Effects of testosterone and 17β-oestradiol on expression of the G protein-coupled receptor P2Y12 in megakaryocytic DAMI cells

References

• Daniel JL, Dangelmaier C, Jin J, Ashby B, Smith JB, Kunapuli SP. Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets. J Biol Chem 1998; 273: 2024–2029
   PubMed Web of Science ®Google Scholar
• O’Donnell CJ, Larson MG, Feng D, Sutherland PA, Lindpaintner K, Myers RH, Myers RH, D’Agostino RA, Levy D, Tofler GH. Framingham Heart Study. Genetic and environmental contributions to platelet aggregation: The Framingham heart study. Circulation 2001; 103: 3051–3056
   PubMed Web of Science ®Google Scholar
• Rudez G, Bouman HJ, van Werkum JW, Leebeek FW, Kruit A, Ruven HJ, ten Berg JM, de Maat MP, Hackeng CM. Common variation in the platelet receptor P2RY12 gene is associated with residual on-clopidogrel platelet reactivity in patients undergoing elective percutaneous coronary interventions. Circ Cardiovasc Genet 2009; 2: 515–521
   PubMedGoogle Scholar
• Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, Ramírez C, Cavallari U, Trabetti E, Sabaté M, Jimenez-Quevedo P, Hernández R, Moreno R, et al. Lack of association between the P2Y12 receptor gene polymorphism and platelet response to clopidogrel in patients with coronary artery disease. Thromb Res 2005; 116: 491–497
   PubMed Web of Science ®Google Scholar
• Haque SF, Matsubayashi H, Izumi S, Sugi T, Arai T, Kondo A, Makino T. Sex difference in platelet aggregation detected by new aggregometry using light scattering. Endocr J 2001; 48: 33–41
   PubMed Web of Science ®Google Scholar
• Kelton JG, Carter CJ, Santos A, Hirsh J. Sex related differences in platelet function: The effect of aspirin. Blood 1982; 59: 625–627
   PubMed Web of Science ®Google Scholar
• Colditz GA, Willett WC, Stampfer MJ, Rosner B, Speizer FE, Hennekens CH. Menopause and the risk of coronary heart disease in women. N Engl J Med 1987; 316: 1105–1110
   PubMed Web of Science ®Google Scholar
• Walsh BW, Schiff I, Rosner B, Ravnikar V, Sacks FM. Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins. N Engl J Med 1991; 325: 1196–1204
   PubMed Web of Science ®Google Scholar
• Sullivan JM, Fowlkes LP. Estrogens, menopause, and coronary artery disease. Cardiol Clin 1996; 14: 105–116
   PubMedGoogle Scholar
• Daly E, Vessey MP, Hawkins MM, Carson JL, Gough P, Marsh S. Risk of venous thromboembolism in users of hormone replacement therapy. Lancet 1996; 348: 977–980
   PubMed Web of Science ®Google Scholar
• Harman SM, Vittinghoff E, Brinton EA, Budoff MJ, Cedars MI, Lobo RA, Merriam GR, Miller VM, Naftolin F, Pal L, et al. Timing and duration of menopausal hormone treatment may affect cardiovascular outcomes. Am J Med 2011; 124: 199–205
   PubMed Web of Science ®Google Scholar
• Johnson M, Ramey E, Ramwell PW. Sex and age differences in human platelet aggregation. Nature 1975; 253: 355–357
   PubMed Web of Science ®Google Scholar
• Johnson M, Ramey E, Ramwell PW. Androgen-mediated sensitivity in platelet aggregation. Am J Physiol 1977; 232: 381–385
   PubMed Web of Science ®Google Scholar
• Price MJ. Bedside evaluation of thienopyridine antiplatelet therapy. Circulation 2009; 119: 2625–2632
   PubMed Web of Science ®Google Scholar
• Marcucci R, Gori AM, Paniccia R, Giusti B, Valente S, Giglioli C, Buonamici P, Antoniucci D, Abbate R, Gensini GF. Cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting are predicted by residual platelet reactivity to ADP detected by a point-of-care assay: A 12–month follow-up. Circulation 2009; 119: 237–242
   PubMed Web of Science ®Google Scholar
• Faraday N, Goldschmidt-Clermont PJ, Bray PF. Gender differences in platelet GPIIb-IIIa activation. Thromb Haemost 1997; 77: 748–754
   PubMed Web of Science ®Google Scholar
• Jones SB, Bylund DB, Rieser CA, Shekim WO, Byer JA, Carr GW. Alpha 2-Adrenergic receptor binding in human platelets: Alterations during the menstrual cycle. Clin Pharmacol Ther 1983; 34: 90–96
   PubMed Web of Science ®Google Scholar
• Brogren H, Karlsson L, Andersson M, Wang L, Erlinge D, Jern S. Platelets synthesize large amounts of active plasminogen activator inhibitor 1. Blood 2004; 104: 3943–3948
   PubMed Web of Science ®Google Scholar
• Lev PR, Goette NP, Glembotsky AC, Laguens RP, Meckert PMC, Salim JP, Heller PG, Pozner RG, Marta RF, Molinas FC. Production of functional platelet-like particles by the megakaryoblastic DAMI cell line provides a model for platelet biogenesis. Platelets 2011; 22: 28–38
   PubMed Web of Science ®Google Scholar
• Greenberg SM, Rosenthal DS, Greeley TA, Tantravahi R, Handin RI. Characterization of a new megakaryocytic cell line: The Dami cell. Blood 1988; 72: 1968–1977
