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Original Article

Ligand-Independent Tyrosine Phosphorylation of the Receptor Encoded by the c-neu Oncogene

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Pages 233-242 | Received 02 Jan 1991, Accepted 25 Apr 1991, Published online: 11 Jul 2009

References

  • Bennet G., Carlet E., Wild G., Parsons S. Influence of colchicine and vinblatine on the intracellular migration of secretory and membrane glycoproteins. Am. J. Anat 1984; 170: 545–566
  • Brandt‐Rauf P. W., Rackovsky S., Pincus M. Correlation of the structure of the transmembrane domain of the neu oncogene‐encoded p185 protein with its function. Proc. Natl. Acad. Sci. USA 1990; 87: 8660–8664
  • Brown K. D., Blay J., Irvine R. F., Heslop J. P., Berridge M. J. Reduction of epidermal growth factor receptor affinity by heterologous ligands: evidence for a mechanism involving the breakdown of phosphoinositides and the activation of protein kinase C. Biochem. Biophys. Res. Commun 1984; 123: 377–384
  • Chapman D., Benga G. Biomembrane fluidity‐studies of model and natural membranes. Biological Membranes. Academic, London 1984; Vol. 5: 1–56
  • Cirillo D. M., Gaudino G., Naldini L., Comoglio P. M. Receptor for Bombesin with associated tyrosine kinase activity. Mol. Cell. Biol 1986; 6: 4641–4649
  • Cochet C., Kashles O., Chambaz E. M., Borello I., King C. R., Schlessinger J. Demonstration of epidermal growth factor induced receptor dimerization in living cells using a chemical covalent cross‐linking agent. J. Biol. Chem 1988; 263: 3290–3295
  • Comoglio P. M., Di Renzo M. F., Tarone G., Giancotti F., Naldini L., Marchisio P. C. Detection of phosphotyrosine‐containing proteins in the detergent‐insoluble fraction of RSV‐transformed fibroblasts by azobenzylphos‐phonate antibodies. EMBO J 1984; 3: 483–489
  • Davis R. J., Gironès N., Faucher M. Two alternative mechanisms control the interconversion of functional states of the epidermal growth factor receptor. J. Biol. Chem 1988; 263: 5373–5379
  • Dobashi K., Weiner D. B., Greene M. I. Differential regulation of oncogenic and cellular p185 by serine/threonine kinases. DNA 1989; 8: 723–732
  • Epstein R. J., Druker B. J., Roberts T. M., Stiles C. D. Modulation of a Mr 175,000 c‐neu receptor isoform in G8/DHFR cells by serum starvation. J. Biol. Chem 1990; 265: 10746–10751
  • Foulkes J. G. Phosphotyrosyl‐Protein Phosphatases. Current Topics in Microbiology and Immunology. Springer Verlag, Berlin, Heidelberg 1983; Vol. 107: 163–180
  • Gullick W. J., Berger M. S., Bennett P. L. P., Rothbard J. B., Waterfield M. D. Expression of the c‐erbB‐2 in normal and transformed cells. Int. J. Cancer 1987; 40: 247
  • Hammacher A., Mellstrom K., Heldin C. H., Westermark B. Isoform‐specific induction of actin reorganization by platelet‐derived growth factor suggests that the functionally active receptor is a dimer. EMBO J 1989; 8: 2489–2495
  • Hanai N., Nores G., Torres‐Mendez C. R., Hakamori S. Modified ganglioside as a possible modulator of transmembrane signaling mechanism through growth factor receptors: a preliminary note. Biochem. Biophys. Res. Commun 1987; 147: 127–134
  • Hasegawa‐Sasaki H., Lutz F., Sasaki T. Pathway of phospholipase C activation initiated with Platelet‐derived growth factor is different from that initiated with vasopressin and bombesin. J. Biol. Chem 1988; 263: 12970–12976
  • Heldin C. H., Ernlund A., Rorsman C., Ronnstrand L. Dimerization of B‐type Platelet‐derived growth factor receptors occurs after ligand binding and is closely associated with receptor kinase activation. J. Biol. Chem 1989; 264: 8905–8912
