34
Views
11
CrossRef citations to date
0
Altmetric
Original Article

Insulin-like Growth Factor-I (IGF-I) and IGF-I Receptor (IGF-IR) Immunoreactivity in Normal and Osteopetrotic (toothless, tl/tl) Rat Tibia

, , , &
Pages 279-291 | Received 07 Jul 1998, Accepted 15 Dec 1998, Published online: 11 Jul 2009

References

  • Aharinejad S., Marks S. C., Böck P., Mason-Savas A., Mac-Kay C. A., Larson E. K., Jackson M. E., Luftensteiner M., Wiesbauer E. CSF-1 treatment promotes angiogenesis in the metaphysis of osteopetrotic (toothless, tl) rats. Bone 1995; 16: 315–324
  • Arkins S., Rebeiz N., Brunke-Reese D. L., Minshall C., Kelley K. W. The colony-stimulating factors induce expression of insulin-like growth factor-I messenger ribonucleic acid during hematopoiesis. Endocrinology 1995; 136: 1153–1160
  • Breier B. H., Gallaher W., Gluckman P. D. Radio-immunoassay for insulin-like factor-1: solutions to some potential problems and pitfalls. J. Endocrinol. 1991; 128: 347–357
  • Cotton W. R., Gaines J. F. Unerupted dentition secondary to congenital osteopetrosis in the Osborne-Mendel rat. Proc. Soc. Exp. Biol. Med. 1974; 146: 554–561
  • Gelato M. C. Growth hormone-insulin-like growth factor I and immune function. Trends Endocrinol. Metals. 1993; 4: 106–110
  • Halenbeck R., Kawasaki E., Wrin J., Koths K. Renaturation and purification of biologically active recombinant human macrophage colony-stimulating factor expressed in E. coli. Bio. Tech. 1989; 7: 710–715
  • Hill P. A., Reynolds J. J., Meikle M. C. Osteoblasts mediate insulin-like growth factor-1 and II stimulation of osteoclast formation and function. Endocrinology 1995; 136: 124–131
  • Horowitz M. C., Einhorn T. A., Philbrick W., Jilka R. L. Functional and molecular changes in colony stimulating factor secretion by osteoblasts. Connec. Tiss. Res. 1989; 20: 159–168
  • Hume D. A., Robinson A. P., Macpherson G. G., Gordon S. The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80. The relationship between Langerhans cells, reticular cells and dendritic cells in lymphoid and haematopoietic cells. J. Exp. Med. 1983; 158: 1522–1536
  • Hume D. A., Loutit J. F., Gordon S. The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80. Macrophages of bone and associated connective tissue. J. Cell. Sci. 1984; 66: 189–194
  • Iizuka T., Cielinski M., Aukerman S. L., Marks S. C. The effects of colony-stimulating factor-1 on tooth eruption in the toothless (osteopetrotic) rat in relation to the critical periods for bone resorption during tooth eruption. Arch. oral Biol. 1992; 37: 629–636
  • Johansson A. G., Lindh E., Ljunghall S. Insulin-like growth factor-I stimulates bone turnover in osteoporosis. Lancet 1992; 339: 1619
  • Joseph B. K., Savage N. W., Young W. G., Gupta G. S., Brier B. H., Waters M. J. Expression and regulation of insulin-like growth factor-I in the rat incisor. Growth Factors 1993; 8: 267–275
  • Joseph B. K., Savage N. W., Young W. G., Waters M. J. Insulin-like growth factor-I receptor in the cell biology of the ameloblast: an immunohistochemical study. Epi. Cell Biol. 1994a; 3: 47–53
  • Joseph B. K., Savage N. W., Young W. G., Waters M. J. Prenatal expression of growth hormone receptor binding protein and insulin-like growth factor-I (IGF-I) in the enamel organ. Role for growth hormone and IGF-I in cellular differentiation during early tooth formation. Anat. Embryol. 1994b; 189: 489–494
