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Gynecological Endocrinology Volume 26, 2010 - Issue 3
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Case Report

Unexplained amenorrhea in a patient taking methotrexate for the treatment of rheumatoid arthritis

Jamie KroftDepartment of Obstetrics and Gynecology, Mount Sinai Hospital, University of TorontoCorrespondence[email protected]
,
Sally SabraDepartment of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto
,
Rebecca ArthurDepartment of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto
&
Wendy WolfmanDepartment of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto
Pages 179-180 | Received 16 Jul 2009, Accepted 20 Jul 2009, Published online: 17 Nov 2009

References

  • Minto SE, Munster PN. Chemotherapy-induced amenorrhea and fertility in women undergoing adjuvant treatment for breast cancer. Cancer Contr 2002;9:466–472.
  • Bines J, Oleske DM, Cobleigh MA. Ovarian function in premenopausal women treated with adjuvant chemotherapy for breast cancer. J Clin Oncol 1996;14:1718–1729.
  • Di Carlo F, Reboani C, Conti G, Genazzani E. Changes in the concentration of uterine cytoplasmic oestrogen receptors induced by doxorubicin and methotrexate. J Endocr 1978;79:201–208.
  • Morris ID, Stephen TM. In vitro and in vivo interactions of methotrexate and other antimetabolites with the oestrogen high affinity receptors of the rat uterus. Br J Cancer 1983;47:433–437.

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