Polymorphisms of the methylenetetrahydrofolate reductase gene (C677T and A1298C) in nulliparous women complicated with preeclampsia

References

• Ngoc NT, Merialdi M, Abdel-Aleem H, et al. Causes of stillbirths and early neonatal deaths: data from 7993 pregnancies in six developing countries. Bull World Health Organ 2006;84:699–705
   PubMed Web of Science ®Google Scholar
• Lindheimer MD, Taler SJ, Cunningham FG. ASH position article. Hypertension in pregnancy. J Am Soc Hypertens 2008;2:484–94
   PubMed Web of Science ®Google Scholar
• Turner JA. Diagnosis and management of pre-eclampsia: an update. Int J Women’s Health 2010;2:327–37
   PubMedGoogle Scholar
• Taylor RN, de Groot CJ, Cho YK, Lim KH. Circulating factors as markers and mediators of endothelial cell dysfunction in preeclampsia. Semin Reprod Endocrinol 1998;16:17–31
   PubMedGoogle Scholar
• Barbosa PR, Stabler SP, Machado AL, et al. Association between decreased vitamin levels and MTHFR, MTR and MTRR gene polymorphisms as determinants for elevated total homocysteine concentrations in pregnant women. Eur J Clin Nutr 2008;62:1010–21
   PubMed Web of Science ®Google Scholar
• Valenzuela FJ, Pérez-Sepúlveda A, Torres MJ, et al. Pathogenesis of preeclampsia: the genetic component. J Pregnancy 2012;2012:632732
   PubMedGoogle Scholar
• Roberts JM, Escudero C. The placenta in preeclampsia. Pregnancy Hypertens 2012;2:72–83
   PubMed Web of Science ®Google Scholar
• Barakonyi A, Miko E, Szereday L, et al. Cell death mechanisms and potentially cytotoxic natural immune cells in Human pregnancies complicated by preeclampsia. Reprod Sci 2014;21:155–66
   PubMed Web of Science ®Google Scholar
• Svensson-Arvelund J, Ernerudh J, Buse E, et al. The placenta in toxicology. Part II: systemic and local immune adaptations in pregnancy. Toxicol Pathol 2014;42:327–38
   PubMed Web of Science ®Google Scholar
• Ostlund E, Al-Nashi M, Hamad RR, et al. Normalized endothelial function but sustained cardiovascular risk profile 11 years following a pregnancy complicated by preeclampsia. Hypertens Res 2013;36:1081–7
   PubMedGoogle Scholar
• Chedraui P, Solis EJ, Bocci G, et al. Feto-placental nitric oxide, asymmetric dimethylarginine and vascular endothelial growth factor (VEGF) levels and VEGF gene polymorphisms in severe preeclampsia. J Matern Fetal Neonatal Med 2013;26:226–32
   PubMed Web of Science ®Google Scholar
• El-Sherbiny WS, Nasr AS, Soliman A. Endothelial nitric oxide synthase (eNOS) (Glu298Asp) and urotensin II (UTS2 S89N) gene polymorphisms in preeclampsia: prediction and correlation with severity in Egyptian females. Hypertens Pregnancy 2013;32:292–303
   PubMed Web of Science ®Google Scholar
• Groten T, Schleussner E, Lehmann T, et al. eNOSI4 and EPHX1 polymorphisms affect maternal susceptibility to preeclampsia: analysis of five polymorphisms predisposing to cardiovascular disease in 279 Caucasian and 241 African women. Arch Gynecol Obstet 2014;289:581–93
   PubMed Web of Science ®Google Scholar
• Song GG, Kim JH, Kim YH, et al. Associations between vascular endothelial growth factor gene polymorphisms and pre-eclampsia susceptibility: a meta-analysis. Hum Immunol 2013;74:1206–13
   PubMed Web of Science ®Google Scholar
• Yang J, Shang J, Zhang S, et al. The role of the renin-angiotensin-aldosterone system in preeclampsia: genetic polymorphisms and microRNA. J Mol Endocrinol 2013;50:R53–66
   PubMed Web of Science ®Google Scholar
• Jacques PF, Bostom AG, Williams RR, et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996;93:7–9
   PubMed Web of Science ®Google Scholar
• Klai S, Fekih-Mrissa N, El Housaini S, et al. Association of MTHFR A1298C polymorphism (but not of MTHFR C677T) with elevated homocysteine levels and placental vasculopathies. Blood Coagul Fibrinolysis 2011;22:374–8
   PubMed Web of Science ®Google Scholar
• Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111–3
   PubMed Web of Science ®Google Scholar
• Van der Put NM, Gabreels F, Stevens EM, et al. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet 1998;62:1044–51