  • Kelley K. W. Growth hormone, lymphocytes and macrophages. Biochem. Pharmacol. 1989; 38: 705–713
  • Ladner M. B., Martin G. A., Noble J. A., Nikolof D. M., Tal R., Kawasaki E. S., White T. J. Human CSF-1: Gene structure and alternative splicing of mRNA precursors. EMBO J. 1987; 6: 2693–2698
  • Lian J. B., Marks S. C. Osteopetrosis in the rat: coexistence of reductions in osteocalcin and bone resorption. Endocrinology 1990; 126: 955–962
  • Malpe R., Baylink D. J., Lijkhart T. A., Weregedal J. E., Mohan S. Insulin-like growth factor (IGF)-I, -II, IGF binding proteins (IGBP)-3, -4 and -5 levels in the conditioned media of normal human bone cells are skeletal site-dependent. J. Bone Mineral Res. 1997; 12: 423–430
  • Marks S. C. Osteopetrosis in the toothless (tl) rat: Presence of osteoclasts but failure to respond to parathyroid extract or to be cured by infusion of spleen or bone marrow cells from normal littermates. Am. J. Anat. 1977; 149: 289–297
  • Marks S. C. Congenital Osteopetrosis in Mammals - new windows on osteoclast biology. Chemistry and Biology of Mineralized Tissues, H. Slavkin, P. Price. Elsevier Science, Amsterdam 1992; 475–482
  • Marks S. C. Osteopetrosis. Curr. Opin. Orthoped. 1994; 5: 39–42
  • Marks S. C., Wojtowicz A., Szperl M., Urbanowska E., Mac-Kay C. A., Wiktor-Jedrzejczak W., Stanley E. R., Aukerman S. L. Administration of colony stimulating factor-1 corrects some macrophage, dental, and skeletal defects in an osteopetrotic mutation (toothless, tl) in the rat. Bone. 1992; 13: 89–93
  • Marks S. C., MacKay C. A., Jackson M. E., Larson E. K., Cielinski M. J., Stanley E. R., Aukerman S. L. The skeletal effects of colony-stimulating factor-1 in toothless (osteopetrotic rats: persistent metaphyseal sclerosis and the failure to restore the subepiphyseal osteoclasts). Bone 1993; 14: 675–680
  • Merchav S., Tatarsky I., Hochberg Z. Enhancement of human granulopoiesis in vitro by biosynthetic insulin-like growth factor 1 somatomedin C and human growth hormone. J. Clin. Invest. 1988; 81: 791–797
  • Middleton J., Arnott N., Walsh S., Beresford J. Osteoblasts and osteoclasts in adult human osteophytic tissue express the mRNAs for insulin-like growth factors I and II and the type I IGF receptor. Bone 1995; 16: 287–293
  • Milhaud G., Labat M. L., Litwin I., Moricard Y., Moutier R., Rimbaut C., Buffe D., Juster M. Osteopetro-rickets: A new congenital bone disorder. Metab. Bone Dis. 1981; 3: 91–97
  • Minkin C. Bone acid phosphatase: Tartrate-resistant acid phosphatase as a marker of osteoclast function. Calcif. Tissue Int. 1982; 34: 285–290
  • Mochizuki H., Hakeda Y., Wakatsuki N., Usui N., et al. Insulin-like growth factor-I supports formation and activation of osteoclasts. Endocrinology 1992; 131: 1075–1080
  • Mohan S., Baylink D. J. Bone growth factors. Clin. Orthop. Rel. Res. 1991; 263: 30–48
  • Oemar B. S., Foellmer H. G., Anandant L. H., Rosenzweig S. A. Regulation of insulin-like growth factor I receptor in diabetic mesangial cells. J. Biol. Chem. 1991; 266: 2369–2373
  • Ralph P., Warren M. K., Lee M. T., Csejtey J., Weaver J. F., Broxmeyer H. E., Williams D. E., Stanley E. R., Kawasaki E. S. Inducible production of human macrophage growth factor, CSF-1. Blood 1986; 68: 633–639
