27
Views
42
CrossRef citations to date
0
Altmetric
Original Article

VEGF mRNA is Reversibly Stabilized by Hypoxia and Persistently Stabilized in VEGF-Overexpressing Human Tumor Cell Lines

, &
Pages 289-301 | Received 01 May 1995, Accepted 03 Aug 1995, Published online: 11 Jul 2009

References

  • Attardi B., Winters S. J. Decay of Follicle-Stimulating Hormone-beta messenger RNA in the presence of transcriptional inhibitors and/or inhibin, or follistatin. Mol. Endocrinol. 1993; 7: 668–680
  • Berglund B. High-altitude training. Aspects of haematological adaptation. Sports Med. 1992; 14: 289–303
  • Berkman R. A., Merrill M. J., Reinhold W. C., Monacci W. T., Saxena A., Clark W. C., Robertson J. T., Ali I. U., Oldfield E. H. Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms. J. Clin. Invest. 1993; 91: 153–159
  • Berse B., Brown L. F., Van de Water L., Dvorak H. F., Senger D. R. Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. Mol. Cell. Biol. 1992; 3: 211–220
  • Breier G., Albrecht U., Sterrer S., Risau W. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development 1992; 114: 521–532
  • Brown L. F., Berse B., Jackman R. W., Tognazzi K., Manseau E. J., Dvorak H. F., Senger D. R. Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas. Am. J. Pathol. 1993; 143: 1255–1262
  • Bruce J. N., Criscuolo G. R., Merrill M. J., Moquin R. R., Blacklock J. B., Oldfield E. H. Vascular permeability induced by protein product of malignant brain tumors: inhibition by dexamethasone. J. Neurosurg. 1987; 67: 880–884
  • Carroll S. M., Magnet A. D., White F. C., Bloor C. M. Vascular endothelial growth factor (VEGF) is increased during collateral development. Circulation 1993; 88: 1–239
  • Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal. Biochem. 1987; 162: 156–159
  • Coleman-Krnacik S., Rosen J. M. Differential temporal and spatial gene expression of fibroblast growth factor family members during mouse mammary gland development. Mol. Endocrinol. 1994; 8: 218–229
  • Conn G., Bayne M. L., Soderman D. D., Kwok P. W., Sullivan K. A., Palisi T. M., Hope D. A., Thomas K. A. Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor. Proc. Natl Acad. Sci. USA 1990; 87: 2628–2632
  • Connolly D. T. Vascular permeability factor: a unique regulator of blood vessel function. J. Cell. Biochem. 1991; 47: 219–223
  • Connolly D. T., Heuvelman D. M., Nelson R., Olander J. V., Eppley B. L., Delfino J. J., Siegel N. R., Leimgruber R. M., Feder J. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J. Clin. Invest. 1989a; 84: 1470–1478
  • Connolly D. T., Olander J. V., Heuvelman D., Nelson R., Monsell R., Siegel N., Haymore B. L., Leimgruber R., Feder J. Human vascular permeability factor. Isolation from U937 cells. J. Biol. Chem. 1989b; 264: 20017–20024
  • Criscuolo G. R. The genesis of peritumoral vasogenic brain edema and tumor cysts: a hypothetical role for tumor-derived vascular permeability factor. Yale J. Biol. Med. 1993; 66: 277–314
  • Cullinan-Bove K., Koos R. D. Vascular endothelial growth factor/vascular permeability factor expression in the rat uterus: Rapid stimulation by estrogen correlates with estrogen-induced increases in uterine capillary permeability and growth. Endocrinology 1993; 133: 829–837
  • Czyzyk-Krzeska M., Dominski Z., Kole R., Millhorn D. E. Hypoxia stimulates binding of a cytoplasmic protein to a pyrimidine-rich sequence in the 3′-untranslated region of rat tyrosine hydroxylase mRNA. J. Biol. Chem. 1994; 269: 9940–9945
  • De Vries C., Escobedo J. A., Ueno H., Houck K., Ferrara N., Williams L. T. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 1992; 225: 989–991
  • Dvorak H. F., Orenstein N. S., Carvalho A. C., Churchill W. H., Dvorak A. M., Galli S. J., Feder J., Bitzer A. M., Rypysc J., Giovinco P. Induction of a fibrin-gel investment: an early event in line 10 hepatocarcinoma growth mediated by tumor-secreted products. J. Immunol. 1979; 122: 166–174
  • Dvorak H. F., Sioussat T. M., Brown L. F., Berse B., Nagy J. A., Sotrel A., Manseau E. J., Van de Water L., Senger D. R. Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: Concentration in tumor blood vessels. J. Exp. Med. 1991; 174: 1275–1278
