291
Views
16
CrossRef citations to date
0
Altmetric
Original Articles

Analysis of Th Cell-related Cytokine Production in Behçet Disease Patients with Uveitis Before and After Infliximab Treatment

, MD, PhD, , PhD, , MD, , MD, , MD, , MD, PhD, , PhD ORCID Icon & , MD, PhD show all
Pages 52-61 | Received 13 Jul 2015, Accepted 16 Feb 2016, Published online: 12 Apr 2016

REFERENCES

  • Chajek T, Fainaru M. Behcet’s disease. Report of 41 cases and a review of the literature. Medicine (Baltimore). 1975;54:179–196.
  • Wong RC, Ellis CN, Diaz LA. Behcet’s disease. Int J Dermatol. 1984;23:25–32.
  • Sakane T, Takeno M, Suzuki N, et al. Behcet’s disease. N Engl J Med. 1999;341:1284–1291.
  • Mege JL, Dilsen N, Sanguedolce V, et al. Overproduction of monocyte derived tumor necrosis factor alpha, interleukin (IL) 6, IL-8 and increased neutrophil superoxide generation in Behcet’s disease. A comparative study with familial Mediterranean fever and healthy subjects. J Rheumatol. 1993;20:1544–1549.
  • de Smet MD, Dayan M. Prospective determination of T-cell responses to S-antigen in Behcet’s disease patients and controls. Invest Ophthalmol Vis Sci. 2000;41:3480–3484.
  • Meguro A, Ota M, Katsuyama Y, et al. Association of the toll-like receptor 4 gene polymorphisms with Behcet’s disease. Ann Rheum Dis. 2008;67:725–727.
  • Nara K, Kurokawa MS, Chiba S, et al. Involvement of innate immunity in the pathogenesis of intestinal Behcet’s disease. Clin Exp Immunol. 2008;152:245–251.
  • Pay S, Simsek I, Erdem H, et al. Immunopathogenesis of Behcet’s disease with special emphasize on the possible role of antigen presenting cells. Rheumatol Int. 2007;27:417–424.
  • Frassanito MA, Dammacco R, Cafforio P, et al. Th1 polarization of the immune response in Behcet’s disease: a putative pathogenetic role of interleukin-12. Arthritis Rheum. 1999;42:1967–1974.
  • Koarada S, Haruta Y, Tada Y, et al. Increased entry of CD4+ T cells into the Th1 cytokine effector pathway during T-cell division following stimulation in Behcet’s disease. Rheumatology (Oxford). 2004;43:843–851.
  • Ahn JK, Yu HG, Chung H, et al. Intraocular cytokine environment in active Behcet uveitis. Am J Ophthalmol. 2006;142:429–434.
  • Zhao C, Yang P, He H, et al. S-antigen specific T helper type 1 response is present in Behcet’s disease. Mol Vis. 2008;14:1456–1464.
  • Langrish CL, Chen Y, Blumenschein WM, et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med. 2005;201:233–240.
  • Chi W, Zhu X, Yang P, et al. Upregulated IL-23 and IL-17 in Behcet patients with active uveitis. Invest Ophthalmol Vis Sci. 2008;49:3058–3064.
  • Amadi-Obi A, Yu CR, Liu X, et al. TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat Med. 2007;13:711–718.
  • Yamamoto JH, Fujino Y, Lin C, et al. S-antigen specific T cell clones from a patient with Behcet’s disease. Br J Ophthalmol. 1994;78:927–932.
  • Jobin D, Thillaye B, de Kozak Y, et al. Severe retinochoroidopathy: variations of humoral and cellular immunity to S-antigen in a longitudinal study. Curr Eye Res. 1990;9 Suppl:91–96.
  • Yamamoto JH, Minami M, Inaba G, et al. Cellular autoimmunity to retinal specific antigens in patients with Behcet’s disease. Br J Ophthalmol. 1993;77:584–589.
  • Takeuchi M, Usui Y, Okunuki Y, et al. Immune responses to interphotoreceptor retinoid-binding protein and S-antigen in Behcet’s patients with uveitis. Invest Ophthalmol Vis Sci. 2010;51:3067–3075.
  • Mamo JG. The rate of visual loss in Behcet’s disease. Arch Ophthalmol. 1970;84:451–452.
