Mechanism of Action of Amphotericin B at the Cellular Level. Its Modulation by Delivery Systems

References

• Brajtburg J., Elberg S., Medoff G., Kobayashi G. S. Increase in colony forming units of Candida albicans after treatment with polyene antibiotics. Antimicrob. Agents Chemother. 1981; 19: 199
   PubMed Web of Science ®Google Scholar
• Foresti M., Amati P. Influence of amphotericin B on leucine uptake in 3T3 cells. Biochim. Biophys. Acta 1983; 732: 251
   PubMedGoogle Scholar
• Kitawaga T., Andoh T. Stimulation by amphotericin B of uridine transport, RNA synthesis, DNA synthesis in density-inhibited fibroblasts. Exp. Cell Res. 1978; 115: 37
   PubMed Web of Science ®Google Scholar
• Rozengurt E., Mendoza S. Monovalent ion fluxes and the control of cell proliferation in cultured fibroblasts. Ann. N. Y. Acad. Sci. 1980; 339: 175
   PubMedGoogle Scholar
• Brajtburg J., Elberg S., Medoff J., Kobayashi G. S., Schlessinger D., Medoff G. Stimulatory, permeabilizing and toxic effects of amphotericin B on L cells. Antimicrob. Agents Chemother. 1984; 26: 892
   PubMed Web of Science ®Google Scholar
• Nugent K. M., Couchot K. R. Effects of sublethal concentrations of amphotericin B on Candida albicans. J. Infect. Dis. 1986; 154: 665
   PubMed Web of Science ®Google Scholar
• Ghannoum M. A., Filler S. G., Ibrahim A. S., Fu Y., Edwards J. E. Modulation of interactions of Candida albicans and endothelial cells by fluconazole and amphotericin B. Antimicrob. Agents Chemother. 1992; 36: 2239
   PubMed Web of Science ®Google Scholar
• Bolard J. How do the polyene macrolide antibiotics affect the cellular membrane properties?. Biochim. Biophys. Acta 1986; 864: 257
   PubMed Web of Science ®Google Scholar
• Binet A., Bolard J. Recovery of hepatocytes from attack by the pore former amphotericin B. Biochem. J. 1988; 253: 435
   PubMed Web of Science ®Google Scholar
• Brajtburg J., Medoff G., Kobayashi G. S., Elberg S., Finegold C. Permeabilizing and hemolytic action of large and small polyene antibiotics on human erythrocytes. Antimicrob. Agents Chemother. 1980; 18: 586
   PubMed Web of Science ®Google Scholar
• Brajtburg J., Medoff G., Kobayashi G. S., Elberg S. Influence of extracellular K+ and Mg++ on the stages of the antifungal effects of amphotericin B and filipin. 1980. Antimicrob. Agents Chemother. 1980; 18: 593
   PubMed Web of Science ®Google Scholar
• Malewicz B., Jenkin H. M., Borowski E. Dissociation beween the induction of potassium efflux and cytostatic activity of polyene macrolides in mammalian cells. Antimicrob. Agents Chemother. 1980; 18(17)699
   PubMedGoogle Scholar
• Malewicz B., Jenkin H. M., Borowski E. Repair of membrane alterations induced in baby hamster kidney cells by polyene macrolides antibiotics. Antimicrob. Agents Chemother. 1981; 19: 238
   PubMed Web of Science ®Google Scholar
• Hsu-Chen C. C., Feingold D. S. Two types of resistance to polyene antibiotics in Candida albicans. Nature (London) 1974; 251: 656
   PubMed Web of Science ®Google Scholar
• Krause H. J., Juliano R. L. Interactions of liposome-incorporated amphotericin B with kidney epithelial cell cultures. Mol. Pharmacol. 1988; 34: 286
   PubMed Web of Science ®Google Scholar
• Joly V., Saint-Julien L., Carbon C., Yeni P. Interactions of free and liposomal amphotericin B with renal tubular cells in primary culture. J. Pharmacol. Exp. Ther. 1990; 255: 17
