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Original Article

Characterization of Growth Factor Responsiveness and Alterations in Growth Factor Homeostasis Involved in the Tumorigenic Conversion of Mouse Oval Cells

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Pages 81-94 | Received 27 Sep 1996, Accepted 19 Mar 1997, Published online: 11 Jul 2009

References

  • Aaronson S. A. Growth factors and cancer. Science 1991; 254: 1146–1153
  • Alison M. R., Poulsom R., Jeffery R., Anilkumar T. V., Jagoe R., Sarraf C. E. Expression of hepatocyte growth factor mRNA during oval cell activation in the rat liver. J. Pathol. 1993; 171: 291–299
  • Aterman K. The stem cells of liver—a selective review. J. Cancer Res. Clin. Oncol. 1992; 118: 87–115
  • Bellusci S., Moens G., Gaudino G., Comoglio P., Nakamura T., Thiery J.-P., Jouanneau J. Creation of an hepatocyte growth factor/scatter factor autocrine loop in carcinoma cells induces invasive properties associated with increased tumorigenicity. Oncogene 1994; 9: 1091–1099
  • Brill S., Hoist P., Sigal S., Zvibel I., Fiorino A., Ochs A., Somasundaran U., Reid L. M. Hepatic progenitor populations in embryonic, neonatal, and adult liver. Proc. Soc. Exp. Biol. Med. 1993; 204: 261–269
  • Coffey R. J., Graves-Deal R., Dempsey P. J., Whitehead R. H., Pittelkow M. R. Differential regulation of transforming growth factor a autoinduction in nontransformed and transformed epithelial cells. Cell Growth Diff. 1992; 3: 347–354
  • Coleman W. B., Wennerberg A. E., Smith G. J., Grisham J. W. Regulation of the differentiation of diploid and some aneuploid rat liver epithelial (stemlike) cells by the hepatic microenvironment. Am. J. Pathol. 1993; 142: 1373–1382
  • Cross M., Dexter T. M. Growth factors in development, transformation, and tumorigenesis. Cell 1991; 64: 271–280
  • Evarts R. P., Nakatsukasa H., Marsden E. R., Hu Z., Thorgeirsson S. S. Expression of transforming growth factor alpha in regenerating liver and during hepatic differentiation. Mol. Carcinogen 1992; 5: 25–31
  • Factor V. M., Radaeva S. A., Thorgeirsson S. S. Origin and fate of oval cells in dipin-induced hepatocarcino-genesis in the mouse. Am. J. Pathol. 1994; 145: 409–422
  • Fausto N. Hepatocyte differentiation and liver progenitor cells. Curr. Opin. Cell Biol. 1990; 2: 1036–1041
  • Fidler I. J., Ellis L. M. The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell 1994; 79: 185–188
  • Fujio K., Evarts R. P., Hu Z., Marsden E. R., Thorgeirsson S. S. Expression of stem cell factor and its receptor, c-kit, during liver regeneration from putative stem cells in adult rat. Lab. Invest. 1994; 70: 511–516
  • Gray T. E., Zhu S.-J., Nettesheim P. Regulation of transformation frequency by exogenous and endogenous growth factors in rat tracheal epithelial cells. Carcinogenesis 1994; 15: 549–555
  • Grisham J. W., Tsao M. -S., Lee D. C., Earp H. S. Sequential changes in epidermal growth factor receptor/ligand function in cultured rat liver epithelial cells transformed chemically in vitro. Pathobiology 1990; 58: 3–14
  • Hague A., Manning A. M., van der Stappen J. W., Paraskeva C. Escape from negative regulation of growth by transforming growth factor beta and from the induction of apoptosis by the dietary agent sodium butyrate may be important in colorectal carcinogenesis. Cancer Metastasis Rev. 1993; 12: 227–237
  • Heldin C. -H., Westermark B. Growth factors: mechanisms of action and relation to oncogenes. Cell 1984; 37: 9–20
  • Hsia C. C., Thorgeirsson S. S., Tabor E. Expression of hepatitis B surface and core antigens and transforming growth factor alpha in “oval cells” of the liver in patients with hepatocellular carcinoma. J. Med. Virol. 1994; 43: 216–221
  • Hu Z., Fujio K., Marsden E. R., Thorgeirsson S. S., Evarts R. P. Hepatic regernation in vitamin A-deficient rats: changes in the expression of transforming growth factor alpha/epidermal growth factor receptor and retinoic acid receptors alpha and beta. Cell Growth Differ. 1994; 5: 503–508
  • Huggett A. C., Hampton L. L., Ford C. P., Wirth P. J., Thorgeirsson S. S. Altered responsiveness of rat liver epithelial cells to transforming growth factor bl following their transformation with v-raf. Cancer Res. 1990; 50: 7468–7475
  • Isfort R. J., Cody D. B., Kerckaert G. A., Le Boeuf R. A. Growth factor responsiveness and alterations in growth factor homeostasis in Syrian hamster embryo cells during in vitro transformation. Carcinogenesis 1994; 15: 1203–1209