  • Honegger A. M., Kris R. M., Ullrich A., Schlessinger J. Evidence that autophosphorylation of solubilized receptors for epidermal growth factor is mediated by inter‐molecular cross‐phosphorylation. Proc. Natl. Acad. Sci. USA 1989; 86: 925–929
  • Honegger A. M., Schmidt A., Ullrich A., Schlessinger J. Evidence for EGF‐induced intermolecular autophosphorylation of EGF‐receptor in living cells. Mol. Cell. Biol 1990; 10: 4035–4044
  • King C. R., Borello I., Bellot F., Comoglio P. M., Schlessinger J. EGF binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB‐2 protein in the mammary tumor cell line SK‐BR‐3. EMBO J 1988; 7: 1647–1651
  • King C. R., Borello I., Porter L., Comoglio P., Schlessinger J. Ligand‐independent tyrosine phosphorylation of EGF receptor and the erbB‐2/neu proto‐oncogene product is induced by hyperosmotic shock. Oncogene 1989; 4: 13–18
  • Koland J. G., Cerione R. A. Growth factor control of epidermal growth factor receptor kinase activity via an intramolecular mechanism. J. Biol. Chem 1988; 263: 2230–2237
  • Laemmli U. K. Cleavage of structural protein during the assembly of the head of bacteriophage T4. Nature 1970; 277: 680–689
  • Molloy C. J., Bottaro D. P., Fleming T. P., Marshall M. S., Gibbs J. B., Aaronson S. A. PDGF induction of tyrosine phosphorylation of GTPase activating protein. Nature 1989; 342: 711–714
  • Morrison D. K., Kaplan D. R., Escobedo J. A., Rapp U. R., Roberts T. M., Williams L. T. Direct activation of the serine/threonine kinase activity of Raf‐1 through tyrosine phosphorylation by PDGF β‐receptor. Cell 1989; 58: 649–657
  • Northwood I. C., Davis R. J. Activation of the epidermal growth factor receptor tyrosine protein kinase in the absence of receptor oligomerization. J. Biol. Chem 1988; 263: 7450–7453
  • Rodriguez‐Pena A., Rozengurt E. Dependence of Ca2+ ‐sensitive phospholipid‐dependent protein kinase activity in phorbol ester‐treated 3T3 cells. Biochem. Biophys. Res. Commun 1984; 120: 1053–1059
  • Stern D. F., Kamps M. P. EGF‐stimulated tyrosine phosphorylation of p185 neu: a potential model for receptor interactions. EMBO J 1988; 7: 995–1001
  • Sturani E., Zippel R., Toschi L., Morello L., Comoglio P. M., Alberghina L. Kinetics and regulation of the tyrosine phosphorylation of epidermal growth factor receptor in Intact A431 Cells. Mol. Cell. Biol 1988; 8: 1345–1351
  • Swarup G., Cohen S., Garbers D. L. Inhibition of membrane phosphotyrosil‐protein phosphatase activity by vanadate. Biochem. Biophys. Res. Commun 1982; 107: 1104–1109
  • Terracio L., Ronnstrand L., Tingstrom A., Rubin K., Claesson‐Welsh L., Funa K., Heldin C. H. Induction of platelet‐derived growth factor receptor expression in smooth muscle cells and fibroblasts upon tissue culturing. J. Cell Biol 1988; 107: 1947–1957
  • Ullrich A., Schlessinger J. Signal transduction by receptors with tyrosine kinase activity. Cell 1990; 61: 203–212
  • Varticovski L., Druker B., Morrison D., Cantley L., Roberts T. The colony stimulating factor‐1 receptor associates with and activates phosphatidy‐inositol‐3 kinase. Nature 1989; 342: 699–702
  • Yarden Y., Schlessinger J. Self‐phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation. Biochemistry 1987b; 26: 1434–1442
  • Yarden Y., Schlessinger J. Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor. Biochemistry 1987b; 26: 1443–1451
  • Yarden Y., Ullrich A. Growth factor receptor tyrosine kinases. Annu. Rev. Biochem 1988; 57: 443–478
  • Zachary J., Sinnett‐Smith J. W., Rozengurt E. Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. I. Activation of protein kinase C and inhibition of epidermal growth factor binding. J. Cell Biol 1986; 102: 2211–2222

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