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Medically Assisted Procreation

Metformin administration in patients with polycystic ovary syndrome who receive gonadotropins for in vitro fertilization cycles: 10-year experience in a large infertile population

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Pages 81-86 | Received 19 Dec 2010, Accepted 12 May 2011, Published online: 20 Jul 2011

References

  • Palomba S , Falbo A , Zullo F , Orio F Jr . Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review. Endocr Rev 2009;30:1–50.
  • Kumbak B , Kahraman S . Efficacy of metformin supplementation during ovarian stimulation of lean PCOS patients undergoing in vitro fertilization. Acta Obstet Gynecol Scand 2009;88:563–568.
  • Shibahara H , Kikuchi K , Hirano Y , Suzuki T , Takamizawa S , Suzuki M . Increase of multiple pregnancies caused by ovulation induction with gonadotropin in combination with metformin in infertile women with polycystic ovary syndrome. Fertil Steril 2007;87:1487–1490.
  • Stadtmauer LA , Toma SK , Riehl RM , Talbert LM . Metformin treatment of patients with polycystic ovary syndrome undergoing in vitro fertilization improves outcomes and is associated with modulation of the insulin-like growth factors. Fertil Steril 2001;75:505–509.
  • Fedorcsák P , Dale PO , Storeng R , Abyholm T , Tanbo T . The effect of metformin on ovarian stimulation and in vitro fertilization in insulin-resistant women with polycystic ovary syndrome: an open-label randomized cross-over trial. Gynecol Endocrinol 2003;17:207–214.
  • Visnová H , Ventruba P , Crha I , Záková J . [Importance of sensitization of insulin receptors in the prevention of ovarian hyperstimulation syndrome]. Ceska Gynekol 2003;68:155–162.
  • Kjøtrød SB , von Düring V , Carlsen SM . Metformin treatment before IVF/ICSI in women with polycystic ovary syndrome; a prospective, randomized, double blind study. Hum Reprod 2004;19:1315–1322.
  • Onalan G , Pabuçcu R , Goktolga U , Ceyhan T , Bagis T , Cincik M . Metformin treatment in patients with polycystic ovary syndrome undergoing in vitro fertilization: a prospective randomized trial. Fertil Steril 2005;84:798–801.
  • Doldi N , Persico P , Di Sebastiano F , Marsiglio E , Ferrari A . Gonadotropin-releasing hormone antagonist and metformin for treatment of polycystic ovary syndrome patients undergoing in vitro fertilization-embryo transfer. Gynecol Endocrinol 2006;22:235–238.
  • Tang T , Glanville J , Orsi N , Barth JH , Balen AH . The use of metformin for women with PCOS undergoing IVF treatment. Hum Reprod 2006;21:1416–1425.
  • Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group . Consensus on infertility treatment related to polycystic ovary syndrome. Hum Reprod 2008;23:462–477.
  • Metformin use in IVF patients . Available from http://www.ivf-worldwide.com/survey/survey-metformin-use-in-ivf-patients.html
  • Zawadzki JK , Dunaif A . Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. In: Dunaif A , Givens JR , Haseltine FP , Merriman GR , editors. Polycystic ovary syndrome. Boston: Blackwell; 1992. pp 337–384.
  • Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group . Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004;81:19–25.
  • Tso LO , Costello MF , Albuquerque LE , Andriolo RB , Freitas V . Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome. Cochrane Database Syst Rev 2009;2:CD006105.
  • Costello MF , Chapman M , Conway U . A systematic review and meta-analysis of randomized controlled trials on metformin co-administration during gonadotrophin ovulation induction or IVF in women with polycystic ovary syndrome. Hum Reprod 2006;21:1387–1399.
  • Palomba S , Falbo A , Orio F Jr , Tolino A , Zullo F . Efficacy predictors for metformin and clomiphene citrate treatment in anovulatory infertile patients with polycystic ovary syndrome. Fertil Steril 2009;91:2557–2567.
  • Maciel GA , Soares Júnior JM , Alves da Motta EL , Abi Haidar M , de Lima GR , Baracat EC . Nonobese women with polycystic ovary syndrome respond better than obese women to treatment with metformin. Fertil Steril 2004;81:355–360.
  • Onalan G , Goktolga U , Ceyhan T , Bagis T , Onalan R , Pabuçcu R . Predictive value of glucose-insulin ratio in PCOS and profile of women who will benefit from metformin therapy: obese, lean, hyper or normoinsulinemic? Eur J Obstet Gynecol Reprod Biol 2005;123:204–211.
  • Ibáñez L , Ong K , de Zegher F , Marcos MV , del Rio L , Dunger DB . Fat distribution in non-obese girls with and without precocious pubarche: central adiposity related to insulinaemia and androgenaemia from prepuberty to postmenarche. Clin Endocrinol (Oxf) 2003;58:372–379.
  • Godoy-Matos AF , Vaisman F , Pedrosa AP , Farias ML , Mendonça LM , Pinheiro MF . Central-to-peripheral fat ratio, but not peripheral body fat, is related to insulin resistance and androgen markers in polycystic ovary syndrome. Gynecol Endocrinol 2009;25:793–798.
  • Pasquali R . Obesity and androgens: facts and perspectives. Fertil Steril 2006;85:1319–1340.
  • Palomba S , Falbo A , Orio F Jr , Manguso F , Russo T , Tolino A , Annamaria C , et al. A randomized controlled trial evaluating metformin pre-treatment and co-administration in non-obese insulin-resistant women with polycystic ovary syndrome treated with controlled ovarian stimulation plus timed intercourse or intrauterine insemination. Hum Reprod 2005;20:2879–2886.
  • Palomba S , Falbo A , Russo T , Orio F , Tolino A , Zullo F . Systemic and local effects of metformin administration in patients with polycystic ovary syndrome (PCOS): relationship to the ovulatory response. Hum Reprod 2010;25:1005–1013.
  • Falbo A , Rocca M , Russo T , D’Ettore A , Tolino A , Zullo F , Orio F , Palomba S . Serum and follicular anti-Mullerian hormone levels in women with polycystic ovary syndrome (PCOS) under metformin. J Ovarian Res 2010;3:16.
  • Palomba S , Falbo A , Russo T , Manguso F , Tolino A , Zullo F , De Feo P , Orio F Jr. Insulin sensitivity after metformin suspension in normal-weight women with polycystic ovary syndrome. J Clin Endocrinol Metab 2007;92:3128–3135.
  • Bayrak A , Terbell H , Urwitz-Lane R , Mor E , Stanczyk FZ , Paulson RJ . Acute effects of metformin therapy include improvement of insulin resistance and ovarian morphology. Fertil Steril 2007;87:870–875.
  • George SS , George K , Irwin C , Job V , Selvakumar R , Jeyaseelan V , Seshadri MS . Sequential treatment of metformin and clomiphene citrate in clomiphene-resistant women with polycystic ovary syndrome: a randomized, controlled trial. Hum Reprod 2003;18:299–304.
  • Sinawat S , Buppasiri P , Lumbiganon P , Pattanittum P . Long versus short course treatment with metformin and clomiphene citrate for ovulation induction in women with PCOS. Cochrane Database Syst Rev 2008;1: CD006226.

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