176
Views
9
CrossRef citations to date
0
Altmetric
Research Article

Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change

, , , , , & show all
Pages 7-18 | Received 28 Apr 2010, Accepted 18 Aug 2010, Published online: 19 Oct 2010

References

  • Paul BZ, Kim S, Dangelmaier C, Nagaswami C, Jin J, Hartwig JH, Weisel JW, Daniel JL, Kunapuli SP. Dynamic regulation of microtubule coils in ADP-induced platelet shape change by p160ROCK (Rho-kinase). Platelets 2003; 14: 159–169
  • Schwarz UR, Walter U, Eigenthaler M. Taming platelets with cyclic nucleotides. Biochem Pharmacol 2001; 62: 1153–1161
  • Cosentino F, Rubattu S, Savoia C, Venturelli V, Pagannonne E, Volpe M. Endothelial dysfunction and stroke. J Cardiovasc Pharmacol 2001; 38(Suppl 2)S75–78
  • Schafer A, Eigenthaler M, Bauersachs J. Platelet activation in heart failure. Clin Lab 2004; 50: 559–566
  • Olas B, Wachowicz B. Role of reactive nitrogen species in blood platelet function. Platelets 2007; 23: 1–11
  • Pepine CJ. The impact of nitric oxide in cardiovascular medicine: untapped potential utility. Am J Med 2009; 122: S10–15
  • Dangel O, Mergia E, Karlisch K, Groneberg D, Koesling D, Friebe A. NO-sensitive guanylyl cyclase is the only NO receptor mediating platelet inhibition. J Thromb Haemost 2010; 8: 1343–1352
  • Sheth S, Colman R. Platelet cAMP and cGMP phosphodiesterases. Platelets 1995; 6: 61–70
  • Ito M, Nishikawa M, Fujioka M, Miyahara M, Isaka N, Shiku H, Nakano T. Characterization of the isoenzymes of cyclic nucleotide phosphodiesterase in human platelets and the effects of E4021. Cell Signal 1996; 8: 575–581
  • Jensen BO, Selheim F, Doskeland SO, Gear AR, Holmsen H. Protein kinase A mediates inhibition of the thrombin-induced platelet shape change by nitric oxide. Blood 2004; 104: 2775–2782
  • Bearer EL, Prakash JM, Manchester RD, Allen PG. VASP protects actin filaments from gelsolin: An in vitro study with implications for platelet actin reorganizations. Cell Motil Cytoskeleton 2000; 47: 351–364
  • Group ES, Halkes P, van Gijn J, Kappelle L, Koudstaal P, Algra A. Aspirin plus dipyridamole versus aspirin alone after cerebral ischemia of arterial origin (ESPRIT): Randomised controlled trial. Lancet 2006; 20: 1665–1673
  • Jensen BO, Skeidsvoll J, Holmsen H. A polarographic method for measuring dissolved nitric oxide. J Biochem Biophys Methods 1997; 35: 185–195
  • Jensen BO, Holmsen H. Nitric oxide (NO)-platelet interactions: Inhibition is independent of the prostanoid and ADP pathways. Platelets 1995; 6: 83–90
  • Doskeland SO, Haga HJ. Measurement of adenosine 3′:5′-cyclic monophosphate by competitive binding to salt-dissociated protein kinase. Biochem J 1978; 174: 363–372
  • Doskeland SO, Ogreid D. Ammonium sulfate precipitation assay for the study of cyclic nucleotide binding to proteins. Methods Enzymol 1988; 159: 147–150
  • Eigenthaler M, Nolte C, Halbrugge M, Walter U. Concentration and regulation of cyclic nucleotides, cyclic- nucleotide-dependent protein kinases and one of their major substrates in human platelets. Estimating the rate of cAMP- regulated and cGMP-regulated protein phosphorylation in intact cells. Eur J Biochem 1992; 205: 471–481
  • Mo E, Amin H, Bianco IH, Garthwaite J. Kinetics of a cellular nitric oxide/cGMP/phosphodiesterase-5 pathway. JBiolChem 2004; 279: 26149–26158
  • Rybalkin SD, Rybalkina IG, Shimizu-Albergine M, Tang XB, Beavo JA. PDE5 is converted to an activated state upon cGMP binding to the GAF A domain. EMBO J 2003; 22: 469–478
  • Aktas B, Utz A, Hoenig-Liedl P, Walter U, Geiger J. Dipyridamole enhances NO/cGMP-mediated vasodilator-stimulated phosphoprotein phosphorylation and signalling in human platelets: In vitro/ex vivo studies. Stroke 2003; 34: 764–769
  • Thomas M, Francis S, Corbin J. Characterization of a purified bovine lung cGMP-binding cGMP phosphodiesterase. J Biol Chem 1990; 265: 14964–14970
  • Kotera J, Grimes KA, Corbin JD, Francis SH. cGMP-dependent protein kinase protects cGMP from hydrolysis by phosphodiesterase-5. Biochem J 2003; 372: 419–426
