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Original Article

Expression of Interleukin-6 (IL-6) Receptor Gene in Acute Myeloblastic Leukemia and Response of Leukemic Cells to Exogenous IL-6. A Comparative Study Between Cell Line Cells and Corresponding Native Cells

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Pages 243-257 | Received 30 Jul 1997, Accepted 15 Oct 1997, Published online: 21 Aug 2009

References

  • Akashi K., Harada M., Shibuya T., Eto T., Takamatsu Y., Teshima T., Niho Y. Effects of interleukin-4 and interleukin-6 on the proliferation of CD 34+ and CD 34-blasts from acute myelogenous leukemia. Blood 1991; 78: 197–204
  • Bennett J. M., Catowsky D., Daniel M. T., Flandrin G., Galton O. A. G., Gralnick H. D., Sultan C. Proposals for the classification of acute leukemias. Br J Haematol 1976; 33: 451–458
  • Buick R. N., Till J. E., McCulloch E. A. Colony assay for proliferative blast cells circulating in myeloblastic leukemia. Lancet 1977; i: 862–863
  • Böyum A. Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest 1968; 21(97)77–89
  • Carlo-Stella C., Mangoni L., Almici C., Frassoni F., Fiers W., Rizzoli V. Growth of CD 34+ acute myeloblastic leukemia colony-forming cells in response to recombinant hematopoietic growth factors. Leukemia 1990; 4: 561–565
  • Celi F. S., Zenilman M. E., Shuldiner A. R. A rapid and versatile method to synthesize internal standards for cornpetetive PCR. Nucleic Acids Res. 1993; 21: 1047
  • Chomczynski P., Sacci N. Signle-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987; 162: 156–159
  • Ferrari S., Grande A., Manfredini R., Tagliafico E., Zucchini P., Torelli G., Torelli U. Expression of interleukins 1, 3, 6, stem cell factor and their receptors in acute leukemia blast cells and in normal peripheral lymphocytes and monocytes. Eur J Haematol 1993; 50: 141–148
  • Förster E. An improved general method to generate internal standards for competitive PCR. Bio Tech. 1994; 16: 18–20
  • Garman R. D., Jacobs K. A., Clark S. C., Raulet H. D. B-cell-stimulatory factor 2 (β2 interferon) functions as a second signal for interleukin 2 production by mature murine T cells. Proc Natl Acad Sci., USA 1987; 84: 7629–7633
  • Gearing D. P., Comeau M. R., Friend D. J., Gimpel S. D., Thut C. J., McGourty J., Brasher K. K., King J. A., Gillis S., Mosley B., Ziegler S. F., Cosman D. The IL-6 signal transducer, gp130: An oncostatin M receptor and affinity converter for the LIF receptor. Science 1992; 255: 1434–1437
  • Givon T., Slavin S., Haran-Ghera N., Michalevicz R., Revel M. Antitumor effects of human recombinant interleukin-6 on acute myeloid leukemia in mice and in cell cultures. Blood 1992; 79: 2392–2398
  • Hibi M., Murakami M., Saito M., Hirano T., Taga T., Kishimoto T. Molecular cloning and expression of an IL-6 signal transducer gp130. Cell 1990; 63: 1149–1157
  • Hilton D. J., Hilton A. A., Raicevic A., Rakar S., Harrison-Smith M., Gough N. M., Begley C. G., Metcalf D., Nicola N. A., Willson T. A. Cloning of a murine IL-11 receptor α-chain: Requirement for gp130 for high affinity binding and signal transduction. EMBO J 1994; 13: 4765–4775
  • Hoang T., McCulloch E. A. Production of leukemic blast growth factor by a human bladder carcinoma cell line. Blood 1985; 66: 748–751
  • Hoang T., Haman A., Goncalves O., Wong G. G., Clark S. C. Interleukin-6 enhances growth factor dependent proliferation of blast cells of acute myeloblastic leukemia. Blood 1988; 72: 823–826
  • Houssiau F. A., Coulie P. G., Olive D., Van Snick J. Synergistic activation of human T cells by interleukin 1 and interleukin 6. Eur J Immunol. 1988; 18: 653–656
  • Ikebuchi K., Wong G.-G., Clark S. C., Ihle J. N., Hirai Y., Ogawa M. Interleukin-6 enhancement of interleukin-3 dependent proliferation of multipotential hematopoietic progenitors. Proc Natl Acad Sci. USA 1987; 84: 9035–9039
