Insulin resistance but not impaired β-cell function: a key feature in Chinese normal-weight PCOS women with normal glucose regulation

References

• Bhattacharya SM. Prevalence of metabolic syndrome in women with polycystic ovary syndrome, using two proposed definitions. Gynecol Endocrinol 2010;26:516–520.
   PubMed Web of Science ®Google Scholar
• Goodarzi MO, Dumesic DA, Chazenbalk G, Azziz R. Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. Nat Rev Endocrinol 2011;7:219–231.
   PubMed Web of Science ®Google Scholar
• Diamanti-Kandarakis E, Xyrafis X, Boutzios G, Christakou C. Pancreatic beta-cells dysfunction in polycystic ovary syndrome. Panminerva Med 2008;50:315–325.
   PubMed Web of Science ®Google Scholar
• Holte J. Disturbances in insulin secretion and sensitivity in women with the polycystic ovary syndrome. Baillieres Clin Endocrinol Metab 1996;10:221–247.
   PubMed Web of Science ®Google Scholar
• Yang S, Li Q, Song Y, Tian B, Cheng Q, Qing H, Zhong L, Xia W. Serum complement C3 has a stronger association with insulin resistance than high-sensitivity C-reactive protein in women with polycystic ovary syndrome. Fertil Steril 2011;95:1749–1753.
   PubMed Web of Science ®Google Scholar
• Cibula D, Sindelka G, Hill M, Fanta M, Skrha J, Zivny J. Insulin sensitivity in non-obese women with polycystic ovary syndrome during treatment with oral contraceptives containing low-androgenic progestin. Hum Reprod 2002;17:76–82.
   PubMed Web of Science ®Google Scholar
• Hudecova M, Holte J, Olovsson M, Larsson A, Berne C, Poromaa IS. Diabetes and impaired glucose tolerance in patients with polycystic ovary syndrome – a long term follow-up. Hum Reprod 2011;26:1462–1468.
   PubMed Web of Science ®Google Scholar
• Gennarelli G, Rovei V, Novi RF, Holte J, Bongioanni F, Revelli A, Pacini G, et al. Preserved insulin sensitivity and {beta}-cell activity, but decreased glucose effectiveness in normal-weight women with the polycystic ovary syndrome. J Clin Endocrinol Metab 2005;90:3381–3386.
   PubMed Web of Science ®Google Scholar
• Dunaif A, Finegood DT. Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome. J Clin Endocrinol Metab 1996;81:942–947.
   PubMed Web of Science ®Google Scholar
• Ehrmann DA, Sturis J, Byrne MM, Karrison T, Rosenfield RL, Polonsky KS. Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus. J Clin Invest 1995;96:520–527.
   PubMed Web of Science ®Google Scholar
• Wang Y, Qu J, Wu X, Hou L, Erkkola R, Wang Y. Different phenotypes of polycystic ovary syndrome by Rotterdam criteria are differently steroidogenic but similarly insulin resistant. Fertil Steril 2010;93:1362–1365.
   PubMed Web of Science ®Google Scholar
• Vrbikova J, Bendlova B, Vankova M, Dvorakova K, Grimmichova T, Vondra K, Pacini G. Beta cell function and insulin sensitivity in women with polycystic ovary syndrome: influence of the family history of type 2 diabetes mellitus. Gynecol Endocrinol 2009;25:597–602.
   PubMed Web of Science ®Google Scholar
• Liao L, Tian YJ, Zhao JJ, Xin Y, Xing HY, Dong JJ. Metformin versus metformin plus rosiglitazone in women with polycystic ovary syndrome. Chin Med J 2011;124:714–718.
   PubMed Web of Science ®Google Scholar
• Song Y, Manson JE, Tinker L, Howard BV, Kuller LH, Nathan L, Rifai N, Liu S. Insulin sensitivity and insulin secretion determined by homeostasis model assessment and risk of diabetes in a multiethnic cohort of women: the Women’s Health Initiative Observational Study. Diabetes Care 2007;30:1747–1752.
   PubMed Web of Science ®Google Scholar
• American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2010;33:S62–S69.
   PubMed Web of Science ®Google Scholar
• Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev 1997;18:774–800.
   PubMed Web of Science ®Google Scholar
• Kanazawa M, Yoshiike N, Osaka T, Numba Y, Zimmet P, Inoue S. Criteria and classification of obesity in Japan and Asia-Oceania. Asia Pac J Clin Nutr 2002;11 Suppl 8:S732–S737.
   Google Scholar
• Yang S, Li Q, Zhong L, Song Y, Tian B, Cheng Q, Qing H, et al. Serum pigment epithelium-derived factor is elevated in women with polycystic ovary syndrome and correlates with insulin resistance. J Clin Endocrinol Metab 2011;96:831–836.
   PubMed Web of Science ®Google Scholar
• Li W, Chen Q, Ma S, Liu X, Qing H, Bai X, Zhang S, Li Q. Elevated serum RBP4 is associated with insulin resistance in women with polycystic ovary syndrome. Endocrine 2006;30:283–287.
   PubMed Web of Science ®Google Scholar
• Tripathy D, Wessman Y, Gullström M, Tuomi T, Groop L. Importance of obtaining independent measures of insulin secretion and insulin sensitivity during the same test: results with the Botnia clamp. Diabetes Care 2003;26:1395–1401.
   PubMed Web of Science ®Google Scholar
• Tfayli H, Lee S, Arslanian S. Declining beta-cell function relative to insulin sensitivity with increasing fasting glucose levels in the nondiabetic range in children. Diabetes Care 2010;33:2024–2030.
   PubMed Web of Science ®Google Scholar
• Tfayli H, Jung Lee S, Bacha F, Arslanian S.One-hour plasma glucose concentration during the OGTT: what does it tell about β-cell function relative to insulin sensitivity in overweight/obese children? Pediatr Diabetes 2011;1111:1399–5448.
   Google Scholar
• Walters KA, Allan CM, Handelsman DJ. Androgen actions and the ovary. Biol Reprod 2008;78:380–389.
   PubMed Web of Science ®Google Scholar
• DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:E214–E223.
   PubMed Web of Science ®Google Scholar