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Original Article

Characterization of Cell-Associated and Soluble Forms of Connective Tissue Growth Factor (CTGF) Produced by Fibroblast Cells In Vitro

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Pages 199-213 | Received 08 Aug 1997, Accepted 03 Sep 1997, Published online: 21 Aug 2009

References

  • Aviezcr D., Yayon A. Heparin-dependent binding and autophosphorylation of epidermal growth factor (EGF) receptor by HB-EGF but not by EGF. Proc. Natl. Acad. Sci. USA 1994; 91: 12173–12177
  • Baird A., Ling N. Fibroblast growth factors are present in the extracellular matrix produced by endothelial cells in vitro: implications for a role of heparinase-like enzymes in the neovascular response. Biochem. Biophys. Res. Comm. 1987; 142: 428–435
  • Bashkin P., Doctrow S., Klagsbrun M., Svahn C. M., Folk-Man J., Vlodavsky I. Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules. Biochemistry 1989; 228: 1737–1743
  • Besner G. E., Whelton D., Crissman-Combs M. A., Stef-Fen C. L., Kim G. Y., Brigstock D. R. Interaction of heparin-binding EGF-like growth factor (HB-EGF) with the epidermal growth factor receptor: Modulation by heparin. heparinase, or synthetic heparin-binding HB-EGF peptides. Growth Factors 1992; 1: 289–296
  • Bork P. The modular architecture of a new family of growth regulators related to connective tissue growth factor. FEBS Letters 1993; 327: 125–130
  • Bradham D. M., Igarashi A., Potter R. L., Grotendorst G. R. Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J. Cell Biol. 1991; 114: 1285–1294
  • Brigstock D. R., Kim G. Y., Steffen C. L. Pig uterine fluid contains the developmentally-regulated neurotrophic factor, pleiotrophin. J. Endocrinol. 1996; 148: 103–111
  • Brigstock D. R., Steffen C. L., Kim G. Y., Vegunta R. K., Diehl J. R., Harding P. A. Purification and characterization of novel heparin-binding growth factors in uterine secretory fluids: Identification as heparin-regulated Mr 10,000 forms of connective tissue growth factor. J. Biol. Chem. 1997; 272: 20275–20282
  • Brunner A., Chinn J., Neubauer M., Purchio A. F. Identification of a gene family regulated by transforming growth factor-β. DNA and Cell Biol. 1991; 10: 293–300
  • Frazier K., Williams S., Kothapalli D., Klapper H., Grotendorst G. R. Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor. J. Invest Dermatol. 1996; 107: 404–411
  • Grotendorst G. R., Okochi H., Hayashi N. A novel transforming growth factor β response element controls the expression of the connective tissue growth factor gene. Cell Growth Differ. 1996; 7: 469–480
  • Hammes M. S., Lieske J. C., Pawar S., Spargo B. H., Toback F. G. Calcium oxalate monohydrate crystals stimulate gene expression in renal epithelial cells. Kidney Int. 1995; 48: 501–509
  • Harding P. A., Surveyor G. A., Brigstock D. R. Characterization of pig connective tissue growth factor (CTGF) cDNA, mRNA and protein from uterine tissue. DNA Sequence 1997, [in press]
  • Higashiyama S., Abraham J. A., Klagsbrun M. Heparin-binding EGF-like growth factor stimulation of smooth muscle cell migration: Dependence on interactions with cell surface heparan sulfate. J. Cell Biol. 1993; 122: 933–940
  • Igarashi A., Bradham D. M., Okochi H., Grotendorst G. R. Connective tissue growth factor. J. Dermatol. 1992; 19: 642–643
  • Igarashi A., Nashiro K., Kikuchi K., Sat S., Ihn H., Grotendorst G. R., Takehara K. Significant correlation between connective tissue growth factor gene expression and skin sclerosis in tissue sections from patients with systemic sclerosis. J. Invest. Dermatol. 1995; 105: 280–284
  • Igarashi A., Okochi H., Bradham D. M., Grotendorst G. R. Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair. Mol. Biol. Cell. 1993; 4: 637–645
  • Kim G. Y., Besner G. E., Steffen C. L., McCarthy D. W., Downing M. T., Luquette M. H., Abad M. S., Brigstock D. R. Purification of heparin-binding EGF-like growth factor from pig uterine luminal flushings and its production by endometrial tissues. Biol. Reprod. 1995; 52: 561–571
  • Moscatelli D. High and low affinity binding sites for basic fibroblast growth factor on cultured cells: absence of a role for low affinity binding in the stimulation of plasminogen activator production by bovine capillary endothelial cells. J. Cell. Physiol. 1987; 131: 123–130
  • O'Brien T. P., Yang G. P., Sanders L., Lau L. F. Expression of cyr61, a growth factor-inducible immediate early gene. Mol. Cell. Biol. 1990; 10: 3569–3577
  • Pawar S., Kartha S., Toback F. G. Differential gene expression in migrating renal epithelial cells after wounding. J Cell Physiol. 1995; 165: 556–565
  • Rogelj S., Klagsbrun M., Atzmon R., Kurokawa M., Haimo-Vitz A., Fuks Z., Vlodavsky I. Basic fibroblast growth factor is an extracellular matrix component required for supporting the proliferation of vascular endothelial cells and the differentiation of PC12 cells. J. Cell. Biol. 1989; 109: 823–831
  • Ryseck R-P., Macdonald-Bravo H., Mattei M-G., Bravo R. Structure, mapping and expression of fisp-12, a growth-factor-inducible gene encoding a secreted cysteine-rich protein. Cell Growth Differ. 1991; 2: 225–233
  • Saksela O., Moscatelli D., Sommer A., Rifkin D. Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation. J. Cell. Biol. 1988; 107: 743–751
  • Seifert R. A., van Koppen A., Bowen-Pope D. F. PDGF-AB requires PDGF receptor α-subunits for high affinity, but not for low-affinity, binding and signal transduction. J. Biol. Chem. 1993; 268: 4473–4480
  • Vlodavsky I., Folkman J., Sullivan R., Fridman R., Ishai-Michaeli R., Sasse J., Klagsbrun M. Endothelial cell-derived basic fibroblast growth factor synthesis and deposition into subendothelial exracellular matrix. Proc. Natl. Acad. Sci. USA 1987; 84: 2292–2296
  • Yang G. P., Lau L. F. Cyr61, product of a growth factor-inducible immediate early gene, is associated with the extracellular matrix and the cell surface. Cell Growth Differ. 1991; 2: 351–357
  • Yayon A., Klagsbrun M., Esko J. D., Leder P., Ornitz D. M. Cell surface, heparin-like molecules are required for binding of bFGF to its high affinity receptor. Cell 1991; 64: 841–848

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