6
Views
17
CrossRef citations to date
0
Altmetric
Original Article

Effects of Interleukin-6 on the Growth of Normal and Transformed Rat Liver Cells in Culture

, &
Pages 83-89 | Received 15 May 1989, Accepted 29 Jun 1989, Published online: 11 Jul 2009

References

  • Andus T., Geiger T., Hirano T., Kishimoto T., Tran-Thi T-A., Decker K., Heinrich P. C. Regulation of secretion and synthesis of major rat acute-phase proteins by recombinant human interleukin-6 (BSF-2/IL-6) in hepatocyte primary cultures. Eur. J. Biochem 1988; 173: 287–293
  • Carr B. I., Hayashi I., Branum E. L., Moses H. L. Inhibition of DNA synthesis in rat hepatocytes by platelet-derived type beta transforming growth factor. Cancer Res 1986; 46: 2330–2334
  • Castell J. V., Gomez-Lechon M. I., David M., Hirano T., Kishimoto T., Heinrich P. C. Recombinant human interleukin-6 (1L-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes. FEBS Lett 1988; 232: 347–350
  • Cone J. L., Brown D. R., De Larco J. E. An improved method for the purification of transforming growth factor beta from platelets. Anal. Biochem 1988; 168: 71–74
  • Evarts R. P., Marsden E., Hanna P., Wirth P. J., Thorgeirsson S. S. Isolation of preneoplastic rat liver cells by centrifugal elutriation and binding to asialofetuin. Cancer Res 1984; 44: 5718–5724
  • Fey G., Gauldie J. The acute-phase response of the liver in inflammation. Progress in Liver Disease, H. Popper, F. Schaffner. W. B. Saunders, Philadelphia 1989, (in press)
  • Fey G. H., Hattori M., Northemann W., Abraham L.]., Baumann M., Braciak T. A., Fletcher R. G., Gauldie J., Lee F., Fey M. F. Regulation of rat liver acute phase genes by interleukin 6 and production of hepatocyte stimulating factors by rat hepatoma cells. Ann. NY Acad. Sci 1989, (in press)
  • Gauldie J., Richards C., Harnish D., Lansdorp P., Baumann H. Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Proc. Natl. Acad. Sci. USA 1987; 84: 7251–7255
  • Hampton L. L., Worland P. J., Huggett A. C., Ford C. F., Thorgeirsson S. S. Altered growth regulation and protein expression in tumorigenic v-raf infected rat liver epithelial cells abstract. J Cell. Biochem 1989; 13: 85
  • Huck K. A., Michalopoulos G. K., Strom S. C. Introduction of a Ha-ras oncogene into rat liver epithelial cells confers resistance to the growth inhibitory effects of TGF-beta. Oncogene 1989; 4: 19–25
  • Huggett A.C., Krutzsch H. C., Thorgeirsson S. S. Characterization of a hepatic proliferation inhibitor (HPI): effect of HPI on the growth of normal liver cells–comparison with transforming growth factor beta. J Cell Biochem 1987; 35: 315–320
  • Iype P. T., McMahon J. B. Hepatic proliferation inhibitor. Mol. Cell. Biochem 1984; 59: 57–80
  • Kishimoto T., Hirano T. Molecular regulation of B lymphocyte response. Anna. Rev. Immunol 1988; 6: 485–512
  • Kohase M., Henriksen-Destefano D., May L. T., Vilcek J., Sehgal P. B. Induction of beta-2 interferon by tumor necrosis factor: a homeostatic mechanism in the control of cell proliferation. Cell 1986; 45: 659–666
  • Lin P., Liu C., Tsao M-S., Grisham J. W. Inhibition of proliferation of cultures of rat liver epithelial cells at specific stages of the cell cycle by transforming growth factor-beta. Biochem. Biophys. Res. Commun 1987; 143: 26–30
  • McMahon W.L., Richards J. B., del Campo A. A., Song M-K., Thorgeirsson S. S. Differential effects of transforming growth factor-beta on proliferation of normal and transformed rat liver epithelial cells in culture. Cancer Res 1986; 46: 4665–4671
  • Nakamura T., Arakaki R., Lchihara A. Lnterleukin-1 beta is a potent growth inhibitor of adult rat hepatocytes in primary culture. Exp. Cell Res 1988; 179: 488–497
  • Norioka K., Hara M., Harigai M., Kitani A., Hirose T., Suzuki K., Kawakami M., Tabata H., Kawagoe M., Nakamura H. Production of B cell stimulatory factor-2/interleukin-6 activity by human endothelial cells. Biochem. Biophys. Res. Commun 1988; 153: 1045–1050
  • Popper H., Roth L., Purcell R. H., Tennant R. C., Gerin J. L. Hepatocarcinogenicity of the woodchuck hepatitis virus. Proc. Natl. Acad. Sri. USA 1987; 84: 866–870
  • Revel M., Zilberstein A., Ruggieri R. M., Rubinstein M., Chen L. Autocrine interferons and interferon beta 2. J Interferon Res 1987; 7: 529–536
  • Resnitzky D., Yarden A., Zipori D., Kimchi A. Autocrine beta-related interferon controls c-myc expression and growth arrest during hematopoietic cell differentiation. Cell 1986; 46: 31–40
  • Richards W. L., Song M-K., Krutzsch H., Evarts R. P., Marsden E., Thorgeirsson S. S. Measurement of cell proliferation in microculture using Hoechst 33342 for the rapid semiautomated microfluorimetric determination of chromatin DNA. Exp. Cell Res 1985; 159: 235–246
  • Sporn M. B., Roberts A. B. Peptide growth factors are multifunctional. Nature 1988; 332: 217–219
  • Van Damme J., Opdenakker G., Simpson R.]., Rubira M. R., Cayphas S., Vink A., Billiau A., Van Snick J. Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2) as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor. J Exp. Med 1987; 165: 914–919
  • Wong G. G., Witek-Giannotti J. S., Temple P. A., Kriz R., Ferenz C., Hewick R. M., Clark S. C., Ikebuchi K., Ogawa M. Stimulation of murine hemopoietic colony formation by human IL-6. J Immunol 1988; 140: 3040–3044

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.