   PubMed Web of Science ®Google Scholar
• Joly V., Saint-Pierre-Chazalet M., Saint-Julien L., Bolard J., Carbon C., Yeni P. Inhibiting cholesterol synthesis reduces the binding and toxicity of amphotericin B against renal tubular cells in primary culture. J. Infect. Dis. 1992; 165: 337
   PubMed Web of Science ®Google Scholar
• Brajtburg J., Elberg S., Schwartz D. R., Vertut-Croquin A., Schlessinger D., Kobayashi S., Medoff G. Involvement of oxydative damage in erythrocyte lysis induced by amphotericin B. Antimicrob. Agents Chemother. 1985; 27: 172
   PubMed Web of Science ®Google Scholar
• Sokol-Anderson M. J., Brajtburg J., Medoff G. Amphotericin B-induced oxidative damage and killing of Candida albicans. J. Infect. Dis. 1986; 154: 76
   PubMed Web of Science ®Google Scholar
• Brajtburg J., Elberg S., Kobayashi G. S., Medoff G. Toxicity and induction of resistance to Listeria monocytogenes by amphotericin B in inbred strains of mice. Infect. Immun. 1986; 54: 303
   PubMed Web of Science ®Google Scholar
• Vertut-Doi A., Hannaert P., Bolard J. The polyene antibiotic amphotericin B inhibits the Na+/K+ pump of human erythrocytes. Biochem. Biophys. Res. Commun. 1988; 157: 692
   PubMed Web of Science ®Google Scholar
• Sawaya B. P., Weihprecht H., Campbell W. R., Lorenz J. N., Webb R. C., Briggs J. P., Schnermann J. Direct vasoconstriction as a possible cause for amphotericin B-induced nephrotoxicity in rats. J. Clin. Invest. 1991; 87: 2097
   PubMed Web of Science ®Google Scholar
• Brajtburg J., Elberg S., Bolard J., et al. Interaction of plasma proteins and lipoproteins with amphotericin B. J. Infect. Dis. 1984; 149: 986
   PubMed Web of Science ®Google Scholar
• Wasan K. M., Brazeau G. A., Keyhani A., Hayman A. C., Lopez Berestein G. Roles of liposome composition and temperature in distribution of amphotericin B in serum lipoproteins. Antimicrob. Agents Chemother. 1993; 37: 246
   PubMed Web of Science ®Google Scholar
• Blum S. F., Shoet S. B., Nathan D. G., Gardner F. H. The effect of amphotericin B on erythrocyte membrane cation permeability. Its relation to in vivo erythrocyte survival. J. Lab. Clin. 1969; 73: 980
   PubMed Web of Science ®Google Scholar
• Vertut-Doi A., Legrand P., Bolard J. Endocytosis of the polyene antibiotic amphotericin B by CHO cells and its effect on the endocytic process, (submitted)
   Google Scholar
• Levy R. A., Ostlund R. E., Jr., Brajtburg J. The effects of amphotericin B on lipid metabolism in cultured human skin fibroblasts. In Vitro. Cell. Dev. Biol. 1985; 21: 26
   PubMed Web of Science ®Google Scholar
• Kerridge D. Mode of action of clinically important antifungal drugs. Adv. Microb. Physiol. 1986; 27: 1
   PubMed Web of Science ®Google Scholar
• Richman-Boytas C. M., Parks L. W. Effects of sterol alterations on nystatin sensitivity in saccharomyces cerevisiae. Microbios. 1989; 59: 101
   PubMedGoogle Scholar
• Krieger M., Martin J., Segal M., Kingsley D. Amphotericin B selection of mutant Chinese hamster cells with defects in the receptor-mediated endocytosis of low density lipoprotein and cholesterol biosynthesis. Proc. Nad. Acad. Sci. USA. 1983; 80: 5607
   PubMed Web of Science ®Google Scholar
• Brajtburg J., Medoff G., Kobayshi G. S., Schlessinger D., Atallah A. Sensitivity to amphotericin B and the cholesterol: Phospholipid molar ratios of 3T3.1, BHK and HeLa cells. Biochem. Pharmacol. 1977; 26: 705