  • Isfort R. J., Cody D. B., Lovell G., Doersen C.-J. Analysis of oncogenes, tumor suppressor genes, autocrine growth factor production, and differentiation state of human osteosarcoma cell lines. Mol. Carcinogenesis 1995; 14: 170–178
  • Kanda H., Tajima H., Lee G. -H., Nomura K., Ohtake K., Matsumoto K., Nakamura T., Kitagawa T. Hepatocyte growth factor transforms immortalized mouse liver epithelial cells. Oncogene 1993; 8: 3047–3053
  • Laird A. D., Brown P. I., Fausto N. Inhibition of tumor growth in liver epithelial cells transfected with a transforming growth factor a antisense gene. Cancer Res. 1994; 54: 4224–4232
  • Liotta L. A., Steeg P. S., Stetler-Stevenson W. G. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 1991; 64: 327–336
  • Liu C., Tsao M. S., Grisham J. W. Transforming growth factors produced by normal and neoplastically transformed rat liver epithelial cells in culture. Cancer Res. 1988; 48: 850–855
  • Lombardi B. On the nature, properties and significance of oval cells. Recent Trends in Chemical Carcinogenesis, P. Pani, F. Feo, A. Columbano. ESA, Cagliari 1982; 1: 36–52
  • Manning A. M., Williams A. C., Game S. M., Paraskeva C. Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor beta (TGF-beta): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGF-beta. Oncogene 1991; 6: 1471–1476
  • Marceau N., Blouin M.-J., Germain L., Noel M. Role of different epithelial cell types in liver ontogenesis, regeneration and neoplasia. In Vitro Cell. Develop. Biol. 1989; 25: 336–341
  • Marceau N. Biology of disease: cell lineages and differentiation programs in epidermal, urothelial and hepatic tissues and their neoplasms. Lab. Invest. 1990; 63: 4–20
  • Massague J. The transforming growth factor-β family. Annu. Rev. Cell Biol. 1990; 6: 597–641
  • McMahon J. B., Richards W. L., del Campo A. A., Song M.-K. H., Thorgeirsson S. S. Differential effects of transforming growth factor-b on proliferation of normal and malignant rat liver epithelial cells in culture. Cancer Res. 1986; 46: 4665–4671
  • Metcalf D. The molecular control of cell division, differentiation, commitment and maturation in haemopoietic cells. Nature 1989; 339: 27–30
  • Michalopoulos G. K. Liver regeneration: molecular mechanisms of growth control. FASEB J. 1990; 4: 176–187
  • Moses H. L., Yang E. Y., Pietenpol J. A. TGF-β stimulation and inhibition of cell proliferation: new mechanistic insights. Cell 1990; 63: 245–247
  • Murakami H., Sanderson N. D., Nagy P., Marino P. A., Merlino G., Thorgeirsson S. S. Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor a in hepatic oncogenesis. Cancer Res. 1993; 53: 1719–1723
  • Richards W. G., Yoder B. K., Isfort R. J., Detilleux P. G., Foster C., Neilsen N., Woychik R. P., Wilkinson J. E. Oval cell proliferation associated with the murine insertional mutation TgN737 Rpw. Am. J. Pathol. 1996, submitted
  • Richards W. G., Yoder B. K., Isfort R. J., Detilleux P. G., Foster C., Neilsen N., Woychik R. P., Wilkinson J. E. Isolation and characterization of liver epithelial cell lines from wild type and mutant TgN737Rpw mouse livers. Am. J. Pathol. 1996, submitted
  • Sandgren E. P., Luetteke N. C., Qiu T. H., Palmiter R. D., Brinster R. L., Lee D. C. Transforming growth factor alpha dramatically enhances oncogene-induced carcinogenesis in transgenic mouse pancreas and liver. Mol. Cell. Biol. 1993; 13: 320–330
  • Sarraf C., Lalani E. N., Golding M., Anilkumar T. V., Poulsom R., Alison M. Cell behavior in the acetyl-aminofluorene-treated regenerating rat liver. Am. J. Pathol. 1994; 145: 1114–1126
  • Sell S. The role of determined stem-cells in the cellular lineage of hepatocellular carcinoma. Int. J. Dev. Biol. 1993; 37: 189–201
  • Sporn M. B., Roberts A. B. TGF-β problems and prospects. Cell Regulation 1990; 1: 875–882
  • Thorgeirsson S. S. Hepatic stem cells. Am. J Pathol. 1993; 142: 1331–1333
  • Vassbotn F. G., Andersson M., Westermark B., Heldin C. -H., Östman A. Reversion of autocrine transformation by a dominant negative platelet-derived growth factor mutant. Mol. Cell. Biol. 1993; 13: 4066–4076
  • Williams A. C., Browne S. J., Manning A. M., Daffada P., Collard T. J., Paraskeva C. Transfection and expression of mutant p53 protein does not alter the in vivo or in vitro growth characteristics of the AA/C1 human adenoma derived cell line, including sensitivity to transforming growth factor beta 1. Oncogene 1994; 9: 1479–1485

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