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Ocular Immunology and Inflammation Volume 25, 2017 - Issue 1
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Original Articles

Safety and Efficacy of Gevokizumab in Patients with Behçet’s Disease Uveitis: Results of an Exploratory Phase 2 Study

Ilknur Tugal-Tutkun MDDepartment of Ophthalmology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, TurkeyView further author information
,
Sibel Kadayifcilar MDDepartment of Ophthalmology, Hacettepe University School of Medicine, Ankara, TurkeyView further author information
,
Moncef Khairallah MDDepartment of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, Monastir University, Monastir, TunisiaView further author information
,
Sung Chul Lee MD, PhDInstitute of Vision Research, Department of Ophthalmology, Severance Eye and ENT Hospital, Yonsei University College of Medicine, Seoul, South KoreaView further author information
,
Pinar OzdalUlucanlar Eye Hospital, Ankara, TurkeyView further author information
,
Yilmaz ÖzyazganDepartment of Ophthalmology, Istanbul University, Cerrahpasa Faculty of Medicine, TurkeyView further author information
,
Ji Hun Song MDDepartment of Ophthalmology, Ajou University School of Medicine, Suwon, South KoreaView further author information
,
Hyeong Gon Yu MD, PhDDepartment of Ophthalmology, Seoul National University College of Medicine, Seoul, South KoreaView further author information
,
Valerie Lehner PhDInstitute de Recherches Internationales Servier, Suresnes, FranceView further author information
,
Agnès de Cordoue MDInstitute de Recherches Internationales Servier, Suresnes, FranceView further author information
,
Oana Bernard MDInstitute de Recherches Internationales Servier, Suresnes, FranceView further author information
&
Ahmet Gül MDDepartment of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, TurkeyCorrespondence[email protected]
View further author information
 show all
Pages 62-70 | Received 29 Apr 2015, Accepted 07 Sep 2015, Published online: 30 Jan 2016

REFERENCES

  • Sakane T, Takeno M, Suzuki N, et al. Behcet’s disease. N Engl J Med. 1999;341:1284–1291.
  • Hatemi G, Yazici Y, Yazici H. Behcet’s syndrome. Rheum Dis Clin North Am. 2013;39:245–261.
  • Tugal-Tutkun I, Onal S, Altan-Yaycioglu R, et al. Uveitis in Behcet disease: an analysis of 880 patients. Am J Ophthalmol. 2004;138:373–380.
  • Hatemi G, Silman A, Bang D, et al. EULAR recommendations for the management of Behcet disease. Ann Rheum Dis. 2008; 67:1656–1662.
  • Owyang AM, Issafras H, Corbin J, et al. XOMA 052, a potent, high-affinity monoclonal antibody for the treatment of IL-1beta-mediated diseases. MAbs. 2011;3:49–60.
  • Roell MK, Issafras H, Bauer RJ, et al. Kinetic approach to pathway attenuation using XOMA 052, a regulatory therapeutic antibody that modulates interleukin-1beta activity. J Biol Chem. 2010;285:20607–20614.
  • Issafras H, Corbin JA, Goldfine ID, et al. Detailed mechanistic analysis of gevokizumab, an allosteric anti-IL-1beta antibody with differential receptor-modulating properties. J Pharmacol Exp Ther. 2014;348:202–215.
  • Gul A, Tugal-Tutkun I, Dinarello CA, et al. Interleukin-1beta-regulating antibody XOMA 052 (gevokizumab) in the treatment of acute exacerbations of resistant uveitis of Behcet’s disease: an open-label pilot study. Ann Rheum Dis. 2012;71:563–566.
  • International Study Group for Behcet’s Disease. Criteria for diagnosis of Behcet’s disease. Lancet. 1990;335:1078–1080.
  • Jabs DA, Nussenblatt RB, Rosenbaum JT. Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol. 2005;140:509–516.
  • Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study report number 1. Early Treatment Diabetic Retinopathy Study research group. Arch Ophthalmol. 1985;103:1796–1806.
  • BenEzra D, Forrester JV, Nussenblatt RB, et al. Uveitis Scoring System. Berlin, Germany: Springer Verlag; 1991.
  • Tugal-Tutkun I, Herbort CP, Khairallah M. Scoring of dual fluorescein and ICG inflammatory angiographic signs for the grading of posterior segment inflammation (dual fluorescein and ICG angiographic scoring system for uveitis). Int Ophthalmol. 2010;30:539–552.
  • Mizushima Y, Inaba G, Mimura Y. Guide for Diagnosis of Behcet’s Disease, Behcet’s Diesase Research Committee, Japan. Tokyo, Japan: Ministry of Health and Welfare; 1987.
  • Lachmann HJ, Quartier P, So A, et al. The emerging role of interleukin-1beta in autoinflammatory diseases. Arthritis Rheum. 2011;63:314–324.
  • Sfikakis PP, Theodossiadis PG, Katsiari CG, et al. Effect of infliximab on sight-threatening panuveitis in Behcet’s disease. Lancet. 2001;358:295–296.
  • Cavelti-Weder C, Babians-Brunner A, Keller C, et al. Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes. Diabetes Care. 2012; 35:1654–1662.
  • Gul A. Standard and novel therapeutic approaches to Behcet’s disease. Drugs. 2007; 67:2013–2022.

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