  • Ferrara N., Houck K., Jakeman L., Leung D. W. Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr. Rev. 1992; 13: 18–32
  • Ferrara N., Winer J., Burton T., Rowland A., Siegel M., Phillips H. S., Terrell T., Keller G. A., Levinson A. D. Expression of vascular endothelial growth factor does not promote transformation but confers a growth advantage in vivo to Chinese hamster ovary cells. J. Clin. Invest. 1993; 91: 160–170
  • Finkenzeller G., Marme D., Weich H. A., Hug H. Platelet-derived growth factor-induced transcription of the vascular endothelial growth factor gene is mediated by protein kinase C(1). Cancer Res. 1992; 52: 4821–4823
  • Folkman J. What is the evidence that tumors are angiogenesis dependent? [editorial]. J. Natl Cancer Inst. 1990; 82: 4–6
  • Folkman J., Watson K., Ingber D., Hanahan D. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 1989; 339: 58–61
  • Garrido C., Saule S., Gospodarowicz D. Transcriptional regulation of vascular endothelial growth factor gene expression in ovarian bovine granuloa cells. Growth Factors 1993; 8: 109–117
  • Gitay-Goren H., Halaban R., Neufeld G. Human melanoma cells but not normal melanocytes express vascular endothelial growth factor receptors. Biochem. Biophys. Res. Commun. 1993; 190: 702–708
  • Goldberg M. A., Gaut C. C., Bunn H. F. Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events. Blood 1991; 77: 271–277
  • Goldberg M. A., Schneider T. J. Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin. J. Biol. Chem. 1994; 269: 4355–4359
  • Gospodarowicz D., Abraham J. A., Schilling J. Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells. Proc. Natl Acad. Sci. USA 1989; 86: 7311–7315
  • Harrold S., Genovese C., Kobrin B., Morrison S. L., Milcarek C. A comparison of apparent mRNA half-life using kinetic labeling techniques vs decay following administration of transcriptional inhibitors. Anal. Biochem. 1991; 198: 19–29
  • Hillis L. D., Braunwald E. Myocardial ischemia. N. Engl. J. Med. 1977; 296: 971–978
  • Iijima K., Yoshikawa N., Connolly D. T., Nakamura H. Human mesangial cells and peripheral blood mononuclear cells produce vascular permeability factor. Kidney Int. 1993; 44: 959–966
  • Iwai Y., Bickel M., Pluznik D. H., Cohen R. B. Identification of sequences within the murine granulocyte-colony-stimulating factor mRNA 3′-untranslated region that mediate mRNA stabilization induced by mitogen treatment of EL-4 thymoma cells. J. Biol. Chem. 1991; 266: 17959–17965
  • Keck P. J., Hauser S. D., Krivi G., Sanzo K., Warren T., Feder J., Connolly D. T. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 1989; 246: 1309–1312
  • Kim K. J., Li B., Winer J., Armanini M., Gillett N., Phillips H. S., Ferrara N. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 1993; 362: 841–844
  • Kondo S., Asano M., Matsuo K., Ohmori I., Suzuki H. Vascular endothelial growth factor/vascular permeability factor is detectable in the sera of tumor-bearing mice and cancer patients. Biochem. Biophys. Acta 1994; 1221: 211–214
  • Kondo S., Asano M, Suzuki H. Significance of vascular endothelial growth factor/vascular permeability for solid tumor growth, and its inhibition by the antibody. Biochem. Biophys. Res. Commun. 1993; 194: 1234–1241
  • Ladoux A., Frelin C. Hypoxia is a strong inducer of vascular endothelial growth factor mRNA expression in the heart. Biochem. Biophys. Res. Commun. 1993; 195: 1005–1010
  • Leung D. W., Cachianes G., Kuang W. J., Goeddel D. V., Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989; 246: 1306–1309
  • Lindsten T., June C. H., Ledbetter J. A., Stella G., Thompson C. B. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 1989; 244: 339–343
  • Lobb R. R., Key M. E., Alderman E. M., Fett J. W. Partial purification and characterization of a vasculars permeability factor secreted by a human colon adenocarcinoma cell line. Int. J. Cancer 1985; 36: 473–478
  • Nguyen M., Folkman J., Bischoff J. 1-Deoxymannojirimycin inhibits capillary tube formation in vitro. Analysis of N-linked oligosaccharides in bovine capillary endothelial cells. J. Biol. Chem. 1992; 267: 26157–26165