  • Rodriguez-Tarduchy G., Collins M. K.L., Garcia I., Lopez-Rivas A. Insulin-like growth factor I inhibits apoptosis in IL-3 dependent hematopoietic cells. J. Immunol. 1992; 149: 535–540
  • Rosenzweig S. A., Zetterstrom C., Benjamin A. Identification of retinal insulin receptors using site-specific antibodies to a carboxyl-terminal peptide of the human insulin receptor α-subunit. J. Biol. Chem. 1990; 265: 18030–18034
  • Scheven B. A.A., Hamilton N. J. Stimulation of macrophage growth and multinucleated cell formation in rat bone marrow cultures by insulin-like growth factor I. Biochem. Biophys. Res. Commun. 1991; 174: 647–653
  • Schneider G. B., Cuenoud M. L., Marks S. C. The diagnosis and cure of neonatal osteopetrosis: Experimental evidence from congenitally osteopetrotic(ia) rats. Metab. Bone Dis. Rel. Res. 1979; 1: 335–339
  • Scifert M. F. Lack of evidence for rickets in the osteopetrotic rat mutation, toothless. J. Bone Miner. Res. 1994; 9: 1813–1821
  • Scifert M. F. Abnormalities in bone cell function and endochondral ossification in osteopetrotic toothless rat. Bone 1996; 19: 329–338
  • Seifert M. F., Popoff S. N., Marks S. C. Skeletal biology in the toothless (osteopetrotic) rat. Am. J. Anat. 1988; 183: 158–165
  • Scifert M. F., Popoff S. N., Jackson M. E., MacKay C. A., Ciclinski M., Marks S. C. Experimental studies of osteopetrosis in laboratory animals. Clin. Orthop. 1993; 294: 23–33
  • Shalhoub V., Jackson M., Lian J. B., Stein G. S., Marks S. C. Gene expression during skeletal development in three osteopetrotic rat mutations: Evidence for osteoblast abnormalities. J. Biol. Chem. 1991; 266: 9847–9856
  • Shalhoub V., Bettencourt B., Jackson M. E., Mackay C. A., Clincher M. J., Marks S. C., Stein G. S., Lian J. B. Abnormalities of phosphoprotein gene expression in three osteopetrotic rat mutations: elevated mRNA transcripts, protein synthesis and accumulation in bone of mutant animals. J. Cell Physiol. 1994; 158: 110–120
  • Slootweg M. C., Most W. W., vanBeek E., et al. Osteoclast formation together with interleukin-6 production in mouse long bones is increased by insulin-like growth factor-I. J. Endocrinol. 1992; 132: 433–438
  • Strobl J. S., Thomas M. J. Human growth hormone. Pharmacol. Rev. 1994; 46: 1–34
  • Symons A. L., MacKay C. A., Leong K., Hume D. A., Waters M. J., Marks S. C. Decreased growth hormone receptor expression in long bones from toothless (osteopetrotic) rats and restoration by treatment with colony-stimulating factor-1. Growth Factors 1996; 13: 1–10
  • Wang L. M., Myers M. G., Sun X., Aaronson S. A., White M., Pierce J. H. IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells. Science 1993; 261: 1591–1594
  • Watanabe H., Mac-Kay C. A., Kislauskis E., Mason-Savas A., Marks S. C. Ultrastructural evidence of abnormally short and maldistributed actin stress fibers in osteopetrotic (toothless) rat osteoblasts in situ after detergent perfusion. Tissue & Cell 1997; 29: 89–98
  • Zerwekh J. E., Marks S. C., McGuire J. L. Elevated serum 1,25 dihydroxyvitamin D in osteopetrotic mutations in three species. Bone and Mineral 1987; 2: 193–1

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.