Investigation of the Molecular Mechanisms Underlying Growth Factor Synergy: The Role of ERK 2 Activation in Synergy

References

• Alai M., Mui A. L., Cutler R. L., Bustelo X. R., Barbacid M., Krystal G. Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells. J Biol Chem 1992; 267: 18021–5
   PubMed Web of Science ®Google Scholar
• Brizzi M. F., Zini M. G., Aronica M. G., Blechman J. M., Yarden Y., Pegoraro L. Convergence of signaling by interleukin-3, granulocyte-macrophage colony-stimulating factor, and mast cell growth factor on JAK2 tyrosine kinase. J Biol Chem 1994; 269: 31680–4
   PubMed Web of Science ®Google Scholar
• Broxmeyer H. E., Cooper S., Lu L., Hangoc G., Anderson D., Cosman D., Lyman S. D., Williams D. E. Effect of murine mast cell growth factor (c-kit proto-oncogene ligand) on colony formation by human marrow hematopoietic progenitor cells. Blood 1991; 77: 2142–9
   PubMed Web of Science ®Google Scholar
• Chuang C. F., Ng S. Y. Functional divergence of the MAP kinase pathway. ERK 1 and ERK 2 activate specific transcription factors. FEBS Lett 1994; 346: 229–234
   PubMedGoogle Scholar
• Corey S., Eguinoa A., Puyana-Theall K., Bolen J. B., Cant-Ley L., Mollinedo F., Jackson T. R., Hawkins P. T., Stephens L. R. Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and src-related tyrosine kinase(s) in human myeloid derived cells. EMBO J 1993; 12: 2681–2690
   PubMed Web of Science ®Google Scholar
• Davis R. J. The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 1993; 268: 14553–14556
   PubMed Web of Science ®Google Scholar
• Dorsch M., Hock H., Diamantstein T. Tyrosine phosphorylation of SHC is induced by IL-3, IL-5 and the alpha subunit of the human granulocyte-macrophage factor receptor signals for glucose transport via a independent pathway. Biochem Biophys Res Commun 1994; 200: 562–568
   Google Scholar
• Duronio V., Welham M. J., Abraham S., Dryden P., Schrader J. W. p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras Gtpase-activating protein. Proc Natl Acad Sci USA 1992; 89: 1587–91
   PubMedGoogle Scholar
• Gasson J. C. Molecular physiology of granulocyte-macrophage colony-stimulating factor. Blood 1991; 77: 1131–45
   PubMed Web of Science ®Google Scholar
• Guan K. L., Butch E. Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase. J Biol Chem 1995; 270: 7197–203
   PubMed Web of Science ®Google Scholar
• Hallek M., Ando K., Eder M., Slattery K., Ajchenbaum-Cymbalista F., Griffin J. D. Signal transduction of steel factor and granulocyte-macrophage colony-stimulating factor: differential regulation of transcription factor and G1 cyclin gene expression, and of proliferation in the human factor-dependent cell line M07. Leukemia 1994; 8: 740–748
   PubMedGoogle Scholar
• Hallek M., Druker B., Lepisto E. M., Wood K. W., Ernst T. J., Griffin J. D. Granulocyte-macrophage colony-stimulating factor and steel factor induce phosphorylation of both unique and overlapping signal transduction intermediates in a human factor-dependent hematopoietic cell line. J Cell Physiol 1992; 153: 176–186
   PubMedGoogle Scholar
• Hendrie P. C., Miyazawa K., Yang Y. C., Langefeld C. D., Broxmeyer H. E. Mast cell growth factor (c-kit ligand) enhances cytokine stimulation of proliferation of the human factor-dependent cell line, M07e. Exp Hematol 1991; 19: 1031–7
   PubMed Web of Science ®Google Scholar
• Heyworth C. M., Alauldin M., Cross M. A., Fairbairn L. J., Dexter T. M., Whetton A. D. Erythroid development of the FDCP-Mix A4 multipotent cell line is governed by the relative concentrations of erythropoietin and interleukin 3. Br J Haematol 1995; 91: 15–22
