Raloxifene modifies the insulin sensitivity and lipid profile of postmenopausal insulin resistant women

References

• Lee CC, Kasa-Vubu JZ, Supiano MA. Differential effects of raloxifene and estrogen on insulin sensitivity in postmenopausal women. J Am Geriatr Soc 2003;51:683–8
   PubMedGoogle Scholar
• Jack L, Boseman L, Vinicor F. Aging Americans and diabetes: a public health and clinical response. Geriatrics 2004;59:14–17
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and Prevention. National diabetes fact sheet: General information and national estimates on diabetes in the United States, 2005. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention; 2005
   Google Scholar
• Gambert SR, Pinkstaff S. Emerging epidemic: diabetes in older adults: demography, economic impact, and pathophysiology. Diabetes Spectr 2006;19:221–8
   Google Scholar
• Rose AJ, Howlett K, King DS, Hargreaves M. Effect of prior exercise on glucose metabolism in trained men. Am J Physiol Endocrinol Metab 2001;281:E766–71
   PubMed Web of Science ®Google Scholar
• Godsland IF. Oestrogens and insulin secretion. Diabetologia 2005;48:2213–20
   PubMed Web of Science ®Google Scholar
• Bonds DE, Lasser N, Qi L, et al. The effect of conjugated equine oestrogen on diabetes incidence: the Women’s Health Initiative randomised trial. Diabetologia 2006;49:459–68
   PubMed Web of Science ®Google Scholar
• Simoncini T, Genazzani AR. Raloxifene acutely stimulates nitric oxide release from human endothelial cells via an activation of endothelial nitric oxide synthase. J Clin Endocrinol Metab 2000;85:2966–9
   PubMed Web of Science ®Google Scholar
• Pinna C, Bolego C, Sanvito P, et al. Raloxifene elicits combined rapid vasorelaxation and long-term anti-inflammatory actions in rat aorta. J Pharmacol Exp Ther 2006;319:1444–51
   PubMed Web of Science ®Google Scholar
• Saitta A, Altavilla D, Cucinotta D. Randomized, double-blind, placebo-controlled study on effects of raloxifene, and hormone replacement therapy on plasma NO concentrations, endothelin-1 levels, and endothelium-dependent vasodilation in postmenopausal women. Arterioscler Thromb Vasc Biol 2001;21:1512–9
   PubMed Web of Science ®Google Scholar
• Delmas PD, Davis SR, Hensen J, et al. Effects of tibolone and raloxifene on bone mineral density in osteopenic postmenopausal women. Osteoporos Int 2008;19:1153–60
   PubMed Web of Science ®Google Scholar
• Roqué M, Sitges M, Sala J, et al. The effect of raloxifene on the endothelial function and hemostasis in women with coronary artery disease. Rev Esp Cardiol 2011;64:572–8
   PubMed Web of Science ®Google Scholar
• Cagnacci A, Paoletti AM, Zanni A, et al. Raloxifene does not modify insulin sensitivity and glucose metabolism in postmenopausal women. J Clin Endocrinol Metab 2002;87:117–4121
   Web of Science ®Google Scholar
• Cucinelli F, Soranna L, Romualdi D, et al. The effect of raloxifene on glyco-insulinemic homeostasis in healthy postmenopausal women: a randomized placebo-controlled study. J Clin Endocrinol Metab 2002;87:4186–92
   PubMed Web of Science ®Google Scholar
• Andersson B, Johannsson G, Holm G, et al. Raloxifene does not affect insulin sensitivity or glycemic control in postmenopausal women with type 2 diabetes mellitus: a randomized clinical trial. J Clin Endocrinol Metab 2002;87:122–8
   PubMed Web of Science ®Google Scholar
• Oleksik AM, Duoung T, Pliester N, et al. Effects of the selective estrogen receptor modulator, raloxifene, on the somatotropic axis and insulin-glucose homeostasis. J Clin Endocrinol Metab 2001;86:2763–8
   PubMed Web of Science ®Google Scholar
• Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412–9
   PubMed Web of Science ®Google Scholar
• Okada M, Nomura S, Ikoma Y, et al. Effects of postmenopausal hormone replacement therapy on HbA1c levels. Diabetes Care 2003;26:1088–92
   PubMed Web of Science ®Google Scholar
• Harano Y, Ohgaku S, Hidaka H, et al. Glucose, insulin and somatostatin infusion for the determination of insulin sensitivity. J Clin Endocrinol Metab 1977;45:1124–7
   PubMed Web of Science ®Google Scholar
• Friedewald WT, Levy RI, Fredrikson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma with out the use of the preoperative ultracentrifuge. Clin Chem 1972;18:499–502
   PubMed Web of Science ®Google Scholar
• Kanaya AM, Herrington D, Vittinghoff E, et al. Glycemic effects of postmenopausal hormone therapy: the heart and estrogen/progestin replacement study. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 2003;138:1–9
   PubMed Web of Science ®Google Scholar
• Luque-Ramirez M, Álvarez-Blasco F, Botella-Carretero JI, et al. Comparison of ethinyl-estradiol plus cyproterone acetate versus metformin effects on classic metabolic cardiovascular risk factors in women with the polycystic ovary syndrome. J Clin Endocrinol Metab 2007;92:2453–61
   PubMed Web of Science ®Google Scholar
• Rossi R, Origliani G, Modena MG. Transdermal 17-β-estradiol and risk of developing type 2 diabetes in a population of healthy, nonobese postmenopausal women. Diabetes Care 2004;27:645–9
   PubMed Web of Science ®Google Scholar
• Zhang Y, Howard BV Cowan LD, et al. The effect of estrogen use on levels of glucose and insulin and the risk of type 2 diabetes in American Indian postmenopausal women. Diabetes Care 2002;25:500–4
   PubMed Web of Science ®Google Scholar
• Greenfield JR, Samaras K, Jenkins AB, et al. Moderate alcohol consumption, estrogen replacement therapy, and physical activity are associated with increased insulin sensitivity. Diabetes Care 2003;26:2734–40
   PubMed Web of Science ®Google Scholar
• Lobo RA. Metabolic syndrome after the menopause and the role of hormones. Rev climaterio 2009;13:1–10
   Google Scholar
• Lindheim SR, Buchanan TA, Duffy DM. Comparison of estimates of insulin sensitivity in pre- and postmenopausal women using the insulin tolerance test and the frequently sampled intravenous glucose tolerance test. J Soc Gynecol Invest 1994;1:150–4
   PubMedGoogle Scholar
• Mori H, Okada Y, Kishikawa H, et al. Effects of raloxifene on lipid and bone metabolism in postmenopausal women with type 2 diabetes. J Bone Miner Metab 2013;31:89–95
   PubMed Web of Science ®Google Scholar
• De Fronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:E214–23
   PubMed Web of Science ®Google Scholar