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Review Article

Aerosol generation using nanometer liposome suspensions for pulmonary drug delivery applications

Pages 255-267 | Received 08 Jan 2013, Accepted 01 May 2013, Published online: 05 Jun 2013

References

  • Anabousi VS. (2006). Liposomal drug carrier systems for inhalation treatment of lung cancer. Chemie, pharmazie, bio- und werkstoffwissenschaften. Saarbrücken, der universität des saarlandes
  • Azarmi S, Roa WH, Loebenberg R. (2008). Targeted delivery of nanoparticles for the treatment of lung diseases. Adv Drug Deliv Rev 60:863–75
  • Bangham AD, Standish MM, Watkins JC. (1965). Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol 13:38--252
  • Behr J, Zimmermann G, Baumgartner R, et al. (2009). Lung deposition of a liposomal cyclosporine a inhalation solution in patients after lung transplantation. J Aerosol Med Pulmonary Drug Deliv 22:121–29
  • Bernard AL, Guedeau-boudeville MA, Marchi-artzner V, et al. (2005). Shear-induced permeation and fusion of lipid vesicles. J Coll Interface Sci 287:298–306
  • Betageri GV, Parsons DL. (1992). Drug encapsulation and release from multilamellar and unilamellar liposomes. Int J Pharmaceut 81:235–41
  • Bhattacharya S, Haldar S. (2000). Interactions between cholesterol and lipids in bilayer membranes. Role of lipid headgroup and hydrocarbon chain-backbone linkage. Biochim Biophys Acta -- Biomembr 1467:39–53
  • Boas U, Heegaard PMH. (2004). Dendrimers in drug research. Chem Soc Rev 33:43–63
  • Borm PJA, Kreyling W. (2004). Toxicological hazards of inhaled nanoparticles -- potential implications for drug delivery. J Nanosci Nanotechnol 4:521–31
  • Brain JD. (1992). Mechanisms, measurement, and significance of lung macrophage function. Environ Health Perspect 97:5–10
  • Brain JD. (2007). Inhalation, deposition, and fate of insulin and other therapeutic proteins. Diabet Technol Therapeut 9:s4–15
  • Bridges PA, Taylor KMG. (1998). Nebulisers for the generation of liposomal aerosols. Int J Pharmaceut 173:117–25
  • Bridges PA, Taylor KMG. (2000). An investigation of some of the factors influencing the jet nebulisation of liposomes. Int J Pharmaceut 204:69–79
  • Bunjes H. (2010). Lipid nanoparticles for the delivery of poorly water-soluble drugs. J Pharm Pharmacol 62:1637–45
  • Chadha TS, Chattopadhyay S, Venkataraman C, Biswas P. (2012). Study of the charge distribution on liposome particles aerosolized by air-jet atomization. J Aerosol Med Pulmon Drug Deliv 25:355–64
  • Chan HK, Gonda I. (1988). Development of a systematic theory of suspension inhalation aerosols. 2. Aggregates of monodisperse particles nebulized in polydisperse droplets. Int J Pharmaceut 41:147–57
  • Chattopadhyay S, Ehrman SH, Bellare J, Venkataraman C. (2012). Morphology and bilayer integrity of small liposomes during aerosol generation by airjet nebulisation. J Nanoparticle Res 14:779, 1--15
  • Chattopadhyay S, Modesto-lopez IB, Venkataraman C, Biswas P. (2010). Size distribution and morphology of liposome aerosols generated by two methodologies. Aerosol Sci Technol 44:972–82
  • Chen DR, Pui DYH. (1997). Experimental investigation of scaling laws for electrospraying: dielectric constant effect. Aerosol Sci Technol 27:367–80
  • Chen DR, Pui DYH, Kaufman SL. (1995). Electrospraying of conducting liquids for monodisperse aerosol generation in the 4 nm to 1.8 mu-m diameter range. J Aerosol Sci 26:963–77