   PubMedGoogle Scholar
• Heyworth C. M., Dexter T. M., Kan O., Whetton A. D. The role of hemopoietic growth factors in self-renewal and differentiation of IL-3-dependent multipotential stem cells. Growth Factors 1990; 2: 197–211
   PubMedGoogle Scholar
• Heyworth C. M., Whetton A. D., Nicholls S., Zsebo K., Dexter T. M. Stem cell factor directly stimulates the development of enriched granulocyte-macrophage colony-forming cells and promotes the effects of other colony-stimulating factors. Blood 1992; 80: 2230–2236
   Google Scholar
• Horie M., Broxmeyer H. E. Involvement of immediate-early gene expression in the synergistic effects of steel factor in combination with granulocyte-macrophage colony-stimulating factor or interleukin-3 on proliferation of a human factor-dependent cell line. J Biol Chem 1993; 268: 968–973
   Google Scholar
• Karasuyama H., Melchers F. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors. Eur-J-Immunol 1988; 18: 97–104
   PubMed Web of Science ®Google Scholar
• Keel B. A., Hildebrandt J. M., May J. V., Davis J. S. Effects of epidermal growth factor on the tyrosine phosphorylation of mitogen-activated protein kinases in monolayer cultures of porcine granulosa cells. Endocrinology 1995; 136: 1197–1204
   Google Scholar
• Keller J. R., Ortiz M., Ruscetti F. W. Steel factor (c-kit ligand) promotes the survival of hematopoietic stem/progenitor cells in the absence of cell division. Blood 1995; 86: 1757–64
   PubMed Web of Science ®Google Scholar
• Kolch W., Heidecker G., Kochs G., Hummel R., Vahidi H., Mischak H., Finkenzeller G., Marme D., Rapp U. R. Protein kinase C alpha activates RAF-1 by direct phosphorylation. Nature 1993; 364: 249–52
   PubMed Web of Science ®Google Scholar
• Krautwald S., Buscher D., Dent P., Ruthenberg K., Baccarini M. Suppression of growth factor-mediated MAP kinase activation by v-raf in macrophages: a putative role for the MKP-1 phosphatase. Oncogene 1995; 10: 1187–1192
   PubMedGoogle Scholar
• Lowry P. A., Deacon D., Whitefield P., McGrath H. E., Quesenberry P. J. Stem cell factor induction of in vitro murine hematopoietic colony formation by “subliminal” cytokine combinations: the role of “anchor factors”. Blood 1992; 80: 663–9
   PubMed Web of Science ®Google Scholar
• Marshall C. J. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 1995; 80: 179–85
   PubMed Web of Science ®Google Scholar
• Matsuguchi T., Inhorn R. C., Carlesso N., Xu G., Druker B., Griffin J. D. Tyrosine phosphorylation of p95Vav in myeloid cells in regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCRIABL. Embo J 1995; 14: 257–65
   PubMed Web of Science ®Google Scholar
• Matsuguchi T., Salgia R., Hallek M., Eder M., Druker B., Ernst T. J., Griffin J. D. Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony-stimulating factor, interleukin-3, and steel factor and is constitutively increased by p210BCRIABL. J Biol Chem 1994; 269: 5016–21
   PubMed Web of Science ®Google Scholar
• McKinstry W. J., Li C. L., Rasko J. E., Nicola N. A., John-Son G. R., Metcalf D. Cytokine receptor expression on hematopoietic stem and progenitor cells. Blood 1997; 89: 65–71
   PubMed Web of Science ®Google Scholar
• McNiece I. K., Langley K. E., Zsebo K. M. Recombinant human stem cell factor synergises with GM-CSF, G-CSF, IL-3 and epo to stimulate human progenitor cells of the myeloid and erythroid lineages. Exp Hematol 1991a; 19: 226–31
   PubMed Web of Science ®Google Scholar
• McNiece I. K., Langley K. E., Zsebo K. M. The role of recombinant stem cell factor in early B cell development. Synergistic interaction with IL-7. J Immunol 1991b; 146: 3785–90
