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Research Paper

The role of FGF-2/HGF and fibronectin matrix on pleomorphic adenoma myoepithelial cell morphology and immunophenotype: an in vitro study

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Pages 50-56 | Received 04 Jun 2014, Accepted 20 Aug 2014, Published online: 26 Sep 2014

References

  • Allinen M, Beroukhim R, Cai L, Brennan C, Lahti-Domenici J, Huang H, Porter D, et al. 2004. Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell 6:17–32
  • Araújo VC, Altemani A, Furuse C, Martins MT, Araújo NS. 2006. Immunoprofile of reatctive salivary myoepithelial cells in intraductal áreas of carcinoma ex-pleomorphic adenoma. Oral Oncol 42:1011–1016
  • Araújo VC, Furuse C, Cury PR, Altemani A, Alves VAF, Araújo NS. 2008. Tenascin and fibronectin expression in carcinoma ex pleomorphic adenoma. Appl Immunohistochem Mol Morphol 16:48–53
  • Barsky SH. 2003. Myoepithelial mRNA expression profiling reveals a common tumor-suppressor phenotype. Exp Mol Pathol 74:113–122
  • Barsky SH, Karlin NJ. 2006. Mechanisms of disease: Breast tumor pathogenesis and the role of the myoepithelial cell. Nat Clin Pract Oncol 3:138–151
  • Bissel MJ, Radisky D. 2001. Putting tumors in context. Nat Rev Cancer 1:46–54
  • Dow JK, de Vere White RW. 2000. Fibroblast growth factor 2: Its structure and property, paracrine function, tumor angiogenesis, and prostate-related mitogenic and oncogenic functions. Urology 55:800–806
  • Eto H, Suga H, Aoi N, Kato H, Doi K, Kuno S, Tabata Y, Yoshimura K. 2012. Therapeutic potential of fibroblast growth factor-2 for hypertrophic scars: Upregulation of MMP-1 and HGF expression. Lab Invest 92:214–223
  • Furuse C, Miguita L, Garcia AC, Soares AB, Martinez EF, Altemani A, Araújo VC. 2010. Study of growth factors and receptors in carcinoma ex pleomorphic adenoma. J Oral Pathol Med 39:540–547
  • García AJ, Vega MD, Boettiger D. 1999. Modulation of cell proliferation and differentiation through substrate-dependent changes in fibronectin conformation. Mol Biol Cell 10:785–798
  • Grose R, Dickson C. 2005. Fibroblast growth factor signaling in tumorigenesis. Cytokine Growth Factor Rev 16:179–186
  • Haddad R, Lipson KE, Webb CP. 2001. Hepatocyte growth factor expression in human cancer and therapy with specific inhibitors. Anticancer Res 21:4243–4252
  • Hara S, Nakashiro K, Goda H, Hamakawa H. 2008. Role of Akt isoforms in HGF-induced invasive growth of human salivary gland cancer cells. Biochem Biophys Res Commun 370:123–128
  • Hu M, Polyak K. 2008. Molecular characterization of the tumour microenvironment in breast cancer. Eur J Cancer 44:2760–2765
  • Lafrenie RM, Yamada KM. 1998. Integrins and matrix molecules in salivary gland cell adhesion, signaling, and gene expression. Ann NY Acad Sci 842:42–48
  • Martinez EF, Demasi AP, Miguita L, Altemani A, Araújo NS, Araújo VC. 2010. FGF-2 is overexpressed in myoepithelial cells of carcinoma ex-pleomorphic adenoma in situ structures. Oncol Rep 24:155–160
  • Martinez EF, Demasi AP, Napimoga MH, Arana-Chavez VE, Altemani A, Araújo NS, Araújo VC. 2012. In vitro influence of the extracellular matrix in myoepithelial cells stimulated by malignant conditioned medium. Oral Oncol 48:102–109
  • Miguita L, Martinez EF, Araújo NS, Araújo VC. 2010. FGF-2, TGFβ-1, PDGF-A and respective receptors expression in pleomorphic adenoma myoepithelial cells: An in vivo and in vitro study. J Appl Oral Sci 18:83–91
  • Miyamoto M, Naruo K, Seko C, Matsumoto S, Kondo T, Kurokawa T. 1993. Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family has a unique secretion property. Mol Cell Biol 13:4251–4259
  • Nakamura T, Mizuno S. 2010. The discovery of hepatocyte growth factor (HGF) and its significance for cell biology, life sciences and clinical medicine. Proc Jpn Acad Ser B Phys Biol Sci 86:588–610
  • Nguyen M, Lee MC, Wang JL, Tomlinson JS, Shao ZM, Alpaugh ML, Barsky SH. 2000. The human myoepithelial cells displays a multifaceted anti-angiogenic phenotype. Oncogene 19:3449–3459
  • Polyak K, Hu M. 2005. Do myoepithelial cells hold the key for breast tumor progression? J Mammary Gland Biol Neoplasia 10:231–247
  • Presta M, Dell’Era P, Mitola S, Moroni E, Ronca R, Rusnati M. 2005. Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. Cytokine Growth Factor Rev 16:159–178
  • Ritzenthaler JD, Han S, Roman J. 2008. Stimulation of lung carcinoma cell growth by fibronectin-integrin signalling. Mol Biosyst 4:1160–1169
  • Shao ZM, Nguyen M, Alpaugh ML, O’Connell JT, Barsky SH. 1998. The human myoepithelial cell exerts anti-proliferative effects on breast carcinoma cells characterized by p21 induction, G2/M arrest, and apoptosis. Exp Cell Res 241:394–403
  • Silva AD, Silva CAB, Montalli VA, Martinez EF, Araújo VC, Furuse C. 2012. In vitro evaluation of the suppressor potential of conditioned medium from benign myoepithelial cells from pleomorphic adenoma in malignant cell invasion. J Oral Pathol Med 41:610–614
  • Steele JG, Johnson G, Underwood PA. 1992. Role of serum vitronectin and fibronectin in adhesion of fibroblasts following seeding onto tissue culture polystyrene. J Biomed Mater Rev 26:861–884
  • Sternlicht MD, Barsky SH. 1997. The myoepithelial defense: A host defense against câncer. Med Hypotheses 48:37–46
  • Sternlicht MD, Kedeshian P, Shao ZM, Safarians S, Barsky SH. 1997. The human myoepithelial cells is a natural tumor suppressor. Clin Cancer Res 3:1949–1958
  • Suzuki K, Cheng J, Watanabe Y. 2003. Hepatocyte growth factor and c-Met (HGF/c-Met) in adenoid cystic carcinoma of the human salivary gland. J Oral Pathol Med 32:84–89
  • Syed ZA, Yin W, Hughes K, Gill JN, Shi R, Clifford JL. 2011. HGF/c-met/Stat3 signaling during skin tumor cell invasion: Indications for a positive feedback loop. BMC Cancer 11:180–191
  • Tlsty TD. 2001. Stromal cells can contribute oncogenic signals. Semin Cancer Biol 11:97–104
  • Tsunoda S, Sakurai H, Saito Y, Ueno Y, Koizumi K, Saiki I. 2009. Massive T-lymphocyte infiltration into the host stroma is essential for fibroblast growth factor-2-promoted growth and metastasis of mammary tumors via neovascular stability. Am J Pathol 174:671–683
  • You WK, McDonald DM. 2008. The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis. BMB Rep 41:833–839

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