   PubMed Web of Science ®Google Scholar
• Khetawat G, Faraday N, Nealen ML, Vijayan KV, Bolton E, Noga SJ, Bray PF. Human megakaryocytes and platelets contain the estrogen receptor beta and androgen receptor (AR): Testosterone regulates AR expression. Blood 2000; 95: 2289–2296
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402–408
   PubMed Web of Science ®Google Scholar
• Harfenist EJ, Packham MA, Kinlough-Rathbone RL, Cattaneo M, Mustard JF. Effect of calcium ion concentration on the ability of fibrinogen and von Willebrand factor to support the ADP-induced aggregation of human platelets. Blood 1987; 70: 827–831
   PubMed Web of Science ®Google Scholar
• Tolhurst G, Vial C, Léon C, Gachet C, Evans RJ, Mahaut-Smith MP. Interplay between P2Y(1), P2Y(12), and P2X(1) receptors in the activation of megakaryocyte cation influx currents by ADP: Evidence that the primary megakaryocyte represents a fully functional model of platelet P2 receptor signaling. Blood 2005; 106: 1644–1651
   PubMed Web of Science ®Google Scholar
• Lee SJ, Jung IS, Jung EJ, Choi JY, Yeo CW, Cho DY, Kim YW, Lee SS, Shin JG. Identification of P2Y12 single-nucleotide polymorphisms and their influences on the variation in ADP-induced platelet aggregation. Thromb Res 2011; 127: 220–227
   PubMed Web of Science ®Google Scholar
• Rudez G, Pons D, Leebeek F, Monraats P, Schrevel M, Zwinderman A, de Winter R, Tio R, Doevendans P, Jukema W, et al. Platelet receptor P2RY12 haplotypes predict restenosis after percutaneous coronary interventions. Hum Mutat 2008; 29: 375–380
   PubMed Web of Science ®Google Scholar
• Wang L, Erling P, Bengtsson AA, Truedsson L, Sturfelt G, Erlinge D. Transcriptional down-regulation of the platelet ADP receptor P2Y(12) and clusterin in patients with systemic lupus erythematosus. J Thromb Haemost 2004; 2: 1436–1442
   PubMed Web of Science ®Google Scholar
• Fox SW, Chambers TJ. The effect of oestrogen on megakaryocyte differentiation and platelet counts in vivo. Int J Cardiol 2006; 109: 359–366
   PubMed Web of Science ®Google Scholar
• Pilo R, Aharony D, Raz A. Testosterone potentiation of ionophore and ADP induced platelet aggregation: Relationship to arachidonic acid metabolism. Thromb Haemost 1981; 46: 538–542
   PubMed Web of Science ®Google Scholar
• Ajayi AA, Mathur R, Halushka PV. Testosterone increases human platelet thromboxane A2 receptor density and aggregation responses. Circulation 1995; 91: 2742–2747
   PubMed Web of Science ®Google Scholar
• Li Z, Ajdic J, Eigenthaler M, Du X. A predominant role for cAMP-dependent protein kinase in the cGMP-induced phosphorylation of vasodilator-stimulated phosphoprotein and platelet inhibition in humans. Blood 2003; 101: 4423–4429
   PubMed Web of Science ®Google Scholar
• Capodanno D, Angiolillo DJ. Impact of race and gender on antithrombotic therapy. Thromb Haemost 2010; 104: 471–484
   PubMed Web of Science ®Google Scholar
• Gordon T, Kannel WB, Hjortland MC, McNamara PM. Menopause and coronary heart disease. The Framingham Study. Ann Intern Med 1978; 89: 157–161
   PubMed Web of Science ®Google Scholar
• Rosenberg L, Hennekens CH, Rosner B. Early menopause and the risk of myocardial infarction. Am J Obstet Gynecol 1981; 139: 47–51
   PubMed Web of Science ®Google Scholar
• Manson JE, Hsia J, Johnson KC, Rossouw JE, Assaf AR, Lasser NL, Trevisan M, Black HR, Heckbert SR, Detrano R, et al. Women's Health Initiative Investigators. Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med 2003; 349: 523–534
   PubMed Web of Science ®Google Scholar
• Frederiksen H, Ravenholt RT. Thromboembolism, oral contraceptives, and cigarettes. Public Health Rep 1970; 85: 197–205
   PubMedGoogle Scholar
• Mikkola T, Turunen P, Avela K, Orpana A, Viinikka L, Ylikorkala O. 17beta-estradiol stimulates prostacyclin, but not endothelin-1, production in human vascular endothelial cells. J Clin Endocrinol Metab 1995; 80: 1832–1836
   PubMed Web of Science ®Google Scholar
• Caulin-Glaser T, García-Cardeña G, Sarrel P, Sessa WC, Bender JR. 17 beta-estradiol regulation of human endothelial cell basal nitric oxide release, independent of cytosolic Ca2+ mobilization. Circ Res 1997; 81: 885–892
   PubMed Web of Science ®Google Scholar
• Lawrence JB, Leifer DW, Moura GL, Southern P, Emery JD, Bodenheimer SL, Kramer WS. Sex differences in platelet adherence to subendothelium: Relationship to platelet function tests and hematologic variables. Am J Med Sci 1995; 309: 201–207
   PubMed Web of Science ®Google Scholar
• Pinto S, Coppo M, Paniccia R, Prisco D, Gori AM, Attanasio M, Abbate R. Sex related differences in platelet TxA2 generation. Prostaglandins Leukot Essent Fatty Acids 1990; 40: 217–221
   PubMed Web of Science ®Google Scholar