   PubMed Web of Science ®Google Scholar
• Chango A, Boisson F, Barbe F, et al. 2000. The effect of 677C–>T and 1298A–>C mutations on plasma homocysteine and 5,10-methylenetetrahydrofolate reductase activity in healthy subjects. Br J Nutr 2000;83:593–6
   PubMed Web of Science ®Google Scholar
• Friso S, Girelli D, Trabetti E, et al. A1298C methylenetetrahydrofolate reductase mutation and coronary artery disease: relationships with C677T polymorphism and homocysteine/folate metabolism. Clin Exp Med 2002;2:7–12
   PubMed Web of Science ®Google Scholar
• Chen M, Xia B, Rodriguez-Gueant RM, et al. Genotypes 677TT and 677CT + 1298AC of methylenetetrahydrofolate reductase are associated with the severity of ulcerative colitis in central China. Gut 2005;54:733–4
   PubMedGoogle Scholar
• Newstead J, von Dadelszen P, Magee LA. Preeclampsia and future cardiovascular risk. Expert Rev Cardiovasc Ther 2007;5:283–94
   PubMedGoogle Scholar
• Thomas P, Fenech M. Methylenetetrahydrofolate reductase, common polymorphisms, and relation to disease. Vitam Horm 2008;79:375–92
   PubMed Web of Science ®Google Scholar
• Mongraw-Chaffin ML, Cirillo PM, Cohn BA. Preeclampsia and cardiovascular disease death: prospective evidence from the child health and development studies cohort. Hypertension 2010;56:166–71
   PubMed Web of Science ®Google Scholar
• Smith GN, Pudwell J, Walker M, Wen SW. Ten-year, thirty-year, and lifetime cardiovascular disease risk estimates following a pregnancy complicated by preeclampsia. J Obstet Gynaecol Can 2012;34:830–5
   PubMedGoogle Scholar
• Ghulmiyyah L, Sibai B. Maternal mortality from preeclampsia/eclampsia. Semin Perinatol 2012;36:56–9
   PubMed Web of Science ®Google Scholar
• Mission JF, Marshall NE, Caughey AB. Obesity in pregnancy: a big problem and getting bigger. Obstet Gynecol Surv 2013;68:389–99
   PubMed Web of Science ®Google Scholar
• Savitz DA, Danilack VA, Engel SM, et al. Descriptive epidemiology of chronic hypertension, gestational hypertension, and preeclampsia in New York state, 1995–2004. Matern Child Health J 2013. [Epub ahead of print]
   Google Scholar
• The tech museum of innovation: what are the A1298C mutation and C677T mutation? Available from: http://genetics.thetech.org/ask/ask425 [last accessed 12 Oct 2013]
   Google Scholar
• Palmirotta R, Leone B, De Marchis ML, et al. An importance of identification of double variant methylenetetrahydrofolate reductase gene C677T and A1298C in cis configuration for pharmacogenetic studies. Blood Coagul Fibrinolysis 2013;24:784–6
   PubMedGoogle Scholar
• Wang XM, Wu HY, Qiu XJ. Methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and risk of preeclampsia: an updated meta-analysis based on 51 studies. Arch Med Res 2013;44:159–68
   PubMed Web of Science ®Google Scholar
• Canto P, Canto-Cetina T, Juárez-Velázquez R, et al. Methylenetetrahydrofolate reductase C677T and glutathione S-transferase P1 A313G are associated with a reduced risk of preeclampsia in Maya-Mestizo women. Hypertens Res 2008;31:1015–9
   PubMed Web of Science ®Google Scholar
• Stonek F, Hafner E, Metzenbauer M, et al. Carriage of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism does not influence the first and second trimester uterine artery Doppler flow. Eur J Obstet Gynecol Reprod Biol 2008;140:178–82
   PubMedGoogle Scholar
• Prasmusinto D, Skrablin S, Hofstaetter C, et al. The methylenetetrahydrofolate reductase 677 C–>T polymorphism and preeclampsia in two populations. Obstet Gynecol 2002;99:1085–92
   PubMed Web of Science ®Google Scholar
• Dávalos IP, Moran MC, Martínez-Abundis E, et al. Methylenetetrahydrofolate reductase C677T polymorphism and Factor V Leiden variant in Mexican women with preeclampsia/eclampsia. Blood Cells Mol Dis 2005;35:66–9
   PubMed Web of Science ®Google Scholar
• Stonek F, Hafner E, Philipp K, et al. Methylenetetrahydrofolate reductase C677T polymorphism and pregnancy complications. Obstet Gynecol 2007;110:363–8
   PubMed Web of Science ®Google Scholar
• Jääskeläinen E, Keski-Nisula L, Toivonen S, et al. MTHFR C677T polymorphism is not associated with placental abruption or preeclampsia in Finnish women. Hypertens Pregnancy 2006;25:73–80
   PubMed Web of Science ®Google Scholar
• Said JM, Higgins JR, Moses EK, et al. Inherited thrombophilias and adverse pregnancy outcomes: a case-control study in an Australian population. Acta Obstet Gynecol Scand 2012;91:250–5
   PubMed Web of Science ®Google Scholar
• Hogg BB, Tamura T, Johnston KE, et al. Second-trimester plasma homocysteine levels and pregnancy-induced hypertension, preeclampsia, and intrauterine growth restriction. Am J Obstet Gynecol 2000;183:805–9
   PubMed Web of Science ®Google Scholar
• Vollset SE, Refsum H, Irgens LM, et al. Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland homocysteine study. Am J Clin Nutr 2000;71:962–8
   PubMed Web of Science ®Google Scholar
• Yanez P, Vásquez CJ, Rodas L, et al. Erythrocyte folate content and serum folic acid and homocysteine levels in preeclamptic primigravidae teenagers living at high altitude. Arch Gynecol Obstet 2013;288:1011–5
   PubMed Web of Science ®Google Scholar
• Lachmeijer AM, Arngrímsson R, Bastiaans EJ, et al. Mutations in the gene for methylenetetrahydrofolate reductase, homocysteine levels, and vitamin status in women with a history of preeclampsia. Am J Obstet Gynecol 2001;184:394–402
   PubMed Web of Science ®Google Scholar
• Oliveira KC, Verreschi ITN, Sugawara EK, et al. C677T and A1298C polymorphisms of MTHFR gene and their relation to homocysteine levels in Turner syndrome. Genet Test Mol Biomarkers 2012;16:396–400
   PubMed Web of Science ®Google Scholar
• ACOG. Optimizing Protocols in Obstetrics. Key elements for the management of hypertensive crisis in pregnancy (In-patient). Available from: http://www.acog.org/~/media/Districts/District%20II/PDFs/Optimizing_Protocols_In_OB_HTN_Series_3-%20Version%201.pdf?dmc=1&ts=20131010T0637065833 [last accessed 12 Oct 2013]
   Google Scholar
• Aliyu MH, Luke S, Kristensen S, et al. Joint effect of obesity and teenage pregnancy on the risk of preeclampsia: a population-based study. J Adolesc Health 2010;46:77–82
   PubMed Web of Science ®Google Scholar
• Mignini LE, Latthe PM, Villar J, et al. Mapping the theories of preeclampsia: the role of homocysteine. Obstet Gynecol 2005;105:411–25
   PubMed Web of Science ®Google Scholar
• Madan J, Chen M, Goodman E, et al. Maternal obesity,gestational hypertension, and preterm delivery. J Matern Fetal Neonatal Med 2010;23:82–8
   PubMed Web of Science ®Google Scholar
• Ursavas A, Karadag M, Nalci N, et al. Self-reported snoring, maternal obesity and neck circumference as risk factors for pregnancy-induced hypertension and preeclampsia. Respiration 2008;76:33–9
   PubMed Web of Science ®Google Scholar
• Hendler I, Blackwell SC, Mehta SH, et al. The levels of leptin, adiponectin, and resistin in normal weight, overweight, and obese pregnant women with and without preeclampsia. Am J Obstet Gynecol 2005;193:979–83
   PubMed Web of Science ®Google Scholar
• Boij R, Svensson J, Nilsson-Ekdahl K, et al. Biomarkers of coagulation, inflammation, and angiogenesis are independently associated with preeclampsia. Am J Reprod Immunol 2012;68:258–70
   PubMed Web of Science ®Google Scholar
• Lynch AM, Eckel RH, Murphy JR, et al. Prepregnancy obesity and complement system activation in early pregnancy and the subsequent development of preeclampsia. Am J Obstet Gynecol 2012;206:428.e1–8
   Web of Science ®Google Scholar
• Institute of Medicine. Weight gain during pregnancy: reexamining the guidelines. Washington, DC: National Academy Press; 2009
   Google Scholar
• Ben-Noun L, Sohar E, Laor A. Neck circumference as a simple screening measure for identifying overweight and obese patients. Obes Res 2001;9:470–7
   PubMedGoogle Scholar
• Hingorjo MR, Qureshi MA, Mehdi A. Neck circumference as a useful marker of obesity: a comparison with body mass index and waist circumference. J Pak Med Assoc 2012;62:36–40
   PubMed Web of Science ®Google Scholar