   PubMed Web of Science ®Google Scholar
• Metcalf D., Nicola N. A. Direct proliferative actions of stem cell factor on murine bone marrow cells in vitro: effects of combination with colony-stimulating factors. Proc Natl Acad Sci USA 1991; 88: 6239–43
   PubMed Web of Science ®Google Scholar
• Migliaccio G., Migliaccio A. R., Druzin M. L., Giardina P. J., Zsebo K. M., Adamson J. W. Effects of recombinant human stem cell factor (SCF) on the growth of human progenitor cells in vitro. J Cell Physiol 1991a; 148: 503–9
   PubMed Web of Science ®Google Scholar
• Migliaccio G., Migliaccio A. R., Valinsky J., Langley K., Zsebo K., Visser J. W., Adamson J. W. Stem cell factor induces proliferation and differentiation of highly enriched murine hematopoietic cells. Proc Natl Acad Sci USA 1991b; 88: 7420–4
   PubMed Web of Science ®Google Scholar
• Miyajima A. Molecular structure of the IL-3, GM-CSF and IL-5 receptors. Int J Cell Cloning 1992; 10: 126–34
   Google Scholar
• Molineux G., Migdalska A., Szmitkowski M., Zsebo K., Dexter T. M. The effects on hematopoiesis of recombinant stem cell factor (ligand for c-kit) administered in vivo to mice either alone or in combination with granulocyte colony-stimulating factor. Blood 1991; 78: 961–6
   PubMed Web of Science ®Google Scholar
• Mordret G. MAP kinase kinase: a node connecting multiple pathways. Biol Cell 1993; 79: 193–207
   PubMed Web of Science ®Google Scholar
• Mui A. L., Miyajima A. Cytokine receptors and signal transduction. Prog Growth Factor Res 1994; 5: 15–35
   Google Scholar
• O'Farrell A. M., Ichihara M., Mui A. L., Miyajima A. Signaling pathways activated in a unique mast cell line where interleukin-3 supports survival and stem cell factor is required for a proliferative response. Blood 1996; 87: 3655–68
   PubMed Web of Science ®Google Scholar
• Okuda K., Sanghera J. S., Pelech S. L., Kanakura Y., Hallek M., Griffin J. D., Druker B. J. Granulocyte-macrophage colony-stimulating factor, interleukin-3, and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase. Blood 1992; 79: 2880–2887
   PubMed Web of Science ®Google Scholar
• Owen Lynch P. J., Wong A. K., Whetton A. D. v-Abl-mediated apoptotic suppression is associated with Shc phosphorylation without concomitant mitogen-activated protein kinase activation. J Biol Chem 1995; 270: 5956–62
   PubMedGoogle Scholar
• Pelech S. L., Sanghera J. S. MAP kinases: charting the regulatory pathways. Science 1992; 257: 1355–1356
   PubMed Web of Science ®Google Scholar
• Quelle F. W., Sato N., Witthuhn B. A., Inhorn R. C., Eder M., Miyajima A., Griffin J. D., Ihle J. N. JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region. Mol Cell Biol 1994; 14: 4335–4341
   PubMed Web of Science ®Google Scholar
• Reith A. D., Ellis C., Lyman S. D., Anderson D. M., Williams D. E., Bernstein A., Pawson T. Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase. EMBO J 1991; 10: 2451–9
   PubMed Web of Science ®Google Scholar
• Rottapel R., Reedijk M., Williams D. E., Lyman S. D., Anderson D. M., Pawson T., Bernstein A. The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor. Mol Cell Biol 1991; 11: 3043–3051
   PubMedGoogle Scholar
• Russell E. S. Hereditary anemias of the mouse: a review for geneticists. Adv Genet 1979; 20: 357–459
   PubMedGoogle Scholar
• Sakamaki K., Miyajima I., Kitamura T., Miyajima A. Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation. EMBOJ 1992; 11: 3541–9
   PubMed Web of Science ®Google Scholar