  • Cheow WS, Hadinoto K. (2010). Enhancing encapsulation efficiency of highly water-soluble antibiotic in poly(lactic-co-glycolic acid) nanoparticles: modifications of standard nanoparticle preparation methods. Colloids Surfaces A-Physicochem Engin Aspect 370:79–86
  • Chono S, Fukuchi R, Seki T, Morimoto K. (2009). Aerosolized liposomes with dipalmitoyl phosphatidylcholine enhance pulmonary insulin delivery. J Control Release 137:104--9
  • Chow AHL, Tong HHY, Chattopadhyay P, Shekunov BY. (2007). Particle engineering for pulmonary drug delivery. Pharmaceut Res 24:411–37
  • Clark AR, Egan M. (1994). Modeling the deposition of inhaled powdered drug aerosols. J Aerosol Sci 25:175–86
  • Cloupeau M, Prunetfoch B. (1989). Electrostatic spraying of liquids in cone-jet mode. J electrostatics 22:135–59
  • Cohen BS, Xiong JQ, Asgharian B, Ayres L. (1995). Deposition of inhaled charged ultrafine particles in a simple tracheal model. J Aerosol Sci 26:1149–60
  • Conley J, Yang HM, Wilson T, et al. (1997). Aerosol delivery of liposome-encapsulated ciprofloxacin: aerosol characterization and efficacy against francisella tularensis infection in mice. Antimicrob Agents Chemother 41:1288–92
  • Dailey LA, Schmehl T, Gessler T, et al. (2003). Nebulization of biodegradable nanoparticles: impact of nebulizer technology and nanoparticle characteristics on aerosol features. J Control Rel 86:131–44
  • Dandekar P, Venkataraman C, Mehra A. (2010). Pulmonary targeting of nanoparticle drug matrices. J Aerosol Med Pulmon Drug Deliv 23:343–53
  • Davies LA, Hannavy K, Davies N, et al. (2005). Electrohydrodynamic comminution: a novel technique for the aerosolisation of plasmid DNA. Pharmaceut Res 22:1294–304
  • Delmas T, Fraichard A, Bayle P, et al. (2012). Encapsulation and release behavior from lipid nanoparticles: model study with nile red fluorophore. J Coll Sci Biotechnol 1:16–25
  • Deng WW, Klemic JF, Li X, et al. (2006). Increase of electrospray throughput using multiplexed microfabricated sources for the scalable generation of monodisperse droplets. J Aerosol Sci 37:696–714
  • Desai TR, Hancock REW, Finlay WH. (2002). A facile method of delivery of liposomes by nebulization. J Control Rel 84:69–78
  • Desai TR, Hancock REW, Finlay WH. (2003). Delivery of liposomes in dry powder form: aerodynamic dispersion properties. Eur J Pharmaceut Sci 20:459–67
  • Dhand R. (2004). New frontiers in aerosol delivery during mechanical ventilation. Respiratory Care 49:666--77
  • Dilraj A, Cutts FT, de castro JF, et al. (2000). Response to different measles vaccine strains given by aerosol and subcutaneous routes to schoolchildren: a randomised trial. Lancet 355:798–803
  • Dolovich MB, Ahrens RC, Hess DR, et al. (2005). Device selection and outcomes of aerosol therapy: evidence-based guidelines. Chest 127:335–71
  • Edwards DA, Ben-jebria A, Langer R. (1998). Recent advances in pulmonary drug delivery using large, porous inhaled particles. J Appl Physiol 85:379–85
  • Elhissi AMA, Faizi M, Naji WF, et al. (2007). Physical stability and aerosol properties of liposomes delivered using an air-jet nebulizer and a novel micropump device with large mesh apertures. Int J Pharmaceut 334:62–70
  • Epstein H, Afergan E, Moise T, et al. (2006). Number-concentration of nanoparticles in liposomal and polymeric multiparticulate preparations: empirical and calculation methods. Biomaterials 27:651–59
  • Farr SJ, Kellaway IW, Parryjones DR, Woolfrey SG. (1985). Technetium-99m as a marker of liposomal deposition and clearance in the human-lung. Int J Pharmaceut 26:303–16
