29
Views
18
CrossRef citations to date
0
Altmetric
Original Article

Tibolone and its metabolites: Pharmacology, tissue specificity and effects in animal models of tumors

Pages 63-68 | Published online: 07 Jul 2009

References

  • Tax L., Goorissen E. M., Kicovic P. M. Clinical profile of Org OD 14. Maturitas 1987, Suppl. 1: 3–13
  • Cittadini J., Ben J., Badano A. R. The use of a new steroid (Org OD 14) in the climacteric syndrome. Reproduction 1982; 6: 69–79
  • Kicovic P. M., Cortes-Prieto J., Luisi M. Placebo-controlled cross-over study of effects of Org OD 14 in menopausal women. Reproduction 1982; 6: 81–91
  • Franchimont P., Franchi F., Luisi M. Ovulation-inhibiting properties of Org OD 14. Reproduction 1982; 6: 61–7
  • Lindsay R., Hart D. M., Kraszewski A. Prospective double-blind trial of synthetic steroid (Org OD 14) for preventing postmenopausal osteoporosis. Br. Med. J. 1978; 280: 1207–9
  • Bjarnason N. H., Bjarnason K., Hassager C., Christiansen C. The response in spinal bone mass to tibolone treatment is related to bone turnover in elderly women. Bone 1997; 20: 151–5
  • Nevinny-Stickel J. Double-blind crossover study with Org OD 14 and placebo in postmenopausal patients. Arch. Gynecol. 1983; 234: 27–31
  • Trévoux R., Dieulangard P., Blum A. Efficacy and safety of Org OD 14 in the treatment of climacteric complaints. Maturitas 1983; 5: 89–96
  • Genazzani A. R., Petraglia F., Facchinetti F. Effects of Org OD 14 on pituitary and peripheral beta-endorphin in castrated rats and postmenopausal women. 1994; 35–48, Presented at the 4th International Congress on the Menopause, Orlando, USA. Maturitas, Suppl.
  • Benedek-Jaszmann L. J. Long-term placebo-controlled efficacy and safety study of Org OD 14 in climacteric women. Maturitas 1987, Suppl. 1: 25–33
  • Markiewicz L., Gurpide E. in vitro evaluation of estrogenic, estrogen antagonistic and progestagenic effects of a steroidal drug (Org OD 14) and its metabolites on human endometrium. J. Steroid. Biochem. 1990; 35: 535–41
  • Kloosterboer H. J., Schoonen W. G., Deckers G. H., Klijn J. G. Effects of progestagens and Org OD 14 inin vitro, in vivo tumour models. J. Steroid. Biochem. Mol. Biol. 1994; 49: 311–18
  • Tang B., Markiewicz L., Kloosterboer H. J., Gurpide E. Human endometrial 3 beta-hydroxysteroid dehydrogenase/isomerase can locally reduce intrinsic estrogenic/progestagenic activity ratios of a steroidal drug (Org OD 14). J. Steroid. Biochem. Mol. Biol. 1993; 45: 345–51

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.