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Original Article

Transforming growth factor-β levels in aqueous humor during experimentally induced uveitis

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Pages 343-354 | Accepted 31 Mar 1993, Published online: 08 Jul 2009

References

  • Franklin R M, Prendergast R A. Primary injection of skin allografts in the anterior chamber of the rabbit eye. J Immunol 1970; 104: 463–469
  • Wilbanks G A, Streilein J W. The differing patterns of antigen release and local retention following anterior chamber and intravenous inoculation of soluble antigen. Evidence that the eye acts as an antigen depot. Reg-Immunol 1989; 2(6)390–398
  • Brubaker R F. Flow of aqueous humor in humans. Invest Ophthalmol Vis Sci 1991; 32(13)3145–3166
  • Wacker W B, Lipton M M. Experimental allergic uveitis. I. Production in the guinea pig and rabbit by immunization with retina in adjuvant. J Immunol 1968; 101: 151
  • Streilein J W, Kaiser C J. Immunosuppressive properties of aqueous humor as it relates to uveitis. Proc First World Uveitis Symposium, R Belfort, Jr, A MN Petrilli, R Nussenblatt. Livraria Roca Ltda, São Paulo 1989; 3–13
  • Streilein J W. Anterior chamber associated immune deviation: The problem of immune privilege in the eye. Surv Ophthalmol 1990; 35: 67–73
  • Streilein J W, Niederkorn J Y. Induction of anterior chamber-associated immune deviation requires an intact, functional spleen. J Exp Med 1981; 153: 1058–1067
  • Granstein R D, Staszewski R, Knisely T L, Zeira E, Nazareno R, Latina M, Albert D M. Aqueous humor contains transforming growth factor-β and a small (< 3500 daltons) inhibitor of thymocyte proliferation. J Immunol 1990; 144(8)3021–3027
  • Massagué J. The TGF-β family of growth and differentiation factors. Cell 1987; 49: 437–438
  • Sporn M B, Roberts A B, Wakefield L M, Assoian R K. Transforming growth factor-β: Biological function and chemical structure. Science 1986; 233: 532–535
  • Ellingsworth L R, Nakayama D, Segarini P, Dasch J, Carrillo P, Waegell W. Transforming growth factor-βs are equipotent growth inhibitors of interleukin-1-induced thymocyte proliferation. Cell Immunol 1988; 114: 41–54
  • Runyan T E, McCombs W B, Holton O D, McCoy C E, Morgan M P. Human ciliary body epithelium in culture. Invest Ophthalmol Vis Sci 1983; 24: 687–696
  • Kondo K, Coca-Prados M, Sears M. Human ciliary epithelia in monolayer culture. Exp Eye Res 1984; 38: 423–433
  • Streilein J W, Bradley D. Analysis of immunosuppressive properties of iris and ciliary body cells and their secretory products. Invest Ophthalmol Vis Sci 1991; 32: 2700–2710
  • Wilbanks G A, Streilein J W. Suppression of delayed hypersensitivity in vivo by an ACAID-inducing signal created in vitro. Invest Ophthalmol Vis Sci 1992; 33(4)1283
  • Cousins S W, McCabe M M, Danielpour D, Streilein J W. Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor. Invest Ophthalmol Vis Sci 1991; 32: 2201–2211
  • Rocha G, Baines M G, Deschênes J, Antecka E. Non-specific suppressor factors associated with uveitis. Can J Ophthalmol 1992; 27(2)101
  • Helbig H, Kittredge K L, Coca-Prados M, Davis J, Palestine A G, Nussenblatt R B. Mammalian ciliary-body epithelial cells in culture produce transforming growth factor-beta. Graefe's Arch Clin Exp Ophthalmol 1991; 229: 84–87
  • Knisely T L, Bleicher P A, Vibbard C A, Granstein R D. Production of latent transforming growth factor-beta and other inhibitory factors by cultured murine iris and ciliary body cells. Curr Eye Res 1991; 10(8)761–771
  • Jampel H D, Roche N, Stark W J, Roberts A B. Transforming growth factor-β in human aqueous humor. Curr Eye Res 1990; 9(10)963–969
  • Hogan M J, Kimura S J, Thygeson P. Signs and symptoms of uveitis. I. Anterior uveitis. Am J Ophthalmol 1959; 47: 155–170
  • Danielpour D, Dart L L, Flanders K C, Roberts A B, Sporn M B. Immunodetection and quantitation of the two forms of transforming growth factor-β (TGF-β1 and TGF-β2) secreted by cells in culture. J Cell Physiol 1989; 138: 79–86
  • Cousins S W, McCabe M M, Danielpour D, Streilein J W. Identification of transforming growth factor-β as an immunosuppressive factor in aqueous humor. Invest Ophthalmol Vis Sci 1991; 32(8)2201–2211
  • Cai F, Backman H A, Baines M G. Thimerosal: an ophthalmic preservative which acts as a hapten to elicit specific antibodies and cell mediated immunity. Curr Eye Res 1988; 7(4)341–351
  • Rocha G, Baines M G, Deschênes J. The immunology of the eye and its systemic interactions. Crit Rev Immunol 1992; 12(3,4)81–100
  • Benson J L, Niederkorn J Y. Interleukin-1 abrogates anterior chamber-associated immune deviation. Invest Ophthalmol Vis Sci 1990; 31: 2123–2128
  • Streilein J W, Cousins S, Bradley D. Effect of intraocular gamma-interferon on immunoregulatory properties of iris and ciliary body cells. Invest Ophthalmol Vis Sci 1992; 33: 2304–2315
  • Easom H A, Zimmerman L E. Sympathetic ophthalmia and bilateral phacoanaphylaxis. Arch Ophthalmol 1964; 72: 9–15
  • Gery I, Nussenblatt R, Ben Ezra D. Dissociation between humoral and cellular responses to lens antigens. Invest Ophthalmol Vis Sci 1981; 20: 32–39
  • Danielpour D, Sporn M. Differential inhibition of transforming growth factor β1 and β2 activity by α2-macroglobulin. J Biol Chem 1990; 265(12)6973–6977
  • Meager A. Assays for transforming growth factor β. J Immunol Meth 1991; 141: 1–14

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