   PubMed Web of Science ®Google Scholar
• Mishra P., Bolard J., Prasad R. Emerging role of lipids of Candida albicans, a pathogenic dimorphic yeast. Biochim. Biophys. Acta. 1992; 1127
   Google Scholar
• Sokol-Anderson M., Sligh J. E., Jr., Brajtburg J., Kobayashi G. S., Medoff G. Role of cell defense against oxidative damage in the resistance of Candida albicans to the killing effect of amphoterincin B. Antimicrob. Agents chemother. 1988; 32: 702
   PubMed Web of Science ®Google Scholar
• Bolard J., Legrand P., Heitz F., Cybulska B. One-sided action of amphotericin B on cholesterol-containing membranes is determined by its selfassociation in the medium. Biochemistry. 1991; 30: 5707
   PubMed Web of Science ®Google Scholar
• Legrand P., Romero E. A., Cohen B. E., Bolard J. Effects of aggregation and solvent on the toxicity of amphotericin B to human erythrocytes. Antimicrob. Agents Chemother. 1992; 36: 2518
   PubMed Web of Science ®Google Scholar
• Cheron M., Cybulska B., Mazerski J., Grzybowska J., Czerwinski A., Borowski E. Quantitative structure-activity relationships in amphotericin B derivatives. Biochem. Pharmacol. 1988; 37: 827
   PubMed Web of Science ®Google Scholar
• Bolard J. Mechanism of action of an anti-candida drug: amphotericin B and its derivatives. “Candida albicans”, R. Prasad. Springer Verlag, Berlin Heidelberg 1991; 214
   Google Scholar
• Lin H. S., Medoff G., Kobayashi G. S. Effects of amphotericin B on macrophages and theri precursor cells. Antimicrob. Agents Chemother. 1977; 11: 154
   PubMed Web of Science ®Google Scholar
• Wolf J. E., Massof S. E. In vitro activation of macrophage oxidative burst activity by cytokines and amphotericin B. Infect. Immun. 1990; 58: 1296
   PubMed Web of Science ®Google Scholar
• Chapman H. A., Jr., Hibbs J. B., Jr. Modulation of macrophage tumoricidal capability by polyene antibiotics: support for membrane lipid as a regulatory determinant of macrophage function. Proc. Natl. Acad. Sci USA. 1978; 75: 4349–4353
   PubMed Web of Science ®Google Scholar
• Perfect J. R., Granger D. L., Durack D. T. Effects of antifungal agents and gamma interferon on macrophage cytotoxicity for fungi and tumor cells. J. Infect. Dis. 1987; 156: 316
   PubMed Web of Science ®Google Scholar
• Bistoni F., Vecchiarelli A., Mazzola R., Pucetti P., Marconi P., Garaci E. Immunoadjuvant activity of amphotericin B as displayed in mice infected with Candida albicans. Antimicrob. Ag. Chemother. 1985; 27: 625
   PubMed Web of Science ®Google Scholar
• Vechiarelli A., Verducci G., Perito S., Pucetti P., Marconi P., Bistoni F. Involvment of host macrophages in the immunoadjuvant activity of amphotericin B in a mouse fungal infection model. J. Antibiotics 1986; 39: 846
   PubMed Web of Science ®Google Scholar
• Wilson E., Thorson L., Speert D. P. Enhancement of macrophage superoxide anion production by amphotericin B. Antimicrob. Agents Chemother. 1991; 35: 796
   PubMed Web of Science ®Google Scholar
• Chia J. K. S., Pollack M. Amphotericin B induces tumor necrosis factor production by murine macrophages. J. Infect. Dis. 1989; 159: 113
   PubMed Web of Science ®Google Scholar
• Gelfand J. A., Kimball K., Burke J. F., Dinarello C. A. Amphotericin B treatment of human mononuclear cells in vitro results in secretion of tumor necrosis factor and interleukin-1. Clin. Res. 1988; 36: 456
   Google Scholar