  • Olson T. A., Mohanraj D., Carson L. F., Ramakrishnan S. Vascular permeability factor gene expression in normal and neoplastic human ovaries. Cancer Res. 1994; 54: 276–280
  • Pertovaara L., Kaipainen A., Mustonen T., Orpana A., Ferrara N., Saksela O., Alitalo K. Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells. J. Biol. Chem. 1994; 269: 6271–6274
  • Phillips H. S., Hains J., Leung D. W., Ferrara N. Vascular endothelial growth factor is expressed in rat corpus luteum. Endocrinology 1990; 127: 965–967
  • Plate K. H., Breier G., Millauer B., Ullrich A., Risau W. Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis. Cancer Res. 1993; 53: 5822–5827
  • Plate K. H., Breier G., Weich H. A., Risaus W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 1992; 359: 845–848
  • Quinn T. P., Peters K. G., De Vries C., Ferrara N., Williams L. T. Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc. Natl Acad. Sci. USA 1993; 90: 7533–7537
  • Ravindranath N., Little-Ihrig L., Phillips H. S., Ferrara N., Zeleznik A. J. Vascular endothelial growth factor messenger ribonucleic acid expression in the primate ovary. Endocrinology 1992; 131: 254–260
  • Risau W. Angiogenic growth factors. Prog. Growth Factors Res. 1990; 2: 71–79
  • Rosenthal R. A., Megyesi J. F., Henzel W. J., Ferrara N., Folkman J. Conditioned medium from mouse sarcoma 180 cells contains vascular endothelial growth factor. Mol. Cell. Biol. 1990; 4: 53–59
  • Sato K., Kato T. [Cancer therapy targeting tumorinduced neovascularization]. Gan. To. Kagaku, Ryoho 1994; 21: 295–300
  • Senger D. R., Perruzzi C. A., Feder J., Dvorak H. F. A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res. 1986; 46: 5629–5632
  • Sharkey A. M., Chamock-Jones D. S., Boocock C. A., Brown K. D., Smith S. K. Expression of mRNA for vascular endothelial growth factor in human placenta. J. Reprod. Fertil. 1993; 99: 609–615
  • Shaw G., Kamen R. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 1986; 46: 659–667
  • Shweiki D., Itin A., Neufeld G., Gitay-Goren H., Keshet E. Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis. J. Clin. Invest. 1993; 91: 2235–2243
  • Shweiki D., Itin A., Soffer D., Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992; 359: 843–845
  • Shyu A.-B., Greenberg M. E., Belasco J. The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways. Genes Dev. 1989; 3: 60–72
  • Sirovskiy E., Kornienko V., Moshkin A., Amcheslavskiy V., Ingorokva G., Glazman L. VPF and interstitial fluid pressure in brain oedema. Acta Neurochir. Suppl. (Wien) 1990; 51: 411–413
  • Takahashi A., Sasaki H., Kim S. J., Tobisu K., Kakizoe T., Tsukamoto T., Kumamoto Y., Sugimura T., Terada M. Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis. Cancer Res. 1994; 54: 4233–4237
  • Tischer E., Mitchell R., Hartman T., Silva M., Gospodarowicz D., Fiddes J. C., Abraham J. A. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J. Biol. Chem. 1991; 266: 11947–11954
  • Vaupel P., Kallinowski F., Okunieff P. Blood flow, oxygen consumption and tissue oxygenation of human tumors. Adv. Exp. Med. Biol. 1990; 277: 895–905
  • Weidner N., Carroll P. R., Flax J., Blumenfeld W., Folkman J. Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am. J. Pathol. 1993; 143: 401–409
  • Weidner N., Semple J. P., Welch W. R., Folkman J. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N. Engl. J. Med. 1991; 324: 1–8
  • Weidner N., Folkman J., Pozza F., Bevilacqua P., Allred E. N., Moore D. H., Meli S., Gasparini G. Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J. Natl Cancer Inst. 1992; 84: 1875–1887
  • Whittemore L.-A., Maniatis T. Postinduction turnoff of beta-interferon gene expression. Mol. Cell. Biol. 1990; 64: 1329–1337
  • Wilting J., Christ B., Bokeloh M., Weich H. A. In vivo effects of vascular endothelial growth factor on the chicken chorioallantoic membrane. Cell Tissue Res. 1993; 274: 163–172
  • Wisdom R., Lee W. The protein-coding region of c-myc mRNA contains a sequence that specifies rapid mRNA turnover and induction by protein synthesis inhibitors. Genes Dev. 1991; 5: 232–243

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.