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Relaxin and Trophoblast

Relaxin has anti-apoptotic effects on human trophoblast-derived HTR-8/SV neo cells

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Pages 1051-1054 | Received 03 Mar 2013, Accepted 24 Jul 2013, Published online: 27 Sep 2013

References

  • Sherwood OD. Relaxin's physiological roles and other diverse actions. Endocr Rev 2004;25:205–34
  • Stoelk E, Chegini N, Lei ZM, et al. Immunocytochemical localization of relaxin in human corpora lutea: cellular and subcellular distribution and dependence on reproductive state. Biol Reprod 1991;44:1140–7
  • Garibay-Tupas JL, Maaskant RA, Greenwood FC, Bryant-Greenwood GD. Characteristics of the binding of 32P-labelled human relaxins to the human fetal membranes. J Endocrinol 1995;145:441–8
  • Sudo S, Kumagai J, Nishi S, et al. H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2. J Biol Chem 2003;278:7855–62
  • Liu C, Eriste E, Sutton S, et al. Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135. J Biol Chem 2003;278:50754–64
  • Liu C, Kuei C, Sutton S, et al. INSL5 is a high affinity specific agonist for GPCR142 (GPR100). J Biol Chem 2005;280:292–300
  • Hsu SY, Nakabayashi K, Nishi S, et al. Activation of orphan receptors by the hormone relaxin. Science 2002;295:671–4
  • Luna JJ, Riesewijk A, Horcajadas JA, et al. Gene expression pattern and immunoreactive protein localization of LGR7 receptor in human endometrium throughout the menstrual cycle. Mol Hum Reprod 2004;10:85–90
  • Bathgate RA, Ivell R, Sanborn, MB, et al. International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides. Pharmacol Rev 2006;58:7–31
  • Xu G, Guimond MJ, Chakraborty C, Lala PK. Control of proliferation, migration, and invasiveness of human extravillous trophoblast by decorin, a decidual product. Biol Reprod 2002;67:681–9
  • Maruo N, Nakabayashi K, Wakahashi S, et al. Effects of recombinant H2 relaxin on the expression of matrix metalloproteinases and tissue inhibitor metalloproteinase in cultured early placental extravillous trophoblasts. Endocrine 2007;32:303–10
  • Moore XL, Tan SL, Lo CY, et al. Relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytes. Endocrinology 2007;148:1582–9
  • Suzuki K, Nakabyayashi K, Yamada AY, et al. Recombinant H2 relaxin inhibits apoptosis and induces cell proliferation in cultured leiomyoma cells without affecting those in cultured normal myometrial cells. Fertil Steril 2012;97:734–41
  • Yao L, Aqoulnik Al, Cooke PS, et al. Relaxin acts on stromal cells to promote epithelial and stromal proliferation and inhibit apoptosis in the mouse cervix and vagina. Endocrinology 2008;149:2072–9
  • Stewart DR, Celniker AC, Taylor CA Jr, et al. Relaxin in the peri-implantation period. J Clin Endocrinol Metab 1990;70:1771–3
  • Emmi AM, Skurnick J, Goldsmith LT, et al. Ovarian control of pituitary hormone secretion in early human pregnancy. J Clin Endocrinol Metab 1991;72:1359–63
  • Goldsmith LT, Weiss G. Relaxin in human pregnancy. Ann N Y Acad Sci 2009;1160:130–5
  • Maruo T. Progesterone, thyroid hormone and relaxin in the regulation of the invasive potential of extravillous trophoblasts in early placental development. Gynecol Endocrinol 2010;26:629–30
  • Laoag-Fernandez JB, Matsuo H, Murakoshi H, et al. 3,5,3′-Triiodothyronine down-regulates Fas and Fas ligand expression and suppresses caspase-3 and poly(adenosine 5′-diphosphate-ribose) polymerase cleavage and apoptosis in early placental extravillous trophoblasts in vitro. J Clin Endocrinol Metab 2004;89:4069–77
  • Liu J, Matsuo H, Laoag-Fernandez JB, et al. The effects of progesterone on apoptosis in the human trophoblast-derived HTR-8/SV neo cells. Mol Hum Reprod 2007;13:869–74
  • Arthur ID, Anthony FW, Adams S, Thomas EJ. Serum relaxin and the major endometrial secretory proteins in in-vitro fertilization and down-regulated hormone-supported and natural cycle frozen embryo transfer. Hum Reprod 1996;11:88–91
  • Yki-Järvinen H, Wahlström T, Seppälä M. Human endometrium contains relaxin that is progesterone-dependent. Acta Obstet Gynecol Scand 1985;64:663–5
  • Butler WR, Hotchkiss J, Knobil E. Functional luteolysis in the rhesus monkey: ovarian estrogen and progesterone during the luteal phase of the menstrual cycle. Endocrinology 1975;96:1509–12

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