  • Fernandez de la mora J, Loscertales IG. (1994). The current emitted by highly conducting taylor cones. J Fluid Mechanics 260:155--84
  • Fink JB. (2000). Aerosol device selection: evidence to practice. Respiratory Care 45:874--85
  • Gagnadoux F, Hureaux J, Vecellio L, et al. (2008). Aerosolized chemotherapy. J Aerosol Med Pulmon Drug Deliv 21:61–69
  • Gaňan-calvo AM. (1994). The size and charge of droplets in the electrospraying of polar liquids in cone-jet mode, and the minimum droplet size. J Aerosol Sci 25:s309–10
  • Gaspar MM, Bakowsky U, Ehrhardt C. (2008). Inhaled liposomes-current strategies and future challenges. J Biomed Nanotechnol 4:245–57
  • Gaspar MM, Gobbo O, Ehrhardt C. (2010). Generation of liposome aerosols with the aeroneb pro and the aeroprobe nebulizers. J Liposome Res 20:55–61
  • Gilbert BE, Six HR, Wilson S, et al. (1988). Small particle aerosols of enviroxime-containing liposomes. Antiviral Res 9:355–65
  • Gomez A. (2002). The electrospray and its application to targeted drug inhalation. Respiratory care 47:1419--31
  • Gomez A, Bingham D, de Juan L, Tang K. (1998). Production of protein nanoparticles by electrospray drying. J Aerosol Sci 29:561–74
  • Gonnet M, Bastiat G, Ivanova T, Boury F. (2012). Interfacial organization of β-carotene loaded lipid nanocapsules modelized by 2d rheological measurements and electrophoretic mobility. J Coll Sci Biotechnol 1:137–46
  • Gradon L, Marijnissen J. (2003). Optimizing of aerosol drug delivery. Dordrecht, The Netherlands: Kluwer Academic
  • Gruner SM, Lenk RP, Janoff AS, Ostro MJ. (1985). Novel multilayered lipid vesicles -- comparison of physical characteristics of multilamellar liposomes and stable plurilamellar vesicles. Biochemistry 24:2833–42
  • Harishchandra RK, Saleem M, Galla HJ. (2010). Nanoparticle interaction with model lung surfactant monolayers. J Royal Soc Interface 7:s15–26
  • Hashizaki K, Taguchi H, Sakai H, et al. (2006). Carboxyfluorescein leakage from poly(ethylene glycol)-grafted liposomes induced by the interaction with serum. Chem Pharmaceut Bull 54:80–84
  • Heyder J, Gebhart J, Rudolf G, et al. (1986). Deposition of particles in the human respiratory-tract in the size range 0.005-15-mu-m. J Aerosol Sci 17:811–25
  • Hinds WC. (1999). Aerosol technology: properties, behavior, and measurement of airborne particles. Hoboken (NJ): John Wiley & Sons
  • Hofmann W. (2011). Modelling inhaled particle deposition in the human lung-a review. J Aerosol Sci 42:693–724
  • Hofmann W, Koblinger L. (1990). Monte-Carlo modeling of aerosol deposition in human lungs. 2. Deposition fractions and their sensitivity to parameter variations. J Aerosol Sci 21:675–88
  • Hogan CJ, Biswas P, Chen DR. (2009). Charged droplet dynamics in the submicrometer size range. J Phys Chem B 113:970–76
  • Hogan CJ, Kettleson EM, Ramaswami B, et al. (2006). Charge reduced electrospray size spectrometry of mega- and gigadalton complexes: whole viruses and virus fragments. Anal Chem 78:844–52
  • Hogan CJ, Yun KM, Chen DR, et al. (2007). Controlled size polymer particle production via electrohydrodynamic atomization. Colloids Surfaces A-Physicochem Engin Aspect 311:67–76
  • Hossann M, Wang TT, Wiggenhorn M, et al. (2010). Size of thermosensitive liposomes influences content release. J Control Rel 147:436–43
  • Huang YY, Wang CH. (2006). Pulmonary delivery of insulin by liposomal carriers. J Control Rel 113:9–14
