References
- Dumont F J, Staruch M J, Koprak S L, Melino M R, Sigal N H. Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin. J Immunol 1990; 144: 251–258
- Bierer E B, Mattila P S, Standaert R F, Herzenberg L A, Burakoff S J, Crabtree G, Schreiber S L. Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin. Proc Natl Acad Sci USA 1990; 87: 9231–9235
- Kuo C J, Chung J, Fiorentino D F, Flanagan W M, Blenis J, Crabtree G R. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature 1992; 358: 70–73
- Calvo V, Crews C M, Vik T A, Bierer B E. Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin. Proc Natl Acad Sci USA 1992; 89: 7571–7575
- Kahan B D, Gibbons S, Tejpal N, Stepkowski S, Chou T C. Synergistic interactions of cyclosporin and rapamycin to inhibit immune performances of normal human peripheral blood lymphocytes in vitro. Transplantation 1991; 51: 232–239
- Kronke M, Leonard W J, Depper J M, Arya S K, Wong-Stall F, Gallo R C, et al. Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. Proc Natl Acad Sci USA 1984; 81: 5214–5218
- Tocci M J, Matkovitch D A, Collier K A, Kwok P, Dumont F, Lin S, et al. The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes. J Immunol 1989; 143: 718–726
- Roberge F G, Xu D, Chan C-C, de Smet M D, Nussenblatt R B, Chen H. Treatment of autoimmune uveoretinitis in the rat with rapamycin, an inhibitor of lymphocyte growth factor signal transduction. Curr Eye Res 1993; 12: 197–203
- de Kozak Y, Sakai J, Thillaye B, Faure J P. S antigen induced experimental autoimmune uveo-retinitis in rats. Curr Eye Res 1981; 1: 327–337
- Kozhich A T, Vistica B P, Gery I, Berzofsky J A, Wauben M, van Eden W. Inhibition of experimental autoimmune uveoretinitis (EAU) by synthetic peptides. Invest Ophthalmol Vis Sci (suppl) 1992; 33: 1025
- Sigal N H, Dumont F J. Cyclosporin A, FK-506, and Rapamycin: Pharmacologic probes of lymphocyte signal transduction. Ann Rev Immunol 1992; 10: 519–560
- Bouwer H GA, Dietsch G N, Hinrichs D J. Adoptive transfer of experimental allergic encephalomyelitis: Conditions influencing memory and effector cell development. Cell Immunol 1990; 131: 219–231
- Ben-Nun A, Cohen I R. Vaccination against autoimmune encephalomyelitis (EAE): Attenuated autoimmune T lymphocytes confer resistance to induction of active EAE but not to EAE mediated by intact T lymphocyte line. Eur J Immunol 1981; 11: 949–952
- Richert J R, Driscoll B F, Kies M W, Alvord E C, Jr. Experimental allergic encephalomyelitis: Activation of myelin basic protein-sensitized spleen cells by specific antigen in culture. Cell Immunol 1981; 59: 42–53
- Willenborg D O, Eichner R D, Waring P, M$uUllbacher A. Replication of donor lymphocytes in recipients is not essential for the passive transfer of allergic encephalomyelitis. J Neuroimmunol 1988; 19: 317–328
- Mannie M D, Paterson P Y, U'Prichard D C, Flouret G. Encephalitogenic and proliferative responses of Lewis rat lymphocytes distinguished by position 75- and 80-substituted peptides of myelin basic protein. J Immunol 1989; 142: 2608–2616
- Fox G M, Redmond T M, Wiggert B, Kuwabara T, Chader G J, Gery I. Dissociation between lymphocyte activation for proliferation and the capacity to adoptively transfer uveoretinitis. J Immunol 1987; 138: 3242–3246
- Gregerson D S, Fling S P, Obritsch W F, Merryman C F, Donoso L A. Identification of T cell recognition sites in S-antigen: Dissociation of proliferative and pathogenic sites. Cell Immunol 1989; 123: 427–440
- Kotake S, Wiggert B, Zhang X-Y, Redmond T M, Chader G J, Gery I. Stimulation in vitro of lymphocytes for induction of uveoretinitis without any significant proliferation. J Immunol 1990; 145: 534–539