  • Mishima S, Masuda K, Izawa Y, et al. The eighth Frederick H. Verhoeff lecture. Presented by Saiichi Mishima, MD. Behcet’s disease in Japan: ophthalmologic aspects. Trans Am Ophthalmol Soc. 1979;77:225–279.
  • Muhaya M, Lightman S, Ikeda E, et al. Behcet’s disease in Japan and in Great Britain: a comparative study. Ocul Immunol Inflamm. 2000;8:141–148.
  • Hamuryudan V, Ozyazgan Y, Hizli N, et al. Azathioprine in Behcet’s syndrome: effects on long-term prognosis. Arthritis Rheum. 1997;40:769–774.
  • Tugal-Tutkun I, Onal S, Altan-Yaycioglu R, et al. Uveitis in Behcet disease: an analysis of 880 patients. Am J Ophthalmol. 2004;138:373–380.
  • Kaklamani VG, Kaklamanis PG. Treatment of Behcet’s disease – an update. Semin Arthritis Rheum. 2001;30:299–312.
  • Okada AA. Drug therapy in Behcet’s disease. Ocul Immunol Inflamm. 2000;8:85–91.
  • Sfikakis PP, Theodossiadis PG, Katsiari CG, et al. Effect of infliximab on sight-threatening panuveitis in Behcet’s disease. Lancet. 2001;358:295–296.
  • Ohno S, Nakamura S, Hori S, et al. Efficacy, safety, and pharmacokinetics of multiple administration of infliximab in Behçet’s disease with refractory uveoretinitis. J Rheumatol. 2004;31:1362–1368.
  • Goossens PH, Verburg RJ, Breedveld FC. Remission of Behcet’s syndrome with tumour necrosis factor alpha blocking therapy. Ann Rheum Dis. 2001;60:637.
  • Munoz-Fernandez S, Hidalgo V, Fernandez-Melon J, et al. Effect of infliximab on threatening panuveitis in Behcet’s disease. Lancet. 2001;358:1644.
  • International Study Group for Behçet’s Disease. Criteria for diagnosis of Behcet’s disease. Lancet. 1990;335:1078–1080.
  • Redmond TM, Wiggert B, Robey FA, et al. Isolation and characterization of monkey interphotoreceptor retinoid-binding protein, a unique extracellular matrix component of the retina. Biochemistry. 1985;24:787–793.
  • Luger D, Silver PB, Tang J, et al. Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med. 2008;205:799–810.
  • Yoshimura T, Sonoda K-H, Miyazaki Y, et al. Differential roles for IFN-γ and IL-17 in experimental autoimmune uveoretinitis. Int Immunol. 2008;20:209–214.
  • Hamzaoui K, Hamzaoui A, Guemira F, et al. Cytokine profile in Behçet’s disease patients. Scand J Rheumatol. 2002;31:205–210.
  • Hamzaoui K, Bouali E, Ghorbel I, et al. Expression of Th-17 and RORgammat mRNA in Behcet’s Disease. Med Sci Monit. 2011;17:CR227–CR234.
  • Sugita S, Kawazoe Y, Imai A, et al. Inhibition of Th17 differentiation by anti-TNF-alpha therapy in uveitis patients with Behcet’s disease. Arthritis Res Ther. 2012;14:R99.
  • Zou J, Rudwaleit M, Brandt J, et al. Down-regulation of the nonspecific and antigen-specific T cell cytokine response in ankylosing spondylitis during treatment with infliximab. Arthritis Rheum. 2003;48:780–790.
  • Schneider K, Potter KG, Ware CF. Lymphotoxin and LIGHT signaling pathways and target genes. Immunol Rev. 2004;202:49–66.
  • Raziuddin S, al-Dalaan A, Bahabri S, et al. Divergent cytokine production profile in Behcet’s disease. Altered Th1/Th2 cell cytokine pattern. J Rheumatol. 1998;25:329–333.
  • Trifari S, Kaplan CD, Tran EH, et al. Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells. Nat Immunol. 2009;10:864–871.
  • Li Z, Liu B, Maminishkis A, et al. Gene expression profiling in autoimmune noninfectious uveitis disease. J Immunol. 2008;181:5147–5157.
  • Sugita S, Kawazoe Y, Imai A, et al. Role of IL-22- and TNF-alpha-producing Th22 cells in uveitis patients with Behcet’s disease. J Immunol. 2013;190:5799–5808.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.