177
Views
11
CrossRef citations to date
0
Altmetric
Art

Poor prognosis for ovarian response to stimulation: results of a randomised trial comparing the flare-up GnRH agonist protocol vs. the antagonist protocol

, , , , , & show all
Pages 509-515 | Received 14 Jul 2009, Accepted 23 Nov 2009, Published online: 02 Mar 2010

References

  • Keay SD, Liversedge NH, Jenkins JM. Assisted conception following poor ovarian response to gonadotrophin stimulation. Br J Obstet Gynaecol 1997;104:521–527.
  • Barri-Soldevila PN, Carreras O, Tur R, Coroleu B, Barri PN. Sonographic assessment of ovarian reserve. Its correlation with outcome of in vitro fertilization cycles. Gynecol Endocrinol 2007;23:206–212.
  • Erdem M, Erdem A, Gursoy R, Biberoglu K. Comparison of basal and clomiphene citrate induced FSH and inhibin B, ovarian volume and antral follicle count as ovarian reserve tests and predictors of poor ovarian response in IVF. J Assist Reprod Genet 2004;21:37–45.
  • Schachter M, Friedler S, Raziel A, Strassburger D, Bern O, Ron-el R. Improvement of IVF outcome in poor responders by discontinuation of GnRH analogue during the gonadotropin stimulation phase – a function of improved embryo quality. J Assist Reprod Genet 2001;18:197–204.
  • Land JA, Yarmolinskaya MI, Dumoulin JC, Evers JL. High-dose human menopausal gonadotropin stimulation in poor responders does not improve in vitro fertilization outcome. Fertil Steril 1996;65:961–965.
  • Schmidt DW, Bremner T, Orris JJ, Maier DB, Benadiva CA, Nulsen JC. A randomized prospective study of microdose leuprolide versus ganirelix in in vitro fertilization cycles for poor responders. Fertil Steril 2005;83:1568–1571.
  • Hughes EG, Fedorkow DM, Daya S, Sagle MA, Van de Koppel P, Collins JA. The routine use of gonadotropin-releasing hormone agonists prior to in vitro fertilization and gamete intrafallopian transfer: a meta-analysis of randomized controlled trials. Fertil Steril 1992;58:888–896.
  • Ubaldi FM, Rienzi L, Ferrero S, Baroni E, Sapienza F, Cobellis L, Greco E. Management of poor responders in IVF. RBM Online 2005;10:235–246.
  • Calderón G, Belil I, Aran B, Veiga A, Gil Y, Boada M, Martínez F, Parera N, Coroleu B, Penella J et al Intracytoplasmatic sperm injection versus convencional IVF: first results. Hum Rep 1995;10:2835–2839.
  • Coroleu B, Carreras O, Veiga A, Martell A, Martínez F, Belil I, Hereter L, Barri PN. Embryo transfer under ultrasound guidance improves pregnancy rates alter in vitro fertilization. Hum Reprod 2000;15:616–620.
  • Verhagen TEM, Hendriks DJ, Bancsi LFJMM, Mol BWJ, Broekmans FJM. The accuracy of multivariate models predicting ovarian reserve and pregnancy after in vitro fertilization: a meta-analysis. Hum Reprod Update 2008;14:95–100.
  • Tarlatzis BC, Zepiridis L, Grimbizis G, Bontis J. Clinical management of low ovarian response to stimulation for IVF: a systematic review. Hum Reprod Update 2003;9:61–76.
  • Berkkanoglu M, Ozgur K. What is the optimum maximal gonadotropin dosage used in microdose flare-up cycles in poor responders? Fertil Steril 14 April 2009 (10.1016/j.fertnstert.2009.03.027).
  • Malmusi S, La Marca A, Giulini S, Xella S, Tagliasacchi D, Marsella T, Volpe A. Comparison of a gonadotropin-releasing hormone (GnRH) antagonist and GnRH agonist flare-up regimen in poor responders undergoing ovarian stimulation. Fertil Steril 2005;84:402–406.
  • Demirol A, Gurgan T. Comparison of microdose flare-up and antagonist multiple-dose protocols for poor-responder patients: a randomized study. Fertil Steril 2009;92:481–485.
  • Akman MA, Erden HF, Tosun SB, Bayazit N, Aksoy E, Bahceci M. Comparison of agonistic flare-up-protocol and antagonistic multiple dose protocol in ovarian stimulation of poor responders: results of a prospective randomized trial. Hum Reprod 2001;16:868–870.