  • Jaafar-maalej C, Andrieu V, Elaissari A, Fessi H. (2011). Beclomethasone-loaded lipidic nanocarriers for pulmonary drug delivery: preparation, characterization and in vitro drug release. J Nanosci Nanotechnol 11:1841–51
  • Jaafar-maalej C, Elaissari A, Fessi H. (2012). Lipid-based carriers: manufacturing and applications for pulmonary route. Expert Opin Drug Deliv 9:1111–27
  • Johnson ACJH, Greenwood P, Hagstrom M, et al. (2008). Aggregation of nanosized colloidal silica in the presence of various alkali cations investigated by the electrospray technique. Langmuir 24:12798–806
  • Johnson DL, Carlson KD, Pearce TA, et al. (1999). Effects of nebulization time and pressure on lipid microtubule suspension and aerosol. Aerosol Sci Technol 30:211–22
  • Jores K, Haberland A, Wartewig S, et al. (2005). Solid lipid nanoparticles (sln) and oil-loaded sln studied by spectrofluorometry and raman spectroscopy. Pharmaceut Res 22:1887–97
  • Kim K, Kim W, Yun S, et al. (2008). Use of an electrospray for the generation of bacterial bioaerosols. J Aerosol Sci 39:365–72
  • Kirby C, Gregoriadis G. (1984). Dehydration-rehydration vesicles -- a simple method for high-yield drug entrapment in liposomes. Bio-technology 2:979–84
  • Kleemann E, Schmehl T, Gessler T, et al. (2007). Iloprost-containing liposomes for aerosol application in pulmonary arterial hypertension: formulation aspects and stability. Pharmaceut Res 24:277–87
  • Kleinstreuer C, Zhang Z. (2011). Optimal drug-aerosol delivery to predetermined lung sites. J Heat Trans-Trans Asme 133:011002, 1--12
  • Koblinger L, Hofmann W. (1990). Monte-Carlo modeling of aerosol deposition in human lungs. 1. Simulation of particle-transport in a stochastic lung structure. J Aerosol Sci 21:661–74
  • Kreyling WG, Hirn S, Schleh C. (2010). Nanoparticles in the lung. Nat Biotechnol 28:1275–76
  • Labiris NR, Dolovich MB. (2003). Pulmonary drug delivery. Part i: physiological factors affecting therapeutic effectiveness of aerosolized medications. Br J Clin Pharmacol 56:588–99
  • Laouini A, Jaafar-maalej C, Limayem-blouza I, et al. (2012). Preparation, characterization and applications of liposomes: state of the art. J Coll Sci Biotechnol 1:147–68
  • Lasic DD. (1993). Liposomes from physics to application. Amsterdam: Elsevier
  • Le brun PPH, de boer AH, Heijerman HGM, Frijlink HW. (2000). A review of the technical aspects of drug nebulization. Pharmacy World Sci 22:75–81
  • Lentz YK, Worden LR, Anchordoquy TJ, Lengsfeld CS. (2005). Effect of jet nebulization on DNA: identifying the dominant degradation mechanism and mitigation methods. J Aerosol Sci 36:973–90
  • Levin Y, Idiart MA. (2004). Pore dynamics of osmotically stressed vesicles. Physica a-statistical mechanics and its applications 331:571–78
  • Li ZL, Zhang YL, Wurtz W, et al. (2008). Characterization of nebulized liposomal amikacin (arikace (tm)) as a function of droplet size. J Aerosol Med Pulmon Drug Deliv 21:245–53
  • Liang E, Hughes JA. (1998). Membrane fusion and rupture in liposomes: effect of biodegradable ph-sensitive surfactants. J Memb Biol 166:37–49
  • Lippmann M. (1990). Effects of fiber characteristics on lung deposition, retention, and disease. Environ Health Perspect 88:311–17
  • Liu FY, Shao ZZ, Kildsig DO, Mitra AK. (1993). Pulmonary delivery of free and liposomal insulin. Pharmaceut Res 10:228–32
  • Mansour HM, Rhee YS, Wu XA. (2009). Nanomedicine in pulmonary delivery. Int J Nanomed 4:299–319