• Van't Wout J., Meynaar I., Linde I., Poell R., Mattie H., Van Furth R. Effect of amphotericin B, fluconazole and itraconazole on intracellular Candida albicans and germ tube development in macrophages. Antimicrob. Chemother. 1990; 25: 803
   Google Scholar
• Mehta K., Claringbold P., Lopez-Berestein G. Amphotericin B inhibits the serum-induced expression of tissue transglutaminase in murine peritoneal macrophages. J. Immun. 1986; 136: 4206
   PubMed Web of Science ®Google Scholar
• Bolard J. Modulation of the immune defenses against fungi by amphotericin B and its derivatives. “Recent progress in antifungal chemotherapy”, H. Yamaguchi, G. S. Kobayashi, H. Takakashi. Marcel Dekker, New York 1991; 293
   Google Scholar
• Cleary J. D., Chapman S. W., Nolan R. L. Pharmacologic modulation of interleukin-1 expression by amphotericin B-stimulated hyman mononuclear cells. Antimicrob. Agents Chemother. 1992; 36: 977
   PubMed Web of Science ®Google Scholar
• Boggs J. M., Chang N. H., Goundalkar A. Liposomal amphotericin B inhibits in Vitro T-lymphocyte. Antimicrob. Agents Chemother. 1991; 35: 879
   PubMed Web of Science ®Google Scholar
• Wolf J. E., Stein S. H., Little K. D., Abegg A. L., Little J. R. Amphotericin B selectively stimulates macrophages from high responder mouse stains. Immun. 1991; 13: 221
   Google Scholar
• Henry-Toulme N., Sarthou P., Bolard J. Early membrane potential and cytoplasmic calcium changes during mitogenic stimulation of WEHI 231 cell line by polyene antibiotics, lipopolysaccharide and antiimmunoglobulin. Biochim. Biophys. Acta. 1990; 1051: 285
   PubMedGoogle Scholar
• Tanabe K., Higuchi Y., Akizuki S., Yamamoto S. Effects of amphotericin B on the function and gene expression in macrophage cell lines. Bio. Res. 1988; 9: 217
   Google Scholar
• Longuet P., Joly V., Amirault P., Seta N., Carbon C., Yeni P. Limited protection by small unilamellar liposomes against the renal tubular toxicity induced by repeated amphotericin B infusions in rats. Antimicrob. Agents Chemother. 1991; 35: 1303
   PubMed Web of Science ®Google Scholar
• Szoka F. C., Milholland D., Barza M. Effect of lipid composition and liposome size on toxicity and in vitro fungicidal activity of liposome-intercalated amphotericin B. Antimicrob. Agents Chemother. 1987; 31: 421
   PubMed Web of Science ®Google Scholar
• Joly V., Bolard J., Saint-Julien L., Carbon C., Yeni P. Influence of the phospholipid /amphotericin B ratio and the phospholipid type on the in vitro renal cell toxicity and fungicidal activity of lipid-associated amphotericin B formulations. Antimicrob. Agents Chemother. 1992; 36: 262
   PubMed Web of Science ®Google Scholar
• Jullien S., Contrepois A., Sligh J. E., Domart Y., Yeni P., Brajtburg J., Medoff G., Bolard J. Study of the effects of liposomal amphotericin B on Candida albicans, Cryptococcus neoformans and erythrocytes by using small unilamellar vesicles prepared from saturated phospholipids. Antimicrob. Agents Chemother. 1989; 33: 345
   PubMed Web of Science ®Google Scholar
• Mehta R., Lopez-Berestein G., Hopfer R., Mills K., Juliano R. L. Liposomal amphoteriicn B is toxic to fungal cells but not to mammalian cells. Biochim. Biophys. Acta 1984; 770: 230
   PubMed Web of Science ®Google Scholar
• Vertut-Croquin A., Bolard J., Gary-Bobo C. Transfer of amphotericin B from gel state vesicles to Mycoplasma cells: biphasic action on potassium transport and permeability. Antimicrob. Ag. Chemother. 1985; 28: 167