  • Mahutte NG, Arici A. Role of gonadotrophin-realising hormona antagonists in poor responders. Fertil Steril 2007;87:241–249.
  • Franco JG Jr, Baruffi RLR, Mauri AL, Petersen CG, Felipe V, Cornicelli J, Cavagna M, Oliveira JBA. GnRH agonist versus GnRH antagonist in poor ovarian responders: a meta-analysis. RBM Online 2006;13:618–627.
  • Lainas TG, Sfontouris IA, Papanikolau EG, Zorzovilis JZ, Petsas GK, Lainas GT, Alexopoulou E, Kolibianakis EM. Flexible GnRH antagonist versus flare-up GnRH agonist protocol in poor responders treated by IVF: a randomized controlled trial. Hum Reprod 2008;23:1355–1358.
  • De Placido G, Mollo A, Clarizia R, Strina I, Conforti S, Alviggi. Gonadotrophin-realising hormone (GnRH) antagonist plus recombinant luteinizing hormone vs. a standard GnRH agonist short protocol in patients at risk for poor ovarian response. Fertil Steril 2006;85:247–250.
  • Barrenetxea G, Agirregoikoa JA, Jiménez MR, Lopez de Larruzea A, Ganzabal T, Carbonero K. Ovarian response and pregnancy outcome in poor-responder women: a randomized trial on the effect of luteinizing hormone supplementation on in vitro fertilization cycles. Fertil Steril 2008;89:546–553.
  • Cheung LP, Lam PM, Lok IH, Chiu TT, Yeung SY, Tjer CC, Kaines CJ. GnRH antagonist versus long GnRH agonist protocol in poor responders undergoing IVF: a randomized controlled trial. Hum Reprod 2005;20:616–621.
  • Griesinger G, Diedrich K, Tarlatzis BC, Kolibianakis EM. GnRH-antagonists in ovarian stimulation for IVF in patients with poor response to gonadotrophins, polycystic ovary syndrome, and risk of ovarian hyperstimulation: a meta-analysis. Reprod Biomed Online 2006;13:628–638.
  • Kyrou D, Kolibianakis EM, Venetis CA, Papanikolau EG, Bontis J, Tarlatzis BC. How to improve the probability of pregnancy in poor responders undergoing in vitro fertilization: a systematic review and meta-analysis. Fertil Steril 2009;91:749–766.
  • Lisi F, Rinaldi L, Fishel S, Lisi R, Pepe GP, Picconeri MG, Campbell A. Use of recombinant LH in a group of unselected IVF patients. Reprod Biomed Online 2002;5:104–108.
  • De Placido G, Alviggi C, Perino A, Strina I, Lisi F, Fasolino A, De Palo R, Ranieri A, Colacurci N, Mollo A. Recombinant human LH supplementation versus recombinant human FSH (rFSH) step-up protocol during controlled ovarian stimulation in normogonadotrophic women with initial inadequate ovarian response to rFSH. A multicentre, prospective, randomized controlled trial. Hum Rep 2005;20:390–396.
  • Humaidan P, Bungum M, Bungum L, Andersen CY. Effects of recombinant LH supplementation in women undergoing assisted reproduction with GnRH agonist down-regulation and stimulation with recombinant FSH: an opening study. Reprod Biomed Online. 2004;8:635–643.
  • Marrs R, Meldrum D, Muasher S, Schoolcraft W, Werlin L, Nelly E. Randomized trial to compare the effect of recombinant human FSH (follitropin alfa) with or without recombinant LH in women undergoing assisted reproduction treatment. Reprod Biomed Online 2004;8:175–182.
  • Baruffi RLR, Mauri AL, Petersen CG, Felipe V, Martins AMC, Cornicelli J, Cavagna M, Oliveira JB, Franco JG. Recombinant LH supplementation to recombinant FSH during induced ovarian stimulation in the GnRH-antagonist protocol: a meta-analysis. Reprod Biomed Online 2007;14:14–25.
  • Oliveira JB, Mauri AL, Petersen CG, Martins AMC, Carnicelli J, Cavanha M, Pontes A, Baruffi RLR, Franco JG. Recombinant luteinising hormone supplementation to recombinant follicle-stimulation hormone during induced ovarian stimulation in the GnRH-agonist protocol: a meta-analysis. J Assist Reprod Genet 2007;24:67–75.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.