185
Views
13
CrossRef citations to date
0
Altmetric
Polycystic Ovary Syndrome and Insulin Resistance

Association of the T45G and G276T polymorphisms in the adiponectin gene with PCOS: A meta-analysis

, , , , &
Pages 106-110 | Received 21 Feb 2010, Accepted 12 Jul 2010, Published online: 10 Nov 2011

References

  • Franks S . Polycystic ovary syndrome. N Engl J Med 1995;333:853–861.
  • Legro RS , Kunselman AR , Dodson WC , Dunaif A . Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. J Clin Endocrinol Metab 1999;84:165–169.
  • Legro RS . Polycystic ovary syndrome and cardiovascular disease: a premature association? Endocr Rev 2003;24:302–312.
  • Héctor F , Escobar-Morreale , Manuel Luque-Ramírez , José, L , San Millán . The Molecular-Genetic Basis of Functional Hyperandrogenism and the Polycystic Ovary Syndrome. Endocrine Reviews 2005;26:251–282.
  • Weyer C , Funahashi T , Tanaka S , Hotta K , Matsuzawa Y , Pratley RE , Tataranni PA . Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 2001;86:1930–1935.
  • Ouchi N , Kihara S , Arita Y , Okamoto Y , Maeda K , Kuriyama H , Hotta K , et al. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation 2000;102:1296–1301.
  • Okamoto Y , Arita Y , Nishida M , Muraguchi M , Ouchi N , Takahashi M , Igura T , et al. An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls. Horm Metab Res 2000;32:47–50.
  • Bruce CR , Mertz VA , Heigenhauser GJ , Dyck DJ . The stimulatory effect of globular adiponectin on insulin-stimulated glucose uptake and fatty acid oxidation is impaired in skeletal muscle from obese subjects. Diabetes 2005;54:3154–3160.
  • Cruz M , García-Macedo R , García-Valerio Y , Gutiérrez M , Medina-Navarro R , Duran G , Wacher N , Kumate J . Low adiponectin levels predict type 2 diabetes in Mexican children. Diabetes Care 2004;27:1451–1453.
  • Duncan BB , Schmidt MI , Pankow JS , Bang H , Couper D , Ballantyne CM , Hoogeveen RC , Heiss G . Adiponectin and the development of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes 2004;53:2473–2478.
  • Tan KC , Xu A , Chow WS , Lam MC , Ai VH , Tam SC , Lam KS . Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilation. J Clin Endocrinol Metab 2004;89:765–769.
  • Arita Y , Kihara S , Ouchi N , Takahashi M , Maeda K , Miyagawa J , Hotta K , et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999;257:79–83.
  • Spranger J , Kroke A , Möhlig M , Bergmann MM , Ristow M , Boeing H , Pfeiffer AF . Adiponectin and protection against type 2 diabetes mellitus. Lancet 2003;361:226–228.
  • Toulis KA , Goulis DG , Farmakiotis D , Georgopoulos NA , Katsikis I , Tarlatzis BC , Papadimas I , Panidis D . Adiponectin levels in women with polycystic ovary syndrome: a systematic review and a meta-analysis. Hum Reprod Update 2009;15:297–307.
  • Stumvoll M , Tschritter O , Fritsche A , Staiger H , Renn W , Weisser M , Machicao F , Häring H . Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes. Diabetes 2002;51:37–41.
  • Hara K , Boutin P , Mori Y , Tobe K , Dina C , Yasuda K , Yamauchi T , et al. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 2002;51:536–540.
  • Fumeron F , Aubert R , Siddiq A , Betoulle D , Péan F , Hadjadj S , Tichet J , et al.; Epidemiologic Data on the Insulin Resistance Syndrome (DESIR) Study Group . Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study. Diabetes 2004;53:1150–1157.
  • Zacharova J , Chiasson JL , Laakso M ; STOP-NIDDM Study Group . The common polymorphisms (single nucleotide polymorphism [SNP] +45 and SNP +276) of the adiponectin gene predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. Diabetes 2005;54:893–899.
  • Takahashi M , Arita Y , Yamagata K , Matsukawa Y , Okutomi K , Horie M , Shimomura I , et al. Genomic structure and mutations in adipose-specific gene, adiponectin. Int J Obes Relat Metab Disord 2000;24:861–868.
  • Vasseur F , Helbecque N , Dina C , Lobbens S , Delannoy V , Gaget S , Boutin P , et al. Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Mol Genet 2002;11:2607–2614.
  • Gu HF , Abulaiti A , Ostenson CG , Humphreys K , Wahlestedt C , Brookes AJ , Efendic S . Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish Caucasians. Diabetes 2004;53:31–35.
  • Panidis D , Kourtis A , Kukuvitis A , Farmakiotis D , Xita N , Georgiou I , Tsatsoulis A . Association of the T45G polymorphism in exon 2 of the adiponectin gene with polycystic ovary syndrome: role of Delta4-androstenedione. Hum Reprod 2004;19:1728–1733.
  • San Millán JL , Cortón M , Villuendas G , Sancho J , Peral B , Escobar-Morreale HF . Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity. J Clin Endocrinol Metab 2004;89:2640–2646.
  • Haap M , Machicao F , Stefan N , Thamer C , Tschritter O , Schnuck F , Wallwiener D , et al. Genetic determinants of insulin action in polycystic ovary syndrome. Exp Clin Endocrinol Diabetes 2005;113:275–281.
