Overweight and obesity negatively affect the outcomes of ovarian stimulation and in vitro fertilisation: a cohort study of 2628 Chinese women

References

• WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 2004;363:157–163.
   PubMed Web of Science ®Google Scholar
• Maheshwari A, Scotland G, Bell J, McTavish A, Hamilton M, Bhattacharya S. The direct health services costs of providing assisted reproduction services in overweight or obese women: a retrospective cross-sectional analysis. Hum Reprod 2009;24:633–639.
   PubMed Web of Science ®Google Scholar
• Rich-Edwards JW, Spiegelman D, Garland M, Hertzmark E, Hunter DJ, Colditz GA, Willett WC, Wand H, Manson JE. Physical activity, body mass index, and ovulatory disorder infertility. Epidemiology 2002;13:184–190.
   PubMed Web of Science ®Google Scholar
• Ahmad OH, Mark G, Peterson CM, Meikle AW, Carrell DT. Impact of male obesity on infertility: a critical review of the current literature. Fertil Steril 2008;90:897–904.
   PubMedGoogle Scholar
• The Practice Committee of the American Society for Reproductive Medicine, American Society for Reproductive Medicine, Birmingham, Alabama. Obesity and reproduction: an educational bulletin. Fertil Steril 2008;90(Suppl 3):S21–S29.
   Google Scholar
• Hugues JN. Impact of overweight on the outcome of ovarian stimulation. Bull Acad Natl Med 2008;192:661–670. discussion 670–671.
   PubMedGoogle Scholar
• van Swieten EC, van der Leeuw-Harmsen L, Badings EA, van der Linden PJ. Obesity and clomiphene challenge test as predictors of outcome of in vitro fertilization and intracytoplasmic sperm injection. Gynecol Obstet Invest 2005;59:220–224.
   PubMed Web of Science ®Google Scholar
• Bellver J, Ayllón Y, Ferrando M, Melo M, Goyri E, Pellicer A, Remohí J, Meseguer M. Female obesity impairs in vitro fertilization outcome without affecting embryo quality. Fertil Steril 2010;93:447–454.
   PubMed Web of Science ®Google Scholar
• Sneed ML, Uhler ML, Grotjan HE, Rapisarda JJ, Lederer KJ, Beltsos AN. Body mass index: impact on IVF success appears age-related. Hum Reprod 2008;23:1835–1839.
   PubMed Web of Science ®Google Scholar
• Veleva Z, Tiitinen A, Vilska S, Hydén-Granskog C, Tomás C, Martikainen H, Tapanainen JS. High and low BMI increase the risk of miscarriage after IVF/ICSI and FET. Hum Reprod 2008;23:878–884.
   PubMed Web of Science ®Google Scholar
• Maheshwari A, Stofberg L, Bhattacharya S. Effect of overweight and obesity on assisted reproductive technology – a systematic review. Hum Reprod Update 2007;13:433–444.
   PubMed Web of Science ®Google Scholar
• Dodson WC, Kunselman AR, Legro RS. Association of obesity with treatment outcomes in ovulatory infertile women undergoing superovulation and intrauterine insemination. Fertil Steril 2006;86:642–646.
   PubMed Web of Science ®Google Scholar
• Dechaud H, Anahory T, Reyftmann L, Loup V, Hamamah S, Hedon B. Obesity does not adversely affect results in patients who are undergoing in vitro fertilization and embryo transfer. Eur J Obstet Gynecol Reprod Biol 2006;127:88–93.
   PubMed Web of Science ®Google Scholar
• Loh S, Wang JX, Matthews CD. The influence of body mass index, basal FSH and age on the response to gonadotrophin stimulation in non-polycystic ovarian syndrome patients. Hum Reprod 2002;17:1207–1211.
   PubMed Web of Science ®Google Scholar
• Metwally M, Ong KJ, Ledger WL, Li TC. Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta-analysis of the evidence. Fertil Steril 2008;90:714–726.
   PubMed Web of Science ®Google Scholar
• Deurenberg-Yap M, Chew SK, Deurenberg P. Elevated body fat percentage and cardiovascular risks at low body mass index levels among Singaporean Chinese, Malays and Indians. Obes Rev 2002;3:209–215.