  • Mayer LD, Bally MB, Hope M, Cullis PR. (1986). Techniques for encapsulating bioactive agents into liposomes. Chem Phys Lipids 40:333–45
  • Mccallion ONM, Taylor KMG, Thomas M, Taylor AJ. (1995). Nebulization of fluids of different physicochemical properties with air-jet and ultrasonic nebulizers. Pharmaceut Res 12:1682–88
  • Mccallion ONM, Taylor KMG, Thomas M, Taylor AJ. (1996a). The influence of surface tension on aerosols produced by medical nebulisers. Int J Pharmaceut 129:123–36
  • Mccallion ONM, Taylor KMG, Thomas M, Taylor AJ. (1996b). Nebulisation of monodisperse latex sphere suspensions in air-jet and ultrasonic nebulisers. Int J Pharmaceut 133:203–14
  • Melandri C, Tarroni G, Prodi V, et al. (1983). Deposition of charged-particles in the human airways. J Aerosol Sci 14:184–86
  • Mezei M, Run O. (1995). Pain management with liposome-encapsulated analgesic drugs usp 5,451,408
  • Mitsakou C, Helmis C, Housiadas C. (2005). Eulerian modelling of lung deposition with sectional representation of aerosol dynamics. J Aerosol Sci 36:75–94
  • Nerbrink O, Dahlback M, Hansson HC. (1994). Why do medical nebulizers differ in their output and particle-size characteristics. J Aerosol Med-Depos Clear Effect Lung 7:259–76
  • Niven RW, Brain JD. (1994). Some functional-aspects of air-jet nebulizers. Int J Pharmaceut 104:73–85
  • Niven RW, Carvajal TM, Schreier H. (1992). Nebulization of liposomes 3. The effects of operating-conditions and local environment. Pharmaceut Res 9:515–20
  • Niven RW, Schreier H. (1990). Nebulization of liposomes. 1. Effects of lipid-composition. Pharmaceut Res 7:1127–33
  • Niven RW, Speer M, Schreier H. (1991). Nebulization of liposomes. 2. The effects of size and modeling of soute release profiles. Pharmaceut Res 8:217–21
  • Ocallaghan C, Barry PW. (1997). The science of nebulised drug delivery. Thorax 52:s31–44
  • Otterson GA, Villalona-calero MA, Sharma S, et al. (2007). Phase i study of inhaled doxorubicin for patients with metastatic tumors to the lungs. Clin Canc Res 13:1246–52
  • Patton JS. (1996). Mechanisms of macromolecule absorption by the lungs. Adv Drug Deliv Rev 19:3–36
  • Patton JS, Brain JD, Davies LA, et al. (2010). The particle has landed-characterizing the fate of inhaled pharmaceuticals. J Aerosol Med Pulmon Drug Deliv 23:s71–87
  • Patton JS, Bukar J, Nagarajan S. (1999). Inhaled insulin. Adv Drug Deliv Rev 35:235–47
  • Patton JS, Byron PR. (2007). inhaling medicines: delivering drugs to the body through the lungs. Nat Rev Drug Discov 6:67–74
  • Perera AD, Kapitza C, Nosek L, et al. (2002). Absorption and metabolic effect of inhaled insulin -- intrapatient variability after inhalation via the aerodose insulin inhaler in patients with type 2 diabetes. Diabetes Care 25:2276–81
  • Perkins WR, Minchey SR, Ahl PL, Janoff AS. (1993). The determination of liposome captured volume. Chem Phys Lipids 64:197–217
  • Reychler G, Keyeux A, Cremers C, et al. (2004). Comparison of lung deposition in two types of nebulization -- intrapulmonary percussive ventilation vs jet nebulization. Chest 125:502–08
  • Rouge N, Buri P, Doelker E. (1996). Drug absorption sites in the gastrointestinal tract and dosage forms for site-specific delivery. Int J Pharmaceut 136:117–39
  • Saari M, Vidgren MT, Koskinen MO, et al. (1999). Pulmonary distribution and clearance of two beclomethasone liposome formulations in healthy volunteers. Int J Pharmaceut 181:1–9
