193
Views
66
CrossRef citations to date
0
Altmetric
Original Article

Six-month oral dehydroepiandrosterone supplementation in early and late postmenopause

, , , , , , , , & show all
Pages 342-363 | Published online: 05 Aug 2009

References

  • Baulieu EE. Dehydroepiandrosterone (DHEA): a fountain of youth?. J Clin Endocrinol Metab 1996; 81: 3147–52
  • Parker LN, Odell WD. Control of adrenal androgen secretion. Endocr Rev 1980; 4: 392–410
  • Yamaji T, Ibayashi H. Serum dehydroepiandrosterone sulphate in normal and pathological conditions. J Clin Endocrinol Metab 1969; 29: 273–8
  • Hopper BR, Yen SSC. Circulating concentrations of dehydroepiandrosterone and dehydroepiandrosterone sulphate during puberty. J Clin Endocrinol Metab 1975; 40: 458–61
  • Arlt W, Justl H-G, Callies F, et al. Oral dehydroepiandrosterone for adrenal androgen replacement: pharmacokinetics and peripheral conversion to androgens and estrogens in young healthy females after dexamethasone suppression. J Clin Endocrinol Metab 1998; 83: 1928–34
  • Liu CH, Laughlin GA, Fischer UG, Yen SSC. Marked attenuation of ultradian and circadian rhythms of dehydroepiandrosterone in postmenopausal women: evidence for a reduced 17,20 desmolase enzymatic activity. J Clin Endocrinol Metab 1990; 71: 900–6
  • Genazzani AR, Pintor C, Corda R. Plasma levels of gonadotropins, prolactin, thyroxine, and adrenal and gonadal steroids in obese prepubertal girls. J Clin Endocrinol Metab 1978; 47: 974–9
  • Azziz R, Zacur HA, Parker Hr CR, et al. Effects of obesity on the response to acute adrenocorticotropin stimulation in eumenorrheic women. Fertil Steril 1991; 56: 427–33
  • Barret-Connor E, Ferrara A. Dehydroepiandrosterone, dehydroepiandrosterone sulphate, obesity, waist-hip ratio, and non insulin-dependent diabetes in postmenopausal women: the Rancho-Bernardo Study. J Clin Endocrinol Metab 1996; 81: 59–64
  • Holte J, Bergh T, Gennarelli G, Wide L. The independent effects of polycystic ovary syndrome and obesity on serum concentrations of gonadotropins and sex steroids in premenopausal women. Clin Endocrinol 1994; 41: 473–81
  • Weiss DJ, Charles MA, Dunaif A, et al. Hyper-insulinemia is associated with menstrual irregularity and altered serum androgens in Pima Indian women. Metabolism 1994; 43: 803–7
  • Leene R, van der Kooy K, Seidell JC, et al. Visceral fat accumulation in relation to sex hormones in obese men and women undergoing weight loss therapy. J Clin Endocrinol Metab 1994; 78: 1515–20
  • Crave JC, Fimbel S, Lejeune H, et al. Effects of diet and metformin administration on sex-hormone binding globulin, androgens and insulin in hirsute and obese women. J Clin Endocrinol Metab 1995; 80: 2057–62
  • Mazza E, Maccario M, Ramunni J, et al. Dehydroepiandrosterone sulphate levels in women. Relationships with age, body mass index and insulin levels. J Endocrinol Invest 1999; 22: 681–7
  • Mortola JF, Yen SSC. The effects of oral dehydroepiandrosterone on endocrine-metabolic parameters in postmenopausal women. J Clin Endocrinol Metab 1990; 71: 696–704
  • Morales AJ, Nolan JJ, Nelson JC, Yen SSC. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. J Clin Endocrinol Metab 1994; 78: 1360–7
  • Berr C, Lafont S, Debuire B, et al. Relationships of dehydroepiandrosterone sulphate in elderly with functional physiological, mental status and short term mortality: a French community-based study. Proc Natl Acad Sci USA 1996; 93: 13410–15
  • Ravaglia G, Forti P, Maioli F, et al. The relationship of dehydroepiandrosterone sulphate (DHEAS) to endocrine-metabolic parameters and functional status in the oldest-old. Results from an Italian study on healthy free-living over-ninety-year-olds. J Clin Endocrinol Metab 1996; 81: 1173–8
  • Yen SSC, Morales AJ, Khorram O, et al. Replacement of DHEA in aging men and women: potential remedial effects. Ann NY Acad Sci 1995; 774: 128–42