   PubMedGoogle Scholar
• Deurenberg P, Deurenberg-Yap M, Guricci S. Asians are different from Caucasians and from each other in their body mass index/body fat per cent relationship. Obes Rev 2002;3:141–146.
   PubMedGoogle Scholar
• Veeck L. Preembryo grading and degree of cytoplasmic fragmentation. In: Veeck L, An atlas of human gametes and conceptuses: an illustrated reference for assisted reproductive technology, editor. Parthenon, New York, USA; 1999. pp 46–51.
   Google Scholar
• Dodson WC, Kunselman AR, Legro RS. Association of obesity with treatment outcomes in ovulatory infertile women undergoing superovulation and intrauterine insemination. Fertil Steril 2006;86:642–646.
   PubMed Web of Science ®Google Scholar
• Dokras A, Baredziak L, Blaine J, Syrop C, VanVoorhis BJ, Sparks A. Obstetric outcomes after in vitro fertilization in obese and morbidly obese women. Obstet Gynecol 2006;108:61–69.
   PubMed Web of Science ®Google Scholar
• Spandorfer SD, Kump L, Goldschlag D, Brodkin T, Davis OK, Rosenwaks Z. Obesity and in vitro fertilization: negative influences on outcome. J Reprod Med 2004;49:973–977.
   PubMed Web of Science ®Google Scholar
• Fedorcsák P, Dale PO, Storeng R, Ertzeid G, Bjercke S, Oldereid N, Omland AK, Abyholm T, Tanbo T. Impact of overweight and underweight on assisted reproduction treatment. Hum Reprod 2004;19:2523–2528.
   PubMed Web of Science ®Google Scholar
• Remorgida V, Giordano M, Lanera P. The relationship between body composition and plasma concentration of exogenously administered urinary follicle stimulating hormone. Hum Reprod 1993;8:1001–1004.
   PubMedGoogle Scholar
• Steinkampf KR, Hammond JE, Nichols S. Effect of body mass on pharmacokinetics of recombinant FSH: sub-cutaneous vs intramuscular administration. Fertil Steril 1998;70(Suppl 1):S54.
   Google Scholar
• Franks S, Hamilton-Fairley D. The role of body weight and metabolic abnormalities in induction of ovulation. Contracept Fertil Sex 1994;22:178–179.
   PubMedGoogle Scholar
• Wittemer C, Ohl J, Bailly M, Bettahar-Lebugle K, Nisand I. Does body mass index of infertile women have an impact on IVF procedure and outcome? J Assist Reprod Genet 2000;17:547–552.
   PubMed Web of Science ®Google Scholar
• Dokras A, Baredziak L, Blaine J, Syrop C, VanVoorhis BJ, Sparks A. Obstetric outcomes after in vitro fertilization in obese and morbidly obese women. Obstet Gynecol 2006;108:61–69.
   PubMed Web of Science ®Google Scholar
• Cano F, García-Velasco JA, Millet A, Remohí J, Simón C, Pellicer A. Oocyte quality in polycystic ovaries revisited: identification of a particular subgroup of women. J Assist Reprod Genet 1997;14:254–261.
   PubMedGoogle Scholar
• Kahn BB, Flier JS. Obesity and insulin resistance. J Clin Invest 2000;106:473–481.
   PubMed Web of Science ®Google Scholar
• Minge CE, Bennett BD, Norman RJ, Robker RL. Peroxisome proliferator-activated receptor gamma agonist rosiglitazone reverses the adverse effects of diet-induced obesity on oocyte quality. Endocrinology 2008;149:2646–2656.
   PubMed Web of Science ®Google Scholar
• Carrell DT, Jones KP, Peterson CM, Aoki V, Emery BR, Campbell BR. Body mass index is inversely related to intrafollicular HCG concentrations, embryo quality and IVF outcome. Reprod Biomed Online 2001;3:109–111.