  • Heinonen S , Korhonen S , Helisalmi S , Koivunen R , Tapanainen J , Hippeläinen M , Laakso M . Associations between two single nucleotide polymorphisms in the adiponectin gene and polycystic ovary syndrome. Gynecol Endocrinol 2005;21:165–169.
  • Xita N , Georgiou I , Chatzikyriakidou A , Vounatsou M , Papassotiriou GP , Papassotiriou I , Tsatsoulis A . Effect of adiponectin gene polymorphisms on circulating adiponectin and insulin resistance indexes in women with polycystic ovary syndrome. Clin Chem 2005;51:416–423.
  • Escobar-Morreale HF , Villuendas G , Botella-Carretero JI , Alvarez-Blasco F , Sanchón R , Luque-Ramírez M , San Millán JL . Adiponectin and resistin in PCOS: a clinical, biochemical and molecular genetic study. Hum Reprod 2006;21:2257–2265.
  • Zhang N , Shi YH , Hao CF , Gu HF , Li Y , Zhao YR , Wang LC , Chen ZJ . Association of +45G15G(T/G) and +276(G/T) polymorphisms in the ADIPOQ gene with polycystic ovary syndrome among Han Chinese women. Eur J Endocrinol 2008;158:255–260.
  • Demirci H , Yilmaz M , Ergun MA , Yurtcu E , Bukan N , Ayvaz G . Frequency of adiponectin gene polymorphisms in polycystic ovary syndrome and the association with serum adiponectin, androgen levels, insulin resistance and clinical parameters. Gynecol Endocrinol 2010;26:348–355.
  • Zintzaras E , Ioannidis JP . HEGESMA: genome search meta-analysis and heterogeneity testing. Bioinformatics 2005;21:3672–3673.
  • Higgins JP , Thompson SG , Deeks JJ , Altman DG . Measuring inconsistency in meta-analyses. BMJ 2003;327:557–560.
  • Baba T , Endo T , Sata F , Nagasawa K , Honnma H , Kitajima Y , Hayashi T , et al. The contributions of resistin and adiponectin gene single nucleotide polymorphisms to the genetic risk for polycystic ovary syndrome in a Japanese population. Gynecol Endocrinol 2009;25:498–503.
  • Li LL , Kang XL , Ran XJ , Wang Y , Wang CH , Huang L , Ren J , et al. Associations between 45T/G polymorphism of the adiponectin gene and plasma adiponectin levels with type 2 diabetes. Clin Exp Pharmacol Physiol 2007;34:1287–1290.
  • González-Sánchez JL , Martínez-Calatrava MJ , Martínez-Larrad MT , Zabena C , Fernández-Pérez C , Laakso M , Serrano-Ríos M . Interaction of the -308G/A promoter polymorphism of the tumor necrosis factor-alpha gene with single-nucleotide polymorphism 45 of the adiponectin gene: effect on serum adiponectin concentrations in a Spanish population. Clin Chem 2006;52:97–103.
  • Alexis S . Antonopoulos, Dimitris Tousoulis, Charalambos Antoniades, Antigoni Miliou, Nikolaos Koumallos, George Hatzis, Michael Dimosthenous, Constantinos Bakogiannis, Costas Tsioufis, Kostas Toutouzas, Christodoulos Stefanadis. The impact of genetic polymorphism T45G on adiponectin gene on the expression of adipokines in arterial hypertension. Hypertension, lipids and prevention 2010;55:1238–1294.
  • Fredriksson J , Carlsson E , Orho-Melander M , Groop L , Ridderstråle M . A polymorphism in the adiponectin gene influences adiponectin expression levels in visceral fat in obese subjects. Int J Obes (Lond) 2006;30:226–232.
  • Psilopanagioti A , Papadaki H , Kranioti EF , Alexandrides TK , Varakis JN . Expression of adiponectin and adiponectin receptors in human pituitary gland and brain. Neuroendocrinology 2009;89:38–47.
  • Lu M , Tang Q , Olefsky JM , Mellon PL , Webster NJ . Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes. Mol Endocrinol 2008;22:760–771.
  • Christine Chabrolle , Lucie, Tosca1 , and Joëlle Dupont . Regulation of adiponectin and its receptors in rat ovary by human chorionic gonadotrophin treatment and potential involvement of adiponectin in granulosa cell steroidogenesis. Reproduction 2007;133:719–731.
  • Virginie Maillard , Svetlana Uzbekova , Florence Guignot Christine, Perreau Christelle, Ramé Stéphanie, Coyral-Castel , and Joëlle Dupont . Effect of adiponectin on bovine granulosa cell steroidogenesis, oocyte maturation and embryo development. Reproductive Biology and Endocrinology 2010;8:23.
  • Lagaly DV , Aad PY , Grado-Ahuir JA , Hulsey LB , Spicer LJ . Role of adiponectin in regulating ovarian theca and granulosa cell function. Mol Cell Endocrinol 2008;284:38–45.
  • Ledoux S , Campos DB , Lopes FL , Dobias-Goff M , Palin MF , Murphy BD . Adiponectin induces periovulatory changes in ovarian follicular cells. Endocrinology 2006;147:5178–5186.
  • Pierre P , Froment P , Nègre D , Ramé C , Barateau V , Chabrolle C , Lecomte P , Dupont J . Role of adiponectin receptors, AdipoR1 and AdipoR2, in the steroidogenesis of the human granulosa tumor cell line, KGN. Hum Reprod 2009;24:2890–2901.
  • Chabrolle C , Tosca L , Ramé C , Lecomte P , Royère D , Dupont J . Adiponectin increases insulin-like growth factor I-induced progesterone and estradiol secretion in human granulosa cells. Fertil Steril 2009;92:1988–1996.
  • Waki H , Yamauchi T , Kamon J , Ito Y , Uchida S , Kita S , Hara K , et al. Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. J Biol Chem 2003;278:40352–40363.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.