• Sato N., Sakamaki K., Terada N., Arai K., Miyajima A. Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta sub-unit responsible for different signaling. EMBO J 1993; 12: 4181–9
   PubMed Web of Science ®Google Scholar
• Saunier B., Tournier C., Jacquemin C., Pierre M. Stimulation of mitogen-activated protein kinase by thyrotropin in primary cultured human thyroid follicles. J Biol Chem 1995; 270: 3693–7
   PubMed Web of Science ®Google Scholar
• Sozeri O., Vollmer K., Liyanage M., Frith D., Kour G., Mark G., Stabel S. Activation of the c-raf protein kinase by protein kinase C phosphorylation. Oncogene 1992; 7: 2259–2262
   PubMed Web of Science ®Google Scholar
• Spooncer E., Heyworth C. M., Dunn A., Dexter T. M. Self-renewal and differentiation of interleukin-3-dependent multipotent stem cells are modulated by stromal cells and serum factors. Differentiation 1986; 31: 111–8
   PubMed Web of Science ®Google Scholar
• Traverse S., Gomez N., Paterson H., Marshall C., Cohen P. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor. Biochem J 1992; 288: 351–355
   PubMed Web of Science ®Google Scholar
• Troppmair J., Bruder J. T., Munoz H., Lloyd P. A., Kyriakis J., Banerjee P., Avruch J., Rapp U. R. Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12–0-tetradecanoylphorbol-13- acetate requires Raf and is necessary for transformation. J Biol Chem 1994; 269: 7030–7035
   PubMedGoogle Scholar
• Tsuji K., Lyman S. D., Sudo T., Clark S. C., Ogawa M. Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture. Blood 1992; 79: 2855–60
   PubMed Web of Science ®Google Scholar
• Ward Y., Gupta S., Jensen P., Wartmann M., Davis R. J., Kelly K. Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PACI. Nature 1994; 367: 651–654
   PubMed Web of Science ®Google Scholar
• Weiler S. R., Mou S., DeBerry C. S., Keller J. R., Ruscetti F. W., Ferris D. K., Longo D. L., Linnekin D. JAK2 is associated with the c-kit protooncogene product and is phosphorylated in response to stem cell factor. Blood 1996; 87: 3688–93
   PubMed Web of Science ®Google Scholar
• Welham M. J., Dechert U., Leslie K. B., Jirik F., Schrader J. W. Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3′-kinase. J Biol Chem 1994a; 269: 23764–23768
   PubMedGoogle Scholar
• Welham M. J., Duronio V., Leslie K. B., Bowtell D., Schrader J. W. Multiple hemopoietins, with the exception of interleukin-4, induce modification of Shc and mSos1, but not their translocation. J Biol Chem 1994b; 269: 21165–21176
   PubMedGoogle Scholar
• Welham M. J., Duronio V., Sanghera J. S., Pelech S. L., Schrader J. W. Multiple hemopoietic growth factors stimulate activation of mitogen- activated protein kinase family members. J Immunol 1992; 149: 1683–1693
   Google Scholar
• Whetton A. D., Valiance S. J., Monk P. N., Cragoe E. J., Dexter T. M., Heyworth C. M. Interleukin-3-stimulated haemopoietic stem cell proliferation. Evidence for activation of protein kinase C and Na+/H+ exchange without inositol lipid hydrolysis. Biochem J 1988; 256: 585–92
   PubMedGoogle Scholar
• Witte O. N. Steel locus defines new multipotent growth factor. Cell 1990; 63: 5–6
   PubMed Web of Science ®Google Scholar
• Yeung Y. G., Jubinsky P. T., Sengupta A., Yeung D. C., Stanley E. R. Purification of the colony-stimulating factor 1 receptor and demonstration of its tyrosine kinase activity. Proc Natl Acad Sci USA 1987; 84: 1268–1271
   PubMedGoogle Scholar
• Zhou G. X., Meier K. E., Buse M. G. Sequential activation of two mitogen activated protein (MAP) kinase isoforms in rat skeletal muscle following insulin injection. Biochem Biophys Res Commun 1993; 197: 578–584
   PubMedGoogle Scholar