Expression of SCUBE2 gene declines in high grade endometrial cancer and associates with expression of steroid hormone receptors and tumor suppressor PTEN

References

• Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin 2012;62:10–29
   PubMed Web of Science ®Google Scholar
• Tsai MT, Cheng CJ, Lin YC, et al. Isolation and characterization of a secreted, cell-surface glycoprotein SCUBE2 from humans. Biochem J 2009;422:119–28
   PubMed Web of Science ®Google Scholar
• Feng YZ, Shiozawa T, Miyamoto T, et al. Overexpression of hedgehog signaling molecules and its involvement in the proliferation of endometrial carcinoma cells. Clin Cancer Res 2007;13:1389–98
   Google Scholar
• Liao X, Siu MK, Au CW, et al. Aberrant activation of hedgehog signaling pathway contributes to endometrial carcinogenesis through beta-catenin. Mod Pathol 2009;22:839–47
   PubMed Web of Science ®Google Scholar
• Cheng CJ, Lin YC, Tsai MT, et al. SCUBE2 suppresses breast tumor cell proliferation and confers a favorable prognosis in invasive breast cancer. Cancer Res 2009;69:3634–41
   PubMed Web of Science ®Google Scholar
• Lin YC, Chen CC, Cheng CJ, Yang RB. Domain and functional analysis of a novel breast tumor suppressor protein, SCUBE2. J Biol Chem 2011;286:27039–47
   PubMed Web of Science ®Google Scholar
• van ‘t Veer LJ, Dai H, van de Vijver MJ, et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002;415:530–6
   PubMed Web of Science ®Google Scholar
• Sánchez-Navarro I, Gámez-Pozo A, Pinto A, et al. An 8-gene qRT-PCR-based gene expression score that has prognostic value in early breast cancer. BMC Cancer 2010;10:336
   PubMedGoogle Scholar
• Paik S, Shak S, Tang G, et al. A. Multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med 2004;351:2817–26
   PubMed Web of Science ®Google Scholar
• Yang RB, Ng CK, Wasserman SM, et al. Identification of a novel family of cell-surface proteins expressed in human vascular endothelium. J Biol Chem 2002;277:46364–73
   PubMed Web of Science ®Google Scholar
• Wu BT, Su YH, Tsai MT, et al. A novel secreted, cell-surface glycoprotein containing multiple epidermal growth factor-like repeats and one CUB domain is highly expressed in primary osteoblasts and bones. J Biol Chem 2004;279:37485–90
   PubMed Web of Science ®Google Scholar
• Woods IG, Talbot WS. The you gene encodes an EGF-CUB protein essential for Hedgehog signaling in zebrafish. PLoS Biol 2005;3:e66
   Web of Science ®Google Scholar
• Kawakami A, Nojima Y, Toyoda A, et al. The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signaling. Curr Biol 2005;15:480–8
   PubMed Web of Science ®Google Scholar
• Hollway GE, Maule J, Gautier P, et al. Scube2 mediates Hedgehog signalling in the zebrafish embryo. Dev Biol 2006;294:104–18
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402–8
   PubMed Web of Science ®Google Scholar
• Lacey JV Jr, Mutter GL, Ronnett BM, et al. PTEN expression in endometrial biopsies as a marker of progression to endometrial carcinoma. Cancer Res 2008;68:6014–20
   PubMed Web of Science ®Google Scholar
• Davis CG. The many faces of epidermal growth factor repeats. New Biol 1990;2:410–9
   PubMedGoogle Scholar
• Sivridis E. Angiogenesis and endometrial cancer. Anticancer Res 2001;21:4383–8
   PubMed Web of Science ®Google Scholar
• Oreskovic S, Babic D, Kalafatic D, et al. A significance of immunohistochemical determination of steroid receptors, cell proliferation factor Ki-67 and protein p53 in endometrial carcinoma. Gynecol Oncol 2004;93:34–40
   PubMed Web of Science ®Google Scholar
• Daikoku T, Hirota Y, Tranguch S, et al. Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice. Cancer Res 2008;68:5619–27
   PubMed Web of Science ®Google Scholar
• Mylonas I. Prognostic significance and clinical importance of estrogen receptor alpha and beta in human endometrioid adenocarcinomas. Oncol Rep 2010;24:385–93
   PubMed Web of Science ®Google Scholar
• Chakravarty D, Gupta N, Goda JS, et al. Steroid receptors, HER2/neu and Ki-67, in endometrioid type of endometrial carcinoma: correlation with conventional histomorphological features of prognosis. Acta Histochem 2010;112:355–63
   PubMed Web of Science ®Google Scholar
• Uchikawa J, Shiozawa T, Shih HC, et al. Expression of steroid receptor coactivators and corepressors in human endometrial hyperplasia and carcinoma with relevance to steroid receptors and Ki-67 expression. Cancer 2003;98:2207–13
   PubMed Web of Science ®Google Scholar
• Penney KL, Sinnott JA, Fall K, et al. mRNA expression signature of Gleason grade predicts lethal prostate cancer. J Clin Oncol 2011; 29:2391–6
   PubMed Web of Science ®Google Scholar
• Krakstad C, Trovik J, Wik E, et al. Loss of GPER identifies new targets for therapy among a subgroup of ERα-positive endometrial cancer patients with poor outcome. Br J Cancer 2012;106:1682–8
   PubMed Web of Science ®Google Scholar
• Wik E, Ræder MB, Krakstad C, et al. Lack of estrogen receptor-α is associated with epithelial-mesenchymal transition and PI3K alterations in endometrial carcinoma. Clin Cancer Res 2013;19:1094–105
   PubMed Web of Science ®Google Scholar
• Lindberg ME, Stodden GR, King ML, et al. Loss of Cdh1 and Pten Accelerates Cellular Invasiveness and Angiogenesis in the Mouse Uterus. Biol Reprod 2013;89:1--10
   Web of Science ®Google Scholar
• Parris TZ, Danielsson A, Nemes S, et al. Clinical implications of gene dosage and gene expression patterns in diploid breast carcinoma. Clin Cancer Res 2010;16:3860–74
   PubMed Web of Science ®Google Scholar
• Calza S, Hall P, Auer G, et al. Intrinsic molecular signature of breast cancer in a population-based cohort of 412 patients. Breast Cancer Res 2006;8:R34
   PubMed Web of Science ®Google Scholar
• Sørlie T, Perou CM, Tibshirani R, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 2001;98:10869–74
   PubMed Web of Science ®Google Scholar
• Sørlie T, Wang Y, Xiao C, et al. Distinct molecular mechanisms underlying clinically relevant subtypes of breast cancer: gene expression analyses across three different platforms. BMC Genomics 2006;7:127
   PubMed Web of Science ®Google Scholar
• Abba MC, Hu Y, Sun H, et al. Gene expression signature of estrogen receptor α status in breast cancer. BMC Genomics 2005;6:37
   PubMed Web of Science ®Google Scholar
• Dvorkin-Gheva A, Hassell JA. Hormone receptor and ERBB2 status in gene expression profiles of human breast tumor samples. PLoS One 2011;6:e26023
   Google Scholar
• Habel LA, Shak S, Jacobs MK, et al. A population-based study of tumor gene expression and risk of breast cancer death among lymph node-negative patients. Breast Cancer Res 2006;8:R25
   PubMed Web of Science ®Google Scholar