  • Rogers WM, Blauer KL, Bernton W. Dehydroepiandrosterone protection against dexametazone induced thymic inovulation: flow cytometric and mechanism studies. In Proceedings of the 71st Annual Meeting of the Endocrine Society. 1989
  • Taelman P, Kayman JM, Janssens X, Varmeulen A. Persistence of increased bone-resorption and possible role of dehydroepiandrosterone as a bone metabolism determinant in osteoporotic women in late menopause. Maturitas 1989; 11: 65–73
  • Nordin BEC, Robertson A, Seamark RF. The relation between calcium absorption, serum DHEA and vertebral mineral density in postmenopausal women. J Clin Endocrinol Metab 1985; 60: 651–7
  • Wolf OT, Neumenn O, Helhammer DH, et al. Effects of a two-week physiological dehydroepiandrosterone substitution on cognitive performance and well-being in healthy elderly women and men. J Clin Endocrinol Metab 1997; 82: 2362–7
  • Wolkowitz OM, Reus VI, Roberts E, et al. Dehydroepiandrosterone (DHEA) treatment of depression. Biol Psychiatry 1997; 41: 311–18
  • Baulieu EE, Thomas G, Legraln S, et al. Dehydroepiandrosterone (DHEA), DHEA sulphate and ageing: contribution of the DHEAge study to a sociobiomedical issue. Proc Natl Acad Sci USA 2000; 97: 3–8
  • Stomati M, Rubino S, Spinetti A, et al. Endocrine, neuroendocrine and behavioral effects of oral dehydroepiandrosterone sulphate supplementation in postmenopausal women. Gynecol Endocrinol 1999; 13: 15–25
  • Wiklund I, Heist J, Horlborg J. A new methodology for evaluating quality of life in postmenopausal women during transdermal estrogen replacement therapy. Maturitas 1992; 14: 211–24
  • Genazzani AR, Petraglia F, Bernardi F, et al. Circulating levels of allopregnanolone in humans: gender, age and endocrine influences. J Clin Endocrinol Metab 1968; 83: 1–5
  • Stomati M, Bersi C, Rubino S, et al. Neuroendocrine effects of different oestradiol-progestin regimens in postmenopausal women. Maturitas 1997; 28: 127–35
  • Parker L, Graf T, Perrigo V, Skowsky R. Decreased adrenal androgen sensitivity to ACTH during aging. Metabolism 1981; 30: 601–4
  • Dorgan JF, Reichman ME, Judd JT, et al. Relationship of age and reproductive characteristics with plasma estrogens and androgens in premenopausal women. Cancer Epidemiol Biomarkers Prev 1995; 4: 381–6
  • Nagasako S. Aging and delta-4 androstenedione and testosterone production in the ovary. Nippon Sanka Fujinka Gakkai Zasshi 1983; 35: 1945–54
  • Meldrum DR, Davidson BJ, Tataryn IV, Judd HL. Changes in circulating steroids with aging in postmenopausal women. Obstet Gynecol 1981; 57: 624–8
  • Van Cauter E, Leuproult R, Kupgfer DJ. Effects of gender and age on the levels and circadian rhythmicity of plasma Cortisol. J Clin Endocrinol Metab 1996; 81: 2468–73
  • Marin P, Darin N, Amemiya T, et al. Cortisol secretion in relation to body fat distribution in obese premenopausal women. Metabolism 1992; 41: 882–6
  • Field AE, Colditz GA, Willet WC, et al. The relation of smoking, age, relative weight, and dietary intake to serum adrenal steroids, sex hormones, and sex hormone-binding globulin in middle aged men. J Clin Endocrinol Metab 1994; 79: 1310–16
  • Lecomte P, Lecureuil N, Lecureuil M, et al. Sex differences in the control of sex hormone-binding globulin in the elderly: role of insulin-like growth factor-1 and insulin. Eur J Endocrinol 1998; 139: 178–73
  • Parker CR, Slayden SM, Azziz R, et al. Effects of aging on adrenal function in the human: responsiveness and sensitivity of adrenal androgens and Cortisol to adrenocorticotropin in premenopausal and postmenopausal women. J Clin Endocrinol Metab 2000; 85: 48–54
  • Nestler JE, Barlascini CO, Clore JN, Blackard WG. Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men. J Clin Endocrinol Metab 1988; 66: 57–61
  • Welle S, Jozefowicz R, Statt M. Failure of DHEA to influence energy and protein metabolism in humans. J Clin Endocrinol Metab 1990; 71: 1259–64
