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Original Article

Identification of Fibroblast Growth Factor 9 (FGF9) as a High Affinity, Heparin Dependent Ligand for FGF Receptors 3 and 2 but not for FGF Receptors 1 and 4

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Pages 223-233 | Received 26 Jun 1995, Accepted 20 Jul 1995, Published online: 11 Jul 2009

References

  • Aviezer D., Levy E., Safran M., Svahn C., Buddecke E., Schmidt A., David G., Vlodavsky I., Yayon A. Differential structural requirements of heparin and heparan sulfate proteoglycans that promote binding of basic fibroblast growth factor to its receptor. J. Biol. Chem. 1994; 269(1)114–121
  • Baird A. Fibroblast growth factors: activities and significance of non-neurotrophin neurotrophic growth factors. Curr. Opin. Neurobiol. 1994; 4(1)78–86
  • Basilico C., Moscatelli D. The FGF family of growth factors and oncogenes. Adv. Cancer Res. 1992; 159: 115–165
  • Chellaiah A. T., McEwen D. G., Werner S., Xu J., Ornitz D. M. Fibroblast growth factor receptor 3. J. Biol. Chem. 1994; 269(15)11620–11622
  • Cheon H. G., LaRochelle W. J., Bottaro D. P., Burgess W. H., Aaronson S. A. High-affinity binding sites for related fibroblast growth factor ligands reside within different receptor immunoglobulin-like domains. Proc. Natl Acad. Sci. USA 1994; 91(3)989–993
  • Dionne C. A., Curmley G., Bellot F., Kaplow J. N., Scartoss G., Ruta M., Burgess D. H., Jaye M., Schlessinger J. Cloning and expression of two distinct high-affinity receptors cross reacting with acidic and basic fibroblast growth factors. EMBO J. 1990; 9: 2685–2692
  • Flanagan J. G., Chan D. C., Leder P. Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant. Cell 1991; 64(5)1025–1035
  • Flanagan J. G., Leder P. The kit Ligand: A cell surface molecule altered in Steel mutant fibroblasts. Cell 1990; 63: 185–194
  • Givol D., Yayon A. Complexity of FGF receptors: genetic basis for structural diversity and functional specificity. FASEB J. 1992; 6: 3362–3369
  • Hou J. Z., Kan M. K., McKeehan K., McBride G., Adams P., McKeehan W. L. Fibroblast growth factor receptors from liver vary in three structural domains. Science 1991; 251(4994)665–668
  • Johnson D. E., Williams L. T. Structural and functional diversity in the FGF receptor multigene family. Adv. Cancer Res. 1993; 160: 1–41
  • Kan M., Wang F., Xu J., Crabb J. W., Hou J., McKeehan W. L. An essential heparin-binding domain in the fibroblast growth factor receptor kinase. Science 1993; 259(5103)1918–21
  • Klagsbrun M. The fibroblast growth factor family: structural and biological properties. Progress in Growth Factor Research 1989; 1: 207–235
  • Mansukhani A., Dell'Era P., Moscatelli D., Kornbluth S., Hanafusa H., Basilico C. Characterization of the murine BEK fibroblast growth factor (FGF) receptor: Activation by three members of the FGF family and requirement for heparin. Proc. Natl Acad. Sci. USA 1992; 89: 3305–3309
  • McKeehan W. L., Kan M. Heparan sulfate fibroblast growth factor receptor complex: structure-function relationships. Mol. Reprod. Dev. 1994; 39(1)69–81
  • Miki T., Bottaro D. P., Fleming T. P., Smith C. L., Burgess W. H., Chan A. M., Aaronson S. A. Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. Proc. Natl Acad. Sci. USA 1992; 89: 246–250
  • Miki T., Fleming T. P., Bottaro D. P., Rubin J. S., Ron D., Aaronson S. A. Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop. Science 1991; 251(4989)72–75
  • Miyamoto M., Naruo K. -I., Matsumoto C. S., Kondo T. S., Kurokawa T. Molecular cloning of cytokine cDNA encoding the ninth member of the fibroblast growth family, which has a unique secretion property. Mol. Cell. Biol. 1993; 13(7)4251–4259
  • Moscatelli D. High and low affinity binding sites for basic fibroblast growth factor on cultured cells: absence of a role for low affinity binding in the stimulation of plasminogen activator production by bovine capillary endothelial cells. J. Cell. Physiol. 1987; 131: 123–130
  • Nauro K. -L., Seko C., Kuroshima K. -I., Matsutani E., Sasada R., Kondo T., Kurokawa T. Novel secretory heparin-binding factor from human glioma cells (glia activating factor) involved in glia cell growth. J. Biol. Chem. 1993; 268(4)2857–2864
  • Ornitz D. M., Leder P. Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3. J. Biol. Chem. 1992; 267: 16305–16311
  • Ornitz D. M., Yayon A., Flanagan J. G., Svahn C. M., Levi E., Leder P. Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells. Mol. Cell. Biol. 1991; 12: 240–247
  • Peters K., Ornitz D., Werner S., Williams L. Unique expression pattern of the FGF receptor 3 gene during mouse organogenesis. Dev. Biol. 1993; 155(2)423–430
  • Rapraeger A. C., Krufka A., Olwin B. B. Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation. Science 1991; 252: 1705–1707
  • Rousseau F., Bonaventure J., Legeal-Mallet L., Pelet A., Rozet J. -M., Maroteaux P., Le-Merrer M., Munnich A. Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia. Nature 1994; 371: 252–254
  • Shiang R., Thompson L. M., Zhu Y. -Z., Church D. M., Winokur S. T., Wasmuth J. J. Mutations in trans-membrane domain of FGFR3 cause the most common genetic form of dwarfism, Achondroplasia. Cell 1994; 78: 335–342
  • Shing Y., Folkman J., Sullivan R., Butterfield C., Murray J., Klagsbrun M. Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor. Science 1984; 223(4642)1296–1299
  • Stanescu R., Stanescu V., Maroteaux P. Homozygous Achondroplasia: Morphologic and Biochemical Study of Cartilage. Am. J. Med. Genet. 1990; 37: 412–421
  • Yayon A., Gray T. E., Zimmer Y., Eisenstein M., Givol D. Ligand binding by fibroblast growth factor receptors investigated using chimeric receptor molecules. J. of Receptor & Signal Transduction Research 1995; 15(1–4)185–197
  • Yayon A., Klagsbrun M., Esko J. D., Leder P., Ornitz D. M. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell 1991; 64: 841–848
  • Yayon A., Zimmer Y., Guo-Hong S., Avivi A., Yarden Y., Givol D. A confined variable region confers ligand specificity on fibroblast growth factor receptors: implications for the origin of the immunoglobulin fold. EMBO J. 1992; 11(5)1885–1890
  • Zimmer Y., Givol D., Yayon A. Multiple structural elements determine ligand binding of fibroblast growth factor receptors. J. Biol. Chem. 1993; 268: 7899–7903

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