  • Inoue K., Sugiyama H., Ogawa H., Yamagami T., Azuma T., Oka Y., Miwa H., Kita K., Hiraoka A., Masaoka T., Nasu K., Kyo T., Dohy H., Hara J., Kanamaru A., Kishimoto T. Expression of the interleukin-6 (IL-6), IL-6 receptor, and gp130 genes in acute leukemia. Blood 1994; 84: 2672–2680
  • Ip N. Y., Nye S. H., Boulton T. G., Davis S., Taga T., Li Y., Birren S. J., Yaukawa K., Kishimoto T., Anderson D. J., Stahl N., Yancopoulos G. D. CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130. Cell 1992; 69: 1121–1132
  • Jernberg H., Pettersson M., Kishimoto T., Nilsson K. Heterogeneity in response to interleukin 6 (IL-6), expression of IL-6 and IL-6 receptor mRNA in a panel of established human multiple myeloma cell lines. Leukemia 1991; 5: 255–265
  • Kellar K. L., Hooper W. C., Benson J. M. MEG-01s cells have receptors for and respond to IL-3, IL-6, and SCF. Exp Hematol 1995; 23: 557–564
  • Koistinen P., Sail Y M., Poromaa N., Savolainen E.-R. Complex effects of interleukin 6 on clonogenic blast cell growth in acute myeloblastic leukemia. Acta Haematol 1997; 98: 14–21
  • Leary A. G., Ikebuchi K., Hirai Y., Wong G. G., Yang Y.-C., Clark S. C., Ogawa M. Synergism between interleukin-6 and interleukin-3 in supporting proliferation of human hematopoietic stem cells: Comparison with interleukinla. Blood 1988; 71: 1759–1763
  • Lopez M., Maroc N., Kerangueven F., Bardin F., Courcoul M., Lavezzi C., Birg F., Mannoni P. Coexpression of the genes for interleukin 6 and its receptor without apparent involvement in the proliferation of acute myeloid leukemia cells. Exp Hematol 1991; 19: 797–803
  • Miyaura C., Onozaki K., Akiyama Y., Taniyama T., Hirano T., Kishimoto T., Suda T. Recombinant human interleukin-6 (B-cell stimulatory factor 2) is a potent inducer of differentiation of mouse myeloid leukemia cells (M1). FEBS Lett. 1988; 234: 17–21
  • Muraguchi A., Hirano T., Tang B., Matsuda T., Horii Y., Nakajima K., Kishimoto T. The essential role of B cell stimulatory factor-2 (BSF-2/IL-6) for the terminal differentiation of B cells. J Exp Med. 1988; 167: 332–344
  • Nakajima-Lijima S., Hamada H., Reddy P., Kakunaga T. Molecular structure of the human cytoplasmic β-actin gene: Interspecies homology of sequences in the introns. Proc Natl Acad Sci. USA 1985; 82: 6133–6137
  • Okada M., Kitahara M., Kishimoto S., Matsida T., Hirano T., Kishimoto T. IL-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells. J Immunol. 1988; 141: 1543–1549
  • Pennica D., Shaw K. J., Swanson T. A., Moore M. W., Shelton D. L., Zioncheck K. A., Rosenthal A., Taga T., Paoni N. F., Wood W. J. Cardiotrophin-1: Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex. J Biol Chem. 1995; 270: 10915–10922
  • Sui K., Tsuji K., Tanaka R., Tajima S., Muraoka K., Ebihara Y., Ikebuchi K., Yasukawa K., Taga T., Kishimoto T., Nakahata T. gp130 and c-Kit signalings synergize of ex vivo expansion of human primitive hemopoietic progenitor cells. Proc Natl Acad Sci. USA 1995; 92: 2859–2863
  • Taga T., Hibi M., Hirata Y., Yamasaki K., Yasukawa K., Matsuda T., Hirano T., Kishimoto T. Interleukin-6 triggers the association of its receptor with a possible signal transducer gp130. Cell 1989; 58: 573–581
  • Tosato G., Pike S. E. Interferon-β 2/interleukin 6 is a co-stimulant for human T lymphocytes. J Immunol. 1988; 141: 1556–1562
  • Yamasaki K., Taga T., Hirata T., Yawata H., Kawanishi Y., Seed B., Taniguchi T., Hirano T., Kishimoto T. Cloning and expression of the human interleukin-6 (BSF-2/IFNb2) receptor. Science 1988; 241: 825–828
  • Zhu Y.-M., Bradbury D. A., Keith F. J., Russel N. Absence of retinoblastoma protein expression results in autocrine production of interleukin-6 and promotes the autonomous growth of acute myeloid leukemia blast cells. Leukemia 1994; 8: 1982–1988

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