  • Antl M, von Bruhl ML, Eiglsperger C, Werner M, Konrad I, Kocher T, Wilm M, Hofmann F, Massberg S, Schlossmann J. IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation. Blood 2007; 109: 552–559
  • Lugnier C, Schoeffter P, Le Bec A, Strouthou E, Stoclet JC. Selective inhibition of cyclic nucleotide phosphodiesterases of human, bovine and rat aorta. Biochem Pharmacol 1986; 35: 1743–1751
  • Dunkern TR, Hatzelmann A. The effect of Sildenafil on human platelet secretory function is controlled by a complex interplay between phosphodiesterases 2, 3 and 5. Cell Signal 2005; 17: 331–339
  • Bult H, Fret HR, Jordaens FH, Herman AG. Dipyridamole Potentiates Platelet Inhibition by Nitric Oxide. Thrombosis Haemostasis 1991; 66: 343–349
  • Wilson LS, Elbatarny HS, Crawley SW, Bennett BM, Maurice DH. Compartmentation and compartment-specific regulation of PDE5 by protein kinase G allows selective cGMP-mediated regulation of platelet functions. Proc Natl Acad Sci U S A 2008; 105: 13650–13655
  • Sabetkar M, Low SY, Bradley NJ, Jacobs M, Naseem KM, Richard Bruckdorfer K. The nitration of platelet vasodilator stimulated phosphoprotein following exposure to low concentrations of hydrogen peroxide. Platelets 2008; 19: 282–292
  • Sabetkar M, Naseem KM, Tullett JM, Friebe A, Koesling D, Bruckdorfer KR. Synergism between nitric oxide and hydrogen peroxide in the inhibition of platelet function: The roles of soluble guanylyl cyclase and vasodilator-stimulated phosphoprotein. Nitric Oxide 2001; 5: 233–242
  • Massberg S, Gruner S, Konrad I, Garcia Arguinzonis MI, Eigenthaler M, Hemler K, Kersting J, Schulz C, Muller I, Besta F, et al. Enhanced in vivo platelet adhesion in vasodilator-stimulated phosphoprotein (VASP)-deficient mice. Blood 2004; 103: 136–142
  • Aszodi A, Pfeifer A, Ahmad M, Glauner M, Zhou XH, Ny L, Andersson KE, Kehrel B, Offermanns S, Fassler R. The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function. EMBO J 1999; 18: 37–48
  • Harbeck B, Huttelmaier S, Schluter K, Jockusch BM, Illenberger S. Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin. J Biol Chem 2000; 275: 30817–30825
  • Lambrechts A, Kwiatkowski AV, Lanier LM, Bear JE, Vandekerckhove J, Ampe C, Gertler FB. cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains. J Biol Chem 2000; 275: 36143–36151
  • Cutler LS, Christian CP, Feinstein MB. Cytochemical localization of adenylate cyclase in the dense tubule system of human blood platelets stimulated by forskolin, prostacyclin and prostaglandin D2. Biochim Biophys Acta 1985; 845: 403–410
  • White JG. Platelet structure. Platelets, AD Michelson. Academic Press, London 2006; 45–73
  • Roberts W, Michno A, Aburima A, Naseem KM. Nitric oxide inhibits von Willebrand factor-mediated platelet adhesion and spreading through regulation of integrin alpha(IIb)beta(3) and myosin light chain. J Thromb Haemost 2009; 7: 2106–2115
  • Maxwell MJ, Westein E, Nesbitt WS, Giuliano S, Dopheide SM, Jackson SP. Identification of a 2-stage platelet aggregation process mediating shear-dependent thrombus formation. Blood 2007; 109: 566–576
  • Pigazzi A, Heydrick S, Folli F, Benoit S, Michelson A, Loscalzo J. Nitric oxide inhibits thrombin receptor-activating peptide-induced phosphoinositide 3-kinase activity in human platelets. J Biol Chem 1999; 274: 14368–14375
  • Plagemann PG. Transport and metabolism of adenosine in human erythrocytes: Effect of transport inhibitors and regulation by phosphate. J Cell Physiol 1986; 128: 491–500
  • Braekkan SK, Mathiesen EB, Njolstad I, Wilsgaard T, Stormer J, Hansen JB. Mean platelet volume is a risk factor for venous thromboembolism: The Tromso Study, Tromso, Norway. J Thromb Haemost 2010; 8: 157–162
  • Nesbitt WS, Westein E, Tovar-Lopez FJ, Tolouei E, Mitchell A, Fu J, Carberry J, Fouras A, Jackson SP. A shear gradient-dependent platelet aggregation mechanism drives thrombus formation. Nat Med 2009; 15: 665–673

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.