   PubMedGoogle Scholar
• Bellver J, Melo MA, Bosch E, Serra V, Remohí J, Pellicer A. Obesity and poor reproductive outcome: the potential role of the endometrium. Fertil Steril 2007;88:446–451.
   PubMed Web of Science ®Google Scholar
• Onalan R, Onalan G, Tonguc E, Ozdener T, Dogan M, Mollamahmutoglu L. Body mass index is an independent risk factor for the development of endometrial polyps in patients undergoing in vitro fertilization. Fertil Steril 2009;91:1056–1060.
   PubMed Web of Science ®Google Scholar
• Shi Y, Guo M, Yan J, Sun W, Zhang X, Geng L, Xu L, Chen Z. Analysis of clinical characteristics in large-scale Chinese women with polycystic ovary syndrome. Neuro Endocrinol Lett 2007;28:807–810.
   PubMed Web of Science ®Google Scholar
• Dokras A, Baredziak L, Blaine J, Syrop C, VanVoorhis BJ, Sparks A. Obstetric outcomes after in vitro fertilization in obese and morbidly obese women. Obstet Gynecol 2006;108:61–69.
   PubMed Web of Science ®Google Scholar
• Dor J, Shulman A, Levran D, Ben-Rafael Z, Rudak E, Mashiach S. The treatment of patients with polycystic ovarian syndrome by in-vitro fertilization and embryo transfer: a comparison of results with those of patients with tubal infertility. Hum Reprod 1990;5:816–818.
   PubMed Web of Science ®Google Scholar
• Homburg R, Berkowitz D, Levy T, Feldberg D, Ashkenazi J, Ben-Rafael Z. In vitro fertilization and embryo transfer for the treatment of infertility associated with polycystic ovary syndrome. Fertil Steril 1993;60:858–863.
   PubMed Web of Science ®Google Scholar
• Urman B, Fluker MR, Yuen BH, Fleige-Zahradka BG, Zouves CG, Moon YS. The outcome of in vitro fertilization and embryo transfer in women with polycystic ovary syndrome failing to conceive after ovulation induction with exogenous gonadotropins. Fertil Steril 1992;57:1269–1273.
   PubMed Web of Science ®Google Scholar
• Jungheim ES, Lanzendorf SE, Odem RR, Moley KH, Chang AS, Ratts VS. Morbid obesity is associated with lower clinical pregnancy rates after in vitro fertilization in women with polycystic ovary syndrome. Fertil Steril 2009;92:256–261.
   PubMed Web of Science ®Google Scholar
• McCormick B, Thomas M, Maxwell R, Williams D, Aubuchon M. Effects of polycystic ovarian syndrome on in vitro fertilization-embryo transfer outcomes are influenced by body mass index. Fertil Steril 2008;90:2304–2309.
   PubMed Web of Science ®Google Scholar
• Deurenberg-Yap M, Deurenberg P. Is a re-evaluation of WHO body mass index cut-off values needed? The case of Asians in Singapore. Nutr Rev 2003;61:S80–S87.
   PubMed Web of Science ®Google Scholar
• Razak F, Anand SS, Shannon H, Vuksan V, Davis B, Jacobs R. Defining obesity cut points in a multiethnic population. Circulation 2007;115:2111–2118.
   PubMed Web of Science ®Google Scholar
• Wildman RP, Gu D, Reynolds K, Duan X, He J. Appropriate body mass index and waist circumference cutoffs for categorization of overweight and central adiposity among Chinese adults. Am J Clin Nutr 2004;80:1129–1136.
   PubMed Web of Science ®Google Scholar
• Pan WH, Flegal KM, Chang HY, Yeh WT, Yeh CJ, Lee WC. Body mass index and obesity-related metabolic disorders in Taiwanese and US whites and blacks: implications for definitions of overweight and obesity for Asians. Am J Clin Nutr 2004;79:31–39.
   PubMed Web of Science ®Google Scholar
• Deurenberg-Yap M, Chew SK, Deurenberg P. Elevated body fat percentage and cardiovascular risks at low body mass index levels among Singaporean Chinese, Malays and Indians. Obes Rev 2002;3:209–215.
   PubMedGoogle Scholar