   PubMed Web of Science ®Google Scholar
• Juliano R. L., Grant C. W., Barber K. R., Kalp M. A. Mechanism of the selective toxicity of amphotericin B incorporated into liposomes. Mol. Pharmacol. 1987; 31: 1
   PubMed Web of Science ®Google Scholar
• Vertut-Croquin A., Bolard J., Gary-Bobo C. Enhancement of amphotericin B selectivity by antibiotic incorporation into gel state vesicle. A circular dichroism and permeability study. Biochem. Biophys. Res. Commun. 1984; 125: 360
   PubMed Web of Science ®Google Scholar
• Jullien S., Brajtburg J., Bolard J. Affinity of amphotericin B for phosphotidylcholine vesicles as a determinant of the in vitro cellular toxicity of liposomal preparations. Biochim. Biophys. Acta 1990; 1021: 39
   PubMed Web of Science ®Google Scholar
• Perkin W. R., Minchey S. R., Boni L. T., Swenson C. E., Popescu M. C., Pasternack R. F., Janoff A. S. Amphotericin b-phospholipid interaction responsible for reduced mammalian cell toxicity. Biochim. Biophys. Acta. 1992; 1170: 271
   Google Scholar
• Janoff A. S., Boni L. T., Popescu M. C., Minchey S. R., Cullis P. R., Madden T. D., Tarashi T., Gruner S. M., Shyamsunder E., Tate M. W., Mendelsohn R., Bonner D. Unusual lipid structures selectively reduce the toxicity of amphotericin B. Proc. Natl. Acad. Sci. USA 1988; 85: 6122
   PubMed Web of Science ®Google Scholar
• Barwicz J., Christian S., Gruda I. Effects of the aggregation state of amphotericin B on its toxicity to mice. Antimicrob. Agents Chemother. 1992; 36: 2310
   PubMed Web of Science ®Google Scholar
• Gruda I., Milette D., Brother M., Kobayashi G. S., Medoff G., Brajtburg J. Structure-activity study of inhibition of amphotericin B (Fungizone) binding to sterols, toxicity to cells and lethality to mice by esters of sucrose. Antimicrob. Agents Chemother. 1991; 35: 24
   PubMed Web of Science ®Google Scholar
• Mehta R., Mehta K., Lopez-Berestein G., Juliano R. L. Effect of liposomal amphotericin B on murine macrophages and lymphocytes. Infect. Immun 1985; 47: 429
   PubMed Web of Science ®Google Scholar
• Sullivan G. W., Carper H. T., Mandell G. L. Lipid complexing decreases amphotericin B inflammatory activation fo human neutrophils compared with that of a desoxycholate-suspended preparation of amphotericin B (fungizone). Antimicrob. Agents Chemother. 1992; 36: 39
   PubMed Web of Science ®Google Scholar
• Edmonds L. C., Davidson L., Bertino J. S. Effect of variation in infusion time and macrophage blockade on organ uptake of amphotericin Bdeoxycholate. J. Antimicrob. Chemother. 1991; 28: 919
   PubMed Web of Science ®Google Scholar
• Legrand P., Vertut-Do-i A., Bolard J., Comparative internalization and recycling of different amphotericin B formulations, by macrophage like cell line J774 (submitted)
   Google Scholar
• Barwicz J., Gareau R., Audet A., Morisset A., Villiard J., Gruda I. Inhibition of the interaction between lipoproteins and amphotericin B by some delivery systems. Biochem. Biophys. Res. Commun. 1991; 181: 722
   PubMed Web of Science ®Google Scholar
• Koldin M. K., Kobayashi G. S., Brajtburg J., Medoff G. Effects of elevation of serum cholesterol and administration of amphotericin B complexed to lipoproteins an amphotericin B-induced toxicity in rabbits. Antimicrob. Agents Chemother. 1985; 28: 144
   PubMed Web of Science ®Google Scholar