  • Sabin J, Prieto G, Ruso JM, et al. (2006). Size and stability of liposomes: a possible role of hydration and osmotic forces. Eur Phys Journal E 20:401–8
  • Schulz H. (1998). Mechanisms and factors affecting intrapulmonary particle deposition: implications for efficient inhalation therapies. Pharmaceut Sci Technol Today 1:336–44
  • Semmler-behnke M, Kreyling WG, Lipka J, et al. (2008). Biodistribution of 1.4-and 18-nm gold particles in rats. Small 4:2108–11
  • Sharma A, Sharma US. (1997). Liposomes in drug delivery: progress and limitations. Int J Pharmaceut 154:123--40
  • Stahlhofen W, Armbruster L, Gebhart J, Grein E. (1975). Particle sizing of aerosols by single-particle observation in a sedimentation cell. Atmos Environ 9:851–57
  • Szoka F, Papahadjopoulos D. (1978). Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation. Proc Natl Acad Sci USA 75:4194–98
  • Tang K, Gomez A. (1994). Generation by electrospray of monodisperse water droplets for targeted drug-delivery by inhalation. J Aerosol Sci 25:1237–49
  • Telko MJ, Hickey AJ. (2005). Dry powder inhaler formulation. Respiratory Care 50:1209--27
  • Vaaraslahti K, Laitinen A, Keskinen J. (2002). Spray charging of droplets in a wet scrubber. J Air Waste Manage Assoc 52:175–80
  • Valdespino-gomez JL, Sepulveda-amor J, Garcia-garcia MD, et al. (2002). A randomized trial demonstrating successful boosting responses following simultaneous aerosols of measles and rubella (mr) vaccines in school age children. Vaccine 20:2790–95
  • Vanbever R, Mintzes JD, Wang J, et al. (1999). Formulation and physical characterization of large porous particles for inhalation. Pharmaceut Res 16:1735–42
  • Verschraegen CF, Gilbert BE, Loyer E, et al. (2004). Clinical evaluation of the delivery and safety of aerosolized liposomal 9-nitro-20(s)-camptothecin in patients with advanced pulmonary malignancies. Clin Canc Res 10:2319–26
  • Wadell C. (2002). Nasal drug delivery- in vitro studies on factors influncing permeability and implications on absorption. Faculty of pharmacy in pharmaceutics. Uppsala: Acta Universitatis Upsaliensis
  • Waldrep JC, Arppe J, Jansa KA, Knight V. (1997). High dose cyclosporin a and budesonide-liposome aerosols. Int J Pharmaceut 152:27–36
  • Waldrep JC, Keyhani K, Black M, Knight V. (1994). Operating characteristics of 18 different continuous-flow jet nebulizers with beclomethasone dipropionate liposome aerosol. Chest 105:106–10
  • Weers J, Metzheiser B, Taylor G, et al. (2009). A gamma scintigraphy study to investigate lung deposition and clearance of inhaled amikacin-loaded liposomes in healthy male volunteers. J Aerosol Med Pulmon Drug Deliv 22:131–38
  • Weibel ER. (2009). What makes a good lung? Swiss Med Weekly, p. 139
  • Wu Y, Yu B, Jackson A, et al. (2009). Coaxial electrohydrodynamic spraying: a novel one-step technique to prepare oligodeoxynucleotide encapsulated lipoplex nanoparticles. Mol Pharmaceut 6:1371–79
  • Yurteri CU, Hartman RPA, Marijnissen JCM. (2010). Producing pharmaceutical particles via electrospraying with an emphasis on nano and nano structured particles -- a review. Kona Powd Part J 91–115
  • Zachariah MR, Li MD, Guha S, et al. (2011). Quantification and compensation of nonspecific analyte aggregation in electrospray sampling. Aerosol Sci Technol 45:849–60
  • Zhang L, Pornpattananangku D, Hu C-MJ, Huang C-M. (2010). Development of nanoparticles for antimicrobial drug delivery. Curr Med Chem 17:585--94

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