  • Young J, Couzinet B, Brailly S, et al. Panhypopituitarism as a model to study the metabolism of dehydroepiandrosterone (DHEA) in humans. J Clin Endocrinol Metab 1997; 82: 2578–85
  • Loncope C. Androgen metabolism and the menopause. Semin Reprod Endocrinol 1998; 16: 111–15
  • Kuhl H. Pharmacokinetics of oestrogens and progestogens. Maturitas 1990; 12: 171–97
  • Labrie F, Diamond P, Cusan L, et al. Effect of 12-month dehydroepiandrosterone replacement therapy on bone, vagina, and endometrium in postmenopausal women. J Clin Endocrinol Metab 1997; 82: 3498–505
  • Labrie F, Belanger A, Van LT, et al. DHEA and the intracrine formation of androgens and estrogens in peripheral target tissues: its role during aging. Steroids 1998; 63: 322–8
  • Stomati M, Hartmann B, Spinetti A, et al. Effects of hormonal replacement therapy on sex hormone-binding globulin, androgen and insulin-like growth factor-1 in postmenopausal women. J Endocrinol Invest 1996; 19: 535–41
  • Luisi S, Petraglia F, Benedetto C, et al. Serum allopregnanolone levels in pregnant women: changes during pregnancy, at delivery and in hypertensive patients. J Clin Endocrinol Metab 2000; 85: 2429–33
  • Robel P, Baulieu EE. Neurosteroids: biosynthesis and function. Trends Endocrinol Metab 1994; 5: 1–8
  • Baulieu EE. Neurosteroids: of the nervous system, by the nervous system, for the nervous system. Recent Prog Horm Res 1997; 52: 1–32
  • Majewska MD. Neurosteroids: endogenous bimodal modulators of the GABA-A receptor. Mechanism of action and physiological significance. Prog Neurobiol 1992; 38: 379–95
  • Corpechot C, Young J, Calvel M, et al. Neurosteroids: 3α-hydroxy-5α-pregnan-20-one and its precursors in the brain, plasma, and steroidogenic glands of male and female rats. Endocrinology 1993; 133: 1003–8
  • Mellon SH. Neurosteroids: biochemistry, modes of action, and clinical relevance. J Clin Endocrinol Metab 1994; 78: 1003–8
  • Majewska MD, Demigoren S, Spivak CE, London ED. The neurosteroid DHEA is an allosteric antagonist of the GABAA receptor. Brain Res 1990; 526: 143–6
  • Dodt C, Dittman J, Hruby J, et al. Different regulation of adrenocorticotropin and Cortisol secretion in young, mentally healthy elderly and patients with senile dementia of Alzheimer's type. J Clin Endocrinol Metab 1991; 72: 272–6
  • Sherman B, Wysham C, Pfohl B. Age-related changes in the circadian rhythm of plasma Cortisol in man. J Clin Endocrinol Metab 1985; 61: 439–43
  • Patchev VK, Hassan AH, Holsboer DF, Almeida OF. The neurosteroid tetrahydroprogesterone attenuates the endocrine response to stress and exerts glucocorticoid-like effects on vasopressin gene transcription in the rat hypothalamus. Neuropsychopharmacology 1996; 15: 533–40
  • Bernardi F, Lanzone A, Cento RM, et al. Allopregnanolone and dehydroepiandrosterone response to corticotropin-releasing factor in patients suffering from Alzheimer's disease and vascular dementia. Eur J Endocrinol 2000; 142: 466–71
  • Carlson LE, Sherwin BB, Chertkow HM. Relationships between dehydroepiandrosterone sulphate (DHEAS) and Cortisol (CRT) plasma levels and everyday memory in Alzheimer's disease patients compared to healthy controls. Horn Behav 1991; 35: 254–63
  • Advis J, McConn S, Negro-Vilar A. Evidence that catecholaminergic and peptidergic (luteinizing hormone-releasing hormone neurons in suprachiasmatic-medial preoptic, medial basal hypothalamus and median eminence are involved in estrogen negative feedback. Endocrinology 1980; 107: 892–901
  • Piva F, Limonta P, Dondi D, et al. Effects of steroids on the brain opioid system. J Steroid Biochem Mol Biol 1995; 53: 343–8
  • Parker CR, Jr. Dehydroepiandrosterone and dehydroepiandrosterone sulphate production in the human adrenal during development and aging. Steroids 1999; 64: 640–7

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.