-like growth factor-I and insulin-like growth factor-II induce c-fos in mouse osteoblastic cells. Calcif Tissue Int 46:258–262
   PubMed Web of Science ®Google Scholar
• Milat F, Ng KW. 2009. Is Wnt signalling the final common pathway leading to bone formation? Mol Cell Endocrinol 310:52–62
   PubMed Web of Science ®Google Scholar
• Nanni P, Nicoletti G, Landuzzi L, Croci S, Murgo A, Palladini A, Antognoli A, et al. 2010. High metastatic efficiency of human sarcoma cells in Rag2/gammac double knockout mice provides a powerful test system for antimetastatic targeted therapy. Eur J Cancer 46:659–668
   PubMedGoogle Scholar
• Ochiai H, Okada S, Saito A, Hoshi K, Yamashita H, Takato T, Azuma T. 2012. Inhibition of insulin-like growth factor-1 (IGF-1) expression by prolonged transforming growth factor-beta1 (TGF-beta1) administration suppresses osteoblast differentiation. J Biol Chem 287:22654–22661
   PubMed Web of Science ®Google Scholar
• Olmos D, Postel-Vinay S, Molife LR, Okuno SH, Schuetze SM, Paccagnella ML, Batzel GN, et al. 2010. Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: A phase 1 expansion cohort study. Lancet Oncol 11:129–135
   PubMed Web of Science ®Google Scholar
• Peister A, Mellad JA, Larson BL, Hall BM, Gibson LF, Prockop DJ. 2004. Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential. Blood 103:1662–1668
   PubMed Web of Science ®Google Scholar
• Pollak M, Richard M. 1990. Suramin blockade of insulinlike growth factor I-stimulated proliferation of human osteosarcoma cells. J Natl Cancer Inst 82:1349–1352
   PubMed Web of Science ®Google Scholar
• Pollak M, Sem AW, Richard M, Tetenes E, Bell R. 1992. Inhibition of metastatic behavior of murine osteosarcoma by hypophysectomy. J Natl Cancer Inst 84:966–971
   Google Scholar
• Reiss K, Wang JY, Romano G, Furnari FB, Cavenee WK, Morrione A, Tu X, Baserga R. 2000. IGF-I receptor signaling in a prostatic cancer cell line with a PTEN mutation. Oncogene 19:2687–2694
   PubMedGoogle Scholar
• Rosen CJ, Dimai HP, Vereault D, Donahue LR, Beamer WG, Farley J, Linkhart S, et al. 1997. Circulating and skeletal insulin-like growth factor-I (IGF-I) concentrations in two inbred strains of mice with different bone mineral densities. Bone 21:217–223
   PubMed Web of Science ®Google Scholar
• Sampson VB, Gorlick R, Kamara D, Anders Kolb E. 2013. A review of targeted therapies evaluated by the pediatric preclinical testing program for osteosarcoma. Front Oncol 3:132 (1--12)
   Google Scholar
• Sangaletti S, Stoppacciaro A, Guiducci C, Torrisi MR, Colombo MP. 2003. Leukocyte, rather than tumor-produced SPARC, determines stroma and collagen type IV deposition in mammary carcinoma. J Exp Med 198:1475–1485
   PubMed Web of Science ®Google Scholar
• Schiller PC, D'Ippolito G, Roos BA, Howard GA. 1999. Anabolic or catabolic responses of MC3T3-E1 osteoblastic cells to parathyroid hormone depend on time and duration of treatment. J Bone Min Res 14:1504–1512
   PubMed Web of Science ®Google Scholar
• Schnoke M, Midura RJ. 2007. Pulsed electromagnetic fields rapidly modulate intracellular signaling events in osteoblastic cells: Comparison to parathyroid hormone and insulin. J Orthop Res 25:933–940
   PubMed Web of Science ®Google Scholar
• Scotlandi K, Manara MC, Nicoletti G, Lollini PL, Lukas S, Benini S, Croci S, et al. 2005. Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors. Cancer Res 65:3868–3876
   PubMed Web of Science ®Google Scholar
• Scotlandi K, Picci P. 2008. Targeting insulin-like growth factor 1 receptor in sarcomas. Curr Opin Oncol 20:419–427
   PubMed Web of Science ®Google Scholar
• Steele-Perkins G, Roth RA. 1990. Monoclonal antibody alpha IR-3 inhibits the ability of insulin-like growth factor II to stimulate a signal from the type I receptor without inhibiting its binding. Biochem Biophys Res Commun 171:1244–1251
   PubMedGoogle Scholar
• Sun XJ, Goldberg JL, Qiao LY, Mitchell JJ. 1999. Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway. Diabetes 48:1359–1364
   PubMedGoogle Scholar
• Sung L, Anderson JR, Donaldson SS, Spunt SL, Crist WM, Pappo AS. 2004. Late events occurring five years or more after successful therapy for childhood rhabdomyosarcoma: A report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group. Eur J Cancer 40:1878–1885
   PubMed Web of Science ®Google Scholar
• Tang N, Song WX, Luo J, Haydon RC, He TC. 2008. Osteosarcoma development and stem cell differentiation. Clin Orthop Relat Res 466:2114–2130
   PubMed Web of Science ®Google Scholar
• Valentinis B, Baserga R. 2001. IGF-I receptor signalling in transformation and differentiation. Mol Pathol 54:133–137
   PubMedGoogle Scholar
• Valentinis B, Romano G, Peruzzi F, Morrione A, Prisco M, Soddu S, Cristofanelli B, et al. 1999. Growth and differentiation signals by the insulin-like growth factor 1 receptor in hemopoietic cells are mediated through different pathways. J Biol Chem 274:12423–12430
   PubMed Web of Science ®Google Scholar
• Wang Y, Nishida S, Elalieh HZ, Long RK, Halloran BP, Bikle DD. 2006. Role of IGF-I signaling in regulating osteoclastogenesis. J Bone Min Res 21:1350–1358
   Google Scholar
• Zhu L, McManus MM, Hughes DP. 2013. Understanding the biology of bone sarcoma from early initiating events through late events in metastasis and disease progression. Front Oncol 3